Aliases for CCDC170 Gene
Aliases for CCDC170 Gene
External Ids for CCDC170 Gene
- HGNC: 21177
- Entrez Gene: 80129
- Ensembl: ENSG00000120262
- UniProtKB: Q8IYT3
Previous HGNC Symbols for CCDC170 Gene
- C6orf97
Previous GeneCards Identifiers for CCDC170 Gene
- GC06P151815
Summaries for CCDC170 Gene
-
The function of this gene and its encoded protein is not known. Several genome-wide association studies have implicated the region around this gene to be involved in breast cancer and bone mineral density, but no link to this specific gene has been found. [provided by RefSeq, May 2010]
GeneCards Summary for CCDC170 Gene
CCDC170 (Coiled-Coil Domain Containing 170) is a Protein Coding gene.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC170 Gene
Genomics for CCDC170 Gene
Regulatory Elements for CCDC170 Gene
Enhancers for CCDC170 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G151492 | 1.2 | FANTOM5 ENCODE | 18.5 | +0.1 | 74 | 2.4 | FOXA2 ARID4B SIN3A DMAP1 ZNF48 ZNF263 MXD4 ZNF579 RFX3 MXD3 | RMND1 CCDC170 ARMT1 ESR1 GC06M151579 |
| GH06G151497 | 1.4 | FANTOM5 Ensembl ENCODE | 10.5 | +4.8 | 4772 | 3.2 | ELF3 FOXA2 ARID4B DMAP1 RAD21 RARA YY1 CREM MIXL1 THAP11 | RMND1 ARMT1 RNU6-813P CCDC170 ZBTB2 GC06M151579 |
| GH06G151668 | 1.2 | ENCODE dbSUPER | 10.6 | +174.8 | 174836 | 1.6 | PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 FOS ZHX2 PPARG | CCDC170 GC06P151669 GC06P151812 |
| GH06G151481 | 1.3 | FANTOM5 Ensembl ENCODE | 8.4 | -11.6 | -11630 | 2.0 | CTCF FOXA2 ZNF644 FOXA1 GATA3 CTBP1 GATA2 FOS FOSL2 PRDM1 | RMND1 CCDC170 ZBTB2 ARMT1 |
| GH06G151666 | 0.8 | FANTOM5 dbSUPER | 11.9 | +172.7 | 172684 | 0.2 | ZNF687 SUZ12 IKZF1 ZNF207 ZNF592 | CCDC170 ESR1 GC06P151669 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CCDC170 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CCDC170 Gene
- Chromosome:
- 6
- Start:
- 151,494,030 bp from pter
- End:
- 151,621,193 bp from pter
- Size:
- 127,164 bases
- Orientation:
- Plus strand
Genomic View for CCDC170 Gene
Genes around CCDC170 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q25.1 by Ensembl
- 6q25.1 by Entrez Gene
- 6q25.1 by HGNC
CCDC170 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCDC170 Gene
Proteins for CCDC170 Gene
-
Protein details for CCDC170 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IYT3-CC170_HUMAN
- Recommended name:
- Coiled-coil domain-containing protein 170
- Protein Accession:
- Q8IYT3
- Q5VXB7
- Q6P9E4
- Q96KA9
- Q9H5M3
Protein attributes for CCDC170 Gene
- Size:
- 715 amino acids
- Molecular mass:
- 82277 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB55025.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH71980.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI10943.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for CCDC170 Gene
Post-translational modifications for CCDC170 Gene
Other Protein References for CCDC170 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CCDC170
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-
Abcam antibodies for CCDC170
- Invitrogen Antibodies for CCDC170
- antibodies-online Antibodies for CCDC170: See all 27
- GeneTex CCDC170 antibody for CCDC170
Protein Products
-
OriGene Purified Proteins for CCDC170
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC170
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- Search GeneTex for Proteins for CCDC170
Assay Products
- antibodies-online Kits for CCDC170: See all 40
No data available for DME Specific Peptides for CCDC170 Gene
Domains & Families for CCDC170 Gene
Protein Domains for CCDC170 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for CCDC170 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC170 Gene
Function for CCDC170 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for CCDC170 Gene
- GenomeRNAi human phenotypes for CCDC170:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCDC170
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CCDC170 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC170 gene
- Search ViGene Biosciences for CCDC170
CRISPR Products
-
OriGene CRISPR knockouts for CCDC170
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC170
- GenScript: Design CRISPR guide RNA sequences for CCDC170
miRNA for CCDC170 Gene
- miRTarBase miRNAs that target CCDC170
miRNA Products
- Search ViGene Biosciences for CCDC170
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCDC170
- Browse OriGene Inhibitory RNA Products For CCDC170
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC170 gene
Clone Products
-
OriGene ORF clones in human for CCDC170
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCDC170
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC170
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CCDC170
-
ViGene Biosciences adenoviral particle packaged cDNA for CCDC170 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCDC170 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC170 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC170 Gene
Localization for CCDC170 Gene
| Compartment | Confidence |
|---|---|
| golgi apparatus | 3 |
| nucleus | 2 |
| cytosol | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC170 Gene
Pathways & Interactions for CCDC170 Gene
No Data Available
Interacting Proteins for CCDC170 Gene
Selected Interacting proteins:
ENSP00000239374
Q8IYT3-CC170_HUMAN
for CCDC170 Gene via
STRING
UniProtKB
IID
No data available for Pathways by source and SIGNOR curated interactions for CCDC170 Gene
Transcripts for CCDC170 Gene
mRNA/cDNA for CCDC170 Gene
- (3) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (29) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CCDC170 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCDC170
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC170
- GenScript: Design CRISPR guide RNA sequences for CCDC170
miRNA Products
- Search ViGene Biosciences for CCDC170
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCDC170
- Browse OriGene Inhibitory RNA Products For CCDC170
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC170 gene
Clone Products
-
OriGene ORF clones in human for CCDC170
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCDC170
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC170
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CCDC170 Gene
mRNA differential expression in normal tissues according to GTEx for CCDC170 Gene
This gene is overexpressed in Ovary (x5.3) and Adrenal Gland (x4.2).
