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Aliases for CCDC189 Gene

Aliases for CCDC189 Gene

  • Coiled-Coil Domain Containing 189 2 3 5
  • C16orf93 3 4
  • Coiled-Coil Domain-Containing Protein 189 3
  • Chromosome 16 Open Reading Frame 93 2

External Ids for CCDC189 Gene

Previous HGNC Symbols for CCDC189 Gene

  • C16orf93

Summaries for CCDC189 Gene

GeneCards Summary for CCDC189 Gene

CCDC189 (Coiled-Coil Domain Containing 189) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC189 Gene

Genomics for CCDC189 Gene

Regulatory Elements for CCDC189 Gene

Enhancers for CCDC189 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G030714 1.2 FANTOM5 Ensembl ENCODE 35.8 +47.2 47154 1.8 FOSL1 PKNOX1 POLR2A CEBPB ZBTB33 PRDM10 EBF1 ZNF652 CCDC189 RNF40 STX4 GDPD3 ZNF646 KAT8 FUS ZNF668 GC16P030714 PIR52044
GH16G030774 1.4 Ensembl ENCODE 27 -14.4 -14380 5.5 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 ENSG00000260267 ENSG00000260304 ZNF764 ZNF720 ZNF785 BCL7C PRR14 NPIPB13 CCDC189 ZNF747
GH16G030872 1.6 FANTOM5 ENCODE 22.8 -112.2 -112175 5.3 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF720 BCL7C CCDC189 ZNF629 HSD3B7 ENSG00000260267 ZNF785 ZNF771 RNF40 ZNF747
GH16G030656 1.4 ENCODE dbSUPER 23.5 +103.1 103142 5.8 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC CCDC189 ENSG00000260304 ENSG00000260267 HSD3B7 GDPD3 PIR57497 PIR35911
GH16G030633 1.8 FANTOM5 Ensembl ENCODE 18.2 +128.0 128010 2.6 PKNOX1 CREB3L1 AGO1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 CCDC189 ZNF764 ZNF688 SRCAP ZNF785 ENSG00000239791 FBRS DCTPP1 ZNF629 RNU6-1043P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC189 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC189 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085244 510 1601 HDGF PKNOX1 MLX ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for CCDC189 Gene

Chromosome:
16
Start:
30,757,423 bp from pter
End:
30,762,710 bp from pter
Size:
5,288 bases
Orientation:
Minus strand

Genomic View for CCDC189 Gene

Genes around CCDC189 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC189 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC189 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC189 Gene

Proteins for CCDC189 Gene

  • Protein details for CCDC189 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1A4V9-CC189_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 189
    Protein Accession:
    A1A4V9
    Secondary Accessions:
    • A1A4V8
    • F5GX13
    • Q569G2

    Protein attributes for CCDC189 Gene

    Size:
    331 amino acids
    Molecular mass:
    37921 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC189 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC189 Gene

Post-translational modifications for CCDC189 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC189 Gene

Domains & Families for CCDC189 Gene

Protein Domains for CCDC189 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC189 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC189: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC189 Gene

Function for CCDC189 Gene

genes like me logo Genes that share phenotypes with CCDC189: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC189 Gene

Localization for CCDC189 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC189 gene
Compartment Confidence
cytosol 4
extracellular 2
cytoskeleton 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC189 Gene

Pathways & Interactions for CCDC189 Gene

SuperPathways for CCDC189 Gene

No Data Available

Interacting Proteins for CCDC189 Gene

Selected Interacting proteins: A1A4V9-CC189_HUMAN for CCDC189 Gene via IID

Symbol External ID(s) Details
SHMT2

Gene Ontology (GO) - Biological Process for CCDC189 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC189 Gene

Transcripts for CCDC189 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC189 Gene

No ASD Table

Relevant External Links for CCDC189 Gene

GeneLoc Exon Structure for
CCDC189
ECgene alternative splicing isoforms for
CCDC189

Expression for CCDC189 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CCDC189 Gene:

CCDC189
genes like me logo Genes that share expression patterns with CCDC189: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC189 Gene

Orthologs for CCDC189 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC189 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C16H16orf93 34 35
  • 98.99 (n)
cow
(Bos Taurus)
Mammalia C25H16orf93 34
  • 82.28 (n)
C16orf93 35
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C6H16orf93 34 35
  • 81.97 (n)
rat
(Rattus norvegicus)
Mammalia LOC691909 34
  • 77.24 (n)
mouse
(Mus musculus)
Mammalia Gm166 34 35
  • 77.1 (n)
Ccdc189 16
oppossum
(Monodelphis domestica)
Mammalia C16orf93 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves C16orf93 35
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C16orf93 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493957 34
  • 51.6 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100151516 34
  • 48.58 (n)
C12H16orf93 35
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToOne
Species where no ortholog for CCDC189 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC189 Gene

ENSEMBL:
Gene Tree for CCDC189 (if available)
TreeFam:
Gene Tree for CCDC189 (if available)

Paralogs for CCDC189 Gene

No data available for Paralogs for CCDC189 Gene

Variants for CCDC189 Gene

Sequence variations from dbSNP and Humsavar for CCDC189 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs886051916 Likely benign 30,757,687(+) GTGAG(A/G)AGAGA intron-variant, utr-variant-3-prime
rs886051919 Likely benign 30,759,636(+) CAGAA(C/T)GTTCC intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon, utr-variant-3-prime
rs371856479 Uncertain significance 30,758,232(+) ACGCC(C/T)GGCTA intron-variant, utr-variant-3-prime
rs61731628 Uncertain significance 30,757,013(+) CCCCC(C/T)GGGCC intron-variant, downstream-variant-500B, reference, synonymous-codon
rs768683366 Uncertain significance 30,757,643(+) GAGGA(C/T)GTGGA intron-variant, nc-transcript-variant, reference, synonymous-codon, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCDC189 Gene

Variant ID Type Subtype PubMed ID
nsv469724 CNV loss 16826518
nsv833188 CNV loss 17160897
nsv9438 CNV gain 18304495

Variation tolerance for CCDC189 Gene

Residual Variation Intolerance Score: 60.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.02; 68.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC189 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC189

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC189 Gene

Disorders for CCDC189 Gene

Relevant External Links for CCDC189

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC189
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC189

No disorders were found for CCDC189 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC189 Gene

Publications for CCDC189 Gene

  1. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for CCDC189 Gene

Sources for CCDC189 Gene

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