Aliases for CCDC43 Gene
External Ids for CCDC43 Gene
- HGNC: 26472
- Entrez Gene: 124808
- Ensembl: ENSG00000180329
- UniProtKB: Q96MW1
Previous GeneCards Identifiers for CCDC43 Gene
- GC17M040112
- GC17M042754
- GC17M038519
Summaries for CCDC43 Gene
GeneCards Summary for CCDC43 Gene
CCDC43 (Coiled-Coil Domain Containing 43) is a Protein Coding gene.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC43 Gene
Genomics for CCDC43 Gene
Regulatory Elements for CCDC43 Gene
Enhancers for CCDC43 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around CCDC43 on UCSC Golden Path with GeneCards custom track
Promoters for CCDC43 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around CCDC43 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CCDC43 gene promoter:
Regulatory Element Products
Genomic Location for CCDC43 Gene
- Chromosome:
- 17
- Start:
- 44,673,069 bp from pter
- End:
- 44,689,797 bp from pter
- Size:
- 16,729 bases
- Orientation:
- Minus strand
Genomic View for CCDC43 Gene
Genes around CCDC43 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.31 by Ensembl
- 17q21.31 by Entrez Gene
- 17q21.31 by HGNC
CCDC43 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCDC43 Gene
Proteins for CCDC43 Gene
-
Protein details for CCDC43 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96MW1-CCD43_HUMAN
- Recommended name:
- Coiled-coil domain-containing protein 43
- Protein Accession:
- Q96MW1
- C9JVK9
Protein attributes for CCDC43 Gene
- Size:
- 224 amino acids
- Molecular mass:
- 25248 Da
- Quaternary structure:
- No Data Available
Protein Expression for CCDC43 Gene
Post-translational modifications for CCDC43 Gene
Other Protein References for CCDC43 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CCDC43
- Search GeneTex for Antibodies for CCDC43
-
Santa Cruz Biotechnology (SCBT) Antibodies for CCDC43
Protein Products
-
OriGene Purified Proteins for CCDC43
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC43
- Origene Custom Protein Services for CCDC43
- ProSpec Recombinant Proteins for CCDC43
- Search GeneTex for Proteins for CCDC43
Assay Products
No data available for DME Specific Peptides for CCDC43 Gene
Domains & Families for CCDC43 Gene
Protein Domains for CCDC43 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for CCDC43 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96MW1- Family:
-
- Belongs to the CCDC43 family.
No data available for Gene Families for CCDC43 Gene
Function for CCDC43 Gene
Phenotypes for CCDC43 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for CCDC43 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC43 gene
- Search ViGene Biosciences for CCDC43
CRISPR Products
-
OriGene CRISPR knockouts for CCDC43
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC43
- GenScript: Design CRISPR guide RNA sequences for CCDC43
miRNA for CCDC43 Gene
- miRTarBase miRNAs that target CCDC43
-
- hsa-mir-145-5p (MIRT021517)
- hsa-mir-1914-5p (MIRT035786)
- hsa-mir-877-3p (MIRT036859)
- hsa-mir-26a-5p (MIRT050168)
- hsa-mir-3064-3p (MIRT479878)
- hsa-mir-4709-3p (MIRT479879)
- hsa-mir-122-5p (MIRT479880)
- hsa-mir-4433b-3p (MIRT479881)
- hsa-mir-599 (MIRT526579)
- hsa-mir-629-3p (MIRT526580)
- hsa-mir-3161 (MIRT526581)
- hsa-mir-6867-3p (MIRT526582)
- hsa-mir-4713-5p (MIRT526583)
- hsa-mir-211-5p (MIRT526584)
- hsa-mir-204-5p (MIRT526585)
- hsa-mir-1206 (MIRT526586)
- hsa-mir-4685-3p (MIRT526587)
- hsa-mir-4287 (MIRT526588)
- hsa-mir-7113-3p (MIRT526589)
- hsa-mir-4469 (MIRT526590)
- hsa-mir-6832-3p (MIRT526591)
- hsa-mir-4277 (MIRT526592)
- hsa-mir-4801 (MIRT526593)
- hsa-mir-4731-3p (MIRT526594)
- hsa-mir-148a-5p (MIRT526595)
miRNA Products
- Search ViGene Biosciences for CCDC43
Clone Products
- OriGene clones in human for CCDC43
- OriGene ORF clones in human,mouse,rat for CCDC43
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CCDC43 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCDC43 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC43 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC43 Gene
Localization for CCDC43 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| nucleus | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC43 Gene
Pathways & Interactions for CCDC43 Gene
More details on SuperPathways for CCDC43
No Data Available
Interacting Proteins for CCDC43 Gene
Selected Interacting proteins:
ENSP00000323782
Q96MW1-CCD43_HUMAN
for CCDC43 Gene via
STRING
UniProtKB
I2D
No data available for Pathways by source and SIGNOR curated interactions for CCDC43 Gene
Transcripts for CCDC43 Gene
mRNA/cDNA for CCDC43 Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (137) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CCDC43 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCDC43
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC43
- GenScript: Design CRISPR guide RNA sequences for CCDC43
miRNA Products
- Search ViGene Biosciences for CCDC43
Clone Products
- OriGene clones in human for CCDC43
- OriGene ORF clones in human,mouse,rat for CCDC43
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||
| SP2: | - | ||||||||||||||||
| SP3: |
Expression for CCDC43 Gene
mRNA differential expression in normal tissues according to GTEx for CCDC43 Gene
This gene is overexpressed in Muscle - Skeletal (x4.8).
