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Aliases for CCDC184 Gene

Aliases for CCDC184 Gene

  • Coiled-Coil Domain Containing 184 2 3 5
  • C12orf68 3 4
  • Coiled-Coil Domain-Containing Protein 184 3
  • Chromosome 12 Open Reading Frame 68 2

External Ids for CCDC184 Gene

Previous HGNC Symbols for CCDC184 Gene

  • C12orf68

Previous GeneCards Identifiers for CCDC184 Gene

  • GC12P048578

Summaries for CCDC184 Gene

GeneCards Summary for CCDC184 Gene

CCDC184 (Coiled-Coil Domain Containing 184) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC184 Gene

Genomics for CCDC184 Gene

Regulatory Elements for CCDC184 Gene

Enhancers for CCDC184 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F049129 1.2 ENCODE 20.7 +947.8 947784 4.6 CREB3L1 MLX YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 DDX23 LOC390314 PRPF40B CCNT1 BCDIN3D KANSL2 ENSG00000257964 LOC100422296 LOC105369760 CCDC184
GH12F048104 1.2 ENCODE 20.4 -77.3 -77294 4.1 PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 DDX23 KANSL2 RPL37P19 CCNT1 LOC390314 SENP1 CACNB3 RPAP3 CCDC184 PRKAG1
GH12F048156 1.1 ENCODE 21.7 -26.1 -26129 2.5 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 DEK SP3 SENP1 DDX23 CCDC184 PFKM RPL37P19 CCNT1 ZNF641 H1FNT ASB8 KANSL2
GH12F048903 1.1 ENCODE 20.7 +720.3 720279 1.6 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF302 ZNF143 ZNF416 ZNF548 CCNT1 DDX23 PRPF40B SENP1 LOC390314 BCDIN3D KANSL2 FAM186B ENSG00000257964 LOC101927267
GH12F048714 1.2 ENCODE 18.8 +532.9 532874 3.0 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 KANSL2 CCNT1 DDX23 SENP1 LOC390314 CACNB3 CCDC184 PRPF40B OR11M1P LALBA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC184 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC184 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000172747 -183 1601 HDAC1 ATF1 PKNOX1 SIN3A BMI1 FEZF1 RAD21 ZBTB40 RFX5 GLIS2

Genomic Location for CCDC184 Gene

Chromosome:
12
Start:
48,183,583 bp from pter
End:
48,185,926 bp from pter
Size:
2,344 bases
Orientation:
Plus strand

Genomic View for CCDC184 Gene

Genes around CCDC184 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC184 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC184 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC184 Gene

Proteins for CCDC184 Gene

  • Protein details for CCDC184 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q52MB2-CC184_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 184
    Protein Accession:
    Q52MB2
    Secondary Accessions:
    • Q96MK5
    • Q96N39

    Protein attributes for CCDC184 Gene

    Size:
    194 amino acids
    Molecular mass:
    20484 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC184 Gene

Post-translational modifications for CCDC184 Gene

No Post-translational modifications

Other Protein References for CCDC184 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC184 Gene

Domains & Families for CCDC184 Gene

Protein Domains for CCDC184 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC184: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CCDC184 Gene

Function for CCDC184 Gene

Gene Ontology (GO) - Molecular Function for CCDC184 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC184: view
genes like me logo Genes that share phenotypes with CCDC184: view

Animal Model Products

miRNA for CCDC184 Gene

miRTarBase miRNAs that target CCDC184

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC184 Gene

Localization for CCDC184 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC184 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CCDC184 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CCDC184: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC184 Gene

Pathways & Interactions for CCDC184 Gene

SuperPathways for CCDC184 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC184 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC184 Gene

Transcripts for CCDC184 Gene

mRNA/cDNA for CCDC184 Gene

(1) REFSEQ mRNAs :
(51) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC184 Gene

No ASD Table

Relevant External Links for CCDC184 Gene

GeneLoc Exon Structure for
CCDC184
ECgene alternative splicing isoforms for
CCDC184

Expression for CCDC184 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC184 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC184 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.3), Brain - Cortex (x5.2), Brain - Anterior cingulate cortex (BA24) (x4.6), and Brain - Hypothalamus (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of CCDC184 Gene:

CCDC184
genes like me logo Genes that share expression patterns with CCDC184: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CCDC184 Gene

Orthologs for CCDC184 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCDC184 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12H12orf68 34
  • 99.48 (n)
C12orf68 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C27H12orf68 34
  • 92.1 (n)
C12ORF68 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C5H12orf68 34 35
  • 91.92 (n)
rat
(Rattus norvegicus)
Mammalia MGC114464 34
  • 89.93 (n)
mouse
(Mus musculus)
Mammalia AI836003 34 35
  • 89.18 (n)
Ccdc184 16
oppossum
(Monodelphis domestica)
Mammalia C12orf68 35
  • 73 (a)
OneToOne
Species where no ortholog for CCDC184 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC184 Gene

ENSEMBL:
Gene Tree for CCDC184 (if available)
TreeFam:
Gene Tree for CCDC184 (if available)

Paralogs for CCDC184 Gene

No data available for Paralogs for CCDC184 Gene

Variants for CCDC184 Gene

Sequence variations from dbSNP and Humsavar for CCDC184 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10783231 -- 48,184,542(+) GAGGA(A/C)GAGGA reference, missense
rs111581589 -- 48,181,635(+) ACATG(A/C)TTGCT upstream-variant-2KB
rs11168441 -- 48,182,271(+) TTTAC(A/G)TAGTT upstream-variant-2KB
rs111850579 -- 48,183,630(+) CGACA(A/C)CCCCG utr-variant-5-prime
rs112123340 -- 48,181,941(+) GAATC(A/G)TTAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC184 Gene

Variant ID Type Subtype PubMed ID
nsv8971 CNV gain+loss 18304495
esv3629429 CNV gain 21293372
esv34439 CNV gain 17911159
esv33956 CNV loss 17666407
esv2759898 CNV gain+loss 17122850

Variation tolerance for CCDC184 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC184 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC184

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC184 Gene

Disorders for CCDC184 Gene

Relevant External Links for CCDC184

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC184

No disorders were found for CCDC184 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC184 Gene

Publications for CCDC184 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3 64
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3 64

Products for CCDC184 Gene

Sources for CCDC184 Gene

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