This gene is overexpressed in Nasal epithelium (68.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC170 Gene
NURSA nuclear receptor signaling pathways regulating expression of CCDC170 Gene:
CCDC170SOURCE GeneReport for Unigene cluster for CCDC170 Gene:
Hs.660044Primer Products
-
OriGene qPCR primer pairs for CCDC170
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC170 Gene
Orthologs for CCDC170 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCDC170 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CCDC170 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CCDC170 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ccdc170 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ccdc170 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CCDC170 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CCDC170 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | C6ORF97 34 |
|
||
| CCDC170 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | CCDC170 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ccdc170 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ccdc170 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007734 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG43338 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for CCDC170 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CCDC170 Gene
No data available for Paralogs for CCDC170 Gene
Variants for CCDC170 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs6929137 | Likely pathogenic | 151,615,542(+) | TGTCT(A/G)TCAAG | intron-variant, reference, missense | |
| rs12662670 | Uncertain significance | 151,597,721(+) | AAACT(C/G/T)ACAAG | intron-variant | |
| rs3734805 | Uncertain significance | 151,618,215(+) | TCCTC(A/C)TGTCT | upstream-variant-2KB, utr-variant-3-prime | |
| rs9383589 | Uncertain significance | 151,619,125(+) | CTTAC(A/G)TAGGT | utr-variant-3-prime | |
| rs1000043357 | -- | 151,579,327(+) | GAATG(G/T)AAAGT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1005109 | CNV | insertion | 20482838 |
| esv2575520 | CNV | deletion | 19546169 |
| esv2732901 | CNV | deletion | 23290073 |
| esv2732902 | CNV | deletion | 23290073 |
| esv2732903 | CNV | deletion | 23290073 |
| esv2761004 | CNV | gain+loss | 21179565 |
| esv28786 | CNV | loss | 19812545 |
| esv3576236 | CNV | gain | 25503493 |
| esv3611268 | CNV | loss | 21293372 |
| esv3611269 | CNV | loss | 21293372 |
| esv3611270 | CNV | gain | 21293372 |
| nsv1016522 | CNV | gain | 25217958 |
| nsv1117674 | CNV | deletion | 24896259 |
| nsv516304 | CNV | loss | 19592680 |
| nsv523861 | CNV | loss | 19592680 |
| nsv604889 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.66;
93.18% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CCDC170 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC170 Gene
Disorders for CCDC170 Gene
Relevant External Links for CCDC170
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CCDC170
No disorders were found for CCDC170 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC170 Gene
Publications for CCDC170 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
- Genome-wide association study using family-based cohorts identifies the WLS and CCDC170/ESR1 loci as associated with bone mineral density. (PMID: 26911590) Mullin B.H. … Wilson S.G. (BMC Genomics 2016) 3 64
- Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. (PMID: 26928228) Dunning A.M. … Edwards S.L. (Nat. Genet. 2016) 3 64
Products for CCDC170 Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Custom Antibody ServicesOriGene Antibodies for CCDC170
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- OriGene Purified Proteins for CCDC170
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- OriGene qPCR primer pairs for CCDC170
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- Novus Biologicals Antibodies for CCDC170
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for CCDC170: See all 27
- antibodies-online Kits for CCDC170: See all 40
- Search antibodies-online for proteins
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- GeneTex CCDC170 antibody for CCDC170
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- ViGene Biosciences adenoviral particle packaged cDNA for CCDC170 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CCDC170 gene
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- Horizon Cell Lines for CCDC170
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCDC170
- VectorBuilder custom plasmid, inducible vectors for CCDC170
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC170
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CCDC170 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer