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Aliases for CCDC27 Gene

Aliases for CCDC27 Gene

  • Coiled-Coil Domain Containing 27 2 3 5

External Ids for CCDC27 Gene

Previous GeneCards Identifiers for CCDC27 Gene

  • GC01P003693
  • GC01P003658
  • GC01P002964
  • GC01P003668

Summaries for CCDC27 Gene

GeneCards Summary for CCDC27 Gene

CCDC27 (Coiled-Coil Domain Containing 27) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC27 Gene

Genomics for CCDC27 Gene

Regulatory Elements for CCDC27 Gene

Enhancers for CCDC27 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC27 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC27 Gene

3,752,398 bp from pter
3,771,645 bp from pter
19,248 bases
Plus strand

Genomic View for CCDC27 Gene

Genes around CCDC27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC27 Gene

Proteins for CCDC27 Gene

  • Protein details for CCDC27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 27
    Protein Accession:
    Secondary Accessions:
    • Q5TBV3
    • Q96M50

    Protein attributes for CCDC27 Gene

    656 amino acids
    Molecular mass:
    75354 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC27 Gene

Proteomics data for CCDC27 Gene at MOPED

Post-translational modifications for CCDC27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC27 Gene

Domains & Families for CCDC27 Gene

Protein Domains for CCDC27 Gene


Suggested Antigen Peptide Sequences for CCDC27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC27: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC27 Gene

Function for CCDC27 Gene

Phenotypes for CCDC27 Gene

genes like me logo Genes that share phenotypes with CCDC27: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC27 Gene

Localization for CCDC27 Gene

Subcellular locations from

Jensen Localization Image for CCDC27 Gene COMPARTMENTS Subcellular localization image for CCDC27 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC27 Gene

Pathways & Interactions for CCDC27 Gene

SuperPathways for CCDC27 Gene

No Data Available

Interacting Proteins for CCDC27 Gene

Gene Ontology (GO) - Biological Process for CCDC27 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC27 Gene

Drugs & Compounds for CCDC27 Gene

No Compound Related Data Available

Transcripts for CCDC27 Gene

mRNA/cDNA for CCDC27 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC27 Gene

Coiled-coil domain containing 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC27 Gene

No ASD Table

Relevant External Links for CCDC27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC27 Gene

mRNA expression in normal human tissues for CCDC27 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC27 Gene

This gene is overexpressed in Testis (x49.4).

Protein differential expression in normal tissues from HIPED for CCDC27 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (48.9) and Heart (20.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC27 Gene

SOURCE GeneReport for Unigene cluster for CCDC27 Gene Hs.348700

genes like me logo Genes that share expression patterns with CCDC27: view

Protein tissue co-expression partners for CCDC27 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CCDC27 Gene

Orthologs for CCDC27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC27 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC27 35
  • 74.48 (n)
  • 62.9 (a)
CCDC27 36
  • 58 (a)
(Canis familiaris)
Mammalia CCDC27 35
  • 71.84 (n)
  • 62.06 (a)
CCDC27 36
  • 54 (a)
(Mus musculus)
Mammalia Ccdc27 35
  • 73.75 (n)
  • 65.64 (a)
Ccdc27 16
Ccdc27 36
  • 50 (a)
(Pan troglodytes)
Mammalia CCDC27 35
  • 94.39 (n)
  • 91.5 (a)
CCDC27 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Ccdc27 35
  • 67.07 (n)
  • 54.55 (a)
(Monodelphis domestica)
Mammalia CCDC27 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC27 36
  • 53 (a)
(Gallus gallus)
Aves CCDC27 36
  • 34 (a)
(Anolis carolinensis)
Reptilia CCDC27 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
Species with no ortholog for CCDC27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC27 Gene

Gene Tree for CCDC27 (if available)
Gene Tree for CCDC27 (if available)

Paralogs for CCDC27 Gene

No data available for Paralogs for CCDC27 Gene

Variants for CCDC27 Gene

Sequence variations from dbSNP and Humsavar for CCDC27 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10910021 - 3,752,641(+) CATCT(C/G)AGAGG nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1181883 - 3,761,369(-) GCTGC(A/G)TCTTC nc-transcript-variant, reference, missense
rs10910024 - 3,763,211(+) GGACA(C/T)GGGTG nc-transcript-variant, reference, missense
rs11806371 - 3,763,322(+) GCTGC(C/G/T)GGAGG nc-transcript-variant, reference, missense
rs1181870 -- 3,768,390(-) gccag(G/T)cacgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC27 Gene

Variant ID Type Subtype PubMed ID
dgv96n71 CNV Loss 21882294
nsv470687 CNV Loss 18288195
dgv99n71 CNV Loss 21882294
nsv871942 CNV Loss 21882294
nsv830314 CNV Gain+Loss 17160897
nsv460061 CNV Loss 19166990
nsv870977 CNV Loss 21882294
nsv830425 CNV Gain 17160897
nsv871323 CNV Loss 21882294
esv2659590 CNV Deletion 23128226
dgv114n71 CNV Loss 21882294

Variation tolerance for CCDC27 Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.96; 74.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCDC27 Gene

Disorders for CCDC27 Gene

Relevant External Links for CCDC27

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC27 Gene

Publications for CCDC27 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The E3 ubiquitin ligase thyroid hormone receptor-interacting protein 12 targets pancreas transcription factor 1a for proteasomal degradation. (PMID: 25355311) Hanoun N. … Dufresne M. (J. Biol. Chem. 2014) 3
  3. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. (PMID: 23720494) Evans D.M. … Whitfield J.B. (Hum. Mol. Genet. 2013) 3
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for CCDC27 Gene

Sources for CCDC27 Gene