CCDC25 Gene
protein-coding GIFtS: 46
GCID: GC08M027590
|
|
coiled-coil domain containing 25
| |
Aliases
for CCDC25 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 251 2 | | FLJ108531 | | Coiled-Coil Domain-Containing Protein 252 |
Export aliases for CCDC25 gene to outside databasesPrevious GC identifers: GC08M027648 GC08M026136 |
Summaries
for CCDC25 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for CCDC25 (Coiled-Coil Domain Containing Protein â€" 25)
|
Genomic Views
for CCDC25 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC25 gene promoter:
TBP NF-YA HNF-1A AREB6 CBF-A CBF-B HNF-1 CP1A CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC25
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC25 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p21.1 Ensembl cytogenetic band: 8p21.1 HGNC cytogenetic band: 8p21.1CCDC25 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M027590: view genomic region
(about GC identifiers)
Start:
|
27,590,833 bp from pter |
End:
|
27,630,170 bp from pter |
Size:
|
39,338 bases |
Orientation:
|
minus strand |
|
Proteins
for CCDC25 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CCD25_HUMAN, Q86WR0 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 25 Size: 208 amino acids; 24479 Da
Sequence caution: Sequence=BAA91857.1; Type=Erroneous initiation;
Secondary accessions: Q96SI2 Q9NV98Explore the universe of human proteins at neXtProt for CCDC25: NX_Q86WR0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86WR0
CCDC25 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060716.2
ENSEMBL proteins: ENSP00000348933 ENSP00000427714 ENSP00000428587 ENSP00000430662 ENSP00000428505 ENSP00000428000 ENSP00000429861 ENSP00000428499 ENSP00000437677
Human Recombinant Protein Products:
CCDC25 Antibody Products:
Assay Products for CCDC25: |
Protein
Domains /
Families
for CCDC25 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCDC25 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86WR0ProtoNet protein and cluster: Q86WR0 1 Blocks protein family: IPB008532 Protein of unknown function DUF814
UniProtKB/Swiss-Prot: CCD25_HUMAN, Q86WR0Similarity: Belongs to the CCDC25 family |
Function
for CCDC25 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC25 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC25 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CCDC25 (NM_018246) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC25 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC25 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC25 |
1 GenomeRNAi human phenotype for CCDC25:
|
Pathways & Interactions
for CCDC25 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC25
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/6 Interacting proteins for CCDC25 (Q86WR03 ENSP000003489334) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for CCDC25 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC25
Search CenterWatch for drugs/clinical trials and news about CCDC25 / CCD25
|
Transcripts
for CCDC25 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC25 gene: NM_018246.2 Unigene Cluster for CCDC25: Coiled-coil domain containing 25 Hs.445512 [show with all ESTs]Unigene Representative Sequence: NM_01824612 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000356537(uc003xgc.3 uc011lan.2 uc011lao.2) ENST00000520486(uc003xgd.3 uc003xge.3)
ENST00000520202 ENST00000523841 ENST00000519509 ENST00000522915 ENST00000521220
ENST00000524084 ENST00000519299 ENST00000519843 ENST00000517979(uc003xgf.1)
ENST00000539095
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC25 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC25 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC25 (NM_018246) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC25 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC25 |
Additional cDNA sequence: AK001715.1 AK027900.1 AK292875.1 AK294848.1 AK311437.1 AK316015.1 BC006239.2 BC032588.1 BC049197.1 BC054039.1 BC065295.1 BC110391.1 20 DOTS entries: DT.100790378 DT.415542 DT.95090320 DT.95090286 DT.100802644 DT.91747204 DT.100675469 DT.100790384 DT.121483658 DT.91747202 DT.91747207 DT.95090318 DT.100790377 DT.121483647 DT.121483651 DT.91641293 DT.95090326 DT.97765532 DT.91866971 DT.95144500 24/313 AceView cDNA sequences (see all 313): AA923065 R05839 CN483161 AI374792 AA453177 CA414014 BM974370 AA374591 BQ775787 BC054039 CK724861 BU633997 AI591071 BF739880 AA236795 AA456693 AA456296 CA417878 BU616543 AA700508 D81764 CR617453 BU619752 AI205480
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC25 (see all 13) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | - | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for CCDC25
|
Expression
for CCDC25 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTGAATGA
About this image
See CCDC25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC25
SOURCE GeneReport for Unigene cluster: Hs.445512
SABiosciences Custom PCR Arrays for CCDC25
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC25
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC25 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC25 |
Orthologs
for CCDC25 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CCDC25 gene from 9/35 species (see all 35) About this table
ENSEMBL Gene Tree for CCDC25 (if available)
TreeFam Gene Tree for CCDC25 (if available) |
Paralogs
for CCDC25 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CCDC25 gene
CCDC25 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for CCDC25
PGOHUM00000248929 PGOHUM00000244682
|
Genomic Variants
for CCDC25 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC25 (27590833 - 27630170 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CCDC25
1 CNV: 95339
1 Indel: 13043 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC25 |
|
Disorders
/ Diseases
for CCDC25 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 CCDC25 for disorders About MalaCards
CCDC25 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: CCDC25 (1 document)
Export disorders for CCDC25 gene to outside databases
|
Publications
for CCDC25 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC25 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with CCDC25) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere s hortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
|
External Searches for CCDC25 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC25 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC25 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC25 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC25 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC25 gene:
Search GeneIP for patents involving CCDC25
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC25 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC25 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC25 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC25 | | | OriGene Protein Over-expression Lysate for CCDC25 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC25 | | OriGene 3'-UTR Clone for CCDC25 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC25 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC25 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CCDC25 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CCDC25 | | OriGene Custom Protein Services for CCDC25 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC25 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC25 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC25 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC25 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CCDC25 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CCDC25 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC25 |
|  |  |  | | | | Search ThermoFisher Antibodies for CCDC25 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC25 |
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