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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCDC173 Gene

protein-coding   GIFtS: 28
GCID: GC02M170502

Coiled-Coil Domain Containing 173

(Previous name: chromosome 2 open reading frame 77)
(Previous symbol: C2orf77)
  Search for CCDC173
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 1731 2
C2orf771 2 3
Chromosome 2 Open Reading Frame 771
Hypothetical LOC1298811
Coiled-Coil Domain-Containing Protein 1732

External Ids:    HGNC: 250641   Entrez Gene: 1298812   Ensembl: ENSG000001544797   UniProtKB: Q0VFZ63   

Export aliases for CCDC173 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CCDC173 Gene: 
CCDC173 (coiled-coil domain containing 173) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CCDC173
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CCDC173

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC173


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

CCDC173 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC173 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M170502:  view genomic region     (about GC identifiers)

Start:
170,501,935 bp from pter      End:
170,550,943 bp from pter
Size:
49,009 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CC173_HUMAN, Q0VFZ6 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 173  
Size: 552 amino acids; 66403 Da
Caution: It is uncertain whether Met-1 or Met-7 is the initiator
Sequence caution: Sequence=AAI17446.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6PJF6

Explore the universe of human proteins at neXtProt for CCDC173: NX_Q0VFZ6

Explore proteomics data for CCDC173 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q0VFZ6

  • CCDC173 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCDC173 Protein Expression
    REFSEQ proteins: NP_001078916.1  
    ENSEMBL proteins: 
     ENSP00000391504   ENSP00000405608   ENSP00000408143  

    Human Recombinant Protein Products for CCDC173: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q0VFZ6


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCDC173 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCDC173 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC173

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCDC173 (CC173)

    Search CenterWatch for drugs/clinical trials and news about CCDC173 / CC173

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCDC173 gene: 
    NM_001085447.1  

    Unigene Cluster for CCDC173:

    Coiled-coil domain containing 173
    Hs.370111  [show with all ESTs]
    Unigene Representative Sequence: NM_001085447
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447353(uc002ufe.2 uc002uff.2) ENST00000421028 ENST00000419478

    miRNA
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC173

    Additional mRNA sequence: 

    AK301851.1 BC015980.2 BC065905.1 BC117445.1 

    4 DOTS entries:

    DT.75162883  DT.92417305  DT.97836552  DT.121029714 

    24/49 AceView cDNA sequences (see all 49):

    AI627449 BU678319 AI239937 BI827094 AA884646 AI608643 BF056506 BU853175 
    AW204436 AW732536 BU853743 AW339899 AI650455 AI123468 AL043871 BG108072 
    BQ441247 BX114742 BU160167 AI041212 BQ438323 AI499506 CD557240 AK001460 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCDC173 expression in normal human tissues (normalized intensities)      CCDC173 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CCDC173 Expression
    About this image


    CCDC173 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Testis (Reproductive System)

    See CCDC173 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCDC173

    SOURCE GeneReport for Unigene cluster: Hs.370111
        SABiosciences Custom PCR Arrays for CCDC173
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC173

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CCDC173 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc1731 , 5 RIKEN cDNA 4930578N16 gene5
    coiled-coil domain containing 1731
    81.32(n)1
    75.46(a)1
      2 (40.95 cM)5
    750511  NM_001077684.11  NP_001071152.11 
     697580335 
    chicken
    (Gallus gallus)
    Aves CCDC1731 coiled-coil domain containing 173 59.94(n)
    46.01(a)
      424161  XM_422007.3  XP_422007.3 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC1736
    Uncharacterized protein
    41(a)
    1 ↔ 1
    GL343362.1(506395-524947)
    zebrafish
    (Danio rerio)
    Actinopterygii ccdc1731 coiled-coil domain containing 173 50.34(n)
    37.94(a)
      559457  XM_002663426.1  XP_002663472.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50626
    --
    11(a)
    1 ↔ 1
    X(5074214-5076402)


    ENSEMBL Gene Tree for CCDC173 (if available)
    TreeFam Gene Tree for CCDC173 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/938 SNPs in CCDC173 are shown (see all 938)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs593003141,2
    C--169908703(+) GAAGA-/AAGA/ 
     AGG
    /GGA
    AAGAG
    3 -- int1 cds11NA 2
    rs75883151,2
    C,F,A,H--170501588(+) tttgtC/Ttcttt 1 -- ds500112Minor allele frequency- T:0.21NS EA NA WA 668
    rs1176213731,2
    F--170501655(+) GACCTC/GAAAAC 1 -- ds50011Minor allele frequency- G:0.02EA 120
    rs1920451921,2
    --170501751(+) AATAAC/TGCTGG 1 -- ds50010--------
    rs1850957701,2
    --170501873(+) ACTGAC/TAAATG 1 -- ds50010--------
    rs126137291,2
    C,F,H--170501908(+) atatgC/Ataagt 1 -- ds50011Minor allele frequency- A:0.50NA 4
    rs772525331,2
    C,F--170501909(+) TATGCT/CAAGTG 1 -- ds50012Minor allele frequency- C:0.10CSA WA 119
    rs1884110821,2
    --170502118(+) GTACTG/TAATAC 1 -- ut310--------
    rs791040831,2
    C,F--170502343(+) AAATAA/TTTTTT 1 -- ut312Minor allele frequency- T:0.12NA EU 712
    rs2015095331,2
    C--170502355(+) TCTACC/TATGTA 2 * W stg10--------

    HapMap Linkage Disequilibrium report for CCDC173 (170501935 - 170550943 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CCDC173: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CCDC173
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC173

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCDC173 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CCDC173)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 129881 HGNC: 25064 AceView: LOC129881 Ensembl:ENSG00000154479 euGenes: HUgn129881
    ECgene: CCDC173 H-InvDB: CCDC173

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCDC173 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCDC173 gene:
    Search GeneIP for patents involving CCDC173

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Search LifeMap BioReagents cell lines for CCDC173
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC173
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CCDC173
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCDC173
    Customized:
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     LSBio Antibodies in human, mouse, rat for CCDC173
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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