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Aliases for CCDC34 Gene

Aliases for CCDC34 Gene

  • Coiled-Coil Domain Containing 34 2 3
  • Renal Carcinoma Antigen NY-REN-41 3 4
  • RAMA3 3 4
  • Coiled-Coil Domain-Containing Protein 34 3
  • NY-REN-41 Antigen 3
  • NY-REN-41 3
  • L15 3

External Ids for CCDC34 Gene

Previous GeneCards Identifiers for CCDC34 Gene

  • GC11M027057

Summaries for CCDC34 Gene

GeneCards Summary for CCDC34 Gene

CCDC34 (Coiled-Coil Domain Containing 34) is a Protein Coding gene. Diseases associated with CCDC34 include spinal stenosis.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC34 Gene

Genomics for CCDC34 Gene

Regulatory Elements for CCDC34 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCDC34 Gene

Start:
27,330,827 bp from pter
End:
27,363,868 bp from pter
Size:
33,042 bases
Orientation:
Minus strand

Genomic View for CCDC34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC34 Gene

Proteins for CCDC34 Gene

  • Protein details for CCDC34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HJ3-CCD34_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 34
    Protein Accession:
    Q96HJ3
    Secondary Accessions:
    • B2R8G2
    • Q8IX69
    • Q9H2A6
    • Q9Y599

    Protein attributes for CCDC34 Gene

    Size:
    373 amino acids
    Molecular mass:
    43225 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Antigen recognized by autologous antibody in patients with renal-cell carcinoma
    SequenceCaution:
    • Sequence=AAD42874.1; Type=Frameshift; Positions=9, 21; Evidence={ECO:0000305}; Sequence=AAO13807.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO13807.1; Type=Frameshift; Positions=142, 243; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC34 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC34 Gene

Proteomics data for CCDC34 Gene at MOPED

Post-translational modifications for CCDC34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC34 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CCDC34 Gene

Domains for CCDC34 Gene

Protein Domains for CCDC34 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC34: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC34 Gene

Function for CCDC34 Gene

Animal Model Products

miRNA for CCDC34 Gene

miRTarBase miRNAs that target CCDC34

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC34

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCDC34 Gene

Localization for CCDC34 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC34 Gene COMPARTMENTS Subcellular localization image for CCDC34 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC34 Gene

Pathways for CCDC34 Gene

SuperPathways for CCDC34 Gene

No Data Available

Interacting Proteins for CCDC34 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000330240%0d%0a9606.ENSP00000360141%0d%0a
Selected Interacting proteins: ENSP00000330240 for CCDC34 Gene via STRING

Symbol External ID(s) Details
GNAS

Gene Ontology (GO) - Biological Process for CCDC34 Gene

None

No data available for Pathways by source for CCDC34 Gene

Transcripts for CCDC34 Gene

mRNA/cDNA for CCDC34 Gene

Unigene Clusters for CCDC34 Gene

Coiled-coil domain containing 34:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC34

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC34 Gene

No ASD Table

Relevant External Links for CCDC34 Gene

GeneLoc Exon Structure for
CCDC34
ECgene alternative splicing isoforms for
CCDC34

Expression for CCDC34 Gene

mRNA expression in normal human tissues for CCDC34 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC34 Gene

This gene is overexpressed in Testis (6.8).

Protein differential expression in normal tissues for CCDC34 Gene

This gene is overexpressed in Plasma (67.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CCDC34 Gene

SOURCE GeneReport for Unigene cluster for CCDC34 Gene Hs.143733

genes like me logo Genes that share expressions with CCDC34: view

Expression partners for CCDC34 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CCDC34 Gene

Orthologs for CCDC34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC34 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC34 35
  • 86.94 (n)
  • 82.47 (a)
CCDC34 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC34 35
  • 84.4 (n)
  • 80.23 (a)
CCDC34 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc34 35
  • 80.04 (n)
  • 71.15 (a)
Ccdc34 16
Ccdc34 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC34 35
  • 99.55 (n)
  • 98.91 (a)
CCDC34 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc34 35
  • 79.13 (n)
  • 68.49 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC34 36
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC34 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC34 35
  • 67.19 (n)
  • 59.45 (a)
CCDC34 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc34 35
  • 57.2 (n)
  • 48.15 (a)
zebrafish
(Danio rerio)
Actinopterygii CCDC34 36
  • 28 (a)
OneToOne
Species with no ortholog for CCDC34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC34 Gene

ENSEMBL:
Gene Tree for CCDC34 (if available)
TreeFam:
Gene Tree for CCDC34 (if available)

Paralogs for CCDC34 Gene

Pseudogenes.org Pseudogenes for CCDC34 Gene

genes like me logo Genes that share paralogs with CCDC34: view

No data available for Paralogs for CCDC34 Gene

Variants for CCDC34 Gene

Sequence variations from dbSNP and Humsavar for CCDC34 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1038101 -- 27,364,392(+) TTCTC(A/G)ACCCT upstream-variant-2KB
rs1478686 -- 27,343,911(+) AGAAT(C/G)TTAAA intron-variant
rs1478687 -- 27,344,470(+) TTATA(A/C)GCATT intron-variant
rs1871253 -- 27,348,346(+) GAGAA(C/T)GAAAA intron-variant
rs1871254 -- 27,348,359(+) GATTT(C/T)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC34 Gene

Variant ID Type Subtype PubMed ID
nsv467782 CNV Gain 19166990

Relevant External Links for CCDC34 Gene

HapMap Linkage Disequilibrium report
CCDC34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC34 Gene

Disorders for CCDC34 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CCDC34 Gene in MalaCards »

(1) Diseases for CCDC34 Gene including...

UniProtKB/Swiss-Prot

CCD34_HUMAN
  • Note=A chromosomal aberration involving CCDC34 is found in a patient with hamartoma of the retinal pigment epithelium and retina. Translocation t(11;18) (p13;p11.2).

(1) University of Copenhagen DISEASES for CCDC34 Gene

genes like me logo Genes that share disorders with CCDC34: view

No data available for OMIM , Novoseek inferred disease relationships , Genatlas and External Links for CCDC34 Gene

Publications for CCDC34 Gene

  1. Cloning and characterization of the breakpoint regions of a chromosome 11;18 translocation in a patient with hamartoma of the retinal pigment epithelium. (PMID: 11173847) Kutsche K. … Gal A. (Cytogenet. Cell Genet. 2000) 2 3 4
  2. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 3 4
  3. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J. … Carter P. (Oncogene 2004) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment. (PMID: 24945404) Kemp J.P. … Evans D.M. (PLoS Genet. 2014) 3

Products for CCDC34 Gene

Sources for CCDC34 Gene

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