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Aliases for CCDC38 Gene

Aliases for CCDC38 Gene

  • Coiled-Coil Domain Containing 38 2 3 5

External Ids for CCDC38 Gene

Previous GeneCards Identifiers for CCDC38 Gene

  • GC12M094764
  • GC12M096260
  • GC12M093325

Summaries for CCDC38 Gene

GeneCards Summary for CCDC38 Gene

CCDC38 (Coiled-Coil Domain Containing 38) is a Protein Coding gene. An important paralog of this gene is CFAP100.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC38 Gene

Genomics for CCDC38 Gene

Regulatory Elements for CCDC38 Gene

Enhancers for CCDC38 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G095994 1.5 Ensembl ENCODE dbSUPER 10.5 -52.7 -52747 2.4 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ELK1 SP5 ZHX2 MXD4 HAL AMDHD1 CCDC38 LOC102723340 GC12M095983
GH12G095965 0.9 ENCODE 12.6 -23.3 -23322 1.9 TBP FOXA2 MLX ARID4B ZNF48 ZSCAN9 RAD21 RARA YY1 MIXL1 AMDHD1 HAL CCDC38 GC12M095961 GC12M095983
GH12G095858 1.1 ENCODE 10.3 +83.9 83869 2.2 HDGF PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 LOC105369921 CCDC38 AMDHD1 SNRPF PIR48032
GH12G095972 1 ENCODE 10.8 -30.2 -30234 2.8 FOXA2 ATF1 MLX ARID4B SLC30A9 ZNF121 GATA2 FOS SP5 MXD4 HAL CCDC38 AMDHD1 LOC102723340 GC12M095983 GC12M095961
GH12G095804 1.4 Ensembl ENCODE dbSUPER 6 +137.1 137056 2.7 PKNOX1 ZSCAN4 BRCA1 YY1 GATA2 HSF1 ETV6 FOS ZNF362 CEBPB LOC105369921 SNRPF CCDC38 GC12P095807 GC12M095850
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC38 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC38 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000055953 353 1800 PKNOX1 ZFP64 SIN3A ARID4B FEZF1 DMAP1 BRCA1 ZNF2 ZNF48 YY1

Genomic Location for CCDC38 Gene

Chromosome:
12
Start:
95,867,048 bp from pter
End:
95,943,254 bp from pter
Size:
76,207 bases
Orientation:
Minus strand

Genomic View for CCDC38 Gene

Genes around CCDC38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC38 Gene

Proteins for CCDC38 Gene

  • Protein details for CCDC38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q502W7-CCD38_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 38
    Protein Accession:
    Q502W7
    Secondary Accessions:
    • Q8N835

    Protein attributes for CCDC38 Gene

    Size:
    563 amino acids
    Molecular mass:
    65315 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC38 Gene

Post-translational modifications for CCDC38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC38 Gene

Domains & Families for CCDC38 Gene

Protein Domains for CCDC38 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC38: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC38 Gene

Function for CCDC38 Gene

genes like me logo Genes that share phenotypes with CCDC38: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC38 Gene

Localization for CCDC38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC38 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC38 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCDC38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 25074808
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CCDC38: view

Pathways & Interactions for CCDC38 Gene

SuperPathways for CCDC38 Gene

No Data Available

Interacting Proteins for CCDC38 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000345470%0d%0a9606.ENSP00000259253%0d%0a
Selected Interacting proteins: ENSP00000345470 for CCDC38 Gene via STRING

Symbol External ID(s) Details
UGGT1

Gene Ontology (GO) - Biological Process for CCDC38 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC38 Gene

Drugs & Compounds for CCDC38 Gene

No Compound Related Data Available

Transcripts for CCDC38 Gene

mRNA/cDNA for CCDC38 Gene

Unigene Clusters for CCDC38 Gene

Coiled-coil domain containing 38:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC38 Gene

No ASD Table

Relevant External Links for CCDC38 Gene

GeneLoc Exon Structure for
CCDC38
ECgene alternative splicing isoforms for
CCDC38

Expression for CCDC38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC38 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC38 Gene

This gene is overexpressed in Testis (x35.5) and Liver (x6.7).

Protein differential expression in normal tissues from HIPED for CCDC38 Gene

This gene is overexpressed in Stomach (25.7), Serum (24.0), Heart (10.5), and Bone marrow mesenchymal stem cell (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC38 Gene



Protein tissue co-expression partners for CCDC38 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC38 Gene:

CCDC38

SOURCE GeneReport for Unigene cluster for CCDC38 Gene:

Hs.210377
genes like me logo Genes that share expression patterns with CCDC38: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC38 Gene

Orthologs for CCDC38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC38 34 35
  • 98.99 (n)
dog
(Canis familiaris)
Mammalia CCDC38 34 35
  • 83.18 (n)
cow
(Bos Taurus)
Mammalia CCDC38 34 35
  • 81.84 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc38 34
  • 76.74 (n)
mouse
(Mus musculus)
Mammalia Ccdc38 34 16 35
  • 75.91 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC38 35
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 42 (a)
OneToMany
-- 35
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToOne
Species where no ortholog for CCDC38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC38 Gene

ENSEMBL:
Gene Tree for CCDC38 (if available)
TreeFam:
Gene Tree for CCDC38 (if available)

Paralogs for CCDC38 Gene

Paralogs for CCDC38 Gene

(1) SIMAP similar genes for CCDC38 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CCDC38: view

Variants for CCDC38 Gene

Sequence variations from dbSNP and Humsavar for CCDC38 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000005429 -- 95,877,887(+) AATTA(A/C)CACCA intron-variant
rs1000022635 -- 95,906,749(+) TCCTG(A/C)AGTGT intron-variant
rs1000034142 -- 95,868,257(+) CTACA(C/T)ATCAA intron-variant
rs1000086146 -- 95,925,480(+) GTCAT(C/T)TGCAA intron-variant
rs1000098398 -- 95,880,733(+) AATAA(A/G)CCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC38 Gene

Variant ID Type Subtype PubMed ID
dgv295e214 CNV loss 21293372
esv3580384 CNV loss 25503493
esv3630439 CNV gain 21293372
esv3630440 CNV gain 21293372
esv3630443 CNV gain 21293372
nsv455693 CNV loss 19166990
nsv455694 CNV loss 19166990
nsv559834 CNV loss 21841781
nsv559835 CNV loss 21841781
nsv559836 CNV loss 21841781
nsv7234 OTHER inversion 18451855
nsv834 CNV deletion 18451855

Variation tolerance for CCDC38 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.77; 86.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC38 Gene

Disorders for CCDC38 Gene

Relevant External Links for CCDC38

Genetic Association Database (GAD)
CCDC38
Human Genome Epidemiology (HuGE) Navigator
CCDC38
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC38

No disorders were found for CCDC38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC38 Gene

Publications for CCDC38 Gene

  1. Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. (PMID: 25074808) Firat-Karalar E.N. … Stearns T. (J. Cell Sci. 2014) 2 3 4 64
  2. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M. … Tobin M.D. (Nat. Genet. 2011) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CCDC38 Gene

Sources for CCDC38 Gene

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