CCDC43 Gene
protein-coding GIFtS: 40
GCID: GC17M042754
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Coiled-Coil Domain Containing 43
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Aliases
for CCDC43 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 431 2 | | Coiled-Coil Domain-Containing Protein 432 |
Export aliases for CCDC43 gene to outside databasesPrevious GC identifers: GC17M040112 GC17M038519 |
Summaries
for CCDC43 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for CCDC43 Gene: 
CCDC43 (coiled-coil domain containing 43) is a protein-coding gene.
|
Genomic Views
for CCDC43 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NT_010783.15 NC_018928.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC43 gene promoter:
HOXA9B HOXA9 p300 HSF1 (long) E47 Meis-1b FOXL1 HSF1short TGIF Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC43
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC43 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31CCDC43 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M042754: view genomic region
(about GC identifiers)
Start:
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42,750,437 bp from pter |
End:
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42,767,165 bp from pter |
Size:
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16,729 bases |
Orientation:
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minus strand |
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Proteins
for CCDC43 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
|
UniProtKB/Swiss-Prot: CCD43_HUMAN, Q96MW1 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 43 Size: 224 amino acids; 25248 Da
Secondary accessions: C9JVK9Alternative splicing: 2 isoforms: Q96MW1-1 Q96MW1-2 Explore the universe of human proteins at neXtProt for CCDC43: NX_Q96MW1
Explore proteomics data for CCDC43 at MOPED
Post-translational modifications:
View modification sites using PhosphoSitePlusView neXtProt modification sites for NX_Q96MW1
CCDC43 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001092695.1 NP_653210.2
ENSEMBL proteins: ENSP00000468079 ENSP00000400845 ENSP00000323782 ENSP00000467630
Human Recombinant Protein Products for CCDC43:
CCDC43 Antibody Products:
Assay Products for CCDC43: |
Protein
Domains /
Families
for CCDC43 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96MW1 UniProtKB/Swiss-Prot: CCD43_HUMAN, Q96MW1Similarity: Belongs to the CCDC43 family |
Function
for CCDC43 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for CCDC43 | |  | Search LifeMap BioReagents cell lines for CCDC43 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC43 |
Pathways & Interactions
for CCDC43 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC43
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for CCDC43 (Q96MW13 ENSP000003237824) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for CCDC43 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC43 (CCD43)
Search CenterWatch for drugs/clinical trials and news about CCDC43 / CCD43
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Transcripts
for CCDC43 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC43 gene (2 alternative transcripts): NM_001099225.1 NM_144609.2 Unigene Cluster for CCDC43: Coiled-coil domain containing 43 Hs.579115 [show with all ESTs]Unigene Representative Sequence: NM_1446095 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000588687 ENST00000457422(uc010czw.1) ENST00000315286(uc021tye.1 uc002ihc.2)
ENST00000588210 ENST00000592333
Primer
Products: |  | OriGene qSTAR qPCR primer pairs in human, mouse for CCDC43
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC43 |
Additional mRNA sequence: AK056357.1 AK098464.1 AL833590.1 BC023298.1 BC047776.2 BX648868.1 5 DOTS entries: DT.443157 DT.100813441 DT.426362 DT.99999565 DT.95267955 24/137 AceView cDNA sequences (see all 137): BC023298 BM843452 BE408705 AI073854 BM351826 CF129680 BC047776 AI687141 AW438632 BQ945564 BM677653 AI472155 BF842785 BU679979 BE504863 BQ051161 BM352137 AW074675 CK822286 AW450917 BQ002285 BQ775811 BM474362 NM_144609
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC43 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
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| SP1: | | | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CCDC43
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Expression
for CCDC43 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC43 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTACCTCTTC
About this image
See CCDC43 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC43
SOURCE GeneReport for Unigene cluster: Hs.579115
SABiosciences Custom PCR Arrays for CCDC43
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for CCDC43
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC43 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC43 |
Orthologs
for CCDC43 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CCDC43 gene from 6/15 species (see all 15) About this table
ENSEMBL Gene Tree for CCDC43 (if available)
TreeFam Gene Tree for CCDC43 (if available) |
Paralogs
for CCDC43 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CCDC43 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC43 (42750437 - 42767165 bp)
Structural Variations
Database of Genomic Variants (DGV) 4 variations for CCDC43: About this table
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC43 |
|
Disorders
/ Diseases
for CCDC43 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CCDC43 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC43 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with CCDC43) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A catalogue of putative HIV-1 protease host cell subst rates. (PubMed id 22944692)1 Impens F....Gevaert K. (2012)
- Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
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External Searches for CCDC43 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CCDC43 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC43 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC43 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC43 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CCDC43 gene:
Search GeneIP for patents involving CCDC43
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC43 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC43 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC43 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC43 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC43 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC43 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CCDC43 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC43 |
| |  |  |  | | | | LSBio Antibodies in human, mouse, rat for CCDC43 |
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