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CCDC167 Gene

protein-coding   GIFtS: 38
GCID: GC06M037450

Coiled-Coil Domain Containing 167

(Previous name: chromosome 6 open reading frame 129)
(Previous symbol: C6orf129)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coiled-Coil Domain Containing 1671 2
C6orf1291 2 3
Chromosome 6 Open Reading Frame 1291
HSPC2652
Coiled-Coil Domain-Containing Protein 1672
Transmembrane And Coiled-Coil Domain-Containing Protein C6orf1292

External Ids:    HGNC: 212391   Entrez Gene: 1544672   Ensembl: ENSG000001989377   UniProtKB: Q9P0B63   

Export aliases for CCDC167 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCDC167 Gene:
CCDC167 (coiled-coil domain containing 167) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CCDC167
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CCDC167

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC167


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.2

CCDC167 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC167 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M037450:  view genomic region     (about GC identifiers)

Start:
37,450,696 bp from pter      End:
37,467,700 bp from pter
Size:
17,005 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CC167_HUMAN, Q9P0B6 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 167  
Size: 97 amino acids; 11459 Da
Sequence caution: Sequence=AAF28943.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH03515.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q5T7F7 Q9BTQ9

Explore the universe of human proteins at neXtProt for CCDC167: NX_Q9P0B6

Explore proteomics data for CCDC167 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCDC167 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612502.1  
    ENSEMBL proteins: 
     ENSP00000362507  

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    antibodies-online antibodies for CCDC167 (13 products) 

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    antibodies-online kits for CCDC167 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028194 CCDC-167

    Graphical View of Domain Structure for InterPro Entry Q9P0B6

    ProtoNet protein and cluster: Q9P0B6


    Find genes that share domains with CCDC167           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CCDC167

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    4 qRT-PCR Assays for microRNAs that regulate CCDC167:
    hsa-miR-512-5p hsa-miR-922 hsa-miR-137 hsa-miR-510
    SwitchGear 3'UTR luciferase reporter plasmidCCDC167 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CC167_HUMAN, Q9P0B6: Membrane; Single-pass membrane protein (Potential)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CCDC167           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC167
    Interactions:

        Search GeneGlobe Interaction Network for CCDC167

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCDC167 (CC167)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCDC167 gene: 
    NM_138493.2  

    Unigene Cluster for CCDC167:

    Coiled-coil domain containing 167
    Hs.284207  [show with all ESTs]
    Unigene Representative Sequence: BU597496
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000373408(uc003ont.3)
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate CCDC167:
    hsa-miR-512-5p hsa-miR-922 hsa-miR-137 hsa-miR-510
    SwitchGear 3'UTR luciferase reporter plasmidCCDC167 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CCDC167
    Clone
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat CCDC167

    Additional mRNA sequence: 

    AF161383.1 BC003515.1 BC104835.1 BC108655.1 

    9 DOTS entries:

    DT.112592  DT.97820552  DT.105060  DT.121317029  DT.95365716  DT.121317017  DT.444760  DT.100824448 
    DT.92421094 

    Selected AceView cDNA sequences (see all 94):

    BM663227 AW137082 BM700506 BQ421248 BC003515 BG166392 CB106262 AI198068 
    AI079384 AI377555 AI863060 AI937798 BE018630 BU855159 BE906570 AI422896 
    BF526092 W79821 AI193925 BU564571 BU740313 BQ001026 BG777412 BE907609 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCDC167 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCTGGTCC
    CCDC167 Expression
    About this image

    CCDC167 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCDC167 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.284207
        Custom PCR Arrays for CCDC167
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC167

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCDC167 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc1671 , 5 RIKEN cDNA 1110021J02 gene5
    coiled-coil domain containing 1671
    81.79(n)1
    78.35(a)1
      17 (15.48 cM)5
    685971  NM_001163741.21  NP_001157213.11 
     296893785 
    chicken
    (Gallus gallus)
    Aves CCDC1671 coiled-coil domain containing 167 65.25(n)
    59.57(a)
      421433  NM_001277596.1  NP_001264525.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC1676
    coiled-coil domain containing 167
    53(a)
    1 ↔ 1
    1(228286493-228302015)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ccdc1671 transmembrane and coiled-coil domain-containing protein more 65.98(n)
    57.73(a)
      100125155  NM_001103049.1  NP_001096519.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CCDC1676
    coiled-coil domain containing 167
    38(a)
    1 ↔ 1
    4(5128290-5147087) ENSDARG00000045850


    ENSEMBL Gene Tree for CCDC167 (if available)
    TreeFam Gene Tree for CCDC167 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCDC167 (see all 404)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs759914481,2
    C--37450264(+) CACTCA/CCAGCC 1 -- ds50010--------
    rs1416753011,2
    C--37450485(+) GTGCCC/TGAGCC 1 -- ds50010--------
    rs1505438071,2
    C--37450523(+) GGAAAG/TTGCTT 1 -- ds50010--------
    rs1401282981,2
    C--37450633(+) GTGCCA/GCCTCT 1 -- ds50010--------
    rs77710021,2
    C,F,H--37450655(+) CTCTTC/TCTGCC 1 -- ds50016Minor allele frequency- T:0.02NS EA CSA WA 515
    rs1851384371,2
    --37450790(+) CGGAAC/GCCCCC 1 -- ut310--------
    rs132168751,2
    C--37450803(+) CAGGCG/CAGGGA 1 -- ut31 ese31Minor allele frequency- C:0.50NA 2
    rs1892662401,2
    --37450812(+) GAGGCA/GAGGCC 1 -- ut310--------
    rs1917064341,2
    --37450844(+) TTGAAC/TACTAG 1 -- ut310--------
    rs37343251,2
    C,F,H--37450851(-) TCCCAA/GCCTAG 1 -- ut3111Minor allele frequency- G:0.05EA NS NA EU 2997

    HapMap Linkage Disequilibrium report for CCDC167 (37450696 - 37467700 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CCDC167:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2752124CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CCDC167
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC167

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCDC167 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with CCDC167)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    2. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    3. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)1 Schaafhausen A....MA1ller C.R. (Thromb. Haemost. 2011)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    5. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PubMed id 19734545)1 Need A.C....Goldstein D.B. (Hum. Mol. Genet. 2009)
    6. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 154467 HGNC: 21239 AceView: C6orf129 Ensembl:ENSG00000198937 euGenes: HUgn154467
    ECgene: CCDC167 H-InvDB: CCDC167

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCDC167 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCDC167 gene:
    Search GeneIP for patents involving CCDC167

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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