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Aliases for CCDC186 Gene

Aliases for CCDC186 Gene

  • Coiled-Coil Domain Containing 186 2 3 5
  • CTCL Tumor Antigen HD-CL-01/L14-2 3 4
  • C10orf118 3 4
  • Chromosome 10 Open Reading Frame 118 2
  • CTCL Tumor Antigen L14-2 3

External Ids for CCDC186 Gene

Previous HGNC Symbols for CCDC186 Gene

  • C10orf118

Summaries for CCDC186 Gene

GeneCards Summary for CCDC186 Gene

CCDC186 (Coiled-Coil Domain Containing 186) is a Protein Coding gene.

Gene Wiki entry for CCDC186 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC186 Gene

Genomics for CCDC186 Gene

Regulatory Elements for CCDC186 Gene

Enhancers for CCDC186 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC186 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC186 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC186 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC186 Gene

114,120,856 bp from pter
114,174,605 bp from pter
53,750 bases
Minus strand

Genomic View for CCDC186 Gene

Genes around CCDC186 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC186 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC186 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC186 Gene

Proteins for CCDC186 Gene

  • Protein details for CCDC186 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 186
    Protein Accession:
    Secondary Accessions:
    • Q2M2V6
    • Q3ZB81
    • Q6NS91
    • Q7RTP1
    • Q8N117
    • Q8N3G3
    • Q8N6C2
    • Q9NWA3

    Protein attributes for CCDC186 Gene

    898 amino acids
    Molecular mass:
    103687 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH70368.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 212.; Evidence={ECO:0000305}; Sequence=AAM44457.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM44457.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 792.; Evidence={ECO:0000305}; Sequence=BAA91480.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03926.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for CCDC186 Gene

Proteomics data for CCDC186 Gene at MOPED

Post-translational modifications for CCDC186 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC186 Gene

No data available for DME Specific Peptides for CCDC186 Gene

Domains & Families for CCDC186 Gene

Protein Domains for CCDC186 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC186: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC186 Gene

Function for CCDC186 Gene

genes like me logo Genes that share phenotypes with CCDC186: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC186 Gene

Localization for CCDC186 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CCDC186 Gene

Pathways & Interactions for CCDC186 Gene

SuperPathways for CCDC186 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC186 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC186 Gene

Drugs & Compounds for CCDC186 Gene

No Compound Related Data Available

Transcripts for CCDC186 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC186 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ·
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4: -
SP6: - -

ExUns: 17c · 17d ^ 18 ^ 19

Relevant External Links for CCDC186 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC186 Gene

mRNA expression in normal human tissues for CCDC186 Gene

Protein differential expression in normal tissues from HIPED for CCDC186 Gene

This gene is overexpressed in Frontal cortex (25.4), Plasma (15.0), and Bone (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC186 Gene

genes like me logo Genes that share expression patterns with CCDC186: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCDC186 Gene

Orthologs for CCDC186 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC186 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C26H10orf118 35
  • 92.09 (n)
  • 91.2 (a)
C10orf118 36
  • 89 (a)
(Canis familiaris)
Mammalia C28H10orf118 35
  • 91.82 (n)
  • 92.19 (a)
C10orf118 36
  • 95 (a)
(Mus musculus)
Mammalia A630007B06Rik 35
  • 83.89 (n)
  • 84.3 (a)
Ccdc186 16
A630007B06Rik 36
  • 82 (a)
(Pan troglodytes)
Mammalia C10H10orf118 35
  • 99.7 (n)
  • 99.11 (a)
C10orf118 36
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1307158 35
  • 80.47 (n)
  • 79.59 (a)
(Monodelphis domestica)
Mammalia C10orf118 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia C10orf118 36
  • 81 (a)
(Gallus gallus)
Aves C6H10ORF118 35
  • 73.86 (n)
  • 75 (a)
C10orf118 36
  • 73 (a)
(Anolis carolinensis)
Reptilia C10orf118 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c10orf118 35
  • 68.16 (n)
  • 71.27 (a)
Str.10253 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16139 35
(Danio rerio)
Actinopterygii si:ch211-225b10.4 35
  • 66.98 (n)
  • 72.63 (a)
C12H10orf118 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4925 35
  • 45.05 (n)
  • 34.32 (a)
CG4925 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea cccp-1 35
  • 45.38 (n)
  • 30.27 (a)
cccp-1 36
  • 24 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12155 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for CCDC186:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC186 Gene

Gene Tree for CCDC186 (if available)
Gene Tree for CCDC186 (if available)

Paralogs for CCDC186 Gene

No data available for Paralogs for CCDC186 Gene

Variants for CCDC186 Gene

Sequence variations from dbSNP and Humsavar for CCDC186 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1061159 - 114,163,015(-) AGACA(C/G/T)AGGCT intron-variant, reference, missense
rs12782946 - 114,162,733(+) GTACT(C/T)GATGT intron-variant, reference, missense
rs7095762 - 114,151,169(+) TAGTT(G/T)ATCTC reference, missense
rs1572285 -- 114,148,097(-) agtgc(A/G)atggt intron-variant
rs3740153 -- 114,127,845(+) ACAGA(A/G)GTACC intron-variant

Variation tolerance for CCDC186 Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.26; 81.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CCDC186 Gene

Disorders for CCDC186 Gene

Relevant External Links for CCDC186

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC186 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC186 Gene

Publications for CCDC186 Gene

  1. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. (PMID: 12783626) Oduru S. … Williams S.C. (BMC Genomics 2003) 2 3 4 67
  2. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for CCDC186 Gene

Sources for CCDC186 Gene