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CCDC26 Gene

RNA gene   GIFtS: 30
GCID: GC08M130434

CCDC26 Long Non-Coding RNA

(Previous name: coiled-coil domain containing 26)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 3

Aliases
CCDC26 Long Non-Coding RNA1 2
RAM2 3 5
Retinoic Acid Modulator1 3
Coiled-Coil Domain Containing 261
CCD265

External Ids:    HGNC: 284161   Entrez Gene: 1371962   Ensembl: ENSG000002291407   OMIM: 6130405   UniProtKB: Q8TAB73   
ORGUL members:         

Export aliases for CCDC26 gene to outside databases

Previous GC identifer: GC08U901094


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCDC26 Gene:
CCDC26 (CCDC26 long non-coding RNA) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with CCDC26 include cleft lip, and cleft palate.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CCDC26
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC26 promoter sequence
   Search Chromatin IP Primers for CCDC26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.21   Ensembl cytogenetic band:  8q24.21   HGNC cytogenetic band: 8q24.21

CCDC26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC26 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M130434:  view genomic region     (about GC identifiers)

Start:
130,363,937 bp from pter      End:
130,692,485 bp from pter
Size:
328,549 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CCDC26

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CCD26_HUMAN, Q8TAB7 (See protein sequence)
Recommended Name: Putative coiled-coil domain-containing protein 26  
Size: 109 amino acids; 13192 Da
Caution: Product of a dubious gene prediction

Explore the universe of human proteins at neXtProt for CCDC26: NX_Q8TAB7

Explore proteomics data for CCDC26 at MOPED


See CCDC26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_659487.1  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q8TAB7


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC26
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular2
mitochondrion2
cytosol1
endoplasmic reticulum1
peroxisome1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC26
Interactions:

    Search GeneGlobe Interaction Network for CCDC26

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for CCDC26 (CCD26)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CCDC26 gene: 
NM_145050.3  

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000523151(lincRNA) ENST00000446592(lincRNA) ENST00000520048(lincRNA) ENST00000595333(lincRNA)
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23 AceView cDNA sequences:

AI032482 BX101553 AA628201 AA009754 AV730804 BC026098 CA391588 BG505008 
BG393734 BG532915 BU186641 NM_145050 BG393664 BG494756 BX097638 BC070152 
BF976785 T83203 BF184063 BG531028 BG528201 BG527998 BF104016 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for CCDC26:none

CCDC26 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATATCAATAT
CCDC26 Expression
About this image

CCDC26 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CCDC26 Protein Expression

UniProtKB/Swiss-Prot: CCD26_HUMAN, Q8TAB7
Tissue specificity: Based on cell line studies, may be restricted to the myelocyte-monocyte lineage

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for CCDC26 (if available)
TreeFam Gene Tree for CCDC26 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing CCDC26
DNA2.0 Custom Variant and Variant Library Synthesis for CCDC26

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 613040    OMIM disorders: --

3 diseases for CCDC26:    
About MalaCards
cleft lip    cleft palate    malignant glioma

1 disease from the University of Copenhagen DISEASES database for CCDC26:
Malignant glioma

CCDC26 for disorders           About GeneDecksing

Genetic Association Database (GAD): CCDC26
Human Genome Epidemiology (HuGE) Navigator: CCDC26 (5 documents)

Export disorders for CCDC26 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CCDC26 gene, integrated from 10 sources (see all 14):
(articles sorted by number of sources associating them with CCDC26)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Co-resistance to retinoic acid and TRAIL by insertion mutagenesis into RAM. (PubMed id 16449964)1, 2, 3, 9 Yin W.... Gronemeyer H. (Oncogene 2006)
  2. Deciphering the 8q24.21 association for glioma. (PubMed id 23399484)1, 3 Enciso-Mora V....Houlston R.S. (Hum. Mol. Genet. 2013)
  3. Interaction between 5 genetic variants and allergy in glioma risk. (PubMed id 20462933)1, 4 Schoemaker M.J....Swerdlow A.J. (Am. J. Epidemiol. 2010)
  4. Genetic risk profiles identify different molecular etiologies for glioma. (PubMed id 20847058)1, 4 Simon M....Sanson M. (Clin. Cancer Res. 2010)
  5. Genome-wide association study identifies five susceptibility loci for glioma. (PubMed id 19578367)1, 4 Shete S....Houlston R.S. (Nat. Genet. 2009)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Differential distribution of CCDC26 glioma-risk alleles in myeloid malignancies with mutant IDH1 compared with their IDH2R140-mutated or IDH-unmutated counterparts. (PubMed id 22116548)1 Lasho T.L....Jenkins R.B. (Leukemia 2012)
  8. Polymorphisms of TREH, IL4R and CCDC26 genes associated with risk of glioma. (PubMed id 22369735)1 Li S....Zhang Y. (Cancer Epidemiol 2012)
  9. Chromosome 7p11.2 (EGFR) variation influences glioma risk. (PubMed id 21531791)1 Sanson M....Simon M. (Hum. Mol. Genet. 2011)
  10. Joint associations between genetic variants and reproductive factors in glioma risk among women. (PubMed id 21920947)1 Wang S.S....Rajaraman P. (Am. J. Epidemiol. 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 137196 HGNC: 28416 AceView: MGC27434 Ensembl:ENSG00000229140 euGenes: HUgn137196
ECgene: CCDC26 H-InvDB: CCDC26

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CCDC26 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CCDC26 gene:
Search GeneIP for patents involving CCDC26

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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