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Aliases for CCDC36 Gene

Aliases for CCDC36 Gene

  • Coiled-Coil Domain Containing 36 2 3 5
  • Cancer/Testis Antigen 74 2 3 4
  • Coiled-Coil Domain-Containing Protein 36 3 4
  • CT74 3 4
  • Interactor Of HORMAD1 Protein 1 3
  • IHO1 4

External Ids for CCDC36 Gene

Previous GeneCards Identifiers for CCDC36 Gene

  • GC03P049212
  • GC03P049084

Summaries for CCDC36 Gene

GeneCards Summary for CCDC36 Gene

CCDC36 (Coiled-Coil Domain Containing 36) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC36 Gene

  • Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC36 Gene

Genomics for CCDC36 Gene

Regulatory Elements for CCDC36 Gene

Enhancers for CCDC36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G049217 1.3 Ensembl ENCODE 12.3 +20.3 20254 2.1 FOXA2 MLX ZNF133 ARID4B DMAP1 ZNF48 GTF3C2 SLC30A9 FOS SP5 AMT WDR6 QRICH1 CCDC71 NME6 MRPS18AP1 ZNF589 SEMA3F-AS1 RHOA-IT1 CCDC36
GH03G049170 1.1 ENCODE 12.3 -25.5 -25513 5.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF766 ZNF143 WDR6 AMT CCDC36 LAMB2 C3orf62 USP4 QARS KLHDC8B C3orf84
GH03G050154 2 FANTOM5 Ensembl ENCODE dbSUPER 6.3 +965.4 965382 18.7 FOXA2 PKNOX1 ARNT MLX ZFP64 SIN3A ARID4B FEZF1 DMAP1 ZNF2 RBM6 RBM5 MON1A GNAI2 HYAL3 SEMA3F CYB561D2 CCDC36 MAPKAPK3 KLHDC8B
GH03G049265 1 Ensembl ENCODE 11.5 +67.9 67903 2.6 HDGF ZFP64 ZNF101 ZNF697 ZNF207 RELB IKZF2 MTA2 BHLHE40 NR2F1 WDR6 QRICH1 NICN1 CCDC36 C3orf84 CCDC71 KLHDC8B ENSG00000223343 LAMB2 RHOA
GH03G050149 1.4 Ensembl ENCODE dbSUPER 6.2 +952.6 952634 2.3 FOXA2 SIN3A ARID4B ZNF48 ZBTB7B SLC30A9 DEK SP5 ZHX2 REST RBM6 CYB561D2 CCDC36 SEMA3F RBM5-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC36 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152192 1172 801 ZBTB33

Genomic Location for CCDC36 Gene

Chromosome:
3
Start:
49,198,428 bp from pter
End:
49,258,157 bp from pter
Size:
59,730 bases
Orientation:
Plus strand

Genomic View for CCDC36 Gene

Genes around CCDC36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC36 Gene

Proteins for CCDC36 Gene

  • Protein details for CCDC36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYA8-IHO1_HUMAN
    Recommended name:
    Interactor of HORMAD1 protein 1
    Protein Accession:
    Q8IYA8
    Secondary Accessions:
    • C9JJL0
    • Q05DG9
    • Q96LP7

    Protein attributes for CCDC36 Gene

    Size:
    594 amino acids
    Molecular mass:
    66343 Da
    Quaternary structure:
    • Interacts with HORMAD1 (PubMed:27723721). Interacts with REC114 (By similarity). Part of the MCD recombinosome complex, at least composed of IHO1/CCDC36, REC114 and MEI4 (By similarity).
    SequenceCaution:
    • Sequence=AAH36202.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC36 Gene

Post-translational modifications for CCDC36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC36 Gene

Domains & Families for CCDC36 Gene

Protein Domains for CCDC36 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC36: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC36 Gene

Function for CCDC36 Gene

Molecular function for CCDC36 Gene

UniProtKB/Swiss-Prot Function:
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

