Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC173 Gene

Aliases for CCDC173 Gene

  • Coiled-Coil Domain Containing 173 2 3 5
  • C2orf77 3 4
  • Coiled-Coil Domain-Containing Protein 173 3
  • Chromosome 2 Open Reading Frame 77 2
  • Hypothetical LOC129881 2

External Ids for CCDC173 Gene

Previous HGNC Symbols for CCDC173 Gene

  • C2orf77

Previous GeneCards Identifiers for CCDC173 Gene

  • GC02M170502

Summaries for CCDC173 Gene

GeneCards Summary for CCDC173 Gene

CCDC173 (Coiled-Coil Domain Containing 173) is a Protein Coding gene.

Additional gene information for CCDC173 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC173 Gene

Genomics for CCDC173 Gene

Regulatory Elements for CCDC173 Gene

Enhancers for CCDC173 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H169583 1.4 ENCODE dbSUPER 15.7 +109.3 109283 2 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 PHOSPHO2 FASTKD1 CCDC173 PPIG SSB GC02P169639
GH02H169715 1.3 Ensembl ENCODE 15.2 -22.1 -22128 2 FOXA2 MLX ARNT ARID4B DMAP1 YY1 SLC30A9 SP5 MXD4 ZNF592 FASTKD1 PHOSPHO2 CCDC173 ENSG00000229827 GC02P169728 KLHL23
GH02H169693 1.1 ENCODE 16.8 -0.4 -381 2 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF143 SP3 PHOSPHO2 FASTKD1 CCDC173 PPIG SSB KLHL23 GC02P169728
GH02H169507 1.5 Ensembl ENCODE dbSUPER 11.4 +183.5 183452 7 PKNOX1 FOXA2 FEZF1 FOS JUNB TSHZ1 MEF2D MAFF SMARCA4 KDM1A BBS5 PPIG CCDC173 PHOSPHO2 FASTKD1 KLHL23 KLHL41 GC02P169518
GH02H169664 1 ENCODE 16.4 +29.0 29032 1 HDGF ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 NCOA1 SMARCB1 MBD2 CCDC173 PHOSPHO2 LOC100421474 GC02M169688
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC173 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC173 Gene

Chromosome:
2
Start:
169,645,425 bp from pter
End:
169,694,433 bp from pter
Size:
49,009 bases
Orientation:
Minus strand

Genomic View for CCDC173 Gene

Genes around CCDC173 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC173 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC173 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC173 Gene

Proteins for CCDC173 Gene

  • Protein details for CCDC173 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VFZ6-CC173_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 173
    Protein Accession:
    Q0VFZ6
    Secondary Accessions:
    • Q6PJF6

    Protein attributes for CCDC173 Gene

    Size:
    552 amino acids
    Molecular mass:
    66403 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI17446.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for CCDC173 Gene

Post-translational modifications for CCDC173 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC173 Gene

No data available for DME Specific Peptides for CCDC173 Gene

Domains & Families for CCDC173 Gene

Gene Families for CCDC173 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC173 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC173: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CCDC173 Gene

Function for CCDC173 Gene

Phenotypes for CCDC173 Gene

GenomeRNAi human phenotypes for CCDC173:
genes like me logo Genes that share phenotypes with CCDC173: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCDC173
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC173 Gene

Localization for CCDC173 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC173 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC173 Gene

Pathways & Interactions for CCDC173 Gene

SuperPathways for CCDC173 Gene

No Data Available

Interacting Proteins for CCDC173 Gene

Gene Ontology (GO) - Biological Process for CCDC173 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC173 Gene

Drugs & Compounds for CCDC173 Gene

No Compound Related Data Available

Transcripts for CCDC173 Gene

Unigene Clusters for CCDC173 Gene

Coiled-coil domain containing 173:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCDC173
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC173 Gene

No ASD Table

Relevant External Links for CCDC173 Gene

GeneLoc Exon Structure for
CCDC173
ECgene alternative splicing isoforms for
CCDC173

Expression for CCDC173 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC173 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC173 Gene

This gene is overexpressed in Testis (x31.2).

Protein differential expression in normal tissues from HIPED for CCDC173 Gene

This gene is overexpressed in Blymphocyte (35.8) and Monocytes (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC173 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCDC173 Gene:

CCDC173

SOURCE GeneReport for Unigene cluster for CCDC173 Gene:

Hs.370111
genes like me logo Genes that share expression patterns with CCDC173: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC173 Gene

Orthologs for CCDC173 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC173 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC173 33 34
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia CCDC173 33 34
  • 90.93 (n)
cow
(Bos Taurus)
Mammalia CCDC173 33 34
  • 90.74 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc173 33
  • 82.78 (n)
mouse
(Mus musculus)
Mammalia Ccdc173 33 16 34
  • 81.32 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC173 34
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC173 34
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101749600 33
  • 59.82 (n)
CCDC173 34
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC173 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc173 33
  • 54.22 (n)
zebrafish
(Danio rerio)
Actinopterygii ccdc173 33 34
  • 50.09 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToOne
Species where no ortholog for CCDC173 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC173 Gene

ENSEMBL:
Gene Tree for CCDC173 (if available)
TreeFam:
Gene Tree for CCDC173 (if available)

Paralogs for CCDC173 Gene

No data available for Paralogs for CCDC173 Gene

Variants for CCDC173 Gene

Sequence variations from dbSNP and Humsavar for CCDC173 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000001069 -- 169,675,537(+) TCTCA(C/T)GAGAA intron-variant
rs1000017178 -- 169,658,869(+) GTCTA(C/T)AATCC intron-variant
rs1000067943 -- 169,658,599(+) GAGGA(A/G)CAGAG intron-variant
rs1000178995 -- 169,696,172(+) TCCAA(C/T)CTGTG intron-variant, upstream-variant-2KB
rs1000203248 -- 169,688,186(+) GTGAA(G/T)GTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC173 Gene

Variant ID Type Subtype PubMed ID
esv2721118 CNV deletion 23290073
esv3593327 CNV loss 21293372
nsv1007492 CNV gain 25217958
nsv1008726 CNV loss 25217958
nsv1011368 CNV loss 25217958
nsv834454 CNV loss 17160897

Variation tolerance for CCDC173 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.65; 78.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC173 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC173

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC173 Gene

Disorders for CCDC173 Gene

Relevant External Links for CCDC173

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC173

No disorders were found for CCDC173 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC173 Gene

Publications for CCDC173 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 60
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for CCDC173 Gene

Sources for CCDC173 Gene

Content
Loading form....