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Aliases for CCDC33 Gene

Aliases for CCDC33 Gene

  • Coiled-Coil Domain Containing 33 2 3 5
  • Cancer/Testis Antigen 61 2 3 4
  • CT61 3 4
  • Coiled-Coil Domain-Containing Protein 33 3
  • Hypothetical Protein HP11097 3
  • HP11097 3

External Ids for CCDC33 Gene

Previous GeneCards Identifiers for CCDC33 Gene

  • GC15P072347
  • GC15P072316
  • GC15P074509
  • GC15P051324

Summaries for CCDC33 Gene

GeneCards Summary for CCDC33 Gene

CCDC33 (Coiled-Coil Domain Containing 33) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC33 Gene

Genomics for CCDC33 Gene

Regulatory Elements for CCDC33 Gene

Enhancers for CCDC33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F074239 1.2 Ensembl ENCODE 15.7 +38.6 38570 4.3 HDGF PKNOX1 SIN3A ZNF121 ZNF766 GLIS2 ZNF143 FOS ZNF263 SP3 ISLR CCDC33 STRA6 LOC283731 ISLR2 RPP25 LOC105370893 PIR42753
GH15F074168 1.4 FANTOM5 ENCODE 10.9 -31.0 -31008 7.2 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ISLR LOC732265 LOC102723657 LOC105370890 GOLGA6A STRA6 ENSG00000261543 CCDC33 ISLR2 SCAMP5
GH15F074249 1.3 Ensembl ENCODE 11.7 +49.1 49146 3.8 HDGF ATF1 PKNOX1 ARNT CREB3L1 SIN3A DMAP1 ZNF2 ZNF48 YY1 CCDC33 STRA6 ISLR RPP25 LOC105370893 PIR42753
GH15F074324 1.3 Ensembl ENCODE 11 +123.8 123826 4.6 HDGF SIN3A ARID4B ZNF2 YY1 GLIS2 ZNF207 DEK ZNF263 REST CCDC33 CSK ISLR ENSG00000261384 ISLR2 ENSG00000277749 GC15P074339
GH15F074314 1.3 Ensembl ENCODE 10.9 +115.1 115061 6.3 HDGF PKNOX1 ARNT SIN3A ZNF766 KLF13 ZNF263 NFYC REST MEF2D ISLR LOC101929333 UBL7-AS1 CCDC33 STRA6 CSK LOXL1 LOC729739 ISLR2 SCAMP5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC33 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000651003 395 201 CTCF TEAD4 KLF17 SIN3A ZNF2 RAD21 ZFHX2 GATA3 GLIS2 EGR1

Genomic Location for CCDC33 Gene

74,202,705 bp from pter
74,336,472 bp from pter
133,768 bases
Plus strand

Genomic View for CCDC33 Gene

Genes around CCDC33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC33 Gene

Proteins for CCDC33 Gene

  • Protein details for CCDC33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 33
    Protein Accession:
    Secondary Accessions:
    • A8K3U4
    • A8MPQ6
    • A8MV61
    • A8MVU9
    • B3KQ49
    • Q8TAX6
    • Q9H5Q6

    Protein attributes for CCDC33 Gene

    958 amino acids
    Molecular mass:
    107216 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC33 Gene


neXtProt entry for CCDC33 Gene

Post-translational modifications for CCDC33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC33 Gene

Domains & Families for CCDC33 Gene

Gene Families for CCDC33 Gene

Protein Domains for CCDC33 Gene


Suggested Antigen Peptide Sequences for CCDC33 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 domain.
  • Contains 1 C2 domain.
genes like me logo Genes that share domains with CCDC33: view

Function for CCDC33 Gene

Gene Ontology (GO) - Molecular Function for CCDC33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CCDC33: view
genes like me logo Genes that share phenotypes with CCDC33: view

Animal Models for CCDC33 Gene

MGI Knock Outs for CCDC33:

Animal Model Products

miRNA for CCDC33 Gene

miRTarBase miRNAs that target CCDC33

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC33 Gene

Localization for CCDC33 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC33 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC33 Gene

Pathways & Interactions for CCDC33 Gene

SuperPathways for CCDC33 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC33 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC33 Gene

Transcripts for CCDC33 Gene

mRNA/cDNA for CCDC33 Gene

(21) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC33 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19
SP1: - - - - -
SP3: -
SP4: -

Relevant External Links for CCDC33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC33 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC33 Gene

This gene is overexpressed in Testis (x25.8), Fallopian Tube (x6.7), and Cervix - Endocervix (x4.2).

Protein differential expression in normal tissues from HIPED for CCDC33 Gene

This gene is overexpressed in Lymph node (18.1), Spleen (7.9), and Colon (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC33 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC33 Gene:


SOURCE GeneReport for Unigene cluster for CCDC33 Gene:

genes like me logo Genes that share expression patterns with CCDC33: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CCDC33 Gene

Orthologs for CCDC33 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC33 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100608474 34
  • 95.34 (n)
CCDC33 35
  • 64 (a)
(Bos Taurus)
Mammalia CCDC33 34 35
  • 84.22 (n)
(Canis familiaris)
Mammalia CCDC33 34 35
  • 84.07 (n)
(Rattus norvegicus)
Mammalia Ccdc33 34
  • 78.96 (n)
(Mus musculus)
Mammalia Ccdc33 34 16 35
  • 78.55 (n)
(Ornithorhynchus anatinus)
Mammalia CCDC33 35
  • 45 (a)
(Monodelphis domestica)
Mammalia CCDC33 35
  • 40 (a)
(Gallus gallus)
Aves CCDC33 35
  • 23 (a)
(Danio rerio)
Actinopterygii ccdc33 35
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
Species where no ortholog for CCDC33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC33 Gene

Gene Tree for CCDC33 (if available)
Gene Tree for CCDC33 (if available)

Paralogs for CCDC33 Gene

No data available for Paralogs for CCDC33 Gene

Variants for CCDC33 Gene

Sequence variations from dbSNP and Humsavar for CCDC33 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs267607096 Pathogenic 74,202,199(-) AGCTG(A/G)TACAT nc-transcript-variant, upstream-variant-2KB, reference, stop-gained, utr-variant-5-prime
rs606231126 Pathogenic 74,202,216(-) AGAGG(ACT/CC)ACTCC nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime
rs77396610 Likely benign 74,332,736(+) CCTGC(C/T)GGTTG nc-transcript-variant, reference, missense
rs1009176 -- 74,311,143(-) AGGGT(A/G)ATGGG intron-variant
rs10152959 -- 74,207,897(+) GTCGT(C/T)GGCTG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CCDC33 Gene

Variant ID Type Subtype PubMed ID
esv2666153 CNV deletion 23128226
esv2674756 CNV deletion 23128226
esv275019 CNV loss 21479260
esv3636902 CNV loss 21293372
nsv1121512 CNV deletion 24896259
nsv1608 CNV insertion 18451855
nsv1609 CNV insertion 18451855
nsv471253 CNV loss 18288195
nsv473435 CNV novel sequence insertion 20440878
nsv510938 OTHER complex 20534489
nsv833053 CNV loss 17160897
nsv833054 CNV loss 17160897

Variation tolerance for CCDC33 Gene

Residual Variation Intolerance Score: 81.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.38; 95.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC33 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC33 Gene

Disorders for CCDC33 Gene

Relevant External Links for CCDC33

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC33 Gene

Publications for CCDC33 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64

Products for CCDC33 Gene

Sources for CCDC33 Gene

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