Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCDC170 Gene

Aliases for CCDC170 Gene

  • Coiled-Coil Domain Containing 170 2 3 5
  • C6orf97 3 4
  • Coiled-Coil Domain-Containing Protein 170 3
  • Chromosome 6 Open Reading Frame 97 2
  • BA282P11.1 3

External Ids for CCDC170 Gene

Previous HGNC Symbols for CCDC170 Gene

  • C6orf97

Previous GeneCards Identifiers for CCDC170 Gene

  • GC06P151815

Summaries for CCDC170 Gene

Entrez Gene Summary for CCDC170 Gene

  • The function of this gene and its encoded protein is not known. Several genome-wide association studies have implicated the region around this gene to be involved in breast cancer and bone mineral density, but no link to this specific gene has been found. [provided by RefSeq, May 2010]

GeneCards Summary for CCDC170 Gene

CCDC170 (Coiled-Coil Domain Containing 170) is a Protein Coding gene.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC170 Gene

Genomics for CCDC170 Gene

Regulatory Elements for CCDC170 Gene

Enhancers for CCDC170 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G151492 1.2 FANTOM5 ENCODE 18.5 +0.1 74 2.4 FOXA2 ARID4B SIN3A DMAP1 ZNF48 ZNF263 MXD4 ZNF579 RFX3 MXD3 RMND1 CCDC170 ARMT1 ESR1 GC06M151579
GH06G151497 1.4 FANTOM5 Ensembl ENCODE 10.6 +4.8 4772 3.2 ELF3 FOXA2 ARID4B DMAP1 RAD21 RARA YY1 CREM MIXL1 THAP11 RMND1 ARMT1 RNU6-813P CCDC170 ZBTB2 GC06M151579
GH06G151668 1.2 ENCODE dbSUPER 10.6 +174.8 174836 1.6 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 FOS ZHX2 PPARG CCDC170 GC06P151669 GC06P151812
GH06G151481 1.3 FANTOM5 Ensembl ENCODE 8.4 -11.6 -11630 2.0 CTCF FOXA2 ZNF644 FOXA1 GATA3 CTBP1 GATA2 FOS FOSL2 PRDM1 RMND1 CCDC170 ZBTB2 ARMT1
GH06G151666 0.8 FANTOM5 dbSUPER 11.9 +172.7 172684 0.2 ZNF687 SUZ12 IKZF1 ZNF207 ZNF592 CCDC170 ESR1 GC06P151669
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC170 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC170 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000205320 370 1601 FOXA2 ARID4B SIN3A DMAP1 ZNF48 ZNF263 MXD4 ZNF579 RFX3 MXD3

Genomic Location for CCDC170 Gene

151,494,030 bp from pter
151,621,193 bp from pter
127,164 bases
Plus strand

Genomic View for CCDC170 Gene

Genes around CCDC170 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC170 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC170 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC170 Gene

Proteins for CCDC170 Gene

  • Protein details for CCDC170 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 170
    Protein Accession:
    Secondary Accessions:
    • Q5VXB7
    • Q6P9E4
    • Q96KA9
    • Q9H5M3

    Protein attributes for CCDC170 Gene

    715 amino acids
    Molecular mass:
    82277 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB55025.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH71980.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI10943.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CCDC170 Gene

Post-translational modifications for CCDC170 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC170 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC170 Gene

Domains & Families for CCDC170 Gene

Protein Domains for CCDC170 Gene


Suggested Antigen Peptide Sequences for CCDC170 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC170: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC170 Gene

Function for CCDC170 Gene

Gene Ontology (GO) - Molecular Function for CCDC170 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC170: view
genes like me logo Genes that share phenotypes with CCDC170: view

Animal Model Products

CRISPR Products

miRNA for CCDC170 Gene

miRTarBase miRNAs that target CCDC170

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC170 Gene

Localization for CCDC170 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC170 gene
Compartment Confidence
golgi apparatus 3
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC170 Gene

Pathways & Interactions for CCDC170 Gene

SuperPathways for CCDC170 Gene

No Data Available

Interacting Proteins for CCDC170 Gene

Gene Ontology (GO) - Biological Process for CCDC170 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC170 Gene

Drugs & Compounds for CCDC170 Gene

No Compound Related Data Available

Transcripts for CCDC170 Gene

Unigene Clusters for CCDC170 Gene

Coiled-coil domain containing 170:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC170 Gene

No ASD Table

Relevant External Links for CCDC170 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC170 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC170 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC170 Gene

This gene is overexpressed in Ovary (x5.3) and Adrenal Gland (x4.2).

