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Aliases for CCDC25 Gene

Aliases for CCDC25 Gene

  • Coiled-Coil Domain Containing 25 2 3 5

External Ids for CCDC25 Gene

Previous GeneCards Identifiers for CCDC25 Gene

  • GC08M027648
  • GC08M027590
  • GC08M026136

Summaries for CCDC25 Gene

GeneCards Summary for CCDC25 Gene

CCDC25 (Coiled-Coil Domain Containing 25) is a Protein Coding gene.

Gene Wiki entry for CCDC25 Gene

Additional gene information for CCDC25 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC25 Gene

Genomics for CCDC25 Gene

Regulatory Elements for CCDC25 Gene

Enhancers for CCDC25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H027386 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.5 +383.5 383526 6 ZNF687 JUN EBF1 RELA POLR2A IKZF1 SCRT2 RUNX3 MAFK IKZF2 CCDC25 EPHX2 PTK2B CHRNA2 ESCO2 RNU6-1276P MIR6842
GH08H027602 1.3 ENCODE dbSUPER 20.2 +169.3 169268 2.5 FOXA2 MLX ARID4B FEZF1 ZNF2 YY1 ZNF302 ZNF143 SP5 MXD4 CCDC25 ENSG00000253875 LOC100130612 LOC100132229 EPHX2 CHRNA2 ELP3 ESCO2 RNU6-1276P GULOP
GH08H027729 0.7 ENCODE 32.6 +42.4 42361 0.7 SMARCE1 TAL1 DPF2 TCF12 NFIC SMARCA4 HDAC2 NCOR1 EGR1 KLF16 CCDC25 CLU RNU6-1276P ESCO2 SCARA3 ENSG00000253875 MIR3622B
GH08H027835 1.4 FANTOM5 ENCODE 15.7 -64.7 -64728 3.1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF143 ZNF207 SP3 CCDC25 ESCO2 PBK RNU6-1276P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC25 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000330460 255 1201 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 ZHX2

Genomic Locations for CCDC25 Gene

Genomic Locations for CCDC25 Gene
39,345 bases
Minus strand

Genomic View for CCDC25 Gene

Genes around CCDC25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC25 Gene

Proteins for CCDC25 Gene

  • Protein details for CCDC25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 25
    Protein Accession:
    Secondary Accessions:
    • Q0P663
    • Q96SI2
    • Q9NV98

    Protein attributes for CCDC25 Gene

    208 amino acids
    Molecular mass:
    24479 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91857.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC25 Gene


neXtProt entry for CCDC25 Gene

Post-translational modifications for CCDC25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC25 Gene

Domains & Families for CCDC25 Gene

Gene Families for CCDC25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC25 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCDC25 family.
  • Belongs to the CCDC25 family.
genes like me logo Genes that share domains with CCDC25: view

Function for CCDC25 Gene

Phenotypes From GWAS Catalog for CCDC25 Gene

Gene Ontology (GO) - Molecular Function for CCDC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC25: view
genes like me logo Genes that share phenotypes with CCDC25: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC25 Gene

Localization for CCDC25 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC25 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 3
cytoskeleton 2
golgi apparatus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CCDC25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC25 Gene

Pathways & Interactions for CCDC25 Gene

SuperPathways for CCDC25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC25 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC25 Gene

Drugs & Compounds for CCDC25 Gene

No Compound Related Data Available

Transcripts for CCDC25 Gene

Unigene Clusters for CCDC25 Gene

Coiled-coil domain containing 25:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC25 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - - - - - - -
SP6: - - -
SP7: - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - -
SP11: - - - - - - -
SP12: - - - - - - -

Relevant External Links for CCDC25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CCDC25 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.6) and Skin (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC25 Gene

Protein tissue co-expression partners for CCDC25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC25 Gene:


SOURCE GeneReport for Unigene cluster for CCDC25 Gene:


Evidence on tissue expression from TISSUES for CCDC25 Gene

  • Liver(4.4)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with CCDC25: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC25 Gene

Orthologs for CCDC25 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCDC25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC25 33 34
  • 100 (n)
(Canis familiaris)
Mammalia CCDC25 33 34
  • 93.27 (n)
(Monodelphis domestica)
Mammalia CCDC25 34
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 92 (a)
-- 34
  • 87 (a)
(Mus musculus)
Mammalia Ccdc25 33 16 34
  • 91.99 (n)
(Bos Taurus)
Mammalia CCDC25 33 34
  • 91.83 (n)
(Rattus norvegicus)
Mammalia Ccdc25 33
  • 91.35 (n)
(Gallus gallus)
Aves CCDC25 33 34
  • 82.93 (n)
(Anolis carolinensis)
Reptilia CCDC25 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc25 33
  • 77.99 (n)
Str.2958 33
African clawed frog
(Xenopus laevis)
Amphibia 2o545-prov 33
(Danio rerio)
Actinopterygii ccdc25 33 34
  • 76.33 (n)
zgc64173 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003621 33
  • 61.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4593 33 34
  • 58.94 (n)
(Caenorhabditis elegans)
Secernentea CELE_Y54G11A.2 33
  • 57 (n)
Y54G11A.2 34
  • 54 (a)
F43C1.7 34
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes JLP2 34 36
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G11500 33
  • 64.81 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6664 33
(Oryza sativa)
Liliopsida Os01g0750500 33
  • 60.44 (n)
(Hordeum vulgare)
Liliopsida Hv.728 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6097 34
  • 65 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06750 33
  • 55.44 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11963 33
Species where no ortholog for CCDC25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC25 Gene

Gene Tree for CCDC25 (if available)
Gene Tree for CCDC25 (if available)

Paralogs for CCDC25 Gene Pseudogenes for CCDC25 Gene

genes like me logo Genes that share paralogs with CCDC25: view

No data available for Paralogs for CCDC25 Gene

Variants for CCDC25 Gene

Sequence variations from dbSNP and Humsavar for CCDC25 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs111510470 Likely benign 27,774,556(+) GACGC(G/T)CACGG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs541613867 Uncertain significance 27,774,586(+) GAGAG(C/G)TCGCC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs886062855 Uncertain significance 27,774,580(+) GCTGA(A/G)GAGAG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs886062856 Uncertain significance 27,774,591(+) CTCGC(C/T)GGGCT intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs886062857 Uncertain significance 27,774,622(+) GGAGT(A/T)GGCCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC25 Gene

Variant ID Type Subtype PubMed ID
nsv981922 CNV duplication 23825009
nsv610867 CNV gain 21841781
nsv528584 CNV gain 19592680
nsv507451 OTHER sequence alteration 20534489
nsv397387 CNV deletion 16902084
nsv1017032 CNV loss 25217958
esv3616726 CNV loss 21293372

Variation tolerance for CCDC25 Gene

Residual Variation Intolerance Score: 39.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC25 Gene

Disorders for CCDC25 Gene

Relevant External Links for CCDC25

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC25 Gene

Publications for CCDC25 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60

Products for CCDC25 Gene

Sources for CCDC25 Gene

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