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Aliases for CCDC176 Gene

Aliases for CCDC176 Gene

  • Coiled-Coil Domain Containing 176 2 3
  • Coiled-Coil Domain-Containing Protein 176 3 4
  • C14orf45 3 4
  • Chromosome 14 Open Reading Frame 45 2
  • Basal Body-Orientation Factor 1 3
  • BBOF1 4

External Ids for CCDC176 Gene

Previous Symbols for CCDC176 Gene

  • C14orf45

Summaries for CCDC176 Gene

GeneCards Summary for CCDC176 Gene

CCDC176 (Coiled-Coil Domain Containing 176) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC176 Gene

  • Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC176 Gene

Genomics for CCDC176 Gene

Genomic Location for CCDC176 Gene

Start:
74,019,351 bp from pter
End:
74,082,863 bp from pter
Size:
63,513 bases
Orientation:
Plus strand

Genomic View for CCDC176 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC176 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC176 Gene

No data available for Regulatory Elements for CCDC176 Gene

Proteins for CCDC176 Gene

  • Protein details for CCDC176 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8ND07-BBOF1_HUMAN
    Recommended name:
    Basal body-orientation factor 1
    Protein Accession:
    Q8ND07
    Secondary Accessions:
    • Q0P604
    • Q9H5P8

    Protein attributes for CCDC176 Gene

    Size:
    529 amino acids
    Molecular mass:
    61987 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI04980.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI04982.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15572.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BC044808; Type=Frameshift; Positions=428, 448; Evidence={ECO:0000305};

neXtProt entry for CCDC176 Gene

Proteomics data for CCDC176 Gene at MOPED

Post-translational modifications for CCDC176 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC176 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC176 Gene

Domains for CCDC176 Gene

Protein Domains for CCDC176 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

BBOF1_HUMAN
Family:
  • Belongs to the BBOF1 family.:
    • Q8ND07
genes like me logo Genes that share domains with CCDC176: view

No data available for Gene Families for CCDC176 Gene

Function for CCDC176 Gene

Molecular function for CCDC176 Gene

UniProtKB/Swiss-Prot Function: Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity).

miRNA for CCDC176 Gene

miRTarBase miRNAs that target CCDC176

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCDC176 Gene

Localization for CCDC176 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC176 Gene

Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to a polar structure adjacent to the basal body. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for CCDC176 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0036064 ciliary basal body ISS --
genes like me logo Genes that share ontologies with CCDC176: view

Pathways for CCDC176 Gene

SuperPathways for CCDC176 Gene

No Data Available

Interacting Proteins for CCDC176 Gene

Gene Ontology (GO) - Biological Process for CCDC176 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044458 motile cilium assembly ISS --
genes like me logo Genes that share ontologies with CCDC176: view

No data available for Pathways by source for CCDC176 Gene

Transcripts for CCDC176 Gene

Unigene Clusters for CCDC176 Gene

Coiled-coil domain containing 176:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC176 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for CCDC176 Gene

GeneLoc Exon Structure for
CCDC176
ECgene alternative splicing isoforms for
CCDC176

Expression for CCDC176 Gene

mRNA expression in normal human tissues for CCDC176 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC176 Gene

This gene is overexpressed in Testis (5.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CCDC176 Gene

SOURCE GeneReport for Unigene cluster for CCDC176 Gene Hs.644621

genes like me logo Genes that share expressions with CCDC176: view

Orthologs for CCDC176 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC176 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC176 36
  • 99.62 (n)
  • 99.24 (a)
CCDC176 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC176 36
  • 88.21 (n)
  • 81.53 (a)
CCDC176 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC176 36
  • 89.43 (n)
  • 84.34 (a)
CCDC176 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc176 36
  • 84.29 (n)
  • 79.49 (a)
Ccdc176 16
Ccdc176 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC176 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC176 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc176 36
  • 83.4 (n)
  • 79.84 (a)
chicken
(Gallus gallus)
Aves C5H14ORF45 36
  • 63.42 (n)
  • 53.53 (a)
CCDC176 37
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC176 37
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc176 36
  • 62.1 (n)
  • 54.4 (a)
zebrafish
(Danio rerio)
Actinopterygii CCDC176 (1 of 2) 37
  • 41 (a)
OneToMany
CCDC176 (2 of 2) 37
  • 39 (a)
OneToMany
si:ch211-163l21.10 36
  • 50.1 (n)
  • 39.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 43 (a)
OneToOne
Species with no ortholog for CCDC176:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC176 Gene

ENSEMBL:
Gene Tree for CCDC176 (if available)
TreeFam:
Gene Tree for CCDC176 (if available)

Paralogs for CCDC176 Gene

Pseudogenes.org Pseudogenes for CCDC176 Gene

genes like me logo Genes that share paralogs with CCDC176: view

No data available for Paralogs for CCDC176 Gene

Variants for CCDC176 Gene

Sequence variations from dbSNP and Humsavar for CCDC176 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1057466 -- 74,048,261(-) TGAGT(C/T)TAATG intron-variant
rs2159156 -- 74,039,979(-) GAGAG(A/T)CAACA intron-variant
rs2190894 -- 74,046,533(-) TAGCC(A/G)GGTGT intron-variant
rs2240625 -- 74,041,056(-) ACAGG(A/C)GTGAG intron-variant
rs2286415 -- 74,034,331(-) AGACC(G/T)TTGGC intron-variant

Relevant External Links for CCDC176 Gene

HapMap Linkage Disequilibrium report
CCDC176

No data available for Structural Variations from Database of Genomic Variants (DGV) for CCDC176 Gene

Disorders for CCDC176 Gene

No disorders were found for CCDC176 Gene.

No data available for UniProtKB/Swiss-Prot for CCDC176 Gene

Publications for CCDC176 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3

Products for CCDC176 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CCDC176
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CCDC176
    • Block miRNA regulation of CCDC176 using miScript Target Protectors

    Sources for CCDC176 Gene

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