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CCDC39 Gene

protein-coding   GIFtS: 44
GCID: GC03M180320

Coiled-Coil Domain Containing 39

  See CCDC39-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Coiled-Coil Domain Containing 391 2
CILD142
FAP592
Coiled-Coil Domain-Containing Protein 392

External Ids:    HGNC: 252441   Entrez Gene: 3398292   Ensembl: ENSG000001450757   OMIM: 6137985   UniProtKB: Q9UFE43   
ORGUL members:         

Export aliases for CCDC39 gene to outside databases

Previous GC identifers: GC03M181815 GC03M177736


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CCDC39 Gene:
The protein encoded by this gene is involved in the motility of cilia and flagella. The encoded protein is
essential for the assembly of dynein regulatory and inner dynein arm complexes, which regulate ciliary beat.
Defects in this gene are a cause of primary ciliary dyskinesia type 14 (CILD14). (provided by RefSeq, Jul 2011)

GeneCards Summary for CCDC39 Gene:
CCDC39 (coiled-coil domain containing 39) is a protein-coding gene. Diseases associated with CCDC39 include ciliary dyskinesia, primary, 14, and primary ciliary dyskinesia14: ccdc39-related primary ciliary dyskinesia.

UniProtKB/Swiss-Prot: CCD39_HUMAN, Q9UFE4
Function: Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are
responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not
required for outer dynein arm complexes assembly




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CCDC39 gene promoter:
         SRF   SRF (504 AA)   NF-AT   MEF-2A   NF-AT4   S8   NF-AT2   NF-AT3   aMEF-2   NF-AT1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CCDC39

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC39


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.33   Ensembl cytogenetic band:  3q26.33   HGNC cytogenetic band: 3q26.33

CCDC39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC39 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M180320:  view genomic region     (about GC identifiers)

Start:
180,320,646 bp from pter      End:
180,588,793 bp from pter
Size:
268,148 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CCD39_HUMAN, Q9UFE4 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 39  
Size: 941 amino acids; 109901 Da
Secondary accessions: B4E2H1
Alternative splicing: 2 isoforms:  Q9UFE4-1   Q9UFE4-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CCDC39: NX_Q9UFE4

Explore proteomics data for CCDC39 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCDC39 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_852091.1  
    ENSEMBL proteins: 
     ENSP00000418482   ENSP00000420025   ENSP00000417960   ENSP00000405708   ENSP00000418702  
     ENSP00000273654  

    CCDC39 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for CCDC39
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    Novus Biologicals CCDC39 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CCDC39

     
    Search eBioscience for Proteins for CCDC39 

     
    Search antibodies-online for proteins for CCDC39 

     
    antibodies-online peptides for CCDC39

    CCDC39 Antibody Products:

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    antibodies-online antibodies for CCDC39 (20 products) 

    CCDC39 Assay Products:

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    Cloud-Clone Corp. ELISAs for CCDC39
    Cloud-Clone Corp. CLIAs for CCDC39
    Search eBioscience for ELISAs for CCDC39 
    antibodies-online kits for CCDC39 (22 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9UFE4

    UniProtKB/Swiss-Prot: CCD39_HUMAN, Q9UFE4
    Similarity: Belongs to the CCDC39 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CCD39_HUMAN, Q9UFE4
    Function: Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are
    responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not
    required for outer dynein arm complexes assembly

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
         
    Find genes that share ontologies with CCDC39           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CCDC39:
     G0/1 arrest  Increased G1 DNA content 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ccdc39):
     cardiovascular system  digestive/alimentary  growth/size/body  hematopoietic system  immune system 
     liver/biliary system  renal/urinary system  respiratory system 

    Find genes that share phenotypes with CCDC39           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC39
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCDC39
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CCDC39

    miRNA
    Products:
        
    miRTarBase miRNAs that target CCDC39:
    hsa-mir-124-3p (MIRT023078)

    Block miRNA regulation of human, mouse, rat CCDC39 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate CCDC39:
    hsa-miR-498 hsa-miR-875-3p hsa-miR-599 hsa-miR-3148 hsa-miR-551b* hsa-miR-3147
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector: CCDC39 (NM_181426)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC39
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CCDC39

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC39


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CCD39_HUMAN, Q9UFE4: Cytoplasm, cytoskeleton, cilium axoneme. Note=CCDC40 is required for localization to
    axonemes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    nucleus3
    cytosol2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005856cytoskeleton IEA--
    GO:0005930axoneme IDA--

    Find genes that share ontologies with CCDC39           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC39
    Interactions:

        Search GeneGlobe Interaction Network for CCDC39

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for CCDC39 (ENSP000004057084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000228854ENSP000003898944STRING: ENSP00000389894
    ENSG00000230341ENSP000004135964STRING: ENSP00000413596
    CCDC65ENSP000003127064STRING: ENSP00000312706
    --ENSP000004077374STRING: ENSP00000407737
    --ENSP000003908774STRING: ENSP00000390877
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001947heart looping IMP--
    GO:0030324lung development IMP--
    GO:0035469determination of pancreatic left/right asymmetry IMP--
    GO:0060285cilium-dependent cell motility IMP--
    GO:0060287epithelial cilium movement involved in determination of left/right asymmetry IMP--

    Find genes that share ontologies with CCDC39           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCDC39 (CCD39)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCDC39 gene: 
    NM_181426.1  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000473854 ENST00000489868 ENST00000476379(uc010hxe.3 uc003fkn.3)
    ENST00000442201 ENST00000471307 ENST00000485055(uc003fko.3) ENST00000495817
    ENST00000273654
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate CCDC39:
    hsa-miR-498 hsa-miR-875-3p hsa-miR-599 hsa-miR-3148 hsa-miR-551b* hsa-miR-3147
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CCDC39
    Predesigned siRNA for gene silencing in human, mouse, rat CCDC39
    Clone
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    OriGene clones in human, mouse for CCDC39 (see all 5)
    OriGene ORF clones in mouse, rat for CCDC39
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    GenScript: all cDNA clones in your preferred vector: CCDC39 (NM_181426)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CCDC39
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CCDC39
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CCDC39
      QuantiTect SYBR Green Assays in human, mouse, rat CCDC39
      QuantiFast Probe-based Assays in human, mouse, rat CCDC39

    21 AceView cDNA sequences:

    AL122120 AW571640 AA897385 BG530127 BC047103 AW593125 AW571667 BF574287 
    AI217488 BG205877 AW181942 CD244387 AI204288 BU568081 AL045951 CA448721 
    BF061321 F34172 BU686455 BI559385 CD000948 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCDC39 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTACATTAA
    CCDC39 Expression
    About this image


    CCDC39 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Ovary (Reproductive System)
             Oviduct
    CCDC39 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCDC39 Protein Expression

    UniProtKB/Swiss-Prot: CCD39_HUMAN, Q9UFE4
    Tissue specificity: Mainly expressed in nasal brushings and, to a lesser extent, in lungs and testis

        Custom PCR Arrays for CCDC39
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC39

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CCDC39 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc391 , 5 coiled-coil domain containing 391, 5 79.15(n)1
    76.87(a)1
      3 (16.32 cM)5
    519381  NM_026222.21  NP_080498.11 
     338123625 
    chicken
    (Gallus gallus)
    Aves CCDC391 coiled-coil domain containing 39 67.2(n)
    58.62(a)
      424969  XM_422777.4  XP_422777.3 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC396
    coiled-coil domain containing 39
    52(a)
    1 ↔ 1
    3(1611691-1645217)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ccdc391 coiled-coil domain containing 39 63.24(n)
    57.11(a)
      779795  NM_001078874.1  NP_001072342.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ccdc391 coiled-coil domain containing 39 58.28(n)
    52.85(a)
      555319  XM_677617.6  XP_682709.6 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG173871 CG17387 39.45(n)
    25.44(a)
      40595  NM_141238.2  NP_649495.1 


    ENSEMBL Gene Tree for CCDC39 (if available)
    TreeFam Gene Tree for CCDC39 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCDC39 (see all 1254)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1410927231,2
    C--177745300(+) GATTT-/TTA   
      TTATTA
    TTATT
    1 -- int10--------
    rs2007999911,2
    --177745335(+) TTATT-/ATGGATTC 1 -- int10--------
    rs285025651,2
    C,F--180194238(+) CCTCTA/GCCTTC 1 -- int18Minor allele frequency- G:0.44NA WA CSA 249
    rs1491742851,2
    --180194354(+) GTCTTA/GTAAAT 1 -- int10--------
    rs1907736111,2
    --180194427(+) TTATTC/TTTGAC 1 -- int10--------
    rs1169183981,2
    C,F--180194598(+) CATTCG/ATGAAT 1 -- spd11Minor allele frequency- A:0.03EA 120
    rs1821861111,2
    --180194663(+) AGTACA/GAAGTG 1 -- ut310--------
    rs1872698371,2
    --180194670(+) AGTGTC/TGGGCA 1 -- ut310--------
    rs1890975771,2
    --180194671(+) GTGTTA/GGGCAC 1 -- ut310--------
    rs1145003101,2
    C,F--180194712(+) TACTAC/TATTTG 1 -- ut311Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for CCDC39 (180320646 - 180570646 bp, first 250kb of CCDC39)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CCDC39:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2244500CNV Deletion18987734
    esv2484281CNV Deletion19546169
    nsv509869CNV Loss20534489

    Human Gene Mutation Database (HGMD): CCDC39
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCDC39
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC39

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613798   
    OMIM disorders: 613807  
    UniProtKB/Swiss-Prot: CCD39_HUMAN, Q9UFE4
  • Ciliary dyskinesia, primary, 14 (CILD14) [MIM:613807]: A disorder characterized by abnormalities of
    motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to
    defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of
    sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to
    dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is
    referred to as Kartagener syndrome. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 3 diseases for CCDC39:    
    About MalaCards
    ciliary dyskinesia, primary, 14    primary ciliary dyskinesia14: ccdc39-related primary ciliary dyskinesia    ciliary dyskinesia, primary, 19

    2 diseases from the University of Copenhagen DISEASES database for CCDC39:
    Primary ciliary dyskinesia     Situs inversus

    Find genes that share disorders with CCDC39           About GenesLikeMe

    Genetic Association Database (GAD): CCDC39
    Human Genome Epidemiology (HuGE) Navigator: CCDC39 (1 document)

    Export disorders for CCDC39 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCDC39 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with CCDC39)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs. (PubMed id 21131972)1, 2, 3 Merveille A.C.... Amselem S. (Nat. Genet. 2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms. (PubMed id 23255504)1 Antony D....Mitchison H.M. (Hum. Mutat. 2013)
    4. Delineation of CCDC39/CCDC40 mutation spectrum and associated phenotypes in primary ciliary dyskinesia. (PubMed id 22693285)1 Blanchon S....Amselem S. (J. Med. Genet. 2012)
    5. The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formation. (PubMed id 21131974)2 Becker-Heck A....Burdine R.D. (Nat. Genet. 2011)
    6. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 339829 HGNC: 25244 AceView: DKFZp434A128 Ensembl:ENSG00000145075 euGenes: HUgn339829
    ECgene: CCDC39 H-InvDB: CCDC39

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCDC39 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCDC39 gene:
    Search GeneIP for patents involving CCDC39

    GeneCards and IP:
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