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Aliases for CCDC42 Gene

Aliases for CCDC42 Gene

  • Coiled-Coil Domain Containing 42 2 3 5
  • CCDC42A 3 4
  • Coiled-Coil Domain-Containing Protein 42A 3
  • Coiled-Coil Domain-Containing Protein 42 3

External Ids for CCDC42 Gene

Previous GeneCards Identifiers for CCDC42 Gene

  • GC17M008575

Summaries for CCDC42 Gene

GeneCards Summary for CCDC42 Gene

CCDC42 (Coiled-Coil Domain Containing 42) is a Protein Coding gene. An important paralog of this gene is CFAP73.

UniProtKB/Swiss-Prot for CCDC42 Gene

  • Required for sperm development.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC42 Gene

Genomics for CCDC42 Gene

Regulatory Elements for CCDC42 Gene

Enhancers for CCDC42 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G008364 1.2 FANTOM5 Ensembl ENCODE 53.6 +379.2 379243 2.4 STAT1 JUN ATF2 POLR2A SMARCA4 ZNF366 ZNF600 RBFOX2 ODF4 CCDC42 SPDYE4 ENSG00000265749 ENSG00000212206 ENSG00000226871 RNF222 NDEL1 MFSD6L CNTROB
GH17G008744 1.3 FANTOM5 ENCODE 34.2 -0.4 -377 1.9 HDGF ARID4B SIN3A DMAP1 ZNF48 GLIS2 ZNF143 FOS SP3 MXD4 CCDC42 SPDYE4 ODF4 MFSD6L
GH17G008723 0.9 ENCODE 24.3 +20.5 20531 2.2 HDAC1 PKNOX1 ARNT TCF12 GATA2 CEBPB KAT8 NFIC KLF16 SMARCA4 CCDC42 MYH10 SPDYE4 RNF222 BORCS6 PIR61588 LOC105371529
GH17G008695 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +47.5 47535 3.6 CTCF RBBP5 ZNF2 RAD21 ETS1 ZFHX2 EGR1 EZH2 EGR2 L3MBTL2 MYH10 CCDC42 SPDYE4 LOC105371526 LOC105371525
GH17G008706 1.3 Ensembl ENCODE dbSUPER 10 +37.1 37050 2.6 TFAP4 FOXA2 IRF2 ZNF140 CEBPG RAD21 THRB RARA TEAD3 CTBP1 SPDYE4 CCDC42 LOC105371526 LOC105371525
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC42 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC42 Gene

Chromosome:
17
Start:
8,729,928 bp from pter
End:
8,745,219 bp from pter
Size:
15,292 bases
Orientation:
Minus strand

Genomic View for CCDC42 Gene

Genes around CCDC42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC42 Gene

Proteins for CCDC42 Gene

  • Protein details for CCDC42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M95-CCD42_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 42
    Protein Accession:
    Q96M95
    Secondary Accessions:
    • Q8N6Q0

    Protein attributes for CCDC42 Gene

    Size:
    316 amino acids
    Molecular mass:
    38019 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC42 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC42 Gene

Post-translational modifications for CCDC42 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC42 Gene

No data available for DME Specific Peptides for CCDC42 Gene

Domains & Families for CCDC42 Gene

Protein Domains for CCDC42 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96M95

UniProtKB/Swiss-Prot:

CCD42_HUMAN :
  • Belongs to the CFAP73 family.
Family:
  • Belongs to the CFAP73 family.
genes like me logo Genes that share domains with CCDC42: view

No data available for Gene Families for CCDC42 Gene

Function for CCDC42 Gene

Molecular function for CCDC42 Gene

UniProtKB/Swiss-Prot Function:
Required for sperm development.

Gene Ontology (GO) - Molecular Function for CCDC42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC42: view
genes like me logo Genes that share phenotypes with CCDC42: view

Animal Models for CCDC42 Gene

MGI Knock Outs for CCDC42:

Animal Model Products

CRISPR Products

miRNA for CCDC42 Gene

miRTarBase miRNAs that target CCDC42

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC42 Gene

Localization for CCDC42 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC42 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC42 Gene

Pathways & Interactions for CCDC42 Gene

SuperPathways for CCDC42 Gene

No Data Available

Interacting Proteins for CCDC42 Gene

Gene Ontology (GO) - Biological Process for CCDC42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development ISS --
genes like me logo Genes that share ontologies with CCDC42: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC42 Gene

Drugs & Compounds for CCDC42 Gene

No Compound Related Data Available

Transcripts for CCDC42 Gene

mRNA/cDNA for CCDC42 Gene

Unigene Clusters for CCDC42 Gene

Coiled-coil domain containing 42:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC42 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: -

Relevant External Links for CCDC42 Gene

GeneLoc Exon Structure for
CCDC42
ECgene alternative splicing isoforms for
CCDC42

Expression for CCDC42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC42 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC42 Gene

This gene is overexpressed in Testis (x50.1).

Protein differential expression in normal tissues from HIPED for CCDC42 Gene

This gene is overexpressed in Cerebrospinal fluid (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC42 Gene



Protein tissue co-expression partners for CCDC42 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC42 Gene:

CCDC42

SOURCE GeneReport for Unigene cluster for CCDC42 Gene:

Hs.121438

Evidence on tissue expression from TISSUES for CCDC42 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with CCDC42: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC42 Gene

Orthologs for CCDC42 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC42 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC42 34 35
  • 99.58 (n)
cow
(Bos Taurus)
Mammalia CCDC42 34 35
  • 88.08 (n)
dog
(Canis familiaris)
Mammalia CCDC42 34 35
  • 86.6 (n)
mouse
(Mus musculus)
Mammalia Ccdc42 34 16 35
  • 84.92 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc42 34
  • 84.07 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC42 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC42 34 35
  • 62.87 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC42 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145050 34
  • 52.93 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100001777 34
  • 50.59 (n)
ccdc42b 35
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4208 35
  • 46 (a)
OneToMany
Species where no ortholog for CCDC42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC42 Gene

ENSEMBL:
Gene Tree for CCDC42 (if available)
TreeFam:
Gene Tree for CCDC42 (if available)

Paralogs for CCDC42 Gene

Paralogs for CCDC42 Gene

(1) SIMAP similar genes for CCDC42 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCDC42: view

Variants for CCDC42 Gene

Sequence variations from dbSNP and Humsavar for CCDC42 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000046352 -- 8,735,315(+) GTGTA(-/TG)TGTGT intron-variant
rs1000518264 -- 8,731,993(+) CCCCA(C/T)CTCTA intron-variant
rs1001103404 -- 8,736,868(+) CTGAA(A/G)GTAGC intron-variant
rs1001270575 -- 8,742,260(+) GGGAG(A/G)CAGGA intron-variant
rs1001317078 -- 8,730,631(+) CACTG(C/T)ACCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC42 Gene

Variant ID Type Subtype PubMed ID
esv2761945 CNV loss 21179565
esv3892957 CNV loss 25118596
nsv518675 CNV gain 19592680

Variation tolerance for CCDC42 Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.82; 73.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC42 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC42 Gene

Disorders for CCDC42 Gene

Relevant External Links for CCDC42

Genetic Association Database (GAD)
CCDC42
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC42

No disorders were found for CCDC42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC42 Gene

Publications for CCDC42 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. (PMID: 24657165) Kim H. … D'Andrea A.D. (Mol. Cell 2014) 3 64
  5. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with BehAset's disease. (PMID: 20622878) Remmers E.F. … GA1l A. (Nat. Genet. 2010) 46 64

Products for CCDC42 Gene

Sources for CCDC42 Gene

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