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Aliases for CCDC159 Gene

Aliases for CCDC159 Gene

  • Coiled-Coil Domain Containing 159 2 3 5

External Ids for CCDC159 Gene

Previous GeneCards Identifiers for CCDC159 Gene

  • GC19P011321
  • GC19P011455
  • GC19P011033

Summaries for CCDC159 Gene

GeneCards Summary for CCDC159 Gene

CCDC159 (Coiled-Coil Domain Containing 159) is a Protein Coding gene.

Additional gene information for CCDC159 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC159 Gene

Genomics for CCDC159 Gene

Regulatory Elements for CCDC159 Gene

Enhancers for CCDC159 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H011373 1.7 FANTOM5 ENCODE dbSUPER 12.2 +31.6 31636 6.2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ILF3 ZNF136 KRI1 ZNF627 ZNF442 ZNF625 ZNF823 ZNF844 ZNF491 ZNF44
GH19H011567 1.6 FANTOM5 Ensembl ENCODE 11.3 +223.6 223581 2.1 HDGF PKNOX1 TCF12 ZNF207 FOS ATF7 RUNX3 NCOA1 ZNF592 MEF2D CCDC159 ACP5 ELOF1 GC19M011558
GH19H011380 1.4 ENCODE dbSUPER 12.2 +37.7 37682 5.1 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ILF3 ZNF136 KRI1 TIMM29 ZNF627 ZNF433 ZNF844 ZNF442 ZNF44 ZNF563
GH19H011086 1.8 FANTOM5 ENCODE dbSUPER 9.4 -252.3 -252314 11 FEZF1 DMAP1 YY1 SLC30A9 SP3 NFYC MEF2D GLIS1 RCOR2 NBN ILF3 ZNF844 ZNF491 ZNF627 ZNF441 RAVER1 PRKCSH ZNF823 ZNF700 C19orf38
GH19H011577 1.7 FANTOM5 Ensembl ENCODE 8 +236.2 236164 7.4 HDGF PKNOX1 ARNT YBX1 TCF12 CBX5 GATA2 ZNF143 ZNF207 FOS ACP5 ILF3 ZNF564 ZNF700 ZNF136 ZNF44 ZNF878 HNRNPA1P10 ZNF442 ZNF799
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC159 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC159 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107168 1716 1201 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS DEK SP3 CEBPZ

Genomic Locations for CCDC159 Gene

Genomic Locations for CCDC159 Gene
chr19:11,344,684-11,354,944
(GRCh38/hg38)
Size:
10,261 bases
Orientation:
Plus strand
chr19:11,455,360-11,465,620
(GRCh37/hg19)

Genomic View for CCDC159 Gene

Genes around CCDC159 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC159 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC159 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC159 Gene

Proteins for CCDC159 Gene

  • Protein details for CCDC159 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7I6-CC159_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 159
    Protein Accession:
    P0C7I6
    Secondary Accessions:
    • B4DEG3
    • B4DWR8
    • B4E133
    • B7ZAM4

    Protein attributes for CCDC159 Gene

    Size:
    412 amino acids
    Molecular mass:
    46012 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG63130.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BC038439; Type=Frameshift; Positions=55; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC159 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC159 Gene

Post-translational modifications for CCDC159 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC159 Gene

Domains & Families for CCDC159 Gene

Gene Families for CCDC159 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC159 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC159 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC159: view

No data available for UniProtKB/Swiss-Prot for CCDC159 Gene

Function for CCDC159 Gene

Phenotypes From GWAS Catalog for CCDC159 Gene

Phenotypes for CCDC159 Gene

genes like me logo Genes that share phenotypes with CCDC159: view

Animal Models for CCDC159 Gene

MGI Knock Outs for CCDC159:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC159 Gene

Localization for CCDC159 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC159 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC159 Gene

Pathways & Interactions for CCDC159 Gene

SuperPathways for CCDC159 Gene

No Data Available

Interacting Proteins for CCDC159 Gene

Selected Interacting proteins: P0C7I6-CC159_HUMAN for CCDC159 Gene via IID

Symbol External ID(s) Details
COIL

Gene Ontology (GO) - Biological Process for CCDC159 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC159 Gene

Drugs & Compounds for CCDC159 Gene

No Compound Related Data Available

Transcripts for CCDC159 Gene

Unigene Clusters for CCDC159 Gene

Coiled-coil domain containing 159:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC159 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - - - - - - -
SP7: -
SP8: - -
SP9:

Relevant External Links for CCDC159 Gene

GeneLoc Exon Structure for
CCDC159
ECgene alternative splicing isoforms for
CCDC159

Expression for CCDC159 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC159 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC159 Gene:

CCDC159

SOURCE GeneReport for Unigene cluster for CCDC159 Gene:

Hs.631636
genes like me logo Genes that share expression patterns with CCDC159: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC159 Gene

Orthologs for CCDC159 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC159 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC159 33 34
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia CCDC159 33 34
  • 86.89 (n)
cow
(Bos Taurus)
Mammalia CCDC159 33 34
  • 83.56 (n)
mouse
(Mus musculus)
Mammalia Ccdc159 33 16 34
  • 81.48 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc159 33
  • 80.68 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC159 34
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC159 34
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC159 34
  • 40 (a)
OneToOne
Species where no ortholog for CCDC159 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC159 Gene

ENSEMBL:
Gene Tree for CCDC159 (if available)
TreeFam:
Gene Tree for CCDC159 (if available)

Paralogs for CCDC159 Gene

No data available for Paralogs for CCDC159 Gene

Variants for CCDC159 Gene

Sequence variations from dbSNP and Humsavar for CCDC159 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000172972 -- 11,354,992(+) CCCTG(A/C)CCTCC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000212178 -- 11,351,302(+) CATGG(A/C/T)GGCGG intron-variant
rs1000270331 -- 11,344,732(+) CTGTT(C/G)TACAG intron-variant, upstream-variant-2KB
rs1000949909 -- 11,349,770(+) GCTGT(C/T)CCCCT intron-variant
rs1001168866 -- 11,352,817(+) ACTTA(A/G)CTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC159 Gene

Variant ID Type Subtype PubMed ID
nsv833752 CNV loss 17160897
nsv519802 CNV loss 19592680

Variation tolerance for CCDC159 Gene

Residual Variation Intolerance Score: 70.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.77; 78.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC159 Gene

Human Gene Mutation Database (HGMD)
CCDC159
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC159

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC159 Gene

Disorders for CCDC159 Gene

Relevant External Links for CCDC159

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC159

No disorders were found for CCDC159 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC159 Gene

Publications for CCDC159 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J … Zoghbi HY (Cell 2006) 3 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for CCDC159 Gene

Sources for CCDC159 Gene

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