Aliases for CCDC43 Gene
External Ids for CCDC43 Gene
- HGNC: 26472
- Entrez Gene: 124808
- Ensembl: ENSG00000180329
- UniProtKB: Q96MW1
Previous GeneCards Identifiers for CCDC43 Gene
- GC17M040112
- GC17M042754
- GC17M038519
Summaries for CCDC43 Gene
GeneCards Summary for CCDC43 Gene
CCDC43 (Coiled-Coil Domain Containing 43) is a Protein Coding gene.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC43 Gene
Genomics for CCDC43 Gene
Regulatory Elements for CCDC43 Gene
Enhancers for CCDC43 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CCDC43 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CCDC43 gene promoter:
Regulatory Element Products
Genomic Location for CCDC43 Gene
- Chromosome:
- 17
- Start:
- 44,673,069 bp from pter
- End:
- 44,689,797 bp from pter
- Size:
- 16,729 bases
- Orientation:
- Minus strand
Genomic View for CCDC43 Gene
Genes around CCDC43 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.31 by Ensembl
- 17q21.31 by Entrez Gene
- 17q21.31 by HGNC
CCDC43 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCDC43 Gene
Proteins for CCDC43 Gene
-
Protein details for CCDC43 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96MW1-CCD43_HUMAN
- Recommended name:
- Coiled-coil domain-containing protein 43
- Protein Accession:
- Q96MW1
- C9JVK9
Protein attributes for CCDC43 Gene
- Size:
- 224 amino acids
- Molecular mass:
- 25248 Da
- Quaternary structure:
- No Data Available
Protein Expression for CCDC43 Gene
Post-translational modifications for CCDC43 Gene
Other Protein References for CCDC43 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CCDC43
- Invitrogen Antibodies for CCDC43
- Search GeneTex for Antibodies for CCDC43
Protein Products
-
OriGene Purified Proteins for CCDC43
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC43
- Origene Custom Protein Services for CCDC43
- ProSpec Recombinant Proteins for CCDC43
- Search GeneTex for Proteins for CCDC43
Assay Products
No data available for DME Specific Peptides for CCDC43 Gene
Domains & Families for CCDC43 Gene
Protein Domains for CCDC43 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for CCDC43 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96MW1- Family:
-
- Belongs to the CCDC43 family.
No data available for Gene Families for CCDC43 Gene
Function for CCDC43 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 21044950 |
Phenotypes for CCDC43 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCDC43
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CCDC43 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC43 gene
- Search ViGene Biosciences for CCDC43
CRISPR Products
-
OriGene CRISPR knockouts for CCDC43
- GenScript: Design CRISPR guide RNA sequences for CCDC43
miRNA for CCDC43 Gene
- miRTarBase miRNAs that target CCDC43
-
- hsa-mir-145-5p (MIRT021517)
- hsa-mir-1914-5p (MIRT035786)
- hsa-mir-877-3p (MIRT036859)
- hsa-mir-26a-5p (MIRT050168)
- hsa-mir-3064-3p (MIRT479878)
- hsa-mir-4709-3p (MIRT479879)
- hsa-mir-122-5p (MIRT479880)
- hsa-mir-4433b-3p (MIRT479881)
- hsa-mir-599 (MIRT526579)
- hsa-mir-629-3p (MIRT526580)
- hsa-mir-3161 (MIRT526581)
- hsa-mir-6867-3p (MIRT526582)
- hsa-mir-4713-5p (MIRT526583)
- hsa-mir-211-5p (MIRT526584)
- hsa-mir-204-5p (MIRT526585)
- hsa-mir-1206 (MIRT526586)
- hsa-mir-4685-3p (MIRT526587)
- hsa-mir-4287 (MIRT526588)
- hsa-mir-7113-3p (MIRT526589)
- hsa-mir-4469 (MIRT526590)
- hsa-mir-6832-3p (MIRT526591)
- hsa-mir-4277 (MIRT526592)
- hsa-mir-4801 (MIRT526593)
- hsa-mir-4731-3p (MIRT526594)
- hsa-mir-148a-5p (MIRT526595)
miRNA Products
- Search ViGene Biosciences for CCDC43
Clone Products
- Sino Biological Human cDNA Clone for CCDC43
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCDC43
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC43
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CCDC43
-
ViGene Biosciences adenoviral particle packaged cDNA for CCDC43 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCDC43 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC43 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC43 Gene
Localization for CCDC43 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| nucleus | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC43 Gene
Pathways & Interactions for CCDC43 Gene
No Data Available
Interacting Proteins for CCDC43 Gene
Selected Interacting proteins:
ENSP00000323782
Q96MW1-CCD43_HUMAN
for CCDC43 Gene via
STRING
UniProtKB
IID
No data available for Pathways by source and SIGNOR curated interactions for CCDC43 Gene
Transcripts for CCDC43 Gene
mRNA/cDNA for CCDC43 Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (137) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CCDC43 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCDC43
- GenScript: Design CRISPR guide RNA sequences for CCDC43
miRNA Products
- Search ViGene Biosciences for CCDC43
Clone Products
- Sino Biological Human cDNA Clone for CCDC43
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCDC43
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC43
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||
| SP2: | - | ||||||||||||||||
| SP3: |
Expression for CCDC43 Gene
mRNA differential expression in normal tissues according to GTEx for CCDC43 Gene
This gene is overexpressed in Muscle - Skeletal (x4.8).
