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Aliases for CCDC178 Gene

Aliases for CCDC178 Gene

  • Coiled-Coil Domain Containing 178 2 3 5
  • C18orf34 3 4
  • Coiled-Coil Domain-Containing Protein 178 3
  • Chromosome 18 Open Reading Frame 34 2

External Ids for CCDC178 Gene

Previous HGNC Symbols for CCDC178 Gene

  • C18orf34

Previous GeneCards Identifiers for CCDC178 Gene

  • GC18M030518

Summaries for CCDC178 Gene

GeneCards Summary for CCDC178 Gene

CCDC178 (Coiled-Coil Domain Containing 178) is a Protein Coding gene.

Additional gene information for CCDC178 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC178 Gene

Genomics for CCDC178 Gene

Regulatory Elements for CCDC178 Gene

Enhancers for CCDC178 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H033442 0.8 ENCODE 20.6 +0.4 364 0.7 LEF1 MXI1 ARNT FOXM1 ZFHX2 GLIS2 ZNF366 EGR1 PRDM10 EGR2 CCDC178 GC18P033181
GH18H033183 1.5 ENCODE 5 +257.0 256969 2.2 CTCF JUN PRDM1 CCDC178 GC18P033181
GH18H033116 0.7 Ensembl ENCODE 5.5 +324.6 324600 0.6 FEZF1 TRIM28 CCDC178 GC18M033047 GC18P033181
GH18H033201 0.7 Ensembl ENCODE 5.4 +239.4 239358 0.3 CTCF RAD21 TRIM28 CCDC178 GC18P033181
GH18H033135 0.2 ENCODE 5 +305.1 305055 1.2 CCDC178 GC18P033181 GC18M033047
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC178 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC178 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000102075 401 1000 CTCF LEF1 ARNT RAD21 FOXM1 ZFHX2 EGR1 PRDM10 EGR2 MAZ

Genomic Locations for CCDC178 Gene

Genomic Locations for CCDC178 Gene
503,700 bases
Minus strand

Genomic View for CCDC178 Gene

Genes around CCDC178 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC178 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC178 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC178 Gene

Proteins for CCDC178 Gene

  • Protein details for CCDC178 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 178
    Protein Accession:
    Secondary Accessions:
    • A6NDC6
    • J3KS92
    • Q6ZP67
    • Q6ZU20

    Protein attributes for CCDC178 Gene

    867 amino acids
    Molecular mass:
    102011 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC85257.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC178 Gene


neXtProt entry for CCDC178 Gene

Post-translational modifications for CCDC178 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC178 Gene

Domains & Families for CCDC178 Gene

Gene Families for CCDC178 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC178 Gene


Suggested Antigen Peptide Sequences for CCDC178 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC178: view

No data available for UniProtKB/Swiss-Prot for CCDC178 Gene

Function for CCDC178 Gene

Phenotypes From GWAS Catalog for CCDC178 Gene

genes like me logo Genes that share phenotypes with CCDC178: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC178 Gene

Localization for CCDC178 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC178 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC178 Gene

Pathways & Interactions for CCDC178 Gene

SuperPathways for CCDC178 Gene

No Data Available

Interacting Proteins for CCDC178 Gene

Gene Ontology (GO) - Biological Process for CCDC178 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC178 Gene

Drugs & Compounds for CCDC178 Gene

No Compound Related Data Available

Transcripts for CCDC178 Gene

Unigene Clusters for CCDC178 Gene

Coiled-coil domain containing 178:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC178 Gene

No ASD Table

Relevant External Links for CCDC178 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC178 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC178 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC178 Gene

This gene is overexpressed in Testis (x11.4) and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for CCDC178 Gene

This gene is overexpressed in Heart (40.0) and Adipocyte (26.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC178 Gene

Protein tissue co-expression partners for CCDC178 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC178 Gene:


SOURCE GeneReport for Unigene cluster for CCDC178 Gene:

genes like me logo Genes that share expression patterns with CCDC178: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC178 Gene

Orthologs for CCDC178 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC178 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC178 33 34
  • 99.12 (n)
(Canis familiaris)
Mammalia CCDC178 33 34
  • 82.05 (n)
(Bos Taurus)
Mammalia CCDC178 33 34
  • 77.6 (n)
(Mus musculus)
Mammalia Ccdc178 33 16 34
  • 66.05 (n)
(Rattus norvegicus)
Mammalia Ccdc178 33
  • 65.19 (n)
(Ornithorhynchus anatinus)
Mammalia CCDC178 34
  • 33 (a)
(Monodelphis domestica)
Mammalia CCDC178 34
  • 28 (a)
(Gallus gallus)
Aves CCDC178 34
  • 38 (a)
(Anolis carolinensis)
Reptilia CCDC178 34
  • 27 (a)
(Danio rerio)
Actinopterygii CCDC178 34
  • 19 (a)
Species where no ortholog for CCDC178 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC178 Gene

Gene Tree for CCDC178 (if available)
Gene Tree for CCDC178 (if available)

Paralogs for CCDC178 Gene

(1) SIMAP similar genes for CCDC178 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CCDC178: view

No data available for Paralogs for CCDC178 Gene

Variants for CCDC178 Gene

Sequence variations from dbSNP and Humsavar for CCDC178 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000001512 -- 33,132,567(+) TTTAA(A/C)AGGTA intron-variant
rs1000011197 -- 32,994,974(+) GAAAA(C/T)AGTAT intron-variant
rs1000021691 -- 33,286,817(+) TTTAT(C/T)ATCAA intron-variant
rs1000028427 -- 33,011,716(+) AGGAA(A/G)GGTTT intron-variant
rs1000028476 -- 33,382,290(+) TTCCA(C/T)ATTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC178 Gene

Variant ID Type Subtype PubMed ID
nsv833618 CNV gain 17160897
nsv833617 CNV gain 17160897
nsv528397 CNV loss 19592680
nsv520131 CNV loss 19592680
nsv478874 CNV novel sequence insertion 20440878
nsv475651 CNV novel sequence insertion 20440878
nsv438279 CNV loss 16468122
nsv131084 CNV deletion 16902084
nsv130684 CNV deletion 16902084
nsv1127625 CNV deletion 24896259
nsv1066607 CNV loss 25217958
nsv1063958 CNV loss 25217958
esv3893088 CNV loss 25118596
esv3642170 CNV loss 21293372
esv3642169 CNV loss 21293372
esv3642167 CNV loss 21293372
esv3642166 CNV loss 21293372
esv3642165 CNV loss 21293372
esv3642164 CNV loss 21293372
esv3642162 CNV gain 21293372
esv3583002 CNV loss 25503493
esv2762000 CNV loss 21179565
esv2758720 CNV loss 17122850
esv2678538 CNV deletion 23128226
esv2676754 CNV deletion 23128226
esv2668525 CNV deletion 23128226
esv2660234 CNV deletion 23128226
esv2634635 CNV deletion 19546169
esv2593101 CNV deletion 19546169
esv2541909 CNV deletion 19546169
esv2453134 CNV deletion 19546169
dgv5883n54 CNV loss 21841781
dgv3333n100 CNV loss 25217958

Variation tolerance for CCDC178 Gene

Residual Variation Intolerance Score: 90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.99; 80.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC178 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC178 Gene

Disorders for CCDC178 Gene

Relevant External Links for CCDC178

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC178 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC178 Gene

Publications for CCDC178 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. (PMID: 23934736) Yu B … Boerwinkle E (Genetic epidemiology 2013) 3 60
  4. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S … Sun J (Carcinogenesis 2012) 3 60
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 60

Products for CCDC178 Gene

Sources for CCDC178 Gene

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