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Aliases for CCDC3 Gene

Aliases for CCDC3 Gene

  • Coiled-Coil Domain Containing 3 2 3 5
  • Favine 2 3 4
  • Fat/Vessel-Derived Secretory Protein 3 4

External Ids for CCDC3 Gene

Previous GeneCards Identifiers for CCDC3 Gene

  • GC10M012943
  • GC10M012978
  • GC10M012938

Summaries for CCDC3 Gene

GeneCards Summary for CCDC3 Gene

CCDC3 (Coiled-Coil Domain Containing 3) is a Protein Coding gene.

Gene Wiki entry for CCDC3 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC3 Gene

Genomics for CCDC3 Gene

Regulatory Elements for CCDC3 Gene

Genomic Location for CCDC3 Gene

Chromosome:
10
Start:
12,896,625 bp from pter
End:
13,099,773 bp from pter
Size:
203,149 bases
Orientation:
Minus strand

Genomic View for CCDC3 Gene

Genes around CCDC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC3 Gene

Proteins for CCDC3 Gene

  • Protein details for CCDC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQI4-CCDC3_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 3
    Protein Accession:
    Q9BQI4
    Secondary Accessions:
    • Q5VYV8
    • Q5VYV9

    Protein attributes for CCDC3 Gene

    Size:
    270 amino acids
    Molecular mass:
    30731 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for CCDC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC3 Gene

Proteomics data for CCDC3 Gene at MOPED

Post-translational modifications for CCDC3 Gene

  • Glycosylation at Asn 100
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC3 Gene

Domains & Families for CCDC3 Gene

Protein Domains for CCDC3 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC3 Gene

Function for CCDC3 Gene

Molecular function for CCDC3 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated by pioglitazone and down-regulated by TNF in HUVEC.
genes like me logo Genes that share phenotypes with CCDC3: view

Animal Models for CCDC3 Gene

MGI Knock Outs for CCDC3:

Animal Model Products

miRNA for CCDC3 Gene

miRTarBase miRNAs that target CCDC3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CCDC3 Gene

Localization for CCDC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC3 Gene COMPARTMENTS Subcellular localization image for CCDC3 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 4
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CCDC3: view

Pathways & Interactions for CCDC3 Gene

SuperPathways for CCDC3 Gene

No Data Available

Interacting Proteins for CCDC3 Gene

Gene Ontology (GO) - Biological Process for CCDC3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC3 Gene

Drugs & Compounds for CCDC3 Gene

No Compound Related Data Available

Transcripts for CCDC3 Gene

mRNA/cDNA for CCDC3 Gene

Unigene Clusters for CCDC3 Gene

Coiled-coil domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC3 Gene

No ASD Table

Relevant External Links for CCDC3 Gene

GeneLoc Exon Structure for
CCDC3
ECgene alternative splicing isoforms for
CCDC3

Expression for CCDC3 Gene

mRNA expression in normal human tissues for CCDC3 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC3 Gene

This gene is overexpressed in Artery - Coronary (x9.3), Artery - Tibial (x6.0), and Artery - Aorta (x5.0).

Protein differential expression in normal tissues from HIPED for CCDC3 Gene

This gene is overexpressed in Gallbladder (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC3 Gene



SOURCE GeneReport for Unigene cluster for CCDC3 Gene Hs.498720

mRNA Expression by UniProt/SwissProt for CCDC3 Gene

Q9BQI4-CCDC3_HUMAN
Tissue specificity: Expressed in umbilical vein endothelial cells (HUVEC), and at lower levels in aortic smooth muscle cells (HASMC).
genes like me logo Genes that share expression patterns with CCDC3: view

Protein tissue co-expression partners for CCDC3 Gene

Primer Products

In Situ Assay Products

Orthologs for CCDC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC3 35
  • 90.34 (n)
  • 91.27 (a)
-- 36
  • 76 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
CCDC3 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CCDC3 35
  • 89.63 (n)
  • 90.37 (a)
CCDC3 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc3 35
  • 88.37 (n)
  • 91.76 (a)
Ccdc3 16
Ccdc3 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC3 35
  • 98.64 (n)
  • 96.3 (a)
CCDC3 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc3 35
  • 87.71 (n)
  • 90.59 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC3 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC3 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC3 35
  • 77.55 (n)
  • 82.85 (a)
CCDC3 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC3 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc3 35
  • 71.37 (n)
  • 73.44 (a)
Str.19636 35
zebrafish
(Danio rerio)
Actinopterygii ccdc3 35
  • 68.68 (n)
  • 68.95 (a)
ccdc3 36
  • 63 (a)
OneToOne
Species with no ortholog for CCDC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC3 Gene

ENSEMBL:
Gene Tree for CCDC3 (if available)
TreeFam:
Gene Tree for CCDC3 (if available)

Paralogs for CCDC3 Gene

No data available for Paralogs for CCDC3 Gene

Variants for CCDC3 Gene

Sequence variations from dbSNP and Humsavar for CCDC3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3232 -- 12,896,754(+) GGGGG(C/T)GCAAA utr-variant-3-prime
rs504545 -- 13,011,942(+) agcaa(C/T)gggaa intron-variant
rs505588 -- 13,024,184(+) TTGGC(A/G)GTCTT intron-variant
rs507767 -- 13,071,402(-) taact(G/T)ccatt intron-variant
rs513155 -- 13,015,482(+) TGTGA(C/T)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC3 Gene

Variant ID Type Subtype PubMed ID
nsv894884 CNV Gain 21882294
nsv5831 CNV Insertion 18451855
nsv521491 CNV Gain 19592680
esv1974400 CNV Deletion 18987734
esv2733295 CNV Deletion 23290073
esv2733306 CNV Deletion 23290073
esv259462 OTHER Complex 20981092

Variation tolerance for CCDC3 Gene

Residual Variation Intolerance Score: 51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC3 Gene

HapMap Linkage Disequilibrium report
CCDC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC3 Gene

Disorders for CCDC3 Gene

Relevant External Links for CCDC3

Genetic Association Database (GAD)
CCDC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC3

No disorders were found for CCDC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC3 Gene

Publications for CCDC3 Gene

  1. Identification of a new secretory factor, CCDC3/Favine, in adipocytes and endothelial cells. (PMID: 20043878) Kobayashi S. … Shimomura I. (Biochem. Biophys. Res. Commun. 2010) 2 3 4 67
  2. Coiled-coil domain containing 3 (CCDC3) represses tumor necrosis factor-I+/nuclear factor I_B-induced endothelial inflammation. (PMID: 25193116) Azad A.K. … Fu Y. (Cell. Signal. 2014) 3
  3. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. (PMID: 20526338) Johnson A.D. … Becker L.C. (Nat. Genet. 2010) 3
  4. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CCDC3 Gene

Sources for CCDC3 Gene

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