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Aliases for CCDC169-SOHLH2 Gene

Aliases for CCDC169-SOHLH2 Gene

  • CCDC169-SOHLH2 Readthrough 2 3 5
  • C13orf38-SOHLH2 Readthrough 2 3
  • CCDC169-SOHLH2 Protein 3
  • C13orf38-SOHLH2 3

External Ids for CCDC169-SOHLH2 Gene

Previous HGNC Symbols for CCDC169-SOHLH2 Gene

  • C13orf38-SOHLH2

Previous GeneCards Identifiers for CCDC169-SOHLH2 Gene

  • GC13U900863
  • GC13M036745

Summaries for CCDC169-SOHLH2 Gene

Entrez Gene Summary for CCDC169-SOHLH2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring C13orf38 (chromosome 13 open reading frame 38) and SOHLH2 (spermatogenesis and oogenesis specific basic helix-loop-helix 2) genes. The read-through transcript encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for CCDC169-SOHLH2 Gene

CCDC169-SOHLH2 (CCDC169-SOHLH2 Readthrough) is a Protein Coding gene. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is SOHLH2.

Additional gene information for CCDC169-SOHLH2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC169-SOHLH2 Gene

Genomics for CCDC169-SOHLH2 Gene

Regulatory Elements for CCDC169-SOHLH2 Gene

Enhancers for CCDC169-SOHLH2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H036332 0.8 Ensembl ENCODE 0.3 -35.3 -35347 1.2 FOSL1 ZNF121 JUND GLIS1 JUN FOS SOHLH2 SPART-AS1 CCDC169-SOHLH2 CCDC169
GH13H036275 0.5 ENCODE 0.3 +21.9 21915 1.6 CTCF ZNF654 JUN SMC3 RAD21 SOHLH2 RFXAP RNU6-71P CCDC169-SOHLH2 CCDC169
GH13H036342 0.5 Ensembl 0.3 -44.2 -44246 0.2 GATA3 IKZF1 CEBPB CEBPG EP300 SPART-AS1 CCDC169 CCDC169-SOHLH2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC169-SOHLH2 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC169-SOHLH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000061287 155 1401 ATF1 FEZF1 GLI4 BRCA1 ZNF2 GLIS2 ATF7 SP3 REST TSHZ1

Genomic Locations for CCDC169-SOHLH2 Gene

Genomic Locations for CCDC169-SOHLH2 Gene
129,648 bases
Minus strand

Genomic View for CCDC169-SOHLH2 Gene

Genes around CCDC169-SOHLH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC169-SOHLH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC169-SOHLH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC169-SOHLH2 Gene

Proteins for CCDC169-SOHLH2 Gene

Post-translational modifications for CCDC169-SOHLH2 Gene

No Post-translational modifications

Other Protein References for CCDC169-SOHLH2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC169-SOHLH2 Gene

Domains & Families for CCDC169-SOHLH2 Gene

Gene Families for CCDC169-SOHLH2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC169-SOHLH2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CCDC169-SOHLH2 Gene

Function for CCDC169-SOHLH2 Gene

Phenotypes From GWAS Catalog for CCDC169-SOHLH2 Gene

Phenotypes for CCDC169-SOHLH2 Gene

genes like me logo Genes that share phenotypes with CCDC169-SOHLH2: view

Animal Models for CCDC169-SOHLH2 Gene

MGI Knock Outs for CCDC169-SOHLH2:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC169-SOHLH2 Gene

Localization for CCDC169-SOHLH2 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CCDC169-SOHLH2 Gene

Pathways & Interactions for CCDC169-SOHLH2 Gene

SuperPathways for CCDC169-SOHLH2 Gene

No Data Available

Interacting Proteins for CCDC169-SOHLH2 Gene

Gene Ontology (GO) - Biological Process for CCDC169-SOHLH2 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC169-SOHLH2 Gene

Drugs & Compounds for CCDC169-SOHLH2 Gene

No Compound Related Data Available

Transcripts for CCDC169-SOHLH2 Gene

mRNA/cDNA for CCDC169-SOHLH2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC169-SOHLH2 Gene

No ASD Table

Relevant External Links for CCDC169-SOHLH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC169-SOHLH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC169-SOHLH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expression patterns with CCDC169-SOHLH2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC169-SOHLH2 Gene

Orthologs for CCDC169-SOHLH2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCDC169-SOHLH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SOHLH2 33
  • 98.8 (n)
-- 34
  • 97 (a)
(Canis familiaris)
Mammalia SOHLH2 33
  • 82.28 (n)
-- 34
  • 72 (a)
(Bos Taurus)
Mammalia SOHLH2 33
  • 80.99 (n)
-- 34
  • 72 (a)
(Rattus norvegicus)
Mammalia Sohlh2 33
  • 70.45 (n)
(Mus musculus)
Mammalia Sohlh2 33 16 34
  • 68.65 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
Species where no ortholog for CCDC169-SOHLH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC169-SOHLH2 Gene

Gene Tree for CCDC169-SOHLH2 (if available)
Gene Tree for CCDC169-SOHLH2 (if available)

Paralogs for CCDC169-SOHLH2 Gene

Paralogs for CCDC169-SOHLH2 Gene

genes like me logo Genes that share paralogs with CCDC169-SOHLH2: view

Variants for CCDC169-SOHLH2 Gene

Sequence variations from dbSNP and Humsavar for CCDC169-SOHLH2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000031280 -- 36,211,420(+) GCTGG(A/G)CGCTA intron-variant
rs1000034709 -- 36,256,715(+) CCACC(A/G)GCCTG intron-variant
rs1000039585 -- 36,298,659(+) CTTCC(A/C)GGTCA upstream-variant-2KB
rs1000066311 -- 36,294,868(+) ATCTA(C/T)AGATA intron-variant
rs1000074576 -- 36,216,412(+) TTGAG(G/T)TCACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC169-SOHLH2 Gene

Variant ID Type Subtype PubMed ID
nsv525432 CNV loss 19592680
nsv515635 CNV gain+loss 19592680
nsv1149953 CNV deletion 26484159
nsv1138215 CNV deletion 24896259
nsv1070583 CNV deletion 25765185
esv3631780 CNV loss 21293372
esv3631778 CNV loss 21293372
esv3631777 CNV loss 21293372
esv3631776 CNV gain 21293372
esv3550316 CNV deletion 23714750
esv3172209 CNV deletion 24192839
esv27520 CNV gain 19812545
esv2747267 CNV deletion 23290073
esv2747266 CNV deletion 23290073
esv2747265 CNV deletion 23290073
esv2747263 CNV deletion 23290073
esv2671981 CNV deletion 23128226
esv2666917 CNV deletion 23128226
esv2095309 CNV deletion 18987734
esv1749604 CNV deletion 17803354
dgv949n106 CNV deletion 24896259
dgv101e215 CNV deletion 23714750

Variation tolerance for CCDC169-SOHLH2 Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.34; 88.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC169-SOHLH2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC169-SOHLH2 Gene

Disorders for CCDC169-SOHLH2 Gene

Relevant External Links for CCDC169-SOHLH2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC169-SOHLH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC169-SOHLH2 Gene

Publications for CCDC169-SOHLH2 Gene

  1. The genetic architecture of economic and political preferences. (PMID: 22566634) Benjamin DJ … Visscher PM (Proceedings of the National Academy of Sciences of the United States of America 2012) 3 60
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 60

Products for CCDC169-SOHLH2 Gene

Sources for CCDC169-SOHLH2 Gene

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