Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC177 Gene

Aliases for CCDC177 Gene

  • Coiled-Coil Domain Containing 177 2 3 5
  • Myelin Proteolipid Protein-Like Protein 2 3 4
  • C14orf162 3 4
  • PLPL 3 4
  • Coiled-Coil Domain-Containing Protein 177 3
  • Chromosome 14 Open Reading Frame 162 2

External Ids for CCDC177 Gene

Previous HGNC Symbols for CCDC177 Gene

  • C14orf162

Previous GeneCards Identifiers for CCDC177 Gene

  • GC14M070037

Summaries for CCDC177 Gene

GeneCards Summary for CCDC177 Gene

CCDC177 (Coiled-Coil Domain Containing 177) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC177 Gene

Genomics for CCDC177 Gene

Regulatory Elements for CCDC177 Gene

Enhancers for CCDC177 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F068674 1.8 FANTOM5 Ensembl ENCODE 9.7 +889.1 889094 22.4 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 RNU6-921P CCDC177 SUSD6 PLEKHD1 ZFP36L1 DCAF5 LOC100996664 ENSG00000258623
GH14F068931 1.8 FANTOM5 Ensembl ENCODE 9.7 +629.2 629183 29.4 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ERH ACTN1 RPL7AP6 CCDC177 ZFP36L1 DCAF5 GALNT16 GC14P068937
GH14F069573 0.9 ENCODE 0.8 +0.8 755 1.7 ZNF48 ZNF2 RAD21 GLIS2 ZNF366 ZNF143 ZNF263 ZNF654 ZEB2 SMARCA4 SUSD6 SRSF5 SLC10A1 CCDC177 GC14M069570
GH14F069572 0.7 ENCODE 0.8 +2.7 2685 0.2 ZNF263 NFIA SUZ12 RNF2 NRF1 E2F1 ZNF610 GLIS1 ZNF341 ZBTB26 CCDC177 GC14M069570
GH14F069579 1.3 Ensembl ENCODE 0.4 -5.2 -5227 1.3 PKNOX1 ATF1 ARID4B SIN3A ZNF2 ZNF48 YY1 ZNF143 FOS MXD4 SUSD6 SRSF5 SLC10A1 GC14P069585 CCDC177
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC177 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC177 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001790433 -17 201 CTCF SUZ12 ZNF48 ZNF2 RAD21 GLIS2 CTBP1 PATZ1 ZNF143 SMC3

Genomic Location for CCDC177 Gene

69,569,814 bp from pter
69,574,883 bp from pter
5,070 bases
Minus strand

Genomic View for CCDC177 Gene

Genes around CCDC177 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC177 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC177 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC177 Gene

Proteins for CCDC177 Gene

  • Protein details for CCDC177 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 177
    Protein Accession:
    Secondary Accessions:
    • B2R5G1
    • Q2M359

    Protein attributes for CCDC177 Gene

    707 amino acids
    Molecular mass:
    79739 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF86288.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAG35108.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CCDC177 Gene

Post-translational modifications for CCDC177 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC177 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC177 Gene

Domains & Families for CCDC177 Gene

Protein Domains for CCDC177 Gene


Suggested Antigen Peptide Sequences for CCDC177 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC177: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC177 Gene

Function for CCDC177 Gene

Phenotypes for CCDC177 Gene

genes like me logo Genes that share phenotypes with CCDC177: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC177 Gene

Localization for CCDC177 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CCDC177 Gene

Pathways & Interactions for CCDC177 Gene

SuperPathways for CCDC177 Gene

No Data Available

Interacting Proteins for CCDC177 Gene

Gene Ontology (GO) - Biological Process for CCDC177 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC177 Gene

Transcripts for CCDC177 Gene

mRNA/cDNA for CCDC177 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC177 Gene

Coiled-coil domain containing 177:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC177 Gene

No ASD Table

Relevant External Links for CCDC177 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC177 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC177 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC177 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x10.1), Brain - Cerebellum (x9.2), Brain - Cortex (x6.1), Brain - Frontal Cortex (BA9) (x5.9), and Brain - Anterior cingulate cortex (BA24) (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of CCDC177 Gene:


SOURCE GeneReport for Unigene cluster for CCDC177 Gene:

genes like me logo Genes that share expression patterns with CCDC177: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CCDC177 Gene

Orthologs for CCDC177 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC177 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC101057527 34
  • 99.17 (n)
(Bos Taurus)
Mammalia -- 35
  • 94 (a)
CCDC177 34
  • 88.83 (n)
(Canis familiaris)
Mammalia -- 35
  • 92 (a)
CCDC177 34
  • 88.02 (n)
(Rattus norvegicus)
Mammalia Ccdc177 34
  • 85 (n)
(Mus musculus)
Mammalia Ccdc177 34 16 35
  • 84.97 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 71 (a)
(Gallus gallus)
Aves CCDC177 34
  • 61.72 (n)
-- 35
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 55 (a)
(Danio rerio)
Actinopterygii ccdc177 34 35
  • 54.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3120 35
  • 17 (a)
Species where no ortholog for CCDC177 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC177 Gene

Gene Tree for CCDC177 (if available)
Gene Tree for CCDC177 (if available)

Paralogs for CCDC177 Gene

No data available for Paralogs for CCDC177 Gene

Variants for CCDC177 Gene

Sequence variations from dbSNP and Humsavar for CCDC177 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs112068716 -- 69,572,805(+) AGCTG(C/T)TCCTG reference, missense
rs112597196 -- 69,572,725(+) GCGGC(C/T)GGTGA reference, missense
rs112790781 -- 69,575,886(+) GAGGC(A/G)GATGG upstream-variant-2KB
rs113077435 -- 69,573,674(+) GACAT(C/G)GAGGA intron-variant
rs113429861 -- 69,569,859(+) TTCCA(-/T)TTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCDC177 Gene

Variant ID Type Subtype PubMed ID
nsv564970 CNV loss 21841781
nsv1335 CNV deletion 18451855
esv25683 CNV loss 19812545
dgv3744n54 CNV loss 21841781
dgv3743n54 CNV loss 21841781

Variation tolerance for CCDC177 Gene

Gene Damage Index Score: 2.65; 45.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC177 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC177 Gene

Disorders for CCDC177 Gene

Relevant External Links for CCDC177

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC177 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC177 Gene

Publications for CCDC177 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. 2',3'-cyclic nucleotide 3'-phosphodiesterase: a novel candidate autoantigen in demyelinating diseases. (PMID: 9143234) RAPsener M. … Martin R. (J. Neuroimmunol. 1997) 22 64

Products for CCDC177 Gene

Sources for CCDC177 Gene

Loading form....