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Aliases for CCDC34 Gene

Aliases for CCDC34 Gene

  • Coiled-Coil Domain Containing 34 2 3 5
  • Renal Carcinoma Antigen NY-REN-41 3 4
  • RAMA3 3 4
  • NY-REN-41 Antigen 3
  • NY-REN-41 3
  • L15 3

External Ids for CCDC34 Gene

Previous GeneCards Identifiers for CCDC34 Gene

  • GC11M027057

Summaries for CCDC34 Gene

GeneCards Summary for CCDC34 Gene

CCDC34 (Coiled-Coil Domain Containing 34) is a Protein Coding gene. Diseases associated with CCDC34 include Renal Cell Carcinoma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC34 Gene

Genomics for CCDC34 Gene

Regulatory Elements for CCDC34 Gene

Enhancers for CCDC34 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC34 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC34 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC34 Gene

27,330,827 bp from pter
27,363,868 bp from pter
33,042 bases
Minus strand

Genomic View for CCDC34 Gene

Genes around CCDC34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC34 Gene

Proteins for CCDC34 Gene

  • Protein details for CCDC34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 34
    Protein Accession:
    Secondary Accessions:
    • B2R8G2
    • Q8IX69
    • Q9H2A6
    • Q9Y599

    Protein attributes for CCDC34 Gene

    373 amino acids
    Molecular mass:
    43225 Da
    Quaternary structure:
    No Data Available
    • Antigen recognized by autologous antibody in patients with renal-cell carcinoma.
    • Sequence=AAD42874.1; Type=Frameshift; Positions=9, 21; Evidence={ECO:0000305}; Sequence=AAO13807.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO13807.1; Type=Frameshift; Positions=142, 243; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC34 Gene


neXtProt entry for CCDC34 Gene

Proteomics data for CCDC34 Gene at MOPED

Post-translational modifications for CCDC34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC34 Gene

Domains & Families for CCDC34 Gene

Protein Domains for CCDC34 Gene


Suggested Antigen Peptide Sequences for CCDC34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC34: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC34 Gene

Function for CCDC34 Gene

genes like me logo Genes that share phenotypes with CCDC34: view

Animal Model Products

miRNA for CCDC34 Gene

miRTarBase miRNAs that target CCDC34

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC34 Gene

Localization for CCDC34 Gene

Subcellular locations from

Jensen Localization Image for CCDC34 Gene COMPARTMENTS Subcellular localization image for CCDC34 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC34 Gene

Pathways & Interactions for CCDC34 Gene

SuperPathways for CCDC34 Gene

No Data Available

Interacting Proteins for CCDC34 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000330240 for CCDC34 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CCDC34 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC34 Gene

Drugs & Compounds for CCDC34 Gene

No Compound Related Data Available

Transcripts for CCDC34 Gene

Unigene Clusters for CCDC34 Gene

Coiled-coil domain containing 34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC34 Gene

No ASD Table

Relevant External Links for CCDC34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC34 Gene

mRNA expression in normal human tissues for CCDC34 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC34 Gene

This gene is overexpressed in Testis (x6.8).

Protein differential expression in normal tissues from HIPED for CCDC34 Gene

This gene is overexpressed in Plasma (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC34 Gene

SOURCE GeneReport for Unigene cluster for CCDC34 Gene Hs.143733

genes like me logo Genes that share expression patterns with CCDC34: view

Protein tissue co-expression partners for CCDC34 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CCDC34 Gene

Orthologs for CCDC34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC34 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC34 35
  • 86.94 (n)
  • 82.47 (a)
CCDC34 36
  • 83 (a)
(Canis familiaris)
Mammalia CCDC34 35
  • 84.4 (n)
  • 80.23 (a)
CCDC34 36
  • 80 (a)
(Mus musculus)
Mammalia Ccdc34 35
  • 80.04 (n)
  • 71.15 (a)
Ccdc34 16
Ccdc34 36
  • 70 (a)
(Pan troglodytes)
Mammalia CCDC34 35
  • 99.55 (n)
  • 98.91 (a)
CCDC34 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ccdc34 35
  • 79.13 (n)
  • 68.49 (a)
(Monodelphis domestica)
Mammalia CCDC34 36
  • 42 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC34 36
  • 65 (a)
(Gallus gallus)
Aves CCDC34 35
  • 67.19 (n)
  • 59.45 (a)
CCDC34 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc34 35
  • 57.2 (n)
  • 48.15 (a)
(Danio rerio)
Actinopterygii CCDC34 36
  • 28 (a)
Species with no ortholog for CCDC34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC34 Gene

Gene Tree for CCDC34 (if available)
Gene Tree for CCDC34 (if available)

Paralogs for CCDC34 Gene Pseudogenes for CCDC34 Gene

genes like me logo Genes that share paralogs with CCDC34: view

No data available for Paralogs for CCDC34 Gene

Variants for CCDC34 Gene

Sequence variations from dbSNP and Humsavar for CCDC34 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11549824 - 27,363,038(-) CGTCG(C/T)CGCCG reference, missense
rs17244028 - 27,340,812(+) GTATT(G/T)CAGCT reference, missense
rs16925453 - 27,338,988(+) CGGAA(A/C/T)TGGAT reference, missense
rs12364852 - 27,350,364(+) CTTGT(G/T)CTTTT reference, missense
rs1038101 -- 27,364,392(+) TTCTC(A/G)ACCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC34 Gene

Variant ID Type Subtype PubMed ID
nsv467782 CNV Gain 19166990

Variation tolerance for CCDC34 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.87; 87.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCDC34 Gene

Disorders for CCDC34 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC34 Gene - From: GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
- elite association - COSMIC cancer census association via MalaCards


  • Note=A chromosomal aberration involving CCDC34 is found in a patient with hamartoma of the retinal pigment epithelium and retina. Translocation t(11;18) (p13;p11.2). {ECO:0000269 PubMed:11173847}.

Relevant External Links for CCDC34

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CCDC34: view

No data available for Genatlas for CCDC34 Gene

Publications for CCDC34 Gene

  1. Cloning and characterization of the breakpoint regions of a chromosome 11;18 translocation in a patient with hamartoma of the retinal pigment epithelium. (PMID: 11173847) Kutsche K. … Gal A. (Cytogenet. Cell Genet. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment. (PMID: 24945404) Kemp J.P. … Evans D.M. (PLoS Genet. 2014) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PMID: 15334068) Petroziello J. … Carter P. (Oncogene 2004) 3

Products for CCDC34 Gene

Sources for CCDC34 Gene