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Aliases for CCDC43 Gene

Aliases for CCDC43 Gene

  • Coiled-Coil Domain Containing 43 2 3

External Ids for CCDC43 Gene

Previous GeneCards Identifiers for CCDC43 Gene

  • GC17M040112
  • GC17M042754
  • GC17M038519

Summaries for CCDC43 Gene

GeneCards Summary for CCDC43 Gene

CCDC43 (Coiled-Coil Domain Containing 43) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC43 Gene

Genomics for CCDC43 Gene

Regulatory Elements for CCDC43 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCDC43 Gene

Chromosome:
17
Start:
44,673,069 bp from pter
End:
44,689,797 bp from pter
Size:
16,729 bases
Orientation:
Minus strand

Genomic View for CCDC43 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC43 Gene

Proteins for CCDC43 Gene

  • Protein details for CCDC43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MW1-CCD43_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 43
    Protein Accession:
    Q96MW1
    Secondary Accessions:
    • C9JVK9

    Protein attributes for CCDC43 Gene

    Size:
    224 amino acids
    Molecular mass:
    25248 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC43 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC43 Gene

Proteomics data for CCDC43 Gene at MOPED

Post-translational modifications for CCDC43 Gene

  • Ubiquitination at Lys 162
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC43 Gene

No data available for DME Specific Peptides for CCDC43 Gene

Domains & Families for CCDC43 Gene

Protein Domains for CCDC43 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC43 Gene

Graphical View of Domain Structure for InterPro Entry

Q96MW1

UniProtKB/Swiss-Prot:

CCD43_HUMAN :
  • Belongs to the CCDC43 family.
Family:
  • Belongs to the CCDC43 family.
genes like me logo Genes that share domains with CCDC43: view

No data available for Gene Families for CCDC43 Gene

Function for CCDC43 Gene

Gene Ontology (GO) - Molecular Function for CCDC43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC43: view

Phenotypes for CCDC43 Gene

genes like me logo Genes that share phenotypes with CCDC43: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC43

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC43 Gene

Localization for CCDC43 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC43 Gene COMPARTMENTS Subcellular localization image for CCDC43 gene
Compartment Confidence
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC43 Gene

Pathways & Interactions for CCDC43 Gene

SuperPathways for CCDC43 Gene

No Data Available

Interacting Proteins for CCDC43 Gene

Gene Ontology (GO) - Biological Process for CCDC43 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC43 Gene

Drugs & Compounds for CCDC43 Gene

No Compound Related Data Available

Transcripts for CCDC43 Gene

Unigene Clusters for CCDC43 Gene

Coiled-coil domain containing 43:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC43

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC43 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3:

Relevant External Links for CCDC43 Gene

GeneLoc Exon Structure for
CCDC43
ECgene alternative splicing isoforms for
CCDC43

Expression for CCDC43 Gene

mRNA expression in normal human tissues for CCDC43 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC43 Gene

This gene is overexpressed in Muscle - Skeletal (x4.8).

Protein differential expression in normal tissues from HIPED for CCDC43 Gene

This gene is overexpressed in Bone marrow stromal cell (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC43 Gene



SOURCE GeneReport for Unigene cluster for CCDC43 Gene Hs.579115

genes like me logo Genes that share expression patterns with CCDC43: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCDC43 Gene

Orthologs for CCDC43 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC43 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC43 35
  • 92.42 (n)
  • 96.68 (a)
CCDC43 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC43 35
  • 92.11 (n)
  • 95.98 (a)
CCDC43 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc43 35
  • 85.74 (n)
  • 89.19 (a)
Ccdc43 16
Ccdc43 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC43 35
  • 99.7 (n)
  • 99.11 (a)
CCDC43 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc43 35
  • 86.19 (n)
  • 90.99 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC43 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC43 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC43 35
  • 73.77 (n)
  • 73.15 (a)
CCDC43 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC43 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc43 35
  • 68.87 (n)
  • 66.04 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ccdc43 35
  • 68.41 (n)
  • 64.29 (a)
ccdc43 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009665 35
  • 48.87 (n)
  • 42.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9586 35
  • 43.76 (n)
  • 36.41 (a)
CG9586 36
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3227 36
  • 28 (a)
OneToOne
Species with no ortholog for CCDC43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC43 Gene

ENSEMBL:
Gene Tree for CCDC43 (if available)
TreeFam:
Gene Tree for CCDC43 (if available)

Paralogs for CCDC43 Gene

No data available for Paralogs for CCDC43 Gene

Variants for CCDC43 Gene

Sequence variations from dbSNP and Humsavar for CCDC43 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs4072728 -- 44,690,586(+) acatg(C/G)tgaaa upstream-variant-2KB
rs10684528 -- 44,689,934(+) CGTGC(-/GG)GGTCG upstream-variant-2KB
rs35274624 -- 44,691,057(+) CAAAC(-/AAAC)GAACA upstream-variant-2KB
rs35949898 -- 44,690,758(+) TAGCC(-/C)GGGCG upstream-variant-2KB
rs62065980 -- 44,690,407(+) TTTCA(G/T)GCATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC43 Gene

Variant ID Type Subtype PubMed ID
nsv908286 CNV Loss 21882294
nsv833456 CNV Gain+Loss 17160897
nsv908287 CNV Loss 21882294
nsv112452 CNV Loss 16902084

Variation tolerance for CCDC43 Gene

Residual Variation Intolerance Score: 44.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC43 Gene

HapMap Linkage Disequilibrium report
CCDC43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC43 Gene

Disorders for CCDC43 Gene

Relevant External Links for CCDC43

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC43
genes like me logo Genes that share disorders with CCDC43: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC43 Gene

Publications for CCDC43 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 67
  5. A catalogue of putative HIV-1 protease host cell substrates. (PMID: 22944692) Impens F. … Gevaert K. (Biol. Chem. 2012) 67

Products for CCDC43 Gene

Sources for CCDC43 Gene

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