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Aliases for CCDC42 Gene

Aliases for CCDC42 Gene

  • Coiled-Coil Domain Containing 42 2 3 5
  • CCDC42A 3 4

External Ids for CCDC42 Gene

Previous GeneCards Identifiers for CCDC42 Gene

  • GC17M008575

Summaries for CCDC42 Gene

GeneCards Summary for CCDC42 Gene

CCDC42 (Coiled-Coil Domain Containing 42) is a Protein Coding gene. An important paralog of this gene is CFAP73.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC42 Gene

Genomics for CCDC42 Gene

Regulatory Elements for CCDC42 Gene

Enhancers for CCDC42 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC42 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC42 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC42 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC42 Gene

Chromosome:
17
Start:
8,729,928 bp from pter
End:
8,745,219 bp from pter
Size:
15,292 bases
Orientation:
Minus strand

Genomic View for CCDC42 Gene

Genes around CCDC42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC42 Gene

Proteins for CCDC42 Gene

  • Protein details for CCDC42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M95-CCD42_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 42A
    Protein Accession:
    Q96M95
    Secondary Accessions:
    • Q8N6Q0

    Protein attributes for CCDC42 Gene

    Size:
    316 amino acids
    Molecular mass:
    38019 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC42 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC42 Gene

Proteomics data for CCDC42 Gene at MOPED

Post-translational modifications for CCDC42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC42 Gene

No data available for DME Specific Peptides for CCDC42 Gene

Domains & Families for CCDC42 Gene

Protein Domains for CCDC42 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96M95

UniProtKB/Swiss-Prot:

CCD42_HUMAN :
  • Belongs to the CCDC42 family.
Family:
  • Belongs to the CCDC42 family.
genes like me logo Genes that share domains with CCDC42: view

No data available for Gene Families for CCDC42 Gene

Function for CCDC42 Gene

Phenotypes for CCDC42 Gene

genes like me logo Genes that share phenotypes with CCDC42: view

Animal Model Products

miRNA for CCDC42 Gene

miRTarBase miRNAs that target CCDC42

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC42 Gene

Localization for CCDC42 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC42 Gene COMPARTMENTS Subcellular localization image for CCDC42 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC42 Gene

Pathways & Interactions for CCDC42 Gene

SuperPathways for CCDC42 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC42 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC42 Gene

Drugs & Compounds for CCDC42 Gene

No Compound Related Data Available

Transcripts for CCDC42 Gene

mRNA/cDNA for CCDC42 Gene

Unigene Clusters for CCDC42 Gene

Coiled-coil domain containing 42:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC42 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: -

Relevant External Links for CCDC42 Gene

GeneLoc Exon Structure for
CCDC42
ECgene alternative splicing isoforms for
CCDC42

Expression for CCDC42 Gene

mRNA expression in normal human tissues for CCDC42 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC42 Gene

This gene is overexpressed in Testis (x50.1).

Protein differential expression in normal tissues from HIPED for CCDC42 Gene

This gene is overexpressed in Cerebrospinal fluid (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC42 Gene



SOURCE GeneReport for Unigene cluster for CCDC42 Gene Hs.121438

genes like me logo Genes that share expression patterns with CCDC42: view

Protein tissue co-expression partners for CCDC42 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CCDC42 Gene

Orthologs for CCDC42 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC42 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC42 35
  • 88.08 (n)
  • 86.39 (a)
CCDC42 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC42 35
  • 86.6 (n)
  • 85.76 (a)
CCDC42 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc42 35
  • 84.92 (n)
  • 86.39 (a)
Ccdc42 16
Ccdc42 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC42 35
  • 99.58 (n)
  • 99.37 (a)
CCDC42 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc42 35
  • 84.07 (n)
  • 85.44 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC42 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC42 35
  • 62.87 (n)
  • 49.51 (a)
CCDC42 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC42 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145050 35
  • 52.93 (n)
  • 41.22 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100001777 35
  • 50.59 (n)
  • 33.17 (a)
ccdc42b 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4208 36
  • 46 (a)
OneToMany
Species with no ortholog for CCDC42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC42 Gene

ENSEMBL:
Gene Tree for CCDC42 (if available)
TreeFam:
Gene Tree for CCDC42 (if available)

Paralogs for CCDC42 Gene

Paralogs for CCDC42 Gene

(1) SIMAP similar genes for CCDC42 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCDC42: view

Variants for CCDC42 Gene

Sequence variations from dbSNP and Humsavar for CCDC42 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2288156 - 8,741,536(-) TGAGC(A/G)CCAAG reference, missense
VAR_057786 -
VAR_057787 -
rs169070 -- 8,731,183(-) cattA(A/G)AACTG intron-variant
rs431445 -- 8,740,592(-) TCCTT(C/T)TCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC42 Gene

Variant ID Type Subtype PubMed ID
nsv518675 CNV Gain 19592680
nsv907667 CNV Gain 21882294
nsv907668 CNV Loss 21882294

Variation tolerance for CCDC42 Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.82; 73.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCDC42 Gene

Disorders for CCDC42 Gene

Relevant External Links for CCDC42

Genetic Association Database (GAD)
CCDC42
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC42

No disorders were found for CCDC42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC42 Gene

Publications for CCDC42 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. (PMID: 24657165) Kim H. … D'Andrea A.D. (Mol. Cell 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for CCDC42 Gene

Sources for CCDC42 Gene

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