CCDC47 Gene
protein-coding GIFtS: 44
GCID: GC17M061822
|
|
coiled-coil domain containing 47
| |
Aliases
for CCDC47 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 471 2 | | GK0011 | | MSTP0412 | | Coiled-Coil Domain-Containing Protein 472 |
Export aliases for CCDC47 gene to outside databasesPrevious GC identifers: GC17M059177 GC17M057190 |
Summaries
for CCDC47 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CCDC47 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC47 gene promoter:
TBP GR Elk-1 AML1a POU3F1 GR-beta AREB6 GR-alpha LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC47
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC47 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q23.3 Ensembl cytogenetic band: 17q23.3 HGNC cytogenetic band: 17q23.3CCDC47 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M061822: view genomic region
(about GC identifiers)
Start:
|
61,822,610 bp from pter |
End:
|
61,853,711 bp from pter |
Size:
|
31,102 bases |
Orientation:
|
minus strand |
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Proteins
for CCDC47 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCD47_HUMAN, Q96A33 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 47 precursor Size: 483 amino acids; 55874 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAG39292.1; Type=Frameshift; Positions=306;
Secondary accessions: B2RAS8 D3DU20 Q96D00 Q96JZ7 Q9H3E4 Q9NRG3Alternative splicing: 2 isoforms: Q96A33-1 Q96A33-2 Explore the universe of human proteins at neXtProt for CCDC47: NX_Q96A33
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96A33
CCDC47 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_064583.2
ENSEMBL proteins: ENSP00000225726 ENSP00000384888 ENSP00000463577 ENSP00000462202
Human Recombinant Protein Products for CCDC47:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CCDC47 for ontologies About GeneDecksing
CCDC47 Antibody Products:
Assay Products for CCDC47: |
Protein
Domains /
Families
for CCDC47 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCDC47 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96A33ProtoNet protein and cluster: Q96A33 1 Blocks protein family: IPB012879 Protein of unknown function DUF1682
|
Function
for CCDC47 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- | | GO:0005515 | protein binding |
IPI | -- |
CCDC47 for ontologies About GeneDecksing
Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ccdc47):
CCDC47 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Ccdc47tm1Hta for CCDC47
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC47 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC47
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCDC47 (NM_020198) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC47 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC47 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC47 |
|
Pathways & Interactions
for CCDC47 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC47
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/29 Interacting proteins for CCDC47 (Q96A331, 2, 3 ENSP000002257264) via UniProtKB, MINT, STRING, and/or I2D (see all 29)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| TOM1L1 | O756742, 3, ENSP000004089584 | MINT-65105 I2D:
score=5 STRING: ENSP00000408958 | | IRF7 | Q929851, 3, ENSP000003294114 | EBI-720151,EBI-2339383 I2D:
score=1 STRING: ENSP00000329411 | | TIRAP | P587531, 3, ENSP000003764454 | EBI-720151,EBI-528644 I2D:
score=1 STRING: ENSP00000376445 | | TMEM173 | Q86WV61, 3, ENSP000003312884 | EBI-720151,EBI-2800345 I2D:
score=1 STRING: ENSP00000331288 | | PHLDA3 | Q9Y5J53, ENSP000003562784 | I2D:
score=2 STRING: ENSP00000356278 |
About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
CCDC47 for ontologies About GeneDecksing
|
Drugs & Compounds
for CCDC47 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC47
Search CenterWatch for drugs/clinical trials and news about CCDC47 / CCD47
|
Transcripts
for CCDC47 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC47 gene: NM_020198.2 Unigene Cluster for CCDC47: Coiled-coil domain containing 47 Hs.202011 [show with all ESTs]Unigene Representative Sequence: NM_0201986 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000225726(uc002jbs.4 uc010ddx.3) ENST00000403162 ENST00000582252(uc002jbt.2)
ENST00000582331 ENST00000584112 ENST00000580986
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC47 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC47
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC47 (NM_020198) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC47 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC47 |
Additional cDNA sequence: AF113221.1 AF226054.1 AK027786.1 AK027844.1 AK075387.1 AK225813.1 AK314328.1 BC001300.1 BC008905.2 BC013600.2 22 DOTS entries: DT.100652059 DT.99951868 DT.456416 DT.95245016 DT.100652058 DT.91941760 DT.92436934 DT.100652055 DT.100652056 DT.95217253 DT.92069117 DT.121007597 DT.100643301 DT.95330272 DT.121007426 DT.121007122 DT.121007296 DT.121007414 DT.120705145 DT.121007117 DT.121007263 DT.86996156 11 AceView cDNA sequences: BC001300 AK027844 BC008905 AK027786 AK075387 BC013600 AF226054 AX810707 NM_020198 AF113221 AX810724
GeneLoc Exon Structure
|
Expression
for CCDC47 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC47 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGCTAATT
About this image
See CCDC47 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC47
SOURCE GeneReport for Unigene cluster: Hs.202011
SABiosciences Custom PCR Arrays for CCDC47
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC47
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC47 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC47 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC47 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC47 |
Orthologs
for CCDC47 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CCDC47 gene from 9/28 species (see all 28) About this table
ENSEMBL Gene Tree for CCDC47 (if available)
TreeFam Gene Tree for CCDC47 (if available) |
Paralogs
for CCDC47 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCDC47 gene
- ENSG000001256952
CCDC47 for paralogs About GeneDecksing
|
Genomic Variants
for CCDC47 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC47 (61822610 - 61853711 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CCDC47
1 Indel: 45568 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC47 |
|
Disorders
/ Diseases
for CCDC47 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CCDC47 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC47 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with CCDC47) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Membrane-associated ubiquitin ligase complex containi ng gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-c oenzyme A reductase. (PubMed id 21343306)1 Jo Y....DeBose-Boyd R.A. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for CCDC47 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC47 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC47 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC47 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC47 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC47 gene:
Search GeneIP for patents involving CCDC47
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC47 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CCDC47 | | OriGene shRNA RFP for CCDC47 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC47 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC47 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC47 | | OriGene 3'-UTR Clone for CCDC47 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC47 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC47 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CCDC47 | | OriGene Custom Protein Services for CCDC47 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC47 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC47 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC47 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC47 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC47 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC47 |
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 |  |  |  | |
| | | | Search Tocris compounds for CCDC47 |
| |  |  |  |  | | | | |
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 | | | CCDC47 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC47 |
|  |  |  |  | | | | ThermoFisher Antibodies for CCDC47 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC47 |
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