Gene Ontology (GO) - Molecular Function for CCDC36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with CCDC36: view
genes like me logo Genes that share phenotypes with CCDC36: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC36 Gene

Localization for CCDC36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC36 Gene

Chromosome. Note=Specifically localizes to unsynapsed chromosomal regions during meiosis. {ECO:0000250 UniProtKB:Q6PDM4}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC36 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCDC36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome ISS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with CCDC36: view

Pathways & Interactions for CCDC36 Gene

SuperPathways for CCDC36 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006310 DNA recombination IEA --
GO:0007129 synapsis IEA,ISS --
GO:0007283 spermatogenesis ISS --
GO:0030154 cell differentiation IEA --
GO:0042138 meiotic DNA double-strand break formation IEA,ISS --
genes like me logo Genes that share ontologies with CCDC36: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC36 Gene

Drugs & Compounds for CCDC36 Gene

No Compound Related Data Available

Transcripts for CCDC36 Gene

mRNA/cDNA for CCDC36 Gene

Unigene Clusters for CCDC36 Gene

Coiled-coil domain containing 36:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC36 Gene

No ASD Table

Relevant External Links for CCDC36 Gene

GeneLoc Exon Structure for
CCDC36
ECgene alternative splicing isoforms for
CCDC36

Expression for CCDC36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC36 Gene

This gene is overexpressed in Testis (x23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC36 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCDC36 Gene:

CCDC36

SOURCE GeneReport for Unigene cluster for CCDC36 Gene:

Hs.631931
genes like me logo Genes that share expression patterns with CCDC36: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC36 Gene

Orthologs for CCDC36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC36 34 35
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia CCDC36 34 35
  • 83.39 (n)
cow
(Bos Taurus)
Mammalia CCDC36 34 35
  • 78.93 (n)
mouse
(Mus musculus)
Mammalia Ccdc36 34 16 35
  • 74.11 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc36 34
  • 73.77 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC36 35
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC36 35
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC36 35
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CCDC36 35
  • 29 (a)
OneToOne
Species where no ortholog for CCDC36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC36 Gene

ENSEMBL:
Gene Tree for CCDC36 (if available)
TreeFam:
Gene Tree for CCDC36 (if available)

Paralogs for CCDC36 Gene

No data available for Paralogs for CCDC36 Gene

Variants for CCDC36 Gene

Sequence variations from dbSNP and Humsavar for CCDC36 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000045735 -- 49,254,370(+) ACCTA(A/G)GTCCC intron-variant
rs1000089295 -- 49,226,239(+) CCTAC(A/G)CCGAG intron-variant
rs1000143530 -- 49,239,152(+) TTTTT(A/G)GTAGA intron-variant
rs1000196326 -- 49,223,309(+) TCGAC(C/T)TTCCC intron-variant
rs1000201112 -- 49,226,202(+) GATCT(C/T)ACTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC36 Gene

Variant ID Type Subtype PubMed ID
esv2675398 CNV deletion 23128226
esv3596121 CNV loss 21293372
nsv1008750 CNV gain 25217958
nsv1123648 CNV deletion 24896259
nsv834686 CNV loss 17160897

Variation tolerance for CCDC36 Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.07; 60.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC36 Gene

Disorders for CCDC36 Gene

Relevant External Links for CCDC36

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC36

No disorders were found for CCDC36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC36 Gene

Publications for CCDC36 Gene

  1. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N. … Roth F.P. (Mol. Syst. Biol. 2016) 3 64
  2. Meiotic DNA break formation requires the unsynapsed chromosome axis- binding protein IHO1 (CCDC36) in mice. (PMID: 27723721) Stanzione M. … Toth A. (Nat. Cell Biol. 2016) 4 64
  3. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N. … Vidal M. (Cell 2015) 3 64
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for CCDC36 Gene

Sources for CCDC36 Gene

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