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CCDC174 Gene

protein-coding   GIFtS: 38
GCID: GC03P014695

Coiled-Coil Domain Containing 174

(Previous name: chromosome 3 open reading frame 19)
(Previous symbol: C3orf19)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coiled-Coil Domain Containing 1741 2
C3orf191 2 3
Chromosome 3 Open Reading Frame 191
Coiled-Coil Domain-Containing Protein 1742

External Ids:    HGNC: 280331   Entrez Gene: 512442   Ensembl: ENSG000001547817   UniProtKB: Q6PII33   

Export aliases for CCDC174 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCDC174 Gene:
CCDC174 (coiled-coil domain containing 174) is a protein-coding gene. Diseases associated with CCDC174 include malaria.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CCDC174
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CCDC174

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC174


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25.1

CCDC174 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC174 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P014695:  view genomic region     (about GC identifiers)

Start:
14,693,253 bp from pter      End:
14,714,166 bp from pter
Size:
20,914 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CC174_HUMAN, Q6PII3 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 174  
Size: 467 amino acids; 53958 Da
Secondary accessions: Q96CS5

Explore the universe of human proteins at neXtProt for CCDC174: NX_Q6PII3

Explore proteomics data for CCDC174 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCDC174 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057558.3  
    ENSEMBL proteins: 
     ENSP00000373304   ENSP00000302344  

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR025066 DUF4078

    Graphical View of Domain Structure for InterPro Entry Q6PII3

    ProtoNet protein and cluster: Q6PII3


    CCDC174 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC174
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CCDC174

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    hsa-mir-192-5p (MIRT026218), hsa-mir-215-5p (MIRT024778)

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    Sino Biological Human cDNA Clone for CCDC174
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC174

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC174


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--

    CCDC174 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC174
    Interactions:

        Search GeneGlobe Interaction Network for CCDC174

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CCDC174 (Q6PII32, 3 ENSP000003733044) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF4A3P389192, 3, ENSP000002693494MINT-67142 I2D: score=5 STRING: ENSP00000269349
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCDC174 (CC174)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCDC174 gene: 
    NM_016474.4  

    Unigene Cluster for CCDC174:

    Coiled-coil domain containing 174
    Hs.517820  [show with all ESTs]
    Unigene Representative Sequence: NM_016474
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463438 ENST00000383794(uc003byw.3) ENST00000303688(uc010hej.3)
    ENST00000465759(uc010hei.1) ENST00000476763
    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate CCDC174
    SwitchGear 3'UTR luciferase reporter plasmidCCDC174 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCDC174
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC174
    Primer
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    OriGene qPCR primer pairs and template standards for CCDC174
    OriGene qSTAR qPCR primer pairs in human, mouse for CCDC174
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CCDC174
      QuantiTect SYBR Green Assays in human, mouse, rat CCDC174
      QuantiFast Probe-based Assays in human, mouse, rat CCDC174

    Additional mRNA sequence: 

    AF151046.1 AK091158.1 AK309525.1 BC005199.1 BC013999.2 BC033897.1 

    8 DOTS entries:

    DT.411103  DT.95118420  DT.427403  DT.100787702  DT.120862295  DT.100646260  DT.101955059  DT.75110669 

    Selected AceView cDNA sequences (see all 162):

    BC005199 CB157565 NM_016474 AI809198 BC013999 BQ015103 AI014881 AW408566 
    AA515283 AI362772 AK023163 AA877406 AI332382 BM977781 AA765835 AW572426 
    CF124982 CR618061 AI521437 AA627354 BI859342 BX505999 AI129593 BU621593 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCDC174 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CCDC174 Expression
    About this image

    CCDC174 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCDC174 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517820
        Custom PCR Arrays for CCDC174
    Primer
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    OriGene qPCR primer pairs and template standards for CCDC174
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    QuantiFast Probe-based Assays in human, mouse, rat CCDC174
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC174

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CCDC174 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc1741 , 5 RIKEN cDNA C130022K22 gene5
    coiled-coil domain containing 1741
    85.77(n)1
    84.98(a)1
      6 (40.90 cM)5
    2322361  NM_172730.21  NP_766318.21 
     918780535 
    chicken
    (Gallus gallus)
    Aves C12H3ORF191 chromosome 12 open reading frame, human C3orf19 69.98(n)
    70.46(a)
      416044  NM_001006140.1  NP_001006140.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC1746
    coiled-coil domain containing 174
    65(a)
    1 ↔ 1
    2(170361153-170380250)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.19492 Xenopus laevis transcribed sequence with weak similarity more 75.07(n)    BX852003.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.168492 Transcribed sequence with weak similarity to protein more 72.45(n)    BI983936.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71836
    --
    21(a)
    1 ↔ 1
    3R(14043850-14046421)


    ENSEMBL Gene Tree for CCDC174 (if available)
    TreeFam Gene Tree for CCDC174 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCDC174 gene

    CCDC174 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCDC174
    PGOHUM00000239831


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCDC174 (see all 565)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs783914721,2
    C--14691316(+) TCTTTC/TAGAAG 1 -- us2k10--------
    rs1113646791,2
    C,F--14691390(+) GAACAA/GGACAA 1 -- us2k12Minor allele frequency- G:0.10CSA WA 119
    rs746234131,2
    C,F--14691403(+) CTATAA/CGGTAT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1429519621,2
    --14691497(+) TTACTA/GTTCTA 1 -- us2k10--------
    rs1462073611,2
    C--14691604(+) TTTTC-/CC    
       ATTTT
    CTCCA
    1 -- us2k10--------
    rs793670571,2
    C,F--14691606(+) TTCCCT/ATTTTC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs170399961,2
    C,F,H--14691685(+) AGGTCC/TGCTTC 1 -- us2k116Minor allele frequency- T:0.04NA NS EA WA 1776
    rs1507029001,2
    --14691705(+) TGCAAA/GGATTA 1 -- us2k10--------
    rs1896404641,2
    --14691708(+) AAGGAG/TTATAT 1 -- us2k10--------
    rs1814541971,2
    --14691710(+) GGATTA/CTATAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CCDC174 (14693253 - 14714166 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCDC174: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCDC174
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC174

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for CCDC174:    
    About MalaCards
    malaria


    CCDC174 for disorders           About GeneDecksing


    Export disorders for CCDC174 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCDC174 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CCDC174)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    5. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    6. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51244 HGNC: 28033 AceView: LOC51244 Ensembl:ENSG00000154781 euGenes: HUgn51244
    ECgene: CCDC174 H-InvDB: CCDC174

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCDC174 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCDC174 gene:
    Search GeneIP for patents involving CCDC174

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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