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Aliases for CCDC18 Gene

Aliases for CCDC18 Gene

  • Coiled-Coil Domain Containing 18 2 3
  • Sarcoma Antigen NY-SAR-24 3 4
  • Coiled-Coil Domain-Containing Protein 18 3
  • Sarcoma Antigen NY-SAR-41 3
  • NY-SAR-41 3

External Ids for CCDC18 Gene

Previous GeneCards Identifiers for CCDC18 Gene

  • GC01P093359
  • GC01P093418
  • GC01P093645
  • GC01P091767

Summaries for CCDC18 Gene

GeneCards Summary for CCDC18 Gene

CCDC18 (Coiled-Coil Domain Containing 18) is a Protein Coding gene. Diseases associated with CCDC18 include sarcoma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC18 Gene

Genomics for CCDC18 Gene

Regulatory Elements for CCDC18 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCDC18 Gene

93,179,919 bp from pter
93,279,211 bp from pter
99,293 bases
Plus strand

Genomic View for CCDC18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC18 Gene

Proteins for CCDC18 Gene

  • Protein details for CCDC18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 18
    Protein Accession:
    Secondary Accessions:
    • Q6ZU17

    Protein attributes for CCDC18 Gene

    1454 amino acids
    Molecular mass:
    168962 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC86410.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC18 Gene


neXtProt entry for CCDC18 Gene

Proteomics data for CCDC18 Gene at MOPED

Post-translational modifications for CCDC18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC18 Gene

No data available for DME Specific Peptides for CCDC18 Gene

Domains for CCDC18 Gene

Protein Domains for CCDC18 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC18: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC18 Gene

Function for CCDC18 Gene

Gene Ontology (GO) - Molecular Function for CCDC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
genes like me logo Genes that share ontologies with CCDC18: view

Phenotypes for CCDC18 Gene

GenomeRNAi human phenotypes for CCDC18:
genes like me logo Genes that share phenotypes with CCDC18: view

miRNA for CCDC18 Gene

miRTarBase miRNAs that target CCDC18

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC18

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCDC18 Gene

Localization for CCDC18 Gene

Subcellular locations from

Jensen Localization Image for CCDC18 Gene COMPARTMENTS Subcellular localization image for CCDC18 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC18 Gene

Pathways for CCDC18 Gene

SuperPathways for CCDC18 Gene

No Data Available

Interacting Proteins for CCDC18 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000359299 for CCDC18 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CCDC18 Gene


No data available for Pathways by source for CCDC18 Gene

Transcripts for CCDC18 Gene

Unigene Clusters for CCDC18 Gene

Coiled-coil domain containing 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC18 Gene

No ASD Table

Relevant External Links for CCDC18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC18 Gene

mRNA expression in normal human tissues for CCDC18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC18 Gene

This gene is overexpressed in Testis (4.5).

Protein differential expression in normal tissues for CCDC18 Gene

This gene is overexpressed in Brain (20.8), Plasma (20.4), and Bone marrow mesenchymal stem cell (17.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC18 Gene

SOURCE GeneReport for Unigene cluster for CCDC18 Gene Hs.745125

genes like me logo Genes that share expressions with CCDC18: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for CCDC18 Gene

Orthologs for CCDC18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC540863 35
  • 91.6 (n)
  • 91.03 (a)
CCDC18 36
  • 89 (a)
(Canis familiaris)
Mammalia CCDC18 35
  • 91.87 (n)
  • 91.17 (a)
CCDC18 36
  • 89 (a)
(Mus musculus)
Mammalia Ccdc18 35
  • 86.73 (n)
  • 86.06 (a)
Ccdc18 16
Ccdc18 36
  • 84 (a)
(Pan troglodytes)
Mammalia CCDC18 35
  • 99.72 (n)
  • 99.38 (a)
CCDC18 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Ccdc18 35
  • 87.13 (n)
  • 86.39 (a)
(Monodelphis domestica)
Mammalia CCDC18 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC18 36
  • 31 (a)
(Gallus gallus)
Aves CCDC18 35
  • 65.11 (n)
  • 55.3 (a)
CCDC18 36
  • 55 (a)
(Anolis carolinensis)
Reptilia CCDC18 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc18 35
  • 56.18 (n)
  • 44.9 (a)
African clawed frog
(Xenopus laevis)
Amphibia sojo-A 35
(Danio rerio)
Actinopterygii si:dkeyp-1a11.3 35
  • 48.19 (n)
  • 35.87 (a)
CCDC18 36
  • 33 (a)
Species with no ortholog for CCDC18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC18 Gene

Gene Tree for CCDC18 (if available)
Gene Tree for CCDC18 (if available)

Paralogs for CCDC18 Gene

genes like me logo Genes that share paralogs with CCDC18: view

No data available for Paralogs for CCDC18 Gene

Variants for CCDC18 Gene

Sequence variations from dbSNP and Humsavar for CCDC18 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs485622 -- 93,230,022(+) CAACA(A/G)TTATG intron-variant
rs488646 -- 93,257,326(+) AAACC(C/T)TTGGT intron-variant
rs504810 -- 93,243,190(-) gttct(C/G)caggc intron-variant
rs505531 -- 93,212,790(+) gggac(A/G)gggtc intron-variant
rs506556 -- 93,217,986(+) AAGAG(C/G)TGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC18 Gene

Variant ID Type Subtype PubMed ID
nsv830614 CNV Loss 17160897
nsv830625 CNV Loss 17160897

Relevant External Links for CCDC18 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC18 Gene

Disorders for CCDC18 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CCDC18 Gene in MalaCards »

(1) Disease for CCDC18 Gene

genes like me logo Genes that share disorders with CCDC18: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CCDC18 Gene

Publications for CCDC18 Gene

  1. Immunomic analysis of human sarcoma. (PMID: 12601173) Lee S.-Y. … Scanlan M.J. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3
  2. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CCDC18 Gene

Sources for CCDC18 Gene

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