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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCDC181 Gene

protein-coding   GIFtS: 37
GCID: GC01M169365

Coiled-Coil Domain Containing 181

(Previous name: chromosome 1 open reading frame 114)
(Previous symbol: C1orf114)
  Search for CCDC181
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 1811 2
C1orf1141 2 3
Chromosome 1 Open Reading Frame 1141
RP1-206D15.22
Coiled-Coil Domain-Containing Protein 1812

External Ids:    HGNC: 280511   Entrez Gene: 578212   Ensembl: ENSG000001174777   UniProtKB: Q5TID73   

Export aliases for CCDC181 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CCDC181 Gene: 
CCDC181 (coiled-coil domain containing 181) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CCDC181
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CCDC181

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC181


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q24

CCDC181 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC181 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M169365:  view genomic region     (about GC identifiers)

Start:
169,364,108 bp from pter      End:
169,429,907 bp from pter
Size:
65,800 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CC181_HUMAN, Q5TID7 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 181  
Size: 509 amino acids; 60103 Da
Sequence caution: Sequence=AAH26073.1; Type=Frameshift; Positions=370; Sequence=CAI19784.1; Type=Erroneous gene
model prediction;
Secondary accessions: O60780 Q53FD5 Q5TID9 Q8TC48
Alternative splicing: 3 isoforms:  Q5TID7-1   Q5TID7-2   Q5TID7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCDC181: NX_Q5TID7

Explore proteomics data for CCDC181 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5TID7

  • CCDC181 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCDC181 Protein Expression
    REFSEQ proteins: NP_067002.1  
    ENSEMBL proteins: 
     ENSP00000356780   ENSP00000356779   ENSP00000411000   ENSP00000442297  

    Human Recombinant Protein Products for CCDC181: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    CCDC181 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026687 UPF_C1orf114

    Graphical View of Domain Structure for InterPro Entry Q5TID7

    ProtoNet protein and cluster: Q5TID7


    CCDC181 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCDC181 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC181

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for CCDC181 (Q5TID72, 3 ENSP000003567794) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAP621362, 3MINT-62202 I2D: score=3 
    YWHAGP619813I2D: score=2 
    CCNB1IP1ENSP000003373964STRING: ENSP00000337396
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCDC181 (CC181)

    Search CenterWatch for drugs/clinical trials and news about CCDC181 / CC181

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCDC181 gene: 
    NM_021179.1  

    Unigene Cluster for CCDC181:

    Coiled-coil domain containing 181
    Hs.567557  [show with all ESTs]
    Unigene Representative Sequence: AK313598
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367806 ENST00000367805(uc001gfz.1 uc001gga.1) ENST00000491570(uc001ggb.3)
    ENST00000456107(uc001ggc.1) ENST00000545005(uc009wvq.1)
    miRNA
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    Inhib. RNA
    Products:
         
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC181
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC181
    Sirion Biotech Customized lentivirus for stable overexpression of CCDC181 
                         Customized lentivirus expression plasmids for stable overexpression of CCDC181 
    Primer
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    OriGene qPCR primer pairs and template standards for CCDC181
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC181
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC181

    Additional mRNA sequence: 

    AK098712.1 AK223354.1 AK313598.1 AL049687.1 BC008388.1 BC008389.1 BC026073.2 

    7 DOTS entries:

    DT.402608  DT.100744726  DT.97821042  DT.91758192  DT.40279203  DT.95195757  DT.121626340 

    24/41 AceView cDNA sequences (see all 41):

    CD679170 AL537439 BP348964 AL049687 BM685150 BU685695 NM_021179 CR599271 
    BU688736 BC008388 BX645229 AA205243 BE877773 BU619840 BM932141 BG717436 
    AK098712 BU675560 BG721365 BX431228 AA776749 BI761685 CA428805 BC026073 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCDC181 expression in normal human tissues (normalized intensities)      CCDC181 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CCDC181 Expression
    About this image


    CCDC181 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             nasopharynx ; respiratory epithelial cells   
             bronchial epithelia   
     
     Lung (Respiratory System)
             bronchus ; respiratory epithelial cells   
     
     Testis (Reproductive System)
             epididymis ; glandular cells   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

    See CCDC181 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCDC181

    SOURCE GeneReport for Unigene cluster: Hs.567557
        SABiosciences Custom PCR Arrays for CCDC181
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC181
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC181

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCDC181 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 4930455F23Rik1 , 5 RIKEN cDNA 4930455F23 gene1, 5 79.62(n)1
    75.35(a)1
      1 (71.59 cM)5
    748951  NM_029115.31  NP_083391.21 
     1642755855 
    chicken
    (Gallus gallus)
    Aves C1H1orf1141 chromosome 1 open reading frame, human C1orf114 61.93(n)
    53.45(a)
      418370  XM_416589.2  XP_416589.3 
    lizard
    (Anolis carolinensis)
    Reptilia C1ORF1146
    Uncharacterized protein
    46(a)
    1 ↔ 1
    3(175662456-175676301)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-232d19.41 si:ch211-232d19.4 51.99(n)
    42.73(a)
      566663  NM_001128540.1  NP_001122012.1 


    ENSEMBL Gene Tree for CCDC181 (if available)
    TreeFam Gene Tree for CCDC181 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCDC181 gene

    CCDC181 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCDC181
    PGOHUM00000239300


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/604 SNPs in CCDC181 are shown (see all 604)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901309771,2
    --169366359(+) AGGTAC/TGTGCT 1 -- int10--------
    rs1467263301,2
    C--169366433(+) TGAACA/GTGAGG 1 -- int10--------
    rs2015132341,2
    --169366434(+) GAACAC/TGAGGA 1 -- int10--------
    rs1441737431,2
    C--169366494(+) TTCCCG/AGCCTT 2 /R /W mis11Minor allele frequency- A:0.00NA 4552
    rs22728011,2
    C,F,O,H--169366516(-) TTATTC/TTTCCT 2 F syn124Minor allele frequency- T:0.18EA NA NS WA EU 9613
    rs2007694421,2
    --169366525(+) AAACAC/TTCCTC 2 E syn10--------
    rs2000914091,2
    --169366557(+) CTGTCC/TTTCTT 2 R G mis10--------
    rs1436419791,2
    C,F--169366558(+) TGTCTT/GTCTTT 2 /E /D mis11Minor allele frequency- G:0.00NA 4550
    rs1827927361,2
    --169366943(+) ATAAGA/GAAAAG 1 -- int10--------
    rs1874806291,2
    --169366959(+) AGGAGG/TGGCTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CCDC181 (169364108 - 169429907 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCDC181: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCDC181
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC181

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCDC181 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CCDC181)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1 Ehret G.B....Chakravarti A. (2009)
    2. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    4. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    8. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57821 HGNC: 28051 AceView: LOC57821 Ensembl:ENSG00000117477 euGenes: HUgn57821
    ECgene: CCDC181 H-InvDB: CCDC181

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCDC181 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCDC181 gene:
    Search GeneIP for patents involving CCDC181

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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