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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CCDC24 Gene

protein-coding GIFtS: 39
GCID: GC01P044457

coiled-coil domain containing 24

Explore 1 disease affiliated with
CCDC24 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 24¹ ²
MGC45441¹
RP5-1198O20.2²
Coiled-Coil Domain-Containing Protein 24²

External Ids:	HGNC: 28688¹	Entrez Gene: 149473²	Ensembl: ENSG00000159214⁷	UniProtKB: Q8N4L8³

Export aliases for CCDC24 gene to outside databases

Previous GC identifers: GC01P044127 GC01P044229 GC01P042572

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CCDC24 gene promoter:
Oct-B1 E2F-3a E2F-4 ER-alpha E2F-5 NF-1 E2F-2 AREB6 E2F E2F-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CCDC24 promoter sequence

Search SABiosciences Chromatin IP Primers for CCDC24

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC24

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1 Ensembl cytogenetic band: 1p34.1 HGNC cytogenetic band: 1p34.1

CCDC24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC24 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P044457: view genomic region (about GC identifiers)

Start:	44,457,031 bp from pter	End:	44,462,200 bp from pter
Size:	5,170 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CCD24_HUMAN, Q8N4L8 (See protein sequence)

Recommended Name: Coiled-coil domain-containing protein 24

Size: 307 amino acids; 34322 Da

Secondary accessions: Q6RWT2

Alternative splicing: 2 isoforms: Q8N4L8-1 Q8N4L8-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCDC24: NX_Q8N4L8

CCDC24 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689712.1

ENSEMBL proteins:

ENSP00000361392

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8N4L8

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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1 GenomeRNAi human phenotype for CCDC24:

Decreased viability of wild-ty

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CCDC24

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for CCDC24 (Q8N4L8³ ENSP00000361392⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DISC1	Q9NRI5³, ENSP00000355596⁴	I2D: score=2 STRING: ENSP00000355596
--	ENSP00000393642⁴	STRING: ENSP00000393642

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CCDC24
Search CenterWatch for drugs/clinical trials and news about CCDC24 / CCD24

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for CCDC24 gene:

NM_152499.1

Unigene Cluster for CCDC24:

Coiled-coil domain containing 24

Hs.632394 [show with all ESTs]

Unigene Representative Sequence: AK092569

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000486064 ENST00000372318(uc001clj.3 uc009vxc.3) ENST00000460543

ENST00000463846 ENST00000490563 ENST00000490064 ENST00000486504 ENST00000485811

ENST00000466180 ENST00000479055 ENST00000472562

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Additional cDNA sequence:

AK024289.1 AK092569.1 AY487420.1 BC033868.1 BC047313.1 BX641142.1

9 DOTS entries:

DT.309161 DT.91709090 DT.100831913 DT.100779570 DT.95157902 DT.92417826 DT.99989961 DT.99996312

DT.95242320

24/65 AceView cDNA sequences (see all 65):

BU185335 BE047349 CD673851 AW589385 BF513559 BC047313 BX641142 NM_152499

AI040409 BC033868 CR619815 BM706484 CB851617 BM673308 CA312831 BI869906

AW512774 BM976756 AI364306 BI770874 BU623205 AY487420 CB853919 BU164878

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC24 (see all 12) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	·	3d	·	3e	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	^	8	^	9a	·	9b	^	10	^	11a	·	11b	·	11c	·	11d
SP1:									-		-						-		-										-		-		-
SP2:																	-		-		-								-		-		-
SP3:									-		-						-		-										-		-		-
SP4:									-		-						-		-		-		-		-		-		-		-		-
SP5:																	-		-		-		-		-		-		-		-		-

ECgene alternative splicing isoforms for CCDC24

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CCDC24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CCDC24 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Left Ventricle

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CCDC24 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC24

SOURCE GeneReport for Unigene cluster: Hs.632394

SABiosciences Custom PCR Arrays for CCDC24

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CCDC24 gene from 2/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ccdc24^{1 , 5}	coiled-coil domain containing 24^{1, 5}	74.1(n)¹ 63.75(a)¹		4 (53.69 cM)⁵ 381546¹ NM_001034876.1¹ NP_001030048.1¹ 117866524⁵
zebrafish (Danio rerio)	Actinopterygii	ccdc24⁶	coiled-coil domain containing 24	24(a)	1 ↔ 1	2(33140286-33173149)

ENSEMBL Gene Tree for CCDC24 (if available)
TreeFam Gene Tree for CCDC24 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs34298087^1,2	C,	--	44458957(+)	`AAGTGAA/-AAAAA`	1	--	int¹		1		CSA	2
rs35911583^1,2	C	--	44459116(+)	`CTAAG-/AAAAAA`	1	--	int¹		2		NA CSA	4
rs36038358^1,2	--	--	44460094(+)	`CCCTG-/TTTC TTTCT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CCDC24 (44457031 - 44462200 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CCDC24
2 CNVs: 84203 84204

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CCDC24 for disorders About GeneDecksing

1 disease for CCDC24: About MalaCards

schizophrenia

Export disorders for CCDC24 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CCDC24 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC24)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PubMed id 17043677)¹ Camargo L.M....Brandon N.J. (2007)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 149473	HGNC: 28688	AceView: MGC45441	Ensembl:ENSG00000159214	euGenes: HUgn149473
ECgene: CCDC24	H-InvDB: CCDC24

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CCDC24	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CCDC24 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CCDC24 gene:
Search GeneIP for patents involving CCDC24

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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	SwitchGear Promoter luciferase reporter plasmids for CCDC24

Search ThermoFisher Antibodies for CCDC24

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC24

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CCDC24 gene at Home site.

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CCDC24 Gene

coiled-coil domain containing 24

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for CCDC24 gene

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CCDC24 Gene

coiled-coil domain containing 24

Aliasesfor CCDC24 gene

Summariesfor CCDC24 gene

Genomic Viewsfor CCDC24 gene

Proteinsfor CCDC24 gene

Protein Domains /Familiesfor CCDC24 gene

Functionfor CCDC24 gene

Pathways & Interactionsfor CCDC24 gene

Drugs & Compoundsfor CCDC24 gene

Transcriptsfor CCDC24 gene

Expression for CCDC24 gene

Orthologsfor CCDC24 gene

Paralogsfor CCDC24 gene

Genomic Variantsfor CCDC24 gene

Disorders / Diseasesfor CCDC24 gene

Publicationsfor CCDC24 gene

External Searches for CCDC24 gene

Genome Databases showing CCDC24 gene

Other Databases showing CCDC24 gene

Specialized Databases showing CCDC24 gene

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Productsfor CCDC24 gene

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Aliases
for CCDC24 gene

Summaries
for CCDC24 gene

Genomic Views
for CCDC24 gene

Proteins
for CCDC24 gene

Protein Domains /
Families
for CCDC24 gene

Function
for CCDC24 gene

Pathways & Interactions
for CCDC24 gene

Drugs & Compounds
for CCDC24 gene

Transcripts
for CCDC24 gene

Expression
for CCDC24 gene

Orthologs
for CCDC24 gene

Paralogs
for CCDC24 gene

Genomic Variants
for CCDC24 gene

Disorders / Diseases
for CCDC24 gene

Publications
for CCDC24 gene

Intellectual Property
for CCDC24 gene

Products
for CCDC24 gene