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Aliases for CCDC178 Gene

Aliases for CCDC178 Gene

  • Coiled-Coil Domain Containing 178 2 3 5
  • C18orf34 3 4
  • Coiled-Coil Domain-Containing Protein 178 3
  • Chromosome 18 Open Reading Frame 34 2

External Ids for CCDC178 Gene

Previous HGNC Symbols for CCDC178 Gene

  • C18orf34

Previous GeneCards Identifiers for CCDC178 Gene

  • GC18M030518

Summaries for CCDC178 Gene

GeneCards Summary for CCDC178 Gene

CCDC178 (Coiled-Coil Domain Containing 178) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC178 Gene

Genomics for CCDC178 Gene

Regulatory Elements for CCDC178 Gene

Enhancers for CCDC178 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F033442 0.5 ENCODE 20.6 +0.4 364 0.7 CTCF ZFHX2 GLIS2 ZNF366 PRDM10 EZH2 EGR2 ZNF263 MAZ L3MBTL2 CCDC178 GC18P033181
GH18F033116 1.1 Ensembl ENCODE 5.5 +324.6 324600 0.6 FEZF1 TRIM28 CCDC178 GC18M033047 GC18P033181
GH18F033201 1.2 Ensembl ENCODE 5.4 +239.3 239335 0.3 CTCF ZNF707 CBX3 RAD21 TRIM28 CCDC178 GC18P033181
GH18F033183 1.4 ENCODE 5 +257.0 256969 2.2 CTCF JUN PRDM1 TRIM28 CCDC178 GC18P033181
GH18F033135 0.6 ENCODE 5 +305.1 305055 1.2 SMARCA4 PBX2 CCDC178 GC18P033181 GC18M033047
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CCDC178 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC178 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001812440 600 1399 ZNF263 CTCF MAZ L3MBTL2 NRF1 ZFP37 ZBTB8A ZBTB7A RAD21 ZFHX2

Genomic Location for CCDC178 Gene

Chromosome:
18
Start:
32,937,402 bp from pter
End:
33,441,101 bp from pter
Size:
503,700 bases
Orientation:
Minus strand

Genomic View for CCDC178 Gene

Genes around CCDC178 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC178 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC178 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC178 Gene

Proteins for CCDC178 Gene

  • Protein details for CCDC178 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BJE1-CC178_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 178
    Protein Accession:
    Q5BJE1
    Secondary Accessions:
    • A6NDC6
    • J3KS92
    • Q6ZP67
    • Q6ZU20

    Protein attributes for CCDC178 Gene

    Size:
    867 amino acids
    Molecular mass:
    102011 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85257.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC178 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC178 Gene

Post-translational modifications for CCDC178 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC178 Gene

Domains & Families for CCDC178 Gene

Protein Domains for CCDC178 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC178 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC178: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC178 Gene

Function for CCDC178 Gene

genes like me logo Genes that share phenotypes with CCDC178: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC178 Gene

Localization for CCDC178 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC178 Gene COMPARTMENTS Subcellular localization image for CCDC178 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC178 Gene

Pathways & Interactions for CCDC178 Gene

SuperPathways for CCDC178 Gene

No Data Available

Interacting Proteins for CCDC178 Gene

Gene Ontology (GO) - Biological Process for CCDC178 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC178 Gene

Transcripts for CCDC178 Gene

Unigene Clusters for CCDC178 Gene

Coiled-coil domain containing 178:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC178 Gene

No ASD Table

Relevant External Links for CCDC178 Gene

GeneLoc Exon Structure for
CCDC178
ECgene alternative splicing isoforms for
CCDC178

Expression for CCDC178 Gene

mRNA expression in normal human tissues for CCDC178 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC178 Gene

This gene is overexpressed in Testis (x11.4) and Adipose - Visceral (Omentum) (x4.2).

Protein differential expression in normal tissues from HIPED for CCDC178 Gene

This gene is overexpressed in Heart (40.0) and Adipocyte (26.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC178 Gene



Protein tissue co-expression partners for CCDC178 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC178 Gene:

CCDC178

SOURCE GeneReport for Unigene cluster for CCDC178 Gene:

Hs.115461
genes like me logo Genes that share expression patterns with CCDC178: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CCDC178 Gene

Orthologs for CCDC178 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC178 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC178 34 35
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia CCDC178 34 35
  • 82.05 (n)
cow
(Bos Taurus)
Mammalia CCDC178 34 35
  • 77.6 (n)
mouse
(Mus musculus)
Mammalia Ccdc178 34 16 35
  • 66.05 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc178 34
  • 65.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC178 35
  • 33 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC178 35
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC178 35
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC178 35
  • 27 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CCDC178 35
  • 19 (a)
OneToOne
Species where no ortholog for CCDC178 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC178 Gene

ENSEMBL:
Gene Tree for CCDC178 (if available)
TreeFam:
Gene Tree for CCDC178 (if available)

Paralogs for CCDC178 Gene

(1) SIMAP similar genes for CCDC178 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CCDC178: view

No data available for Paralogs for CCDC178 Gene

Variants for CCDC178 Gene

Sequence variations from dbSNP and Humsavar for CCDC178 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs10163576 -- 33,049,880(+) agttc(G/T)agacc intron-variant
rs10221307 -- 33,238,434(+) taaat(A/C)caaca intron-variant
rs10221314 -- 33,238,502(+) taaat(C/G)aaata intron-variant
rs10221398 -- 33,238,429(+) aatga(G/T)aaata intron-variant
rs10221445 -- 33,240,851(+) cattc(C/T)atgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC178 Gene

Variant ID Type Subtype PubMed ID
dgv3333n100 CNV loss 25217958
dgv5883n54 CNV loss 21841781
esv2453134 CNV deletion 19546169
esv2541909 CNV deletion 19546169
esv2593101 CNV deletion 19546169
esv2634635 CNV deletion 19546169
esv2660234 CNV deletion 23128226
esv2668525 CNV deletion 23128226
esv2676754 CNV deletion 23128226
esv2678538 CNV deletion 23128226
esv2758720 CNV loss 17122850
esv2762000 CNV loss 21179565
esv3583002 CNV loss 25503493
esv3642162 CNV gain 21293372
esv3642164 CNV loss 21293372
esv3642165 CNV loss 21293372
esv3642166 CNV loss 21293372
esv3642167 CNV loss 21293372
esv3642169 CNV loss 21293372
esv3642170 CNV loss 21293372
esv3893088 CNV loss 25118596
nsv1063958 CNV loss 25217958
nsv1066607 CNV loss 25217958
nsv1127625 CNV deletion 24896259
nsv130684 CNV deletion 16902084
nsv131084 CNV deletion 16902084
nsv438279 CNV loss 16468122
nsv475651 CNV novel sequence insertion 20440878
nsv478874 CNV novel sequence insertion 20440878
nsv520131 CNV loss 19592680
nsv528397 CNV loss 19592680
nsv833617 CNV gain 17160897
nsv833618 CNV gain 17160897

Variation tolerance for CCDC178 Gene

Residual Variation Intolerance Score: 90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.99; 80.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC178 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC178

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC178 Gene

Disorders for CCDC178 Gene

Relevant External Links for CCDC178

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC178

No disorders were found for CCDC178 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC178 Gene

Publications for CCDC178 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. (PMID: 23934736) Yu B. … Boerwinkle E. (Genet. Epidemiol. 2013) 3 64
  4. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64

Products for CCDC178 Gene

Sources for CCDC178 Gene

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