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Aliases for CCDC18 Gene

Aliases for CCDC18 Gene

  • Coiled-Coil Domain Containing 18 2 3 5
  • Sarcoma Antigen NY-SAR-24 3 4
  • Coiled-Coil Domain-Containing Protein 18 3
  • Sarcoma Antigen NY-SAR-41 3
  • NY-SAR-41 3

External Ids for CCDC18 Gene

Previous GeneCards Identifiers for CCDC18 Gene

  • GC01P093359
  • GC01P093418
  • GC01P093645
  • GC01P091767

Summaries for CCDC18 Gene

GeneCards Summary for CCDC18 Gene

CCDC18 (Coiled-Coil Domain Containing 18) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding.

Additional gene information for CCDC18 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC18 Gene

Genomics for CCDC18 Gene

Regulatory Elements for CCDC18 Gene

Enhancers for CCDC18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H093221 0.9 ENCODE 21.1 +42.2 42225 1 FOXA2 MLX DMAP1 RAD21 ZEB1 RARA ZNF366 CREM MIXL1 THAP11 CCDC18 TMED5 MTF2 ENSG00000225297 LOC100130531
GH01H092482 1.6 FANTOM5 ENCODE dbSUPER 10.2 -695.0 -695035 5 HDGF SIN3A ARID4B DMAP1 ZNF2 ZNF143 ZNF207 SP3 MXD4 REST MTF2 FAM69A CCDC18-AS1 SNORD21 EVI5 SNORA66 GLMN CCDC18 ENSG00000189195 GFI1
GH01H093590 1.5 Ensembl ENCODE dbSUPER 10.2 +414.1 414120 6 FOXA2 MLX ARID4B FEZF1 DMAP1 YY1 SLC30A9 GLIS2 RUNX3 SP5 MTF2 CCDC18-AS1 ENSG00000230439 SNORA66 EVI5 CCDC18 BCAR3 LOC100129046 GC01M093588
GH01H093446 1.6 FANTOM5 Ensembl ENCODE 9.3 +268.9 268901 4 ATF1 ARID4B SIN3A DMAP1 TCF12 SLC30A9 ZNF766 GLIS2 GATA2 ZNF143 CCDC18 FNBP1L RNA5SP53 GC01M093489
GH01H093177 1.4 ENCODE dbSUPER 10.5 +0.1 105 4 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 CCDC18-AS1 SNORA66 SNORD21 RPL5 ENSG00000230439 DNTTIP2 GLMN LOC100289500 ENSG00000233482 MTCO3P21
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC18 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000009907 -319 4001 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766

Genomic Location for CCDC18 Gene

Chromosome:
1
Start:
93,179,919 bp from pter
End:
93,279,037 bp from pter
Size:
99,119 bases
Orientation:
Plus strand

Genomic View for CCDC18 Gene

Genes around CCDC18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC18 Gene

Proteins for CCDC18 Gene

  • Protein details for CCDC18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T9S5-CCD18_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 18
    Protein Accession:
    Q5T9S5
    Secondary Accessions:
    • Q6ZU17

    Protein attributes for CCDC18 Gene

    Size:
    1454 amino acids
    Molecular mass:
    168962 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86410.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC18 Gene

Post-translational modifications for CCDC18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC18 Gene

Domains & Families for CCDC18 Gene

Gene Families for CCDC18 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC18 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC18: view

No data available for UniProtKB/Swiss-Prot for CCDC18 Gene

Function for CCDC18 Gene

Phenotypes From GWAS Catalog for CCDC18 Gene

genes like me logo Genes that share phenotypes with CCDC18: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC18 Gene

Localization for CCDC18 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC18 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC18 Gene

Pathways & Interactions for CCDC18 Gene

SuperPathways for CCDC18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC18 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC18 Gene

Drugs & Compounds for CCDC18 Gene

No Compound Related Data Available

Transcripts for CCDC18 Gene

Unigene Clusters for CCDC18 Gene

Coiled-coil domain containing 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC18 Gene

No ASD Table

Relevant External Links for CCDC18 Gene

GeneLoc Exon Structure for
CCDC18
ECgene alternative splicing isoforms for
CCDC18

Expression for CCDC18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC18 Gene

This gene is overexpressed in Testis (x4.5).

Protein differential expression in normal tissues from HIPED for CCDC18 Gene

This gene is overexpressed in Brain (20.8), Plasma (20.4), and Bone marrow mesenchymal stem cell (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CCDC18 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCDC18 Gene:

CCDC18

SOURCE GeneReport for Unigene cluster for CCDC18 Gene:

Hs.745125
genes like me logo Genes that share expression patterns with CCDC18: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC18 Gene

Orthologs for CCDC18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC18 33 34
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia CCDC18 33 34
  • 91.87 (n)
cow
(Bos Taurus)
Mammalia LOC540863 33
  • 91.6 (n)
CCDC18 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc18 33
  • 87.13 (n)
mouse
(Mus musculus)
Mammalia Ccdc18 33 16 34
  • 86.73 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC18 34
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC18 34
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC18 33 34
  • 65.11 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC18 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc18 33
  • 56.18 (n)
African clawed frog
(Xenopus laevis)
Amphibia sojo-A 33
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-1a11.3 33
  • 48.19 (n)
CCDC18 34
  • 33 (a)
OneToOne
Species where no ortholog for CCDC18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC18 Gene

ENSEMBL:
Gene Tree for CCDC18 (if available)
TreeFam:
Gene Tree for CCDC18 (if available)

Paralogs for CCDC18 Gene

genes like me logo Genes that share paralogs with CCDC18: view

No data available for Paralogs for CCDC18 Gene

Variants for CCDC18 Gene

Sequence variations from dbSNP and Humsavar for CCDC18 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000006426 -- 93,224,022(+) AAATT(A/C)AATAG intron-variant, nc-transcript-variant
rs1000027098 -- 93,212,537(+) CCTCT(A/G)TGTTT intron-variant
rs1000038747 -- 93,212,873(+) GTTGA(A/G)ATAAT intron-variant
rs1000054194 -- 93,262,740(+) TGGCC(C/T)TCTTC intron-variant
rs1000210042 -- 93,228,044(+) GTCCA(A/G)TGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC18 Gene

Variant ID Type Subtype PubMed ID
esv3586825 CNV loss 21293372
esv3586826 CNV loss 21293372
nsv830614 CNV loss 17160897
nsv830625 CNV loss 17160897
nsv946080 CNV duplication 23825009
nsv946082 CNV duplication 23825009

Relevant External Links for CCDC18 Gene

Human Gene Mutation Database (HGMD)
CCDC18
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CCDC18 Gene

Disorders for CCDC18 Gene

Relevant External Links for CCDC18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC18

No disorders were found for CCDC18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC18 Gene

Publications for CCDC18 Gene

  1. Immunomic analysis of human sarcoma. (PMID: 12601173) Lee SY … Scanlan MJ (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for CCDC18 Gene

Sources for CCDC18 Gene

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