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Aliases for CCDC180 Gene

Aliases for CCDC180 Gene

  • Coiled-Coil Domain Containing 180 2 3 5
  • KIAA1529 2 3 4
  • Behcets Disease Associated Gene 1 2 3
  • C9orf174 3 4
  • Chromosome 9 Open Reading Frame 174 2
  • BDAG1 3

External Ids for CCDC180 Gene

Previous HGNC Symbols for CCDC180 Gene

  • KIAA1529
  • C9orf174

Previous GeneCards Identifiers for CCDC180 Gene

  • GC09P100028
  • GC09P100033

Summaries for CCDC180 Gene

GeneCards Summary for CCDC180 Gene

CCDC180 (Coiled-Coil Domain Containing 180) is a Protein Coding gene. Diseases associated with CCDC180 include cataract 36.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC180 Gene

Genomics for CCDC180 Gene

Regulatory Elements for CCDC180 Gene

Promoters for CCDC180 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC180 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC180 Gene

97,307,304 bp from pter
97,378,524 bp from pter
71,221 bases
Plus strand

Genomic View for CCDC180 Gene

Genes around CCDC180 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC180 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC180 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC180 Gene

Proteins for CCDC180 Gene

  • Protein details for CCDC180 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 180
    Protein Accession:
    Secondary Accessions:
    • Q2KHR6
    • Q5VV25
    • Q68DP5
    • Q69YV9
    • Q6AHY0

    Protein attributes for CCDC180 Gene

    1646 amino acids
    Molecular mass:
    191100 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA96053.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH18175.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC180 Gene


neXtProt entry for CCDC180 Gene

Proteomics data for CCDC180 Gene at MOPED

Post-translational modifications for CCDC180 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC180 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC180 Gene

Domains & Families for CCDC180 Gene

Protein Domains for CCDC180 Gene


Suggested Antigen Peptide Sequences for CCDC180 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC180: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC180 Gene

Function for CCDC180 Gene

Phenotypes for CCDC180 Gene

genes like me logo Genes that share phenotypes with CCDC180: view

Animal Model Products

miRNA for CCDC180 Gene

miRTarBase miRNAs that target CCDC180

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC180 Gene

Localization for CCDC180 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC180 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for CCDC180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CCDC180: view

No data available for Subcellular locations from COMPARTMENTS for CCDC180 Gene

Pathways & Interactions for CCDC180 Gene

SuperPathways for CCDC180 Gene

No Data Available

Interacting Proteins for CCDC180 Gene

Selected Interacting proteins: Q9P1Z9-CC180_HUMAN for CCDC180 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CCDC180 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC180 Gene

Drugs & Compounds for CCDC180 Gene

No Compound Related Data Available

Transcripts for CCDC180 Gene

mRNA/cDNA for CCDC180 Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC180 Gene

Coiled-coil domain containing 180:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC180 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^

ExUns: 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30a · 30b
SP2: -
SP3: -

Relevant External Links for CCDC180 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC180 Gene

mRNA expression in normal human tissues for CCDC180 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC180 Gene

This gene is overexpressed in Testis (x5.3).

Protein differential expression in normal tissues from HIPED for CCDC180 Gene

This gene is overexpressed in Brain (53.7) and Nasal epithelium (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC180 Gene

SOURCE GeneReport for Unigene cluster for CCDC180 Gene Hs.435629

genes like me logo Genes that share expression patterns with CCDC180: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCDC180 Gene

Orthologs for CCDC180 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC180 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC180 35
  • 81.53 (n)
  • 71.46 (a)
CCDC180 36
  • 67 (a)
(Canis familiaris)
Mammalia C11H9orf174 35
  • 81.05 (n)
  • 71.64 (a)
CCDC180 36
  • 64 (a)
(Mus musculus)
Mammalia E230008N13Rik 35
  • 75.65 (n)
  • 67.58 (a)
Ccdc180 16
E230008N13Rik 36
  • 64 (a)
(Pan troglodytes)
Mammalia LOC464596 35
  • 99.08 (n)
  • 98.3 (a)
CCDC180 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ccdc180 35
  • 73.66 (n)
  • 64.88 (a)
(Monodelphis domestica)
Mammalia CCDC180 36
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 45 (a)
-- 36
  • 39 (a)
-- 36
  • 49 (a)
(Gallus gallus)
Aves C17H9ORF174 35
  • 53.6 (n)
  • 38.97 (a)
CCDC180 36
  • 35 (a)
(Anolis carolinensis)
Reptilia CCDC180 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492567 35
  • 51.13 (n)
  • 38.81 (a)
(Danio rerio)
Actinopterygii LOC100538012 35
  • 48.08 (n)
  • 35.7 (a)
CCDC180 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for CCDC180:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC180 Gene

Gene Tree for CCDC180 (if available)
Gene Tree for CCDC180 (if available)

Paralogs for CCDC180 Gene

(2) SIMAP similar genes for CCDC180 Gene using alignment to 4 proteins: Pseudogenes for CCDC180 Gene

genes like me logo Genes that share paralogs with CCDC180: view

No data available for Paralogs for CCDC180 Gene

Variants for CCDC180 Gene

Sequence variations from dbSNP and Humsavar for CCDC180 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_038151 -
VAR_038152 -
VAR_038153 -
VAR_038154 -
VAR_038155 -

Variation tolerance for CCDC180 Gene

Residual Variation Intolerance Score: 30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.44; 94.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC180 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCDC180 Gene

Disorders for CCDC180 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CCDC180 Gene - From: OMIM

Disorder Aliases PubMed IDs
cataract 36
  • cataract, autosomal recessive congenital 4
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CCDC180

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CCDC180: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCDC180 Gene

Publications for CCDC180 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  3. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira A.R. … Marazita M.L. (Genet. Med. 2008) 3
  4. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS spectra. (PMID: 17924679) Yu L.R. … Veenstra T.D. (J. Proteome Res. 2007) 3
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 3

Products for CCDC180 Gene

Sources for CCDC180 Gene

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