Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC178 Gene

Aliases for CCDC178 Gene

  • Coiled-Coil Domain Containing 178 2 3 5
  • C18orf34 3 4
  • Chromosome 18 Open Reading Frame 34 2

External Ids for CCDC178 Gene

Previous HGNC Symbols for CCDC178 Gene

  • C18orf34

Previous GeneCards Identifiers for CCDC178 Gene

  • GC18M030518

Summaries for CCDC178 Gene

GeneCards Summary for CCDC178 Gene

CCDC178 (Coiled-Coil Domain Containing 178) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC178 Gene

Genomics for CCDC178 Gene

Regulatory Elements for CCDC178 Gene

Enhancers for CCDC178 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC178 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC178 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC178 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC178 Gene

32,937,402 bp from pter
33,441,101 bp from pter
503,700 bases
Minus strand

Genomic View for CCDC178 Gene

Genes around CCDC178 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC178 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC178 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC178 Gene

Proteins for CCDC178 Gene

  • Protein details for CCDC178 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 178
    Protein Accession:
    Secondary Accessions:
    • A6NDC6
    • J3KS92
    • Q6ZP67
    • Q6ZU20

    Protein attributes for CCDC178 Gene

    867 amino acids
    Molecular mass:
    102011 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC85257.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC178 Gene


neXtProt entry for CCDC178 Gene

Proteomics data for CCDC178 Gene at MOPED

Post-translational modifications for CCDC178 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC178 Gene

Domains & Families for CCDC178 Gene

Protein Domains for CCDC178 Gene


Suggested Antigen Peptide Sequences for CCDC178 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC178: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC178 Gene

Function for CCDC178 Gene

genes like me logo Genes that share phenotypes with CCDC178: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC178 Gene

Localization for CCDC178 Gene

Subcellular locations from

Jensen Localization Image for CCDC178 Gene COMPARTMENTS Subcellular localization image for CCDC178 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC178 Gene

Pathways & Interactions for CCDC178 Gene

SuperPathways for CCDC178 Gene

No Data Available

Interacting Proteins for CCDC178 Gene

Gene Ontology (GO) - Biological Process for CCDC178 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC178 Gene

Drugs & Compounds for CCDC178 Gene

No Compound Related Data Available

Transcripts for CCDC178 Gene

Unigene Clusters for CCDC178 Gene

Coiled-coil domain containing 178:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC178 Gene

No ASD Table

Relevant External Links for CCDC178 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC178 Gene

mRNA expression in normal human tissues for CCDC178 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC178 Gene

This gene is overexpressed in Testis (x11.4) and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for CCDC178 Gene

This gene is overexpressed in Heart (40.0) and Adipocyte (26.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC178 Gene

SOURCE GeneReport for Unigene cluster for CCDC178 Gene Hs.115461

genes like me logo Genes that share expression patterns with CCDC178: view

Protein tissue co-expression partners for CCDC178 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CCDC178 Gene

Orthologs for CCDC178 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC178 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC178 35
  • 77.6 (n)
  • 61.9 (a)
CCDC178 36
  • 60 (a)
(Canis familiaris)
Mammalia CCDC178 35
  • 82.05 (n)
  • 68.76 (a)
CCDC178 36
  • 67 (a)
(Mus musculus)
Mammalia Ccdc178 35
  • 66.05 (n)
  • 50.46 (a)
Ccdc178 16
Ccdc178 36
  • 50 (a)
(Pan troglodytes)
Mammalia CCDC178 35
  • 99.12 (n)
  • 97.81 (a)
CCDC178 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Ccdc178 35
  • 65.19 (n)
  • 50.43 (a)
(Monodelphis domestica)
Mammalia CCDC178 36
  • 28 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC178 36
  • 33 (a)
(Gallus gallus)
Aves CCDC178 36
  • 38 (a)
(Anolis carolinensis)
Reptilia CCDC178 36
  • 27 (a)
(Danio rerio)
Actinopterygii CCDC178 36
  • 19 (a)
Species with no ortholog for CCDC178:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC178 Gene

Gene Tree for CCDC178 (if available)
Gene Tree for CCDC178 (if available)

Paralogs for CCDC178 Gene

(1) SIMAP similar genes for CCDC178 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CCDC178: view

No data available for Paralogs for CCDC178 Gene

Variants for CCDC178 Gene

Sequence variations from dbSNP and Humsavar for CCDC178 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs12606658 - 33,389,624(+) CATGG(C/T)ATTGC reference, missense
rs9965081 - 33,266,931(+) TTTTT(A/T)CTGTT reference, missense
rs457896 - 33,224,794(-) AAGTC(A/G/T)CGACA reference, missense
rs466113 - 33,224,792(-) GTCTC(A/G)ACAAA reference, missense
rs58448816 - 33,267,216(+) AAAAT(C/T)ATTAA reference, missense

Variation tolerance for CCDC178 Gene

Residual Variation Intolerance Score: 90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.99; 80.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CCDC178 Gene

Disorders for CCDC178 Gene

Relevant External Links for CCDC178

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC178 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC178 Gene

Publications for CCDC178 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. (PMID: 23934736) Yu B. … Boerwinkle E. (Genet. Epidemiol. 2013) 3
  3. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3

Products for CCDC178 Gene

Sources for CCDC178 Gene