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Aliases for CCDC185 Gene

Aliases for CCDC185 Gene

  • Coiled-Coil Domain Containing 185 2 3
  • C1orf65 3 4
  • Chromosome 1 Open Reading Frame 65 2

External Ids for CCDC185 Gene

Previous HGNC Symbols for CCDC185 Gene

  • C1orf65

Summaries for CCDC185 Gene

GeneCards Summary for CCDC185 Gene

CCDC185 (Coiled-Coil Domain Containing 185) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC185 Gene

Genomics for CCDC185 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCDC185 Gene

223,393,373 bp from pter
223,395,470 bp from pter
2,098 bases
Plus strand

Genomic View for CCDC185 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC185 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC185 Gene

No data available for Regulatory Elements for CCDC185 Gene

Proteins for CCDC185 Gene

  • Protein details for CCDC185 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 185
    Protein Accession:
    Secondary Accessions:
    • Q8N746
    • Q8NA93

    Protein attributes for CCDC185 Gene

    623 amino acids
    Molecular mass:
    72349 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC185 Gene

Proteomics data for CCDC185 Gene at MOPED

Post-translational modifications for CCDC185 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC185 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC185 Gene

Domains & Families for CCDC185 Gene

Protein Domains for CCDC185 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC185: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CCDC185 Gene

Function for CCDC185 Gene

Gene Ontology (GO) - Molecular Function for CCDC185 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC185: view

Phenotypes for CCDC185 Gene

GenomeRNAi human phenotypes for CCDC185:
genes like me logo Genes that share phenotypes with CCDC185: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC185

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC185 Gene

Localization for CCDC185 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CCDC185 Gene

Pathways & Interactions for CCDC185 Gene

SuperPathways for CCDC185 Gene

No Data Available

Interacting Proteins for CCDC185 Gene

Gene Ontology (GO) - Biological Process for CCDC185 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC185 Gene

Drugs & Compounds for CCDC185 Gene

No Compound Related Data Available

Transcripts for CCDC185 Gene

mRNA/cDNA for CCDC185 Gene

(1) REFSEQ mRNAs :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC185

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC185 Gene

No ASD Table

Relevant External Links for CCDC185 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC185 Gene

mRNA expression in normal human tissues for CCDC185 Gene

Protein differential expression in normal tissues from HIPED for CCDC185 Gene

This gene is overexpressed in Frontal cortex (29.7), Fetal gut (15.9), and Tlymphocyte (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC185 Gene

genes like me logo Genes that share expression patterns with CCDC185: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCDC185 Gene

Orthologs for CCDC185 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC185 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C16H1orf65 35
  • 74.78 (n)
  • 61.2 (a)
C16H1orf65 36
  • 60 (a)
(Mus musculus)
Mammalia 4922505E12Rik 35
  • 71.36 (n)
  • 56.79 (a)
4922505E12Rik 16
4922505E12Rik 36
  • 54 (a)
(Pan troglodytes)
Mammalia C1H1orf65 35
  • 98.98 (n)
  • 98.23 (a)
C1orf65 36
  • 98 (a)
(Rattus norvegicus)
Mammalia LOC289334 35
  • 71.57 (n)
  • 56.36 (a)
(Canis familiaris)
Mammalia C1orf65 36
  • 48 (a)
(Monodelphis domestica)
Mammalia C1orf65 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia C1orf65 36
  • 40 (a)
(Anolis carolinensis)
Reptilia C1orf65 36
  • 36 (a)
Species with no ortholog for CCDC185:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC185 Gene

Gene Tree for CCDC185 (if available)
Gene Tree for CCDC185 (if available)

Paralogs for CCDC185 Gene

No data available for Paralogs for CCDC185 Gene

Variants for CCDC185 Gene

Sequence variations from dbSNP and Humsavar for CCDC185 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs36041842 -- 223,395,795(+) GGTTT(-/T)GTTGT downstream-variant-500B
rs75183206 -- 223,395,217(+) AGACC(C/G)AAACT reference, missense
rs112123353 -- 223,395,318(+) AGCTC(C/T)GTGCC reference, missense
rs113174873 -- 223,395,282(+) CCAAC(A/G)GCTCC reference, missense
rs115900818 -- 223,395,415(+) TGTAA(C/T)CTGAT utr-variant-3-prime

Variation tolerance for CCDC185 Gene

Residual Variation Intolerance Score: 41.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.64; 72.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC185 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCDC185 Gene

Disorders for CCDC185 Gene

Relevant External Links for CCDC185

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CCDC185: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC185 Gene

Publications for CCDC185 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 67
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 67
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 67

Products for CCDC185 Gene

Sources for CCDC185 Gene

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