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CCDC178 Gene

protein-coding   GIFtS: 32
GCID: GC18M030518

Coiled-Coil Domain Containing 178

(Previous name: chromosome 18 open reading frame 34)
(Previous symbol: C18orf34)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coiled-Coil Domain Containing 1781 2
C18orf341 2 3
Chromosome 18 Open Reading Frame 341
Coiled-Coil Domain-Containing Protein 1782

External Ids:    HGNC: 295881   Entrez Gene: 3748642   Ensembl: ENSG000001669607   UniProtKB: Q5BJE13   

Export aliases for CCDC178 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCDC178 Gene:
CCDC178 (coiled-coil domain containing 178) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010966.15  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CCDC178
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CCDC178

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC178


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.1   Ensembl cytogenetic band:  18q12.1   HGNC cytogenetic band: 18q12.1

CCDC178 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC178 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M030518:  view genomic region     (about GC identifiers)

Start:
30,517,366 bp from pter      End:
31,021,065 bp from pter
Size:
503,700 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CC178_HUMAN, Q5BJE1 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 178  
Size: 867 amino acids; 102011 Da
Sequence caution: Sequence=BAC85257.1; Type=Erroneous initiation;
Secondary accessions: A6NDC6 J3KS92 Q6ZP67 Q6ZU20
Alternative splicing: 4 isoforms:  Q5BJE1-1   Q5BJE1-2   Q5BJE1-3   Q5BJE1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCDC178: NX_Q5BJE1

Explore proteomics data for CCDC178 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCDC178 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001098998.1  NP_945346.2  

    ENSEMBL proteins: 
     ENSP00000464295   ENSP00000462651   ENSP00000372576   ENSP00000300227   ENSP00000462153  
     ENSP00000463254   ENSP00000462370   ENSP00000382130   ENSP00000463236   ENSP00000385591  
     ENSP00000385867   ENSP00000385234  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q5BJE1


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC178
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC178
    Interactions:

        Search GeneGlobe Interaction Network for CCDC178

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCDC178 (CC178)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCDC178 gene (2 alternative transcripts): 
    NM_001105528.1  NM_198995.2  

    Unigene Cluster for CCDC178:

    Coiled-coil domain containing 178
    Hs.115461  [show with all ESTs]
    Unigene Representative Sequence: NM_001105528
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000581852(uc010xbq.1) ENST00000581524 ENST00000383096(uc002kxo.2)
    ENST00000300227 ENST00000579916 ENST00000583930 ENST00000579947(uc002kxp.3)
    ENST00000577268 ENST00000399177 ENST00000577766 ENST00000583550 ENST00000403303(uc010dme.1 uc002kxn.2 uc010xbr.1 uc010dmf.1)
    ENST00000406524 ENST00000402325
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    Additional mRNA sequence: 

    AK000027.1 AK126038.1 AK129955.1 BC062719.1 BC091517.1 BC130535.1 BC144178.1 BC144179.1 

    5 DOTS entries:

    DT.101980995  DT.99959297  DT.40119431  DT.65285606  DT.99928170 

    22 AceView cDNA sequences:

    AI656667 CD514175 BX096117 AA971579 AI243275 BG196231 AK129955 AK126038 
    AA429660 AK000027 AA969721 BU569536 NM_198995 BU852453 BC062719 AA320869 
    BG202531 BG181709 AI375673 BG208112 AA446150 BG207238 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCDC178 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CCDC178 Expression
    About this image

    CCDC178 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCDC178 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.115461
        Custom PCR Arrays for CCDC178
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC178

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCDC178 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc1781 , 5 RIKEN cDNA 4921528I01 gene5
    coiled coil domain containing 1781
    66.05(n)1
    50.46(a)1
      18 (11.96 cM)5
    709501  NM_027616.31  NP_081892.21 
     218108975 
    chicken
    (Gallus gallus)
    Aves CCDC1786
    coiled-coil domain containing 178
    38(a)
    1 ↔ 1
    2(106537940-106579883)
    lizard
    (Anolis carolinensis)
    Reptilia CCDC1786
    coiled-coil domain containing 178
    27(a)
    1 ↔ 1
    GL343207.1(2778247-2962714)
    zebrafish
    (Danio rerio)
    Actinopterygii CCDC1786
    coiled-coil domain containing 178
    19(a)
    1 ↔ 1
    24(37284106-37343667) ENSDARG00000090429


    ENSEMBL Gene Tree for CCDC178 (if available)
    TreeFam Gene Tree for CCDC178 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCDC178 gene
    1 SIMAP similar gene for CCDC178 using alignment to 6 protein entries:     CC178_HUMAN (see all proteins):
    C18orf34

    Find genes that share paralogs with CCDC178           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCDC178 (see all 8688)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58238921,2
    C--27784015(+) AACAA-/TTAA  
            
    ATAAA
    2 -- int11Minor allele frequency- TTAA:0.00NA 2
    rs1806927341,2
    --30517120(+) TAAAGC/TGCCCC 2 -- int10--------
    rs2006648331,2
    --30517178(+) TTCTC-/TGTCTGT 2 -- int10--------
    rs2000935091,2
    C--30517179(+) TCTCT-/GT/TG 
            
    CTGTG
    2 -- int10--------
    rs99478741,2
    C,A,H--30517180(+) TCTCTG/CTGTGT 2 -- int14Minor allele frequency- C:0.00NA WA 12
    rs345510161,2
    C--30517223(+) TGTGTGT/-CTTCA 2 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs746897641,2
    --30517223(+) CTCTGC/TGTGTG 2 -- int10--------
    rs1442491771,2
    C--30517371(+) TGGACA/GAAATG 2 -- ut310--------
    rs1837779821,2
    --30517394(+) TTATTC/TATTAA 2 -- ut310--------
    rs1893470211,2
    --30517402(+) TAATCA/GTTCAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CCDC178 (30517366 - 30767366 bp, first 250kb of CCDC178)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCDC178: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCDC178
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC178

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCDC178 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CCDC178)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. (PubMed id 23934736)1 Yu B....Boerwinkle E. (Genet. Epidemiol. 2013)
    4. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (Carcinogenesis 2012)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (Cell 2006)
    7. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (Nature 2005)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 374864 HGNC: 29588 AceView: C18orf34 Ensembl:ENSG00000166960 euGenes: HUgn374864
    ECgene: CCDC178 H-InvDB: CCDC178

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCDC178 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCDC178 gene:
    Search GeneIP for patents involving CCDC178

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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     Browse ESI BIO Cell Lines and PureStem Progenitors for CCDC178
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC178
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     Search Addgene for plasmids for CCDC178
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