This gene is overexpressed in Bone marrow stromal cell (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC43 Gene
NURSA nuclear receptor signaling pathways regulating expression of CCDC43 Gene:
CCDC43SOURCE GeneReport for Unigene cluster for CCDC43 Gene:
Hs.579115Primer Products
-
OriGene qPCR primer pairs for CCDC43
-
OriGene qPCR primer pairs and template standards for CCDC43
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CCDC43 Gene
Orthologs for CCDC43 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCDC43 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CCDC43 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CCDC43 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ccdc43 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ccdc43 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CCDC43 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CCDC43 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CCDC43 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CCDC43 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ccdc43 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ccdc43 34 35 |
|
||
| -- 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009665 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9586 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3227 35 |
|
OneToOne |
- Species where no ortholog for CCDC43 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CCDC43 Gene
No data available for Paralogs for CCDC43 Gene
Variants for CCDC43 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10680341 | -- | 44,682,413(+) | AAAAA(-/A)GGTTG | intron-variant | |
| rs10684528 | -- | 44,689,934(+) | CGTGC(-/GG)GGTCG | intron-variant, upstream-variant-2KB | |
| rs10707920 | -- | 44,677,186(+) | TAATA(-/G)TAAGG | downstream-variant-500B, upstream-variant-2KB | |
| rs11079295 | -- | 44,682,780(+) | GAACC(C/T)GGGGA | intron-variant | |
| rs112111104 | -- | 44,679,347(+) | AATGA(A/G)ATTTC | intron-variant |
Residual Variation Intolerance Score:
44.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.76;
16.08% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CCDC43 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCDC43
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC43 Gene
Disorders for CCDC43 Gene
Relevant External Links for CCDC43
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CCDC43
No disorders were found for CCDC43 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC43 Gene
Publications for CCDC43 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. (PMID: 24999758) Elzi D.J. … Shiio Y. (J. Proteome Res. 2014) 3 64
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
Products for CCDC43 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CCDC43
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC43
- Origene Custom Protein Services for CCDC43
- Origene mouse_rna, siRNA, rat_shrna, shRNA, and RNAi products in human, mouse, rat for CCDC43
- Browse OriGene Inhibitory RNA Products For CCDC43
- OriGene qPCR primer pairs for CCDC43
- OriGene qPCR primer pairs and template standards for CCDC43
- OriGene CRISPR knockouts for CCDC43
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CCDC43
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for CCDC43
- GenScript Custom Assay Services for CCDC43
- GenScript Custom overexpressing Cell Line Services for CCDC43
- GenScript: Design CRISPR guide RNA sequences for CCDC43
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CCDC43
- Sino Biological Human cDNA Clone for CCDC43
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CCDC43
- Novus Biologicals proteins and lysates for CCDC43
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for CCDC43
- ViGene Biosciences adenoviral particle packaged cDNA for CCDC43 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CCDC43 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CCDC43 gene
- Search ViGene Biosciences for CCDC43
- Horizon Cell Lines for CCDC43
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCDC43
- VectorBuilder custom plasmid, inducible vectors for CCDC43
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC43
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CCDC43 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab