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Aliases for CCDC186 Gene

Aliases for CCDC186 Gene

  • Coiled-Coil Domain Containing 186 2 3 5
  • CTCL Tumor Antigen HD-CL-01/L14-2 3 4
  • C10orf118 3 4
  • Coiled-Coil Domain-Containing Protein 186 3
  • Chromosome 10 Open Reading Frame 118 2
  • CTCL Tumor Antigen L14-2 3

External Ids for CCDC186 Gene

Previous HGNC Symbols for CCDC186 Gene

  • C10orf118

Summaries for CCDC186 Gene

GeneCards Summary for CCDC186 Gene

CCDC186 (Coiled-Coil Domain Containing 186) is a Protein Coding gene.

Gene Wiki entry for CCDC186 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC186 Gene

Genomics for CCDC186 Gene

Regulatory Elements for CCDC186 Gene

Enhancers for CCDC186 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F114181 0.4 ENCODE 0.4 -7.9 -7903 1.6 MYNN CCDC186 VWA2
GH10F114228 0.4 ENCODE 0.2 -53.8 -53772 0.2 OSR2 TRIM28 TDRD1 PLEKHS1 VWA2 CCDC186
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC186 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC186 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001427374 1004 3599 HDGF PKNOX1 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1

Genomic Location for CCDC186 Gene

Chromosome:
10
Start:
114,120,856 bp from pter
End:
114,174,605 bp from pter
Size:
53,750 bases
Orientation:
Minus strand

Genomic View for CCDC186 Gene

Genes around CCDC186 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC186 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC186 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC186 Gene

Proteins for CCDC186 Gene

  • Protein details for CCDC186 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3E2-CC186_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 186
    Protein Accession:
    Q7Z3E2
    Secondary Accessions:
    • Q2M2V6
    • Q3ZB81
    • Q6NS91
    • Q7RTP1
    • Q8N117
    • Q8N3G3
    • Q8N6C2
    • Q9NWA3

    Protein attributes for CCDC186 Gene

    Size:
    898 amino acids
    Molecular mass:
    103687 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH70368.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 212.; Evidence={ECO:0000305}; Sequence=AAM44457.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM44457.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 792.; Evidence={ECO:0000305}; Sequence=BAA91480.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03926.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

neXtProt entry for CCDC186 Gene

Post-translational modifications for CCDC186 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC186 Gene

No data available for DME Specific Peptides for CCDC186 Gene

Domains & Families for CCDC186 Gene

Protein Domains for CCDC186 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC186: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC186 Gene

Function for CCDC186 Gene

genes like me logo Genes that share phenotypes with CCDC186: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC186 Gene

Localization for CCDC186 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC186 gene
Compartment Confidence
nucleus 3
golgi apparatus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC186 Gene

Pathways & Interactions for CCDC186 Gene

SuperPathways for CCDC186 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC186 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC186 Gene

Transcripts for CCDC186 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC186 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ·
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4: -
SP5:
SP6: - -
SP7:
SP8:
SP9:

ExUns: 17c · 17d ^ 18 ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CCDC186 Gene

GeneLoc Exon Structure for
CCDC186
ECgene alternative splicing isoforms for
CCDC186

Expression for CCDC186 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC186 Gene

Protein differential expression in normal tissues from HIPED for CCDC186 Gene

This gene is overexpressed in Frontal cortex (25.4), Plasma (15.0), and Bone (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCDC186 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCDC186 Gene:

CCDC186
genes like me logo Genes that share expression patterns with CCDC186: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CCDC186 Gene

Orthologs for CCDC186 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC186 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C10H10orf118 34
  • 99.7 (n)
C10orf118 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C10orf118 35
  • 95 (a)
OneToOne
C28H10orf118 34
  • 91.82 (n)
cow
(Bos Taurus)
Mammalia C26H10orf118 34
  • 92.09 (n)
C10orf118 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A630007B06Rik 34 35
  • 83.89 (n)
Ccdc186 16
oppossum
(Monodelphis domestica)
Mammalia C10orf118 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C10orf118 35
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1307158 34
  • 80.47 (n)
chicken
(Gallus gallus)
Aves C6H10ORF118 34
  • 73.86 (n)
C10orf118 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C10orf118 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c10orf118 34
  • 68.16 (n)
Str.10253 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16139 34
zebrafish
(Danio rerio)
Actinopterygii si:ch211-225b10.4 34
  • 66.98 (n)
C12H10orf118 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4925 34 35
  • 45.05 (n)
worm
(Caenorhabditis elegans)
Secernentea cccp-1 34 35
  • 45.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12155 34
Species where no ortholog for CCDC186 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC186 Gene

ENSEMBL:
Gene Tree for CCDC186 (if available)
TreeFam:
Gene Tree for CCDC186 (if available)

Paralogs for CCDC186 Gene

No data available for Paralogs for CCDC186 Gene

Variants for CCDC186 Gene

Sequence variations from dbSNP and Humsavar for CCDC186 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10509996 -- 114,149,976(+) CAATT(A/G)GTACA intron-variant
rs10509997 -- 114,164,562(+) TCTTT(C/T)GTCAG intron-variant
rs10509998 -- 114,165,010(+) TAACA(C/T)TAGTA intron-variant
rs10509999 -- 114,167,520(+) ATACA(A/G)GCCAA intron-variant
rs10593761 -- 114,162,327(+) ATTTC(-/CTTTT)GAGTT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCDC186 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER inversion 18451855
nsv1052267 CNV loss 25217958
nsv1045020 CNV loss 25217958
esv2741151 CNV deletion 23290073
esv2560217 CNV deletion 19546169
dgv288e212 CNV loss 25503493
dgv287e212 CNV loss 25503493

Variation tolerance for CCDC186 Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.26; 81.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC186 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC186

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC186 Gene

Disorders for CCDC186 Gene

Relevant External Links for CCDC186

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC186

No disorders were found for CCDC186 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC186 Gene

Publications for CCDC186 Gene

  1. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. (PMID: 12783626) Oduru S. … Williams S.C. (BMC Genomics 2003) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma. (PMID: 14996095) Hartmann T.B. … Eichmueller S. (Br. J. Dermatol. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3 64

Products for CCDC186 Gene

Sources for CCDC186 Gene

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