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Aliases for CCDC181 Gene

Aliases for CCDC181 Gene

  • Coiled-Coil Domain Containing 181 2 3 5
  • C1orf114 3 4
  • Coiled-Coil Domain-Containing Protein 181 3
  • Chromosome 1 Open Reading Frame 114 2

External Ids for CCDC181 Gene

Previous HGNC Symbols for CCDC181 Gene

  • C1orf114

Previous GeneCards Identifiers for CCDC181 Gene

  • GC01M169365

Summaries for CCDC181 Gene

GeneCards Summary for CCDC181 Gene

CCDC181 (Coiled-Coil Domain Containing 181) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC181 Gene

Genomics for CCDC181 Gene

Regulatory Elements for CCDC181 Gene

Enhancers for CCDC181 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F169427 0.2 ENCODE 30.7 +33.3 33295 0.7 ZNF223 BMI1 CTBP1 ZNF366 POLR2A ZNF600 ZBTB20 EZH2 RFX1 MAZ CCDC181 NME7 METTL18 LOC105371605
GH01F169362 1 Ensembl ENCODE 19.6 +94.7 94681 7.2 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 NME7 SCYL3 RN7SL333P CCDC181 METTL18 BLZF1 ENSG00000235575
GH01F169326 1 Ensembl ENCODE 13.3 +133.7 133745 1.4 LEF1 PKNOX1 TAL1 JUN ZNF316 NCOR1 NFE2 NR2F6 TRIM24 ZNF584 NME7 CCDC181 ATP1B1 LOC101928596 ENSG00000235575 BLZF1
GH01F169240 0.2 Ensembl 12.2 +219.8 219819 0.7 ZNF316 MAFF MAFK NME7 CCDC181 ENSG00000235575 GC01P169290 GC01P169292 PIR51723
GH01F169482 1.1 ENCODE 10.8 -24.9 -24902 5.7 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SCYL3 NME7 CCDC181 ENSG00000213062 METTL18 PIR61656
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CCDC181 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC181 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001751434 368 600 CTCF NRF1 ZBTB33

Genomic Location for CCDC181 Gene

Chromosome:
1
Start:
169,394,870 bp from pter
End:
169,460,669 bp from pter
Size:
65,800 bases
Orientation:
Minus strand

Genomic View for CCDC181 Gene

Genes around CCDC181 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC181 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC181 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC181 Gene

Proteins for CCDC181 Gene

  • Protein details for CCDC181 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TID7-CC181_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 181
    Protein Accession:
    Q5TID7
    Secondary Accessions:
    • O60780
    • Q53FD5
    • Q5TID9
    • Q8TC48

    Protein attributes for CCDC181 Gene

    Size:
    509 amino acids
    Molecular mass:
    60103 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH26073.1; Type=Frameshift; Positions=370; Evidence={ECO:0000305}; Sequence=CAI19784.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC181 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC181 Gene

Post-translational modifications for CCDC181 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC181 Gene

Domains & Families for CCDC181 Gene

Protein Domains for CCDC181 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC181: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CCDC181 Gene

Function for CCDC181 Gene

Phenotypes for CCDC181 Gene

GenomeRNAi human phenotypes for CCDC181:
genes like me logo Genes that share phenotypes with CCDC181: view

Animal Model Products

miRNA for CCDC181 Gene

miRTarBase miRNAs that target CCDC181

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC181 Gene

Localization for CCDC181 Gene

Gene Ontology (GO) - Cellular Components for CCDC181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with CCDC181: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for CCDC181 Gene

Pathways & Interactions for CCDC181 Gene

SuperPathways for CCDC181 Gene

No Data Available

Interacting Proteins for CCDC181 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356779%0d%0a9606.ENSP00000337396%0d%0a
Selected Interacting proteins: Q5TID7-CC181_HUMAN ENSP00000356779 for CCDC181 Gene via IID MINT STRING

Gene Ontology (GO) - Biological Process for CCDC181 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC181 Gene

Transcripts for CCDC181 Gene

Unigene Clusters for CCDC181 Gene

Coiled-coil domain containing 181:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC181 Gene

No ASD Table

Relevant External Links for CCDC181 Gene

GeneLoc Exon Structure for
CCDC181
ECgene alternative splicing isoforms for
CCDC181

Expression for CCDC181 Gene

mRNA expression in normal human tissues for CCDC181 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC181 Gene

This gene is overexpressed in Testis (x5.9) and Pituitary (x5.3).

Protein differential expression in normal tissues from HIPED for CCDC181 Gene

This gene is overexpressed in CD8 Tcells (31.9), Testis (25.0), and Spinal cord (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC181 Gene



Protein tissue co-expression partners for CCDC181 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC181 Gene:

CCDC181

SOURCE GeneReport for Unigene cluster for CCDC181 Gene:

Hs.567557
genes like me logo Genes that share expression patterns with CCDC181: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CCDC181 Gene

Orthologs for CCDC181 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC181 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC181 34
  • 99.67 (n)
C1ORF114 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC181 34 35
  • 89.28 (n)
cow
(Bos Taurus)
Mammalia CCDC181 34 35
  • 88.19 (n)
mouse
(Mus musculus)
Mammalia Ccdc181 34 16 35
  • 79.62 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc181 34
  • 79.16 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC181 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC181 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H1ORF114 34
  • 61.95 (n)
CCDC181 35
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC181 35
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-232d19.4 34
  • 52.17 (n)
CCDC181 35
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
OneToOne
Species where no ortholog for CCDC181 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC181 Gene

ENSEMBL:
Gene Tree for CCDC181 (if available)
TreeFam:
Gene Tree for CCDC181 (if available)

Paralogs for CCDC181 Gene

Pseudogenes.org Pseudogenes for CCDC181 Gene

genes like me logo Genes that share paralogs with CCDC181: view

No data available for Paralogs for CCDC181 Gene

Variants for CCDC181 Gene

Sequence variations from dbSNP and Humsavar for CCDC181 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1014965 -- 169,396,838(-) AAAAG(C/T)TGCAT intron-variant, downstream-variant-500B
rs10465576 -- 169,397,974(+) CTGTT(G/T)CCTAT intron-variant
rs10465577 -- 169,428,775(+) cttag(A/C)cccca intron-variant, upstream-variant-2KB
rs10489186 -- 169,422,736(-) TTCAT(C/G)CTTGA intron-variant
rs10489187 -- 169,422,491(-) GTCAC(A/G)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC181 Gene

Variant ID Type Subtype PubMed ID
esv22143 CNV gain+loss 19812545
esv2663262 CNV deletion 23128226
nsv1001454 CNV gain 25217958
nsv1005941 CNV loss 25217958
nsv1078878 OTHER inversion 25765185
nsv831871 CNV loss 17160897

Variation tolerance for CCDC181 Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC181 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC181

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC181 Gene

Disorders for CCDC181 Gene

Relevant External Links for CCDC181

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC181

No disorders were found for CCDC181 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC181 Gene

Publications for CCDC181 Gene

  1. DNA methylation signatures for prediction of biochemical recurrence after radical prostatectomy of clinically localized prostate cancer. (PMID: 23918943) Haldrup C. … rensen K.D. (J. Clin. Oncol. 2013) 3 64
  2. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 64
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  5. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3 64

Products for CCDC181 Gene

Sources for CCDC181 Gene

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