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Aliases for CCDC198 Gene

Aliases for CCDC198 Gene

  • Coiled-Coil Domain Containing 198 2 3
  • C14orf105 3 4 5
  • Chromosome 14 Open Reading Frame 105 2 5
  • Uncharacterized Protein C14orf105 3

External Ids for CCDC198 Gene

Previous HGNC Symbols for CCDC198 Gene

  • C14orf105

Summaries for CCDC198 Gene

GeneCards Summary for CCDC198 Gene

CCDC198 (Coiled-Coil Domain Containing 198) is a Protein Coding gene.

Additional gene information for CCDC198 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC198 Gene

Genomics for CCDC198 Gene

Regulatory Elements for CCDC198 Gene

Enhancers for CCDC198 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H057461 0.4 ENCODE 11.3 +31.7 31705 1 FOS CCDC198 GC14P057427
GH14H057463 0.4 ENCODE 11.1 +29.8 29764 0 HNF1A CCDC198 GC14P057427
GH14H057486 0.7 FANTOM5 5.8 +6.9 6938 0 CTCF ZNF654 TRIM22 RAD21 SCRT2 ZNF143 SMC3 ZNF24 MIXL1 NAA30 CCDC198 GC14P057427
GH14H057491 1.2 Ensembl ENCODE 0.7 +0.2 208 4 PKNOX1 FOXA2 INSM2 BMI1 FEZF1 YY1 ZNF366 ZSCAN5C SCRT2 FOS CCDC198 GC14P057427
GH14H057478 0.2 ENCODE 0.4 +15.7 15654 0 CCDC198 GC14P057427
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC198 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC198 Gene

Chromosome:
14
Start:
57,469,300 bp from pter
End:
57,493,891 bp from pter
Size:
24,592 bases
Orientation:
Minus strand

Genomic View for CCDC198 Gene

Genes around CCDC198 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC198 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC198 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC198 Gene

Proteins for CCDC198 Gene

  • Protein details for CCDC198 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVL8-CN105_HUMAN
    Recommended name:
    Uncharacterized protein C14orf105
    Protein Accession:
    Q9NVL8
    Secondary Accessions:
    • Q17R99
    • Q53G04

    Protein attributes for CCDC198 Gene

    Size:
    296 amino acids
    Molecular mass:
    34690 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC198 Gene

Post-translational modifications for CCDC198 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC198 Gene

Domains & Families for CCDC198 Gene

Gene Families for CCDC198 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC198 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC198 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC198: view

No data available for UniProtKB/Swiss-Prot for CCDC198 Gene

Function for CCDC198 Gene

Gene Ontology (GO) - Molecular Function for CCDC198 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC198: view
genes like me logo Genes that share phenotypes with CCDC198: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC198 Gene

Localization for CCDC198 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC198 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleus (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC198 Gene

Pathways & Interactions for CCDC198 Gene

SuperPathways for CCDC198 Gene

No Data Available

Interacting Proteins for CCDC198 Gene

Gene Ontology (GO) - Biological Process for CCDC198 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC198 Gene

Drugs & Compounds for CCDC198 Gene

No Compound Related Data Available

Transcripts for CCDC198 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC198 Gene

No ASD Table

Relevant External Links for CCDC198 Gene

GeneLoc Exon Structure for
CCDC198
ECgene alternative splicing isoforms for
CCDC198

Expression for CCDC198 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CCDC198 Gene:

CCDC198

Evidence on tissue expression from TISSUES for CCDC198 Gene

  • Liver(5)
  • Kidney(2)
genes like me logo Genes that share expression patterns with CCDC198: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC198 Gene

Orthologs for CCDC198 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC198 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14H14orf105 33
  • 99.32 (n)
C14orf105 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C8H14orf105 33
  • 86.23 (n)
C14orf105 34
  • 69 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C10H14orf105 33
  • 85.94 (n)
C14orf105 34
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700011H14Rik 33 16 34
  • 78.31 (n)
rat
(Rattus norvegicus)
Mammalia LOC102556129 33
  • 78.22 (n)
oppossum
(Monodelphis domestica)
Mammalia C14orf105 34
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C14orf105 34
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves C5H14ORF105 33
  • 53.91 (n)
C14orf105 34
  • 32 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496610 33
  • 53.66 (n)
Species where no ortholog for CCDC198 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC198 Gene

ENSEMBL:
Gene Tree for CCDC198 (if available)
TreeFam:
Gene Tree for CCDC198 (if available)

Paralogs for CCDC198 Gene

No data available for Paralogs for CCDC198 Gene

Variants for CCDC198 Gene

Sequence variations from dbSNP and Humsavar for CCDC198 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs34960436 Benign 57,480,703(+) ACTTT(A/G)CTTAT nc-transcript-variant, reference, stop-gained
rs1000117454 -- 57,484,989(+) TTCAT(C/T)ATGGT intron-variant
rs1000299211 -- 57,488,577(+) TAAGA(C/G)ATAGT intron-variant
rs1000341873 -- 57,471,595(+) CCTAC(-/A)AAAAA intron-variant
rs1000500759 -- 57,476,982(+) GAGTC(A/G)GGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC198 Gene

Variant ID Type Subtype PubMed ID
nsv1046422 CNV gain 25217958
nsv1053638 CNV loss 25217958
nsv832806 CNV loss 17160897

Variation tolerance for CCDC198 Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC198 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC198

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC198 Gene

Disorders for CCDC198 Gene

Relevant External Links for CCDC198

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC198
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC198

No disorders were found for CCDC198 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC198 Gene

Publications for CCDC198 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 60

Products for CCDC198 Gene

Sources for CCDC198 Gene

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