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Aliases for CCDC186 Gene

Aliases for CCDC186 Gene

  • Coiled-Coil Domain Containing 186 2 3 5
  • CTCL Tumor Antigen HD-CL-01/L14-2 3 4
  • C10orf118 3 4
  • Coiled-Coil Domain-Containing Protein 186 3
  • Chromosome 10 Open Reading Frame 118 2
  • CTCL Tumor Antigen L14-2 3

External Ids for CCDC186 Gene

Previous HGNC Symbols for CCDC186 Gene

  • C10orf118

Summaries for CCDC186 Gene

GeneCards Summary for CCDC186 Gene

CCDC186 (Coiled-Coil Domain Containing 186) is a Protein Coding gene.

Gene Wiki entry for CCDC186 Gene

Additional gene information for CCDC186 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC186 Gene

Genomics for CCDC186 Gene

Regulatory Elements for CCDC186 Gene

Enhancers for CCDC186 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H113851 1.4 Ensembl ENCODE 13.7 +320.5 320466 5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 CCDC186 TCF7L2 DCLRE1A ENSG00000212589
GH10H114879 1.1 Ensembl ENCODE 16.6 -706.4 -706351 3 PKNOX1 ZSCAN4 INSM2 ZNF76 FEZF1 ZNF2 RAD21 GTF3C2 SCRT2 ZNF143 FAM160B1 ATRNL1 CCDC186 UBE2V1P5 RPL15P13
GH10H114647 1.4 Ensembl ENCODE dbSUPER 12.6 -473.5 -473531 1 FEZF1 BRCA1 ZNF2 YY1 FOS DEK TSHZ1 REST STAT3 HNF4A FAM160B1 CCDC186 PPIAP19 ENSG00000229668
GH10H114042 1.1 ENCODE dbSUPER 13.8 +129.6 129575 5 FOXA2 ZNF76 ZNF2 GLIS2 RUNX3 ZNF202 SP3 ELF1 REST ZNF398 CCDC186 ADRB1 GC10P114045 GC10M114041
GH10H114649 1.1 Ensembl dbSUPER 13.7 -475.1 -475096 0 ZNF493 INSM2 ZEB1 KLF7 ZNF202 ZNF362 OVOL3 ZNF518A ZNF781 ZNF610 CCDC186 PPIAP19 ENSG00000229668
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC186 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC186 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000033738 705 2601 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FOS

Genomic Location for CCDC186 Gene

114,120,856 bp from pter
114,174,605 bp from pter
53,750 bases
Minus strand

Genomic View for CCDC186 Gene

Genes around CCDC186 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC186 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC186 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC186 Gene

Proteins for CCDC186 Gene

  • Protein details for CCDC186 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 186
    Protein Accession:
    Secondary Accessions:
    • Q2M2V6
    • Q3ZB81
    • Q6NS91
    • Q7RTP1
    • Q8N117
    • Q8N3G3
    • Q8N6C2
    • Q9NWA3

    Protein attributes for CCDC186 Gene

    898 amino acids
    Molecular mass:
    103687 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH70368.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 212.; Evidence={ECO:0000305}; Sequence=AAM44457.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM44457.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 792.; Evidence={ECO:0000305}; Sequence=BAA91480.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03926.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for CCDC186 Gene

Post-translational modifications for CCDC186 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC186 Gene

No data available for DME Specific Peptides for CCDC186 Gene

Domains & Families for CCDC186 Gene

Gene Families for CCDC186 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC186 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC186: view

No data available for UniProtKB/Swiss-Prot for CCDC186 Gene

Function for CCDC186 Gene

Phenotypes From GWAS Catalog for CCDC186 Gene

genes like me logo Genes that share phenotypes with CCDC186: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC186 Gene

Localization for CCDC186 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC186 gene
Compartment Confidence
nucleus 3
golgi apparatus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC186 Gene

Pathways & Interactions for CCDC186 Gene

SuperPathways for CCDC186 Gene

No Data Available

Interacting Proteins for CCDC186 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
Selected Interacting proteins: ENSP00000358293 Q7Z3E2-CC186_HUMAN for CCDC186 Gene via STRING IID MINT

Gene Ontology (GO) - Biological Process for CCDC186 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC186 Gene

Drugs & Compounds for CCDC186 Gene

No Compound Related Data Available

Transcripts for CCDC186 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC186 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ·
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4: -
SP6: - -

ExUns: 17c · 17d ^ 18 ^ 19

Relevant External Links for CCDC186 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC186 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC186 Gene

Protein differential expression in normal tissues from HIPED for CCDC186 Gene

This gene is overexpressed in Frontal cortex (25.4), Plasma (15.0), and Bone (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CCDC186 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC186 Gene:

genes like me logo Genes that share expression patterns with CCDC186: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC186 Gene

Orthologs for CCDC186 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC186 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C10H10orf118 33
  • 99.7 (n)
C10orf118 34
  • 99 (a)
(Canis familiaris)
Mammalia C10orf118 34
  • 95 (a)
C28H10orf118 33
  • 91.82 (n)
(Bos Taurus)
Mammalia C26H10orf118 33
  • 92.09 (n)
C10orf118 34
  • 89 (a)
(Mus musculus)
Mammalia A630007B06Rik 33 34
  • 83.89 (n)
Ccdc186 16
(Monodelphis domestica)
Mammalia C10orf118 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia C10orf118 34
  • 81 (a)
(Rattus norvegicus)
Mammalia RGD1307158 33
  • 80.47 (n)
(Gallus gallus)
Aves C6H10ORF118 33
  • 73.86 (n)
C10orf118 34
  • 73 (a)
(Anolis carolinensis)
Reptilia C10orf118 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c10orf118 33
  • 68.16 (n)
Str.10253 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16139 33
(Danio rerio)
Actinopterygii si:ch211-225b10.4 33
  • 66.98 (n)
C12H10orf118 34
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4925 33 34
  • 45.05 (n)
(Caenorhabditis elegans)
Secernentea cccp-1 33 34
  • 45.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12155 33
Species where no ortholog for CCDC186 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC186 Gene

Gene Tree for CCDC186 (if available)
Gene Tree for CCDC186 (if available)

Paralogs for CCDC186 Gene

No data available for Paralogs for CCDC186 Gene

Variants for CCDC186 Gene

Sequence variations from dbSNP and Humsavar for CCDC186 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000014741 -- 114,141,252(+) TGCCT(C/G)TTTGC intron-variant
rs1000273737 -- 114,123,711(+) ATTCA(A/G)TGACA nc-transcript-variant, utr-variant-3-prime
rs1000283398 -- 114,120,654(+) TACAA(C/G)CCAGC downstream-variant-500B
rs1000321418 -- 114,153,638(+) AAAAT(C/T)AGCTG intron-variant
rs1000321755 -- 114,166,467(+) GCATT(C/T)ACACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC186 Gene

Variant ID Type Subtype PubMed ID
dgv287e212 CNV loss 25503493
dgv288e212 CNV loss 25503493
esv2560217 CNV deletion 19546169
esv2741151 CNV deletion 23290073
nsv1045020 CNV loss 25217958
nsv1052267 CNV loss 25217958
nsv7211 OTHER inversion 18451855

Variation tolerance for CCDC186 Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.26; 81.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC186 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC186 Gene

Disorders for CCDC186 Gene

Relevant External Links for CCDC186

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC186 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC186 Gene

Publications for CCDC186 Gene

  1. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. (PMID: 12783626) Oduru S … Williams SC (BMC genomics 2003) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma. (PMID: 14996095) Hartmann TB … Eichmüller S (The British journal of dermatology 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for CCDC186 Gene

Sources for CCDC186 Gene

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