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Aliases for CCDC168 Gene

Aliases for CCDC168 Gene

  • Coiled-Coil Domain Containing 168 2 3 5
  • C13orf40 3 4
  • Coiled-Coil Domain-Containing Protein 168 3
  • Chromosome 13 Open Reading Frame 40 2

External Ids for CCDC168 Gene

Previous HGNC Symbols for CCDC168 Gene

  • C13orf40

Previous GeneCards Identifiers for CCDC168 Gene

  • GC13M103384

Summaries for CCDC168 Gene

GeneCards Summary for CCDC168 Gene

CCDC168 (Coiled-Coil Domain Containing 168) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC168 Gene

Genomics for CCDC168 Gene

Regulatory Elements for CCDC168 Gene

Enhancers for CCDC168 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G102591 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +166.4 166364 2.4 HDGF ARID4B SIN3A ZNF2 YY1 GLIS2 ZNF143 ZNF207 FOS SP3 LINC00283 CCDC168 TPP2 ERCC5 LINC00555 ENSG00000276957
GH13G102844 1.4 ENCODE dbSUPER 10.7 -87.4 -87428 3.9 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 BIVM TEX30 METTL21EP CCDC168 LINC00283 ERCC5 METTL21C GC13M102871
GH13G102759 0.3 FANTOM5 46 -0.7 -711 0.1 CCDC168 KDELC1 BIVM ERCC5 TEX30 LOC105370337
GH13G102825 1.1 Ensembl ENCODE dbSUPER 10.5 -67.2 -67171 2.0 CTCF JUN CEBPB EP300 RAD21 RFX5 JUND SMC3 STAT3 FOS CCDC168 LINC00283 METTL21C ENSG00000272542 METTL21EP RNY5P8 GC13P102835
GH13G102706 1 Ensembl ENCODE 11.4 +51.5 51457 1.8 TBP ZNF146 MXI1 JUN MAX ZEB1 RFX5 FOSL1 GATA2 ZNF366 LINC00283 CCDC168 METTL21C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC168 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC168 Gene

Chromosome:
13
Start:
102,729,367 bp from pter
End:
102,759,072 bp from pter
Size:
29,706 bases
Orientation:
Minus strand

Genomic View for CCDC168 Gene

Genes around CCDC168 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC168 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC168 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC168 Gene

Proteins for CCDC168 Gene

  • Protein details for CCDC168 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDH2-CC168_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 168
    Protein Accession:
    Q8NDH2
    Secondary Accessions:
    • Q8N800

    Protein attributes for CCDC168 Gene

    Size:
    2452 amino acids
    Molecular mass:
    277951 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CCDC168 Gene

Post-translational modifications for CCDC168 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC168 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC168 Gene

Domains & Families for CCDC168 Gene

Protein Domains for CCDC168 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC168: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CCDC168 Gene

Function for CCDC168 Gene

Phenotypes for CCDC168 Gene

genes like me logo Genes that share phenotypes with CCDC168: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC168 Gene

Localization for CCDC168 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC168 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC168 Gene

Pathways & Interactions for CCDC168 Gene

SuperPathways for CCDC168 Gene

No Data Available

Interacting Proteins for CCDC168 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000320232%0d%0a9606.ENSP00000440586%0d%0a
Selected Interacting proteins: ENSP00000320232 Q8NDH2-CC168_HUMAN for CCDC168 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CCDC168 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC168 Gene

Drugs & Compounds for CCDC168 Gene

No Compound Related Data Available

Transcripts for CCDC168 Gene

mRNA/cDNA for CCDC168 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC168 Gene

Coiled-coil domain containing 168:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC168 Gene

No ASD Table

Relevant External Links for CCDC168 Gene

GeneLoc Exon Structure for
CCDC168
ECgene alternative splicing isoforms for
CCDC168

Expression for CCDC168 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC168 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC168 Gene

This gene is overexpressed in Testis (x48.3).

Protein differential expression in normal tissues from HIPED for CCDC168 Gene

This gene is overexpressed in Cervix (20.3), Monocytes (16.6), Rectum (7.3), and Plasma (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC168 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCDC168 Gene:

CCDC168

SOURCE GeneReport for Unigene cluster for CCDC168 Gene:

Hs.368382
genes like me logo Genes that share expression patterns with CCDC168: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC168 Gene

Orthologs for CCDC168 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCDC168 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC452647 34
  • 99.21 (n)
CCDC168 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100855512 34
  • 74.19 (n)
CCDC168 35
  • 58 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC168 35
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm8251 35
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC168 35
  • 16 (a)
OneToOne
Species where no ortholog for CCDC168 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC168 Gene

ENSEMBL:
Gene Tree for CCDC168 (if available)
TreeFam:
Gene Tree for CCDC168 (if available)

Paralogs for CCDC168 Gene

No data available for Paralogs for CCDC168 Gene

Variants for CCDC168 Gene

Sequence variations from dbSNP and Humsavar for CCDC168 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs796052147 Likely benign 102,741,045(-) AAATC(A/G)TGAGT reference, missense
rs796052148 Likely benign 102,746,859(-) ATTCA(A/G)AGACG reference, missense
rs1000141080 -- 102,754,196(+) TGAGA(C/T)TCCAT intron-variant
rs1000390675 -- 102,748,125(+) GCTAT(G/T)TGTTT reference, missense
rs1000420057 -- 102,731,500(+) TGCTG(C/T)GTTTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CCDC168 Gene

Variant ID Type Subtype PubMed ID
nsv1044052 CNV gain 25217958
nsv474088 CNV novel sequence insertion 20440878
nsv478982 CNV novel sequence insertion 20440878

Variation tolerance for CCDC168 Gene

Gene Damage Index Score: 9.82; 89.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC168 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC168

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC168 Gene

Disorders for CCDC168 Gene

Relevant External Links for CCDC168

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC168

No disorders were found for CCDC168 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC168 Gene

Publications for CCDC168 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 64
  3. Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity. (PMID: 22792062) van Zuylen W.J. … Servant M.J. (PLoS Pathog. 2012) 3 64
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for CCDC168 Gene

Sources for CCDC168 Gene

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