External Ids for CCDC28B Gene
Previous GeneCards Identifiers for CCDC28B Gene
The product of this gene localizes to centrosomes and basal bodies. The protein colocalizes with several proteins associated with Bardet-Biedl syndrome (BBS) and participates in the regulation of cilia development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for CCDC28B Gene
CCDC28B (Coiled-Coil Domain Containing 28B) is a Protein Coding gene. Diseases associated with CCDC28B include bardet-biedl syndrome 1 and bardet-biedl syndrome. An important paralog of this gene is CCDC28A.
UniProtKB/Swiss-Prot for CCDC28B Gene
Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex.