CCDC34 Gene
protein-coding GIFtS: 40
GCID: GC11M027327
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coiled-coil domain containing 34
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Aliases
for CCDC34 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 341 2 | | L151 | | RAMA31 2 3 | | Coiled-Coil Domain-Containing Protein 342 | | NY-REN-411 2 | | NY-REN-41 Antigen2 | | Renal Carcinoma Antigen NY-REN-412 3 | | |
Export aliases for CCDC34 gene to outside databasesPrevious GC identifer: GC11M027057 |
Summaries
for CCDC34 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CCDC34 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC34 gene promoter:
Oct-B1 oct-B2 GATA-3 oct-B3 POU2F2 GATA-2 GATA-1 POU2F2C POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC34
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC34 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p14.1 Ensembl cytogenetic band: 11p14.1 HGNC cytogenetic band: 11p14.1CCDC34 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M027327: view genomic region
(about GC identifiers)
Start:
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27,352,374 bp from pter |
End:
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27,385,415 bp from pter |
Size:
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33,042 bases |
Orientation:
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minus strand |
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Proteins
for CCDC34 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCD34_HUMAN, Q96HJ3 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 34 Size: 373 amino acids; 43225 Da
Miscellaneous: Antigen recognized by autologous antibody in patients with renal-cell carcinoma
Sequence caution: Sequence=AAD42874.1; Type=Frameshift; Positions=9, 21; Sequence=AAO13807.1; Type=Erroneousinitiation; Note=Translation N-terminally extended; Sequence=AAO13807.1; Type=Frameshift; Positions=142, 243;
Secondary accessions: B2R8G2 Q8IX69 Q9H2A6 Q9Y599Alternative splicing: 2 isoforms: Q96HJ3-1 Q96HJ3-2 Explore the universe of human proteins at neXtProt for CCDC34: NX_Q96HJ3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96HJ3
CCDC34 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_110398.1 NP_542385.1
ENSEMBL proteins: ENSP00000330240 ENSP00000321563
Human Recombinant Protein Products:
CCDC34 Antibody Products:
Assay Products for CCDC34: |
Protein
Domains /
Families
for CCDC34 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96HJ3 |
Function
for CCDC34 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC34 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC34 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CCDC34 (NM_080654) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC34 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC34 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC34 |
|
Pathways & Interactions
for CCDC34 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC34
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for CCDC34 (ENSP000003302404) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CCDC34 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC34
Search CenterWatch for drugs/clinical trials and news about CCDC34 / CCD34
|
Transcripts
for CCDC34 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC34 gene (2 alternative transcripts): NM_030771.1 NM_080654.2 Unigene Cluster for CCDC34: Coiled-coil domain containing 34 Hs.143733 [show with all ESTs]Unigene Representative Sequence: BC0084963 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000529615 ENST00000328697(uc001mrh.1) ENST00000317945(uc001mri.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC34 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC34 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CCDC34 (NM_080654) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC34 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC34 |
Additional cDNA sequence: AF155108.1 AF301222.1 AF382034.1 AK308494.1 AK313358.1 AY598334.1 BC008496.1 BC029421.1 8 DOTS entries: DT.314193 DT.91749133 DT.95234691 DT.100743401 DT.99974394 DT.99987343 DT.120758807 DT.95238375 24/152 AceView cDNA sequences (see all 152): AI479296 AA449090 BM763395 BG213196 AA115878 BG941410 BG944076 BU071514 BX109360 NM_080654 AA747313 AY598334 BM782278 CR597641 CR600953 BP376820 BC008496 AA687242 BQ949991 AA458934 AA648459 BM684222 BG779078 BX097073
GeneLoc Exon Structure
|
Expression
for CCDC34 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC34 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTTTTGCA
About this image
See CCDC34 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC34
SOURCE GeneReport for Unigene cluster: Hs.143733
SABiosciences Custom PCR Arrays for CCDC34
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC34
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC34 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC34 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC34 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC34 |
Orthologs
for CCDC34 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CCDC34 gene from 2/13 species (see all 13) About this table
ENSEMBL Gene Tree for CCDC34 (if available)
TreeFam Gene Tree for CCDC34 (if available) |
Paralogs
for CCDC34 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCDC34 gene
- MAP92
CCDC34 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CCDC34
PGOHUM00000246029
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Genomic Variants
for CCDC34 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC34 (27352374 - 27385415 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CCDC34: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC34 |
|
Disorders
/ Diseases
for CCDC34 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCDC34 for disorders About GeneDecksing
OMIM gene information: 612324
OMIM disorders: --
UniProtKB/Swiss-Prot: CCD34_HUMAN, Q96HJ3
Note=A chromosomal aberration involving CCDC34 is found in a patient with hamartoma of the retinal pigmentepithelium and retina. Translocation t(11;18) (p13;p11.2)
6  diseases for CCDC34: About MalaCardsrenal carcinoma spinal stenosis carcinoma renal cell carcinoma
lung cancer retinitis
1 disease from the University of Copenhagen DISEASES database for CCDC34:Spinal stenosis Export disorders for CCDC34 gene to outside databases
|
Publications
for CCDC34 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC34 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC34) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of the breakpoint regions of a chromosome 11;18 translocation in a patient with hamartoma of the retinal pigment epithelium. (PubMed id 11173847)1, 2, 3 Kutsche K.... Gal A. (2000)
- Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2 Petroziello J.... Carter P. (2004)
- Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CCDC34 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC34 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC34 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC34 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC34 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CCDC34 gene:
Search GeneIP for patents involving CCDC34
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC34 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC34 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC34 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC34 | | | OriGene Protein Over-expression Lysate for CCDC34 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC34 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC34 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC34 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CCDC34 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 |  |  |  | |
| | | | Search Tocris compounds for CCDC34 |
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 | | | CCDC34 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC34 |
|  |  |  | | | | ThermoFisher Antibodies for CCDC34 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC34 |
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