CCDC28A Gene
protein-coding GIFtS: 44
GCID: GC06P139094
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coiled-coil domain containing 28A(Previous name: chromosome 6 open reading frame 80 )
(Previous symbol: C6orf80)
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Aliases
for CCDC28A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 28A1 2 | | Chromosome 6 Open Reading Frame 801 | | C6orf801 2 3 | | Chemokine C-C Motif Receptor-Like 1 Adjacent2 | | CCRL1AP1 2 3 | | Coiled-Coil Domain-Containing Protein 28A2 | | DKFZp586D06231 | | |
Export aliases for CCDC28A gene to outside databasesPrevious GC identifers: GC06P139137 GC06P139138 GC06P136656 |
Summaries
for CCDC28A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CCDC28A:
This gene is located in a region close to the locus of the pseudogene of chemokine (C-C motif) receptor-like 1 onchromosome 6. The specific function of this gene has not yet been determined. (provided by RefSeq, Jul 2008)
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Genomic Views
for CCDC28A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC28A gene promoter:
Bach1 NRSF form 1 SREBP-1c Ik-3 Tal-1beta SREBP-1b AREB6 SREBP-1a Sox9 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC28A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC28A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q23.1-q24.1 Ensembl cytogenetic band: 6q24.1 HGNC cytogenetic band: 6q23.1-q24.1CCDC28A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P139094: view genomic region
(about GC identifiers)
Start:
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139,094,657 bp from pter |
End:
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139,114,456 bp from pter |
Size:
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19,800 bases |
Orientation:
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plus strand |
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Proteins
for CCDC28A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CC28A_HUMAN, Q8IWP9 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 28A Size: 274 amino acids; 30367 Da
Secondary accessions: E1P591 Q32NC7 Q66K67 Q96E23 Q9Y430Explore the universe of human proteins at neXtProt for CCDC28A: NX_Q8IWP9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IWP9
CCDC28A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056254.1
ENSEMBL proteins: ENSP00000332716
Human Recombinant Protein Products:
CCDC28A Antibody Products:
Assay Products for CCDC28A: |
Protein
Domains /
Families
for CCDC28A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCDC28A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IWP9ProtoNet protein and cluster: Q8IWP9 |
Function
for CCDC28A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC28A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC28A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CCDC28A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC28A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC28A |
1 GenomeRNAi human phenotype for CCDC28A:
|
Pathways & Interactions
for CCDC28A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC28A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for CCDC28A (Q8IWP93 ENSP000003327164) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CCDC28A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC28A
Search CenterWatch for drugs/clinical trials and news about CCDC28A / CC28A
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Transcripts
for CCDC28A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC28A gene: NM_015439.2 Unigene Cluster for CCDC28A: Coiled-coil domain containing 28A Hs.412019 [show with all ESTs]Unigene Representative Sequence: AY1675711 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000332797(uc003qie.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC28A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC28A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC28A (NM_015439) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC28A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC28A |
Additional cDNA sequence: AJ420568.1 AK300672.1 AL050197.1 AY167571.1 BC000758.2 BC004464.1 BC013019.2 BC080566.1 BC108717.1 3 DOTS entries: DT.116570 DT.92428207 DT.100783458 24/205 AceView cDNA sequences (see all 205): AW450332 BE796708 AI401355 BU558161 AL553003 BM982747 BU191366 BM560189 BU539807 N64827 BE392093 CR626300 AI474821 CR626831 AV702199 BQ690351 CR598704 AA456015 BF439581 N62426 BU956891 BM910674 BQ944306 BF355521
GeneLoc Exon Structure
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Expression
for CCDC28A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC28A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGTGTGTT
About this image
See CCDC28A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC28A
SOURCE GeneReport for Unigene cluster: Hs.412019
SABiosciences Custom PCR Arrays for CCDC28A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC28A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC28A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC28A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC28A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC28A |
Orthologs
for CCDC28A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CCDC28A gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for CCDC28A (if available)
TreeFam Gene Tree for CCDC28A (if available) |
Paralogs
for CCDC28A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCDC28A gene
- CCDC28B2
1 SIMAP similar gene for CCDC28A using alignment to 2 protein entries: CC28A_HUMAN (see all proteins):CCDC28B
CCDC28A for paralogs About GeneDecksing
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Genomic Variants
for CCDC28A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for CCDC28A (139094657 - 139114456 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CCDC28A
1 Inversion: 59833 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC28A |
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Disorders
/ Diseases
for CCDC28A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCDC28A for disorders About GeneDecksing
5  diseases for CCDC28A: About MalaCardsmegakaryoblastic leukemia acute megakaryoblastic leukemia acute myeloid leukemia myeloid leukemia
leukemia
Export disorders for CCDC28A gene to outside databases
|
Publications
for CCDC28A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC28A gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC28A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Functional analysis of the NUP98-CCDC28A fusion protei n. (PubMed id 22058212)1 Petit A....Penard-Lacronique V. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Characterization of 6q abnormalities in childhood acute myeloid leukemia and identification of a novel t(6;11)(q24.1;p15.5) resulting in a NUP98-C6orf80 fusion in a case of acute megakaryoblastic leukemia. (PubMed id 16028218)1 Tosi S....Harbott J. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for CCDC28A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CCDC28A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC28A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC28A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC28A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CCDC28A gene:
Search GeneIP for patents involving CCDC28A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC28A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC28A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC28A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC28A | | | OriGene Protein Over-expression Lysate for CCDC28A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC28A | | OriGene 3'-UTR Clone for CCDC28A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC28A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC28A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 |  |  |  | |
| | | | Search Tocris compounds for CCDC28A |
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 | | | CCDC28A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC28A |
|  |  |  | | | | Search ThermoFisher Antibodies for CCDC28A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC28A |
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