Protein differential expression in normal tissues from HIPED for CCDC170 Gene

This gene is overexpressed in Nasal epithelium (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC170 Gene

Protein tissue co-expression partners for CCDC170 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC170 Gene:


SOURCE GeneReport for Unigene cluster for CCDC170 Gene:

genes like me logo Genes that share expression patterns with CCDC170: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC170 Gene

Orthologs for CCDC170 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC170 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC170 34 35
  • 99.16 (n)
(Canis familiaris)
Mammalia CCDC170 34 35
  • 87.16 (n)
(Bos Taurus)
Mammalia CCDC170 34 35
  • 86.65 (n)
(Rattus norvegicus)
Mammalia Ccdc170 34
  • 79.15 (n)
(Mus musculus)
Mammalia Ccdc170 34 16 35
  • 78 (n)
(Ornithorhynchus anatinus)
Mammalia CCDC170 35
  • 69 (a)
(Monodelphis domestica)
Mammalia CCDC170 35
  • 55 (a)
(Gallus gallus)
Aves C6ORF97 34
  • 64.44 (n)
CCDC170 35
  • 52 (a)
(Anolis carolinensis)
Reptilia CCDC170 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc170 34
  • 65.25 (n)
(Danio rerio)
Actinopterygii ccdc170 34 35
  • 52.37 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007734 34
  • 42.06 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG43338 34 35
  • 40.13 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
Species where no ortholog for CCDC170 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC170 Gene

Gene Tree for CCDC170 (if available)
Gene Tree for CCDC170 (if available)

Paralogs for CCDC170 Gene

No data available for Paralogs for CCDC170 Gene

Variants for CCDC170 Gene

Sequence variations from dbSNP and Humsavar for CCDC170 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs6929137 Likely pathogenic 151,615,542(+) TGTCT(A/G)TCAAG intron-variant, reference, missense
rs12662670 Uncertain significance 151,597,721(+) AAACT(C/G/T)ACAAG intron-variant
rs3734805 Uncertain significance 151,618,215(+) TCCTC(A/C)TGTCT upstream-variant-2KB, utr-variant-3-prime
rs9383589 Uncertain significance 151,619,125(+) CTTAC(A/G)TAGGT utr-variant-3-prime
rs1000043357 -- 151,579,327(+) GAATG(G/T)AAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC170 Gene

Variant ID Type Subtype PubMed ID
esv1005109 CNV insertion 20482838
esv2575520 CNV deletion 19546169
esv2732901 CNV deletion 23290073
esv2732902 CNV deletion 23290073
esv2732903 CNV deletion 23290073
esv2761004 CNV gain+loss 21179565
esv28786 CNV loss 19812545
esv3576236 CNV gain 25503493
esv3611268 CNV loss 21293372
esv3611269 CNV loss 21293372
esv3611270 CNV gain 21293372
nsv1016522 CNV gain 25217958
nsv1117674 CNV deletion 24896259
nsv516304 CNV loss 19592680
nsv523861 CNV loss 19592680
nsv604889 CNV loss 21841781

Variation tolerance for CCDC170 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.66; 93.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC170 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC170 Gene

Disorders for CCDC170 Gene

Relevant External Links for CCDC170

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC170 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC170 Gene

Publications for CCDC170 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  4. Genome-wide association study using family-based cohorts identifies the WLS and CCDC170/ESR1 loci as associated with bone mineral density. (PMID: 26911590) Mullin B.H. … Wilson S.G. (BMC Genomics 2016) 3 64
  5. Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. (PMID: 26928228) Dunning A.M. … Edwards S.L. (Nat. Genet. 2016) 3 64

Products for CCDC170 Gene

Sources for CCDC170 Gene

Loading form....