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CCDC166 Gene

protein-coding   GIFtS: 23
GCID: GC08M144789

Coiled-Coil Domain Containing 166

  Search for CCDC166
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coiled-Coil Domain Containing 1661 2
Coiled-Coil Domain-Containing Protein 1662

External Ids:    HGNC: 419101   Entrez Gene: 1001302742   Ensembl: ENSG000002551817   UniProtKB: P0CW273   

Export aliases for CCDC166 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCDC166 Gene:
CCDC166 (coiled-coil domain containing 166) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CCDC166
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CCDC166

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC166


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

CCDC166 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC166 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M144789:  view genomic region     (about GC identifiers)

Start:
144,788,864 bp from pter      End:
144,790,279 bp from pter
Size:
1,416 bases      Orientation:
minus strand

1 alternative location:
Chr8-,NW_003315923 45,339-46,754     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CC166_HUMAN, P0CW27 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 166  
Size: 439 amino acids; 48709 Da

Explore the universe of human proteins at neXtProt for CCDC166: NX_P0CW27

Explore proteomics data for CCDC166 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCDC166 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001156386.1  
    ENSEMBL proteins: 
     ENSP00000437315   ENSP00000437468  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: P0CW27


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC166
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC166
    Interactions:

        Search GeneGlobe Interaction Network for CCDC166

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCDC166 (CC166)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CCDC166 gene: 
    NM_001162914.1  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533508 ENST00000542437(uc011lkr.2)
    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCDC166 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACGCGGGTG
    CCDC166 Expression
    About this image

    CCDC166 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCDC166 Protein Expression
        Custom PCR Arrays for CCDC166
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC166

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCDC166 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc1661 , 5 RIKEN cDNA 2410075B13 gene5
    coiled-coil domain containing 1661
    71.16(n)1
    64.58(a)1
      15 (35.18 cM)5
    2236481  NM_146059.21  NP_666171.21 
     759798725 
    chicken
    (Gallus gallus)
    Aves LOC1008590661 coiled-coil domain-containing protein 166-like 53.22(n)
    40.74(a)
      100859066  XM_003640877.2  XP_003640925.1 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC1666
    coiled-coil domain containing 166
    49(a)
    1 ↔ 1
    GL343916.1(131831-133021)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017318771 coiled-coil domain-containing protein 166-like 55.96(n)
    37.8(a)
      101731877  XM_004920292.1  XP_004920349.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005382281 coiled-coil domain-containing protein 150-like 42.88(n)
    27.27(a)
      100538228  XM_003198948.2  XP_003198996.1 


    ENSEMBL Gene Tree for CCDC166 (if available)
    TreeFam Gene Tree for CCDC166 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCDC166 (see all 59)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs792448421,2
    F--144788388(+) ATGGCG/AGTCCC 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs349928891,2
    C,F--144788471(+) AGGTTG/AAACAT 1 -- ds50014Minor allele frequency- A:0.06NA EA 126
    rs1174824471,2
    F--144788544(+) CCCAGC/GTGCCA 1 -- ds50011Minor allele frequency- G:0.08NA 120
    rs1433553791,2
    --144788642(+) GGATGC/TGGGGT 1 -- ds50010--------
    rs1907404241,2
    --144788904(+) CAGCGC/TTCACG 2 N S mis10--------
    rs1136648051,2
    C--144788948(+) TCCCGA/TTCCCG 2 E D mis13Minor allele frequency- T:0.04CSA WA 121
    rs737181421,2
    C--144789080(+) GCCCGG/AGAGCC 2 /S syn12Minor allele frequency- A:0.08WA 120
    rs753683831,2
    C,F--144789624(+) CCGCCT/CTGTCC 2 /K /R mis11Minor allele frequency- C:0.14WA 118
    rs1483752681,2
    --144789840(+) CCTTGC/TAGGGC 2 Y C mis10--------
    rs617313751,2
    C--144789973(+) CTGCGC/ATAGGT 2 /A /S mis11Minor allele frequency- A:0.03NS 32

    HapMap Linkage Disequilibrium report for CCDC166 (144788864 - 144790279 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CCDC166:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv891751CNV Loss21882294
    nsv891747CNV Loss21882294
    dgv7939n71CNV Loss21882294
    dgv7941n71CNV Loss21882294
    nsv466007CNV Loss19166990
    dgv7935n71CNV Loss21882294
    nsv519816CNV Loss19592680
    dgv7940n71CNV Loss21882294
    dgv7938n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CCDC166
    DNA2.0 Custom Variant and Variant Library Synthesis for CCDC166

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed article for CCDC166 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CCDC166)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100130274 HGNC: 41910 Ensembl:ENSG00000255181 euGenes: HUgn100130274 ECgene: CCDC166
    H-InvDB: CCDC166

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCDC166 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCDC166 gene:
    Search GeneIP for patents involving CCDC166

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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