Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC183 Gene

Aliases for CCDC183 Gene

  • Coiled-Coil Domain Containing 183 2 3 5
  • KIAA1984 2 3 4
  • Coiled-Coil Domain-Containing Protein 183 3
  • BA216L13.7 3
  • PARF 3

External Ids for CCDC183 Gene

Previous HGNC Symbols for CCDC183 Gene

  • KIAA1984

Previous GeneCards Identifiers for CCDC183 Gene

  • GC09P139691

Summaries for CCDC183 Gene

GeneCards Summary for CCDC183 Gene

CCDC183 (Coiled-Coil Domain Containing 183) is a Protein Coding gene. An important paralog of this gene is CCDC151.

Additional gene information for CCDC183 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC183 Gene

Genomics for CCDC183 Gene

Regulatory Elements for CCDC183 Gene

Enhancers for CCDC183 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H136925 1.3 Ensembl ENCODE dbSUPER 15.9 +130.9 130914 3 HDGF CTCF PKNOX1 ESRRA RAD21 FOSL1 ZFHX2 ZNF316 POLR2A ZNF600 LCN12 TRAF2 CCDC183 PRR31 MAMDC4 PHPT1 C9orf172 RABL6 CCDC183-AS1 LCNL1
GH09H136990 1.7 FANTOM5 Ensembl ENCODE 11.4 +199.7 199678 10 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 LCN12 EHMT1 SEC16A ABCA2 SDCCAG3 ANAPC2 PRR31 C9orf139 MAN1B1 SNHG7
GH09H136697 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -98.0 -98049 2 FOXA2 ATF1 MLX ARID4B YY1 ZNF207 SP5 REST PPARG KAT8 CCDC183 RABL6 LCN8 EGFL7 C8G FAM69B AGPAT2
GH09H136881 1.6 Ensembl ENCODE dbSUPER 11.4 +86.3 86325 2 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS PHPT1 MAMDC4 C9orf172 TMEM141 LCN12 PRR31 C8G FBXW5 RABL6 ABCA2
GH09H136700 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -95.2 -95234 1 PKNOX1 ATF1 TBL1XR1 RB1 ZNF121 ZNF143 ZNF207 ATF7 RUNX3 IKZF2 ANAPC2 MAN1B1 CCDC183 RABL6 ABCA2 PAXX LCNL1 SEC16A FUT7 FAM69B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC183 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC183 Gene

Chromosome:
9
Start:
136,796,338 bp from pter
End:
136,807,741 bp from pter
Size:
11,404 bases
Orientation:
Plus strand

Genomic View for CCDC183 Gene

Genes around CCDC183 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC183 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC183 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC183 Gene

Proteins for CCDC183 Gene

  • Protein details for CCDC183 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T5S1-CC183_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 183
    Protein Accession:
    Q5T5S1
    Secondary Accessions:
    • B2RP89
    • C9JD38
    • Q6P2D9
    • Q8NAI4
    • Q8TF18

    Protein attributes for CCDC183 Gene

    Size:
    534 amino acids
    Molecular mass:
    62689 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85570.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI12681.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC183 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC183 Gene

Post-translational modifications for CCDC183 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC183 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC183 Gene

Domains & Families for CCDC183 Gene

Gene Families for CCDC183 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC183 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC183 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC183: view

No data available for UniProtKB/Swiss-Prot for CCDC183 Gene

Function for CCDC183 Gene

Phenotypes for CCDC183 Gene

GenomeRNAi human phenotypes for CCDC183:
genes like me logo Genes that share phenotypes with CCDC183: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCDC183
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC183 Gene

Localization for CCDC183 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC183 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for CCDC183 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005930 axoneme IBA --
genes like me logo Genes that share ontologies with CCDC183: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CCDC183 Gene

Pathways & Interactions for CCDC183 Gene

SuperPathways for CCDC183 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC183 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003341 cilium movement IBA --
GO:0036158 outer dynein arm assembly IBA --
genes like me logo Genes that share ontologies with CCDC183: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC183 Gene

Drugs & Compounds for CCDC183 Gene

No Compound Related Data Available

Transcripts for CCDC183 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCDC183
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC183 Gene

No ASD Table

Relevant External Links for CCDC183 Gene

GeneLoc Exon Structure for
CCDC183
ECgene alternative splicing isoforms for
CCDC183

Expression for CCDC183 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC183 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC183 Gene

This gene is overexpressed in Testis (x8.2).

Protein differential expression in normal tissues from HIPED for CCDC183 Gene

This gene is overexpressed in Breast (42.2) and Skin (25.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC183 Gene



Protein tissue co-expression partners for CCDC183 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC183 Gene:

CCDC183

Evidence on tissue expression from TISSUES for CCDC183 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with CCDC183: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC183 Gene

Orthologs for CCDC183 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC183 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC183 33 34
  • 98.45 (n)
cow
(Bos Taurus)
Mammalia CCDC183 33
  • 84.07 (n)
KIAA1984 34
  • 78 (a)
OneToMany
dog
(Canis familiaris)
Mammalia KIAA1984 33
  • 83.49 (n)
-- 34
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cccd183 33
  • 79.96 (n)
4921530D09Rik 34
  • 76 (a)
OneToMany
Ccdc183 16
rat
(Rattus norvegicus)
Mammalia Ccdc183 33
  • 79.52 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 43 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
chicken
(Gallus gallus)
Aves KIAA1984 33
  • 56.24 (n)
-- 34
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
OneToMany
Species where no ortholog for CCDC183 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC183 Gene

ENSEMBL:
Gene Tree for CCDC183 (if available)
TreeFam:
Gene Tree for CCDC183 (if available)

Paralogs for CCDC183 Gene

Paralogs for CCDC183 Gene

(1) SIMAP similar genes for CCDC183 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CCDC183: view

Variants for CCDC183 Gene

Sequence variations from dbSNP and Humsavar for CCDC183 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000208688 -- 136,798,953(+) CAGGA(C/T)AGGGC intron-variant
rs1000274682 -- 136,807,463(+) TCCCT(C/G)GGGCA intron-variant, upstream-variant-2KB
rs1000549405 -- 136,797,954(+) TAGTT(C/G)GGACA intron-variant
rs1000648900 -- 136,803,369(+) CCAGA(A/G)GGATC intron-variant
rs1000881418 -- 136,806,278(+) CCCAG(A/T)CTCAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC183 Gene

Variant ID Type Subtype PubMed ID
dgv1246n67 CNV gain 20364138
esv1071938 CNV insertion 17803354
esv1285258 CNV insertion 17803354
esv1788395 CNV insertion 17803354
esv2422220 CNV deletion 17116639
esv2739393 CNV deletion 23290073
esv2739394 CNV deletion 23290073
esv2759720 CNV loss 17122850
esv29973 CNV loss 17803354
esv3891732 CNV loss 25118596
esv998506 CNV deletion 20482838
nsv1139382 CNV deletion 24896259
nsv416390 CNV deletion 16902084
nsv466681 CNV loss 19166990
nsv469918 CNV loss 18288195
nsv524322 CNV loss 19592680
nsv615982 CNV loss 21841781
nsv818738 CNV gain 17921354
nsv951204 CNV deletion 24416366

Variation tolerance for CCDC183 Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.38; 54.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC183 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC183

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC183 Gene

Disorders for CCDC183 Gene

Relevant External Links for CCDC183

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC183

No disorders were found for CCDC183 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC183 Gene

Publications for CCDC183 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PMID: 21048031) Casabonne D … de Sanjose S (Haematologica 2011) 3 60

Products for CCDC183 Gene

Sources for CCDC183 Gene

Content
Loading form....