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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCDC17 Gene

protein-coding   GIFtS: 41
GCID: GC01M046086

Coiled-Coil Domain Containing 17

  Search for CCDC17
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 171 2
Coiled-Coil Domain-Containing Protein 172

External Ids:    HGNC: 265741   Entrez Gene: 1494832   Ensembl: ENSG000001595887   UniProtKB: Q96LX73   

Export aliases for CCDC17 gene to outside databases

Previous GC identifers: GC01M045755 GC01M045858 GC01M044196


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CCDC17 Gene: 
CCDC17 (coiled-coil domain containing 17) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCDC17 gene promoter:
         STAT4   STAT1beta   Nkx2-5   POU3F2   STAT1alpha   PPAR-gamma1   FAC1   STAT2   STAT3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC17 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCDC17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1

CCDC17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC17 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M046086:  view genomic region     (about GC identifiers)

Start:
46,085,716 bp from pter      End:
46,089,731 bp from pter
Size:
4,016 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CCD17_HUMAN, Q96LX7 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 17  
Size: 622 amino acids; 67721 Da
Sequence caution: Sequence=BAB71539.1; Type=Miscellaneous discrepancy; Note=Incompletely spliced mRNA;
Secondary accessions: A1A4Y7 B4DNX7 B4E1Q5 C9J8L2 Q0P683 Q5T629
Alternative splicing: 4 isoforms:  Q96LX7-4   Q96LX7-5   Q96LX7-2   Q96LX7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCDC17: NX_Q96LX7

Explore proteomics data for CCDC17 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96LX7

  • CCDC17 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCDC17 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001108410.2  NP_001177111.1  

    ENSEMBL proteins: 
     ENSP00000361114   ENSP00000389415   ENSP00000432172   ENSP00000411335   ENSP00000437072  
     ENSP00000341451  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96LX7


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCDC17 
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    SwitchGear 3'UTR luciferase reporter plasmidCCDC17 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC17

    1 Interacting protein for CCDC17 (Q96LX73) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FGFR3P226073I2D: score=3 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCDC17 (CCD17)

    Search CenterWatch for drugs/clinical trials and news about CCDC17 / CCD17

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCDC17 gene (3 alternative transcripts): 
    NM_152500.2  NM_001114938.2  NM_001190182.1  

    Unigene Cluster for CCDC17:

    Coiled-coil domain containing 17
    Hs.18912  [show with all ESTs]
    Unigene Representative Sequence: NM_001114938
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372044 ENST00000482416 ENST00000491755(uc010olt.2) ENST00000421127(uc010ols.2)
    ENST00000528266 ENST00000445048 ENST00000479529 ENST00000464739 ENST00000525599
    ENST00000343901(uc001com.4 uc001con.4 uc009vxz.3)
    miRNA
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    hsa-miR-181c hsa-miR-589* hsa-miR-181a hsa-miR-181d hsa-miR-181b hsa-miR-4262
    SwitchGear 3'UTR luciferase reporter plasmidCCDC17 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene RNAi products in human, mouse, rat for CCDC17
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC17
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    OriGene ORF clones in mouse, rat for CCDC17
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    GenScript: all cDNA clones in your preferred vector (see all 2): CCDC17 (NM_001114938)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CCDC17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC17
    Sirion Biotech Customized lentivirus for stable overexpression of CCDC17 
                         Customized lentivirus expression plasmids for stable overexpression of CCDC17 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC17
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC17

    Additional mRNA sequence: 

    AK298104.1 AK303939.1 BC029888.1 BC128177.1 BC128178.1 

    4 DOTS entries:

    DT.108418  DT.95366533  DT.95366534  DT.91935752 

    24/25 AceView cDNA sequences (see all 25):

    AK057646 NM_152500 BC065201 BI820653 BC029888 BM982802 BI825081 BX282368 
    CA450000 BX114295 BM982784 BM981839 AI560239 AW946466 AA702960 AI186852 
    BU677500 BI772657 AW946509 CA311428 AI829420 AA010540 BF846269 AA010539 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC17    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
    SP1:                    -                                                                                       
    SP2:                                                                                            -               
    SP3:                    -     -                                                                                 
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for CCDC17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCDC17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGACATT
    CCDC17 Expression
    About this image


    See CCDC17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCDC17

    SOURCE GeneReport for Unigene cluster: Hs.18912
        SABiosciences Custom PCR Arrays for CCDC17
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC17
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCDC17 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc171 , 5 coiled-coil domain containing 171, 5 73.19(n)1
    67.39(a)1
      4 (53.24 cM)5
    6226651  NM_001037916.31  NP_001033005.11 
     1165966545 
    chicken
    (Gallus gallus)
    Aves CCDC176
    Uncharacterized protein
    28(a)
    1 ↔ 1
    8(20086382-20088299)
    lizard
    (Anolis carolinensis)
    Reptilia CCDC176
    Uncharacterized protein
    42(a)
    1 ↔ 1
    4(110092305-110098567)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000011321 coiled-coil domain-containing protein 17-like 46.76(n)
    36.45(a)
      100001132  XM_001341164.3  XP_001341200.3 


    ENSEMBL Gene Tree for CCDC17 (if available)
    TreeFam Gene Tree for CCDC17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/203 SNPs in CCDC17 are shown (see all 203)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2007135731,2
    --46085239(+) AACTC-/ATATGGT 2 -- int10--------
    rs773770651,2
    C--46085241(+) CTCAT-/ACGGTTG 2 -- int10--------
    rs617899881,2
    C--46085242(+) CTCATA/C/GGTTGC 2 -- int11NA 2
    rs782426231,2
    F--46085287(+) TCCTGA/GTGTTG 2 -- int11Minor allele frequency- G:0.01NA 120
    rs15479251,2
    C,F,O,A,H--46085356(+) AGTCAT/CGATGT 2 -- int134Minor allele frequency- C:0.31NS EA NA WA CSA 2921
    rs1445766571,2
    --46085378(+) AGGCAC/TTTGAC 2 -- int10--------
    rs1841068001,2
    --46085501(+) AGTACA/GTAAGG 2 -- int10--------
    rs1887981521,2
    --46085522(+) TTCCTC/GTTTAT 2 -- int10--------
    rs22750841,2
    C,F,H--46085639(+) GAATTT/GAAAGT 2 -- int110Minor allele frequency- G:0.04EA NS NA 2758
    rs1160783841,2
    F--46085681(+) CCTTTC/TGGAGA 2 -- int11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for CCDC17 (46085716 - 46089731 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CCDC17:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv829726CNV Loss17160897
    nsv822509CNV Loss20364138
    nsv871928CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCDC17 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CCDC17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    3. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 149483 HGNC: 26574 AceView: FLJ33084 Ensembl:ENSG00000159588 euGenes: HUgn149483
    ECgene: CCDC17 H-InvDB: CCDC17

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCDC17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCDC17 gene:
    Search GeneIP for patents involving CCDC17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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