This gene is overexpressed in Bone marrow stromal cell (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CCDC43 Gene
SOURCE GeneReport for Unigene cluster for CCDC43 Gene Hs.579115
Primer Products
-
OriGene qPCR primer pairs for CCDC43
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCDC43 Gene
Orthologs for CCDC43 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | CCDC43 35 |
|
||
| CCDC43 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | CCDC43 35 |
|
||
| CCDC43 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Ccdc43 35 |
|
||
| Ccdc43 16 |
|
||||
| Ccdc43 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | CCDC43 35 |
|
||
| CCDC43 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Ccdc43 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CCDC43 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CCDC43 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CCDC43 35 |
|
||
| CCDC43 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | CCDC43 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ccdc43 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | -- 35 |
|
||
| ccdc43 35 |
|
||||
| ccdc43 36 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009665 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9586 35 |
|
||
| CG9586 36 |
|
OneToOne | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3227 36 |
|
OneToOne |
- Species with no ortholog for CCDC43:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CCDC43 Gene
No data available for Paralogs for CCDC43 Gene
Variants for CCDC43 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs4072728 | -- | 44,690,586(+) | acatg(C/G)tgaaa | upstream-variant-2KB | |
| rs10684528 | -- | 44,689,934(+) | CGTGC(-/GG)GGTCG | upstream-variant-2KB | |
| rs35274624 | -- | 44,691,057(+) | CAAAC(-/AAAC)GAACA | upstream-variant-2KB | |
| rs35949898 | -- | 44,690,758(+) | TAGCC(-/C)GGGCG | upstream-variant-2KB | |
| rs62065980 | -- | 44,690,407(+) | TTTCA(G/T)GCATT | upstream-variant-2KB |
Residual Variation Intolerance Score:
44.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.76;
16.08% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCDC43 Gene
Disorders for CCDC43 Gene
Relevant External Links for CCDC43
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CCDC43
No disorders were found for CCDC43 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC43 Gene
Publications for CCDC43 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. (PMID: 24999758) Elzi D.J. … Shiio Y. (J. Proteome Res. 2014) 3
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
Products for CCDC43 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CCDC43
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC43
- Origene Custom Protein Services for CCDC43
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for CCDC43
- Browse OriGene Inhibitory RNA Products For CCDC43
- OriGene qPCR primer pairs for CCDC43
- OriGene CRISPR knockouts for CCDC43
- OriGene clones in human for CCDC43
- OriGene ORF clones in human,mouse,rat for CCDC43
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for CCDC43
- GenScript Custom Assay Services for CCDC43
- GenScript Custom overexpressing Cell Line Services for CCDC43
- GenScript: Design CRISPR guide RNA sequences for CCDC43
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CCDC43
- Novus Biologicals Antibodies for CCDC43
- Novus Biologicals proteins and lysates for CCDC43
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for CCDC43
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for CCDC43 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CCDC43 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CCDC43 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CCDC43 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CCDC43 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CCDC43 gene
- Search ViGene Biosciences for CCDC43
- Search ViGene Biosciences for CCDC43
- Santa Cruz Biotechnology (SCBT) Antibodies for CCDC43
- Search Santa Cruz Biotechnology (SCBT) for CCDC43 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CCDC43
Sources for CCDC43 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon