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Aliases for CCDC191 Gene

Aliases for CCDC191 Gene

  • Coiled-Coil Domain Containing 191 2 3 5
  • KIAA1407 2 3 4
  • Coiled-Coil Domain-Containing Protein 191 3

External Ids for CCDC191 Gene

Previous HGNC Symbols for CCDC191 Gene

  • KIAA1407

Summaries for CCDC191 Gene

GeneCards Summary for CCDC191 Gene

CCDC191 (Coiled-Coil Domain Containing 191) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC191 Gene

Genomics for CCDC191 Gene

Regulatory Elements for CCDC191 Gene

Enhancers for CCDC191 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G114110 1.2 Ensembl ENCODE 10.7 -54.6 -54560 1.6 ELF3 HDGF PKNOX1 FOXA2 ARID4B THRB RARA GATA2 ETV6 FOS QTRT2 CCDC191 LOC391566 GC03M114171 GC03M114172
GH03G113829 1.2 Ensembl ENCODE 10.6 +225.2 225234 3.4 HDGF PKNOX1 FOXA2 ARID4B GATA2 FOS JUNB TBX21 KAT8 MBD2 GRAMD1C QTRT2 CCDC191 GC03M113852
GH03G113736 1.2 Ensembl ENCODE dbSUPER 9.8 +319.4 319425 2.3 CTCF ZNF654 ESRRA HLF TRIM22 ZNF384 REST RAD21 RCOR2 CREB1 USF3 QTRT2 CCDC191 ATP6V1A ENSG00000239280 GC03P113719
GH03G113838 1 ENCODE 10.6 +217.7 217670 1.5 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF48 ZNF143 ZNF207 FOS GRAMD1C QTRT2 CCDC191 GC03M113852
GH03G113912 0.8 ENCODE 9.9 +143.4 143367 0.8 ELF3 CTCF FOXA2 JUN RAD21 FOSL1 FOXK2 ZNF143 SMC3 FOSL2 QTRT2 CCDC191 GRAMD1C VPS26AP1 LOC100420528
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC191 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC191 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000156746 -159 2401 PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Location for CCDC191 Gene

Chromosome:
3
Start:
113,964,137 bp from pter
End:
114,056,641 bp from pter
Size:
92,505 bases
Orientation:
Minus strand

Genomic View for CCDC191 Gene

Genes around CCDC191 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC191 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC191 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC191 Gene

Proteins for CCDC191 Gene

  • Protein details for CCDC191 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCU4-CC191_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 191
    Protein Accession:
    Q8NCU4
    Secondary Accessions:
    • B4DYL1
    • Q9P2E0

    Protein attributes for CCDC191 Gene

    Size:
    936 amino acids
    Molecular mass:
    110568 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC191 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC191 Gene

Post-translational modifications for CCDC191 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC191 Gene

Domains & Families for CCDC191 Gene

Protein Domains for CCDC191 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC191 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC191: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC191 Gene

Function for CCDC191 Gene

genes like me logo Genes that share phenotypes with CCDC191: view

Animal Model Products

miRNA for CCDC191 Gene

miRTarBase miRNAs that target CCDC191

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC191 Gene

Localization for CCDC191 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC191 gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC191 Gene

Pathways & Interactions for CCDC191 Gene

SuperPathways for CCDC191 Gene

No Data Available

Interacting Proteins for CCDC191 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000295878%0d%0a9606.ENSP00000258947%0d%0a
Selected Interacting proteins: ENSP00000295878 Q8NCU4-CC191_HUMAN for CCDC191 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CCDC191 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC191 Gene

Drugs & Compounds for CCDC191 Gene

No Compound Related Data Available

Transcripts for CCDC191 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC191 Gene

No ASD Table

Relevant External Links for CCDC191 Gene

GeneLoc Exon Structure for
CCDC191
ECgene alternative splicing isoforms for
CCDC191

Expression for CCDC191 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CCDC191 Gene:

CCDC191
genes like me logo Genes that share expression patterns with CCDC191: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC191 Gene

Orthologs for CCDC191 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC191 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1407 35 34
  • 99.18 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1407 34 35
  • 86.42 (n)
dog
(Canis familiaris)
Mammalia KIAA1407 34 35
  • 84.29 (n)
mouse
(Mus musculus)
Mammalia 2610015P09Rik 34 35
  • 79.44 (n)
Ccdc191 16
rat
(Rattus norvegicus)
Mammalia RGD1566314 34
  • 78.72 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1407 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1407 35
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1407 34 35
  • 58.98 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1407 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1407 34
  • 55.23 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:92218 34 35
  • 48.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17258 35
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 11 (a)
OneToOne
Species where no ortholog for CCDC191 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC191 Gene

ENSEMBL:
Gene Tree for CCDC191 (if available)
TreeFam:
Gene Tree for CCDC191 (if available)

Paralogs for CCDC191 Gene

No data available for Paralogs for CCDC191 Gene

Variants for CCDC191 Gene

Sequence variations from dbSNP and Humsavar for CCDC191 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000031383 -- 113,985,480(+) AAGGG(A/G)AAAAG intron-variant
rs1000040874 -- 113,998,902(+) TCACA(A/G)CAAAG intron-variant
rs1000134358 -- 113,991,582(+) ATACT(C/G)AATGC intron-variant
rs1000162439 -- 114,027,804(+) CTAGT(C/T)ACTCC intron-variant
rs1000171401 -- 114,013,047(+) GAGTT(G/T)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC191 Gene

Variant ID Type Subtype PubMed ID
esv3597447 CNV loss 21293372
nsv822222 CNV loss 20364138

Variation tolerance for CCDC191 Gene

Residual Variation Intolerance Score: 98.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.85; 79.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC191 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC191

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC191 Gene

Disorders for CCDC191 Gene

Relevant External Links for CCDC191

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC191
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC191

No disorders were found for CCDC191 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC191 Gene

Publications for CCDC191 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PMID: 21903422) Li S. … Dorf M.E. (Immunity 2011) 3 64
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for CCDC191 Gene

Sources for CCDC191 Gene

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