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Aliases for CCDC177 Gene

Aliases for CCDC177 Gene

  • Coiled-Coil Domain Containing 177 2 3
  • Myelin Proteolipid Protein-Like Protein 2 3 4
  • C14orf162 3 4
  • PLPL 3 4
  • Chromosome 14 Open Reading Frame 162 2

External Ids for CCDC177 Gene

Previous HGNC Symbols for CCDC177 Gene

  • C14orf162

Previous GeneCards Identifiers for CCDC177 Gene

  • GC14M070037

Summaries for CCDC177 Gene

GeneCards Summary for CCDC177 Gene

CCDC177 (Coiled-Coil Domain Containing 177) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC177 Gene

Genomics for CCDC177 Gene

Genomic Location for CCDC177 Gene

69,569,814 bp from pter
69,574,883 bp from pter
5,070 bases
Minus strand

Genomic View for CCDC177 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC177 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC177 Gene

No data available for Regulatory Elements for CCDC177 Gene

Proteins for CCDC177 Gene

  • Protein details for CCDC177 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 177
    Protein Accession:
    Secondary Accessions:
    • B2R5G1
    • Q2M359

    Protein attributes for CCDC177 Gene

    707 amino acids
    Molecular mass:
    79739 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF86288.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAG35108.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CCDC177 Gene

Proteomics data for CCDC177 Gene at MOPED

Post-translational modifications for CCDC177 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC177 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC177 Gene

Domains & Families for CCDC177 Gene

Protein Domains for CCDC177 Gene


Suggested Antigen Peptide Sequences for CCDC177 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC177: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC177 Gene

Function for CCDC177 Gene

Phenotypes for CCDC177 Gene

GenomeRNAi human phenotypes for CCDC177:
genes like me logo Genes that share phenotypes with CCDC177: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC177 Gene

Localization for CCDC177 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CCDC177 Gene

Pathways & Interactions for CCDC177 Gene

SuperPathways for CCDC177 Gene

No Data Available

Interacting Proteins for CCDC177 Gene

Gene Ontology (GO) - Biological Process for CCDC177 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC177 Gene

Drugs & Compounds for CCDC177 Gene

No Compound Related Data Available

Transcripts for CCDC177 Gene

mRNA/cDNA for CCDC177 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC177 Gene

Coiled-coil domain containing 177:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC177

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC177 Gene

No ASD Table

Relevant External Links for CCDC177 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC177 Gene

mRNA expression in normal human tissues for CCDC177 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC177 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x10.1), Brain - Cerebellum (x9.2), Brain - Cortex (x6.1), Brain - Frontal Cortex (BA9) (x5.9), and Brain - Anterior cingulate cortex (BA24) (x4.9).

SOURCE GeneReport for Unigene cluster for CCDC177 Gene Hs.458319

genes like me logo Genes that share expression patterns with CCDC177: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCDC177 Gene

Orthologs for CCDC177 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC177 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC177 35
  • 88.83 (n)
  • 93.12 (a)
-- 36
  • 94 (a)
(Canis familiaris)
Mammalia CCDC177 35
  • 88.02 (n)
  • 90.58 (a)
-- 36
  • 92 (a)
(Mus musculus)
Mammalia Ccdc177 35
  • 84.97 (n)
  • 90.04 (a)
Ccdc177 36
  • 91 (a)
(Pan troglodytes)
Mammalia LOC101057527 35
  • 99.17 (n)
  • 99.46 (a)
(Rattus norvegicus)
Mammalia Ccdc177 35
  • 85 (n)
  • 90.74 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
(Gallus gallus)
Aves CCDC177 35
  • 61.72 (n)
  • 57.53 (a)
-- 36
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
(Danio rerio)
Actinopterygii ccdc177 35
  • 54.33 (n)
  • 53.06 (a)
ccdc177 36
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3120 36
  • 17 (a)
Species with no ortholog for CCDC177:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC177 Gene

Gene Tree for CCDC177 (if available)
Gene Tree for CCDC177 (if available)

Paralogs for CCDC177 Gene

No data available for Paralogs for CCDC177 Gene

Variants for CCDC177 Gene

Sequence variations from dbSNP and Humsavar for CCDC177 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs4048622 -- 69,573,107(+) gcggc(-/GGCGGC)CGCGG cds-indel
rs4899302 -- 69,574,770(+) TCCCT(A/G)AAATA utr-variant-5-prime
rs4902734 -- 69,573,164(+) ATGCG(C/G)TCGCG missense, reference
rs4902735 -- 69,575,747(+) ACAGA(C/T)CGGAG upstream-variant-2KB
rs6573892 -- 69,573,506(+) GAGGA(A/G)GCTGC synonymous-codon, reference

Variation tolerance for CCDC177 Gene

Gene Damage Index Score: 2.65; 45.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC177 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCDC177 Gene

Disorders for CCDC177 Gene

Relevant External Links for CCDC177

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CCDC177: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC177 Gene

Publications for CCDC177 Gene

  1. 2',3'-cyclic nucleotide 3'-phosphodiesterase: a novel candidate autoantigen in demyelinating diseases. (PMID: 9143234) RAPsener M. … Martin R. (J. Neuroimmunol. 1997) 23 67
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for CCDC177 Gene

Sources for CCDC177 Gene

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