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Aliases for CCDC38 Gene

Aliases for CCDC38 Gene

  • Coiled-Coil Domain Containing 38 2 3 5

External Ids for CCDC38 Gene

Previous GeneCards Identifiers for CCDC38 Gene

  • GC12M094764
  • GC12M096260
  • GC12M093325

Summaries for CCDC38 Gene

GeneCards Summary for CCDC38 Gene

CCDC38 (Coiled-Coil Domain Containing 38) is a Protein Coding gene. An important paralog of this gene is CFAP100.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC38 Gene

Genomics for CCDC38 Gene

Regulatory Elements for CCDC38 Gene

Promoters for CCDC38 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC38 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC38 Gene

95,867,048 bp from pter
95,943,254 bp from pter
76,207 bases
Minus strand

Genomic View for CCDC38 Gene

Genes around CCDC38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC38 Gene

Proteins for CCDC38 Gene

  • Protein details for CCDC38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 38
    Protein Accession:
    Secondary Accessions:
    • Q8N835

    Protein attributes for CCDC38 Gene

    563 amino acids
    Molecular mass:
    65315 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC38 Gene

Proteomics data for CCDC38 Gene at MOPED

Post-translational modifications for CCDC38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC38 Gene

No data available for DME Specific Peptides for CCDC38 Gene

Domains & Families for CCDC38 Gene

Protein Domains for CCDC38 Gene


Suggested Antigen Peptide Sequences for CCDC38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC38: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC38 Gene

Function for CCDC38 Gene

genes like me logo Genes that share phenotypes with CCDC38: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC38 Gene

Localization for CCDC38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC38 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Jensen Localization Image for CCDC38 Gene COMPARTMENTS Subcellular localization image for CCDC38 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCDC38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CCDC38: view

Pathways & Interactions for CCDC38 Gene

SuperPathways for CCDC38 Gene

No Data Available

Interacting Proteins for CCDC38 Gene

Gene Ontology (GO) - Biological Process for CCDC38 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC38 Gene

Drugs & Compounds for CCDC38 Gene

No Compound Related Data Available

Transcripts for CCDC38 Gene

mRNA/cDNA for CCDC38 Gene

Unigene Clusters for CCDC38 Gene

Coiled-coil domain containing 38:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC38 Gene

No ASD Table

Relevant External Links for CCDC38 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC38 Gene

mRNA expression in normal human tissues for CCDC38 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC38 Gene

This gene is overexpressed in Testis (x35.5) and Liver (x6.7).

Protein differential expression in normal tissues from HIPED for CCDC38 Gene

This gene is overexpressed in Stomach (25.7), Serum (24.0), Heart (10.5), and Bone marrow mesenchymal stem cell (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC38 Gene

SOURCE GeneReport for Unigene cluster for CCDC38 Gene Hs.210377

genes like me logo Genes that share expression patterns with CCDC38: view

Protein tissue co-expression partners for CCDC38 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CCDC38 Gene

Orthologs for CCDC38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC38 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC38 35
  • 81.84 (n)
  • 73.12 (a)
CCDC38 36
  • 71 (a)
(Canis familiaris)
Mammalia CCDC38 35
  • 83.18 (n)
  • 73.35 (a)
CCDC38 36
  • 70 (a)
(Mus musculus)
Mammalia Ccdc38 35
  • 75.91 (n)
  • 69.77 (a)
Ccdc38 16
Ccdc38 36
  • 69 (a)
(Pan troglodytes)
Mammalia CCDC38 35
  • 98.99 (n)
  • 98.05 (a)
CCDC38 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ccdc38 35
  • 76.74 (n)
  • 69.77 (a)
(Monodelphis domestica)
Mammalia CCDC38 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
-- 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for CCDC38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC38 Gene

Gene Tree for CCDC38 (if available)
Gene Tree for CCDC38 (if available)

Paralogs for CCDC38 Gene

Paralogs for CCDC38 Gene

(1) SIMAP similar genes for CCDC38 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CCDC38: view

Variants for CCDC38 Gene

Sequence variations from dbSNP and Humsavar for CCDC38 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs12368787 - 95,918,908(+) TTTGA(A/C)AAGAA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs10859974 - 95,895,082(+) AGACA(C/T)TTGCA nc-transcript-variant, reference, missense
rs726869 -- 95,939,757(-) CATGG(G/T)GTTCA intron-variant
rs964127 -- 95,896,955(-) ATAGA(A/C/T)TATTT intron-variant, upstream-variant-2KB
rs1036429 -- 95,877,650(+) CTGAA(C/T)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC38 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv455693 CNV Loss 19166990
nsv455694 CNV Loss 19166990
nsv834 CNV Loss 18451855

Variation tolerance for CCDC38 Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.77; 86.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC38 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC38 Gene

Disorders for CCDC38 Gene

Relevant External Links for CCDC38

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC38 Gene

Publications for CCDC38 Gene

  1. Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. (PMID: 25074808) Firat-Karalar E.N. … Stearns T. (J. Cell Sci. 2014) 2 3 4 67
  2. Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction. (PMID: 24786987) Wain L.V. … Tobin M.D. (PLoS Genet. 2014) 3
  3. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. (PMID: 24925725) Chung S.A. … Langefeld C.D. (J. Am. Soc. Nephrol. 2014) 3
  4. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (PMID: 23284291) Hancock D.B. … London S.J. (PLoS Genet. 2012) 3
  5. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M. … Tobin M.D. (Nat. Genet. 2011) 3

Products for CCDC38 Gene

Sources for CCDC38 Gene

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