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Aliases for CCDC25 Gene

Aliases for CCDC25 Gene

  • Coiled-Coil Domain Containing 25 2 3 5

External Ids for CCDC25 Gene

Previous GeneCards Identifiers for CCDC25 Gene

  • GC08M027648
  • GC08M027590
  • GC08M026136

Summaries for CCDC25 Gene

GeneCards Summary for CCDC25 Gene

CCDC25 (Coiled-Coil Domain Containing 25) is a Protein Coding gene.

Gene Wiki entry for CCDC25 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC25 Gene

Genomics for CCDC25 Gene

Regulatory Elements for CCDC25 Gene

Enhancers for CCDC25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G027744 1.1 dbSUPER 32.5 +27.4 27364 2.3 HNRNPUL1 FOXA2 MLX ARID4B DMAP1 FEZF1 ZNF2 YY1 SLC30A9 ZNF302 CCDC25 ESCO2 RNU6-1276P CLU ENSG00000253875
GH08G027771 1.5 FANTOM5 ENCODE 22.5 -0.9 -895 4.0 HDGF PKNOX1 FOXA2 CREB3L1 ARNT MLX AGO1 ZFP64 WRNIP1 SIN3A CCDC25 ESCO2 CLU SCARA3 GC08P027774
GH08G027731 1 dbSUPER 33.2 +38.1 38054 6.6 HDGF ATF1 FOXA2 CREB3L1 ARID4B ZNF48 ZNF2 YY1 CBX5 ZNF143 CCDC25 ESCO2 RNU6-1276P CLU SCARA3 ENSG00000253875
GH08G027740 0.8 dbSUPER 32.4 +32.0 31971 1.3 DRAP1 CTCF PKNOX1 ATF1 ARID4B DNMT3B RAD21 GATA3 SMC3 EGR2 CCDC25 ESCO2 RNU6-1276P CLU ENSG00000253875
GH08G027729 0.7 ENCODE 32.6 +42.4 42361 0.7 CTCF KLF1 TAL1 TEAD4 TCF12 NCOR1 EGR1 NR2F6 TRIM24 EZH2 CCDC25 CLU RNU6-1276P ESCO2 SCARA3 ENSG00000253875 MIR3622B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC25 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000330460 255 1201 PKNOX1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for CCDC25 Gene

Chromosome:
8
Start:
27,733,311 bp from pter
End:
27,772,655 bp from pter
Size:
39,345 bases
Orientation:
Minus strand

Genomic View for CCDC25 Gene

Genes around CCDC25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC25 Gene

Proteins for CCDC25 Gene

  • Protein details for CCDC25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WR0-CCD25_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 25
    Protein Accession:
    Q86WR0
    Secondary Accessions:
    • Q0P663
    • Q96SI2
    • Q9NV98

    Protein attributes for CCDC25 Gene

    Size:
    208 amino acids
    Molecular mass:
    24479 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91857.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC25 Gene

Post-translational modifications for CCDC25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC25 Gene

Domains & Families for CCDC25 Gene

Protein Domains for CCDC25 Gene

Graphical View of Domain Structure for InterPro Entry

Q86WR0

UniProtKB/Swiss-Prot:

CCD25_HUMAN :
  • Belongs to the CCDC25 family.
Family:
  • Belongs to the CCDC25 family.
genes like me logo Genes that share domains with CCDC25: view

No data available for Gene Families for CCDC25 Gene

Function for CCDC25 Gene

Gene Ontology (GO) - Molecular Function for CCDC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC25: view
genes like me logo Genes that share phenotypes with CCDC25: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC25 Gene

Localization for CCDC25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC25 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 3
cytoskeleton 2
golgi apparatus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCDC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CCDC25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC25 Gene

Pathways & Interactions for CCDC25 Gene

SuperPathways for CCDC25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC25 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC25 Gene

Transcripts for CCDC25 Gene

Unigene Clusters for CCDC25 Gene

Coiled-coil domain containing 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC25 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - - - - - - -
SP6: - - -
SP7: - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - -
SP11: - - - - - - -
SP12: - - - - - - -
SP13:

Relevant External Links for CCDC25 Gene

GeneLoc Exon Structure for
CCDC25
ECgene alternative splicing isoforms for
CCDC25

Expression for CCDC25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC25 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.6) and Skin (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC25 Gene



Protein tissue co-expression partners for CCDC25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC25 Gene:

CCDC25

SOURCE GeneReport for Unigene cluster for CCDC25 Gene:

Hs.445512

Evidence on tissue expression from TISSUES for CCDC25 Gene

  • Liver(4.4)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with CCDC25: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC25 Gene

Orthologs for CCDC25 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCDC25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC25 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia CCDC25 34 35
  • 93.27 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC25 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 92 (a)
OneToMany
-- 35
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ccdc25 34 16 35
  • 91.99 (n)
cow
(Bos Taurus)
Mammalia CCDC25 34 35
  • 91.83 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc25 34
  • 91.35 (n)
chicken
(Gallus gallus)
Aves CCDC25 34 35
  • 82.93 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC25 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc25 34
  • 77.99 (n)
Str.2958 34
African clawed frog
(Xenopus laevis)
Amphibia 2o545-prov 34
zebrafish
(Danio rerio)
Actinopterygii ccdc25 34 35
  • 76.33 (n)
zgc64173 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003621 34
  • 61.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4593 34 35
  • 58.94 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y54G11A.2 34
  • 57 (n)
Y54G11A.2 35
  • 54 (a)
OneToMany
F43C1.7 35
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes JLP2 35 37
  • 36 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G11500 34
  • 64.81 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6664 34
rice
(Oryza sativa)
Liliopsida Os01g0750500 34
  • 60.44 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.728 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6097 35
  • 65 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU06750 34
  • 55.44 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11963 34
Species where no ortholog for CCDC25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC25 Gene

ENSEMBL:
Gene Tree for CCDC25 (if available)
TreeFam:
Gene Tree for CCDC25 (if available)

Paralogs for CCDC25 Gene

Pseudogenes.org Pseudogenes for CCDC25 Gene

genes like me logo Genes that share paralogs with CCDC25: view

No data available for Paralogs for CCDC25 Gene

Variants for CCDC25 Gene

Sequence variations from dbSNP and Humsavar for CCDC25 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs111510470 Likely benign 27,774,556(+) GACGC(G/T)CACGG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs541613867 Uncertain significance 27,774,586(+) GAGAG(C/G)TCGCC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs886062855 Uncertain significance 27,774,580(+) GCTGA(A/G)GAGAG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs886062856 Uncertain significance 27,774,591(+) CTCGC(C/T)GGGCT intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs886062857 Uncertain significance 27,774,622(+) GGAGT(A/T)GGCCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC25 Gene

Variant ID Type Subtype PubMed ID
esv3616726 CNV loss 21293372
nsv1017032 CNV loss 25217958
nsv397387 CNV deletion 16902084
nsv507451 OTHER sequence alteration 20534489
nsv528584 CNV gain 19592680
nsv610867 CNV gain 21841781
nsv981922 CNV duplication 23825009

Variation tolerance for CCDC25 Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC25 Gene

Disorders for CCDC25 Gene

Relevant External Links for CCDC25

Genetic Association Database (GAD)
CCDC25
Human Genome Epidemiology (HuGE) Navigator
CCDC25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC25

No disorders were found for CCDC25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC25 Gene

Publications for CCDC25 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for CCDC25 Gene

Sources for CCDC25 Gene

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