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Aliases for CCDC158 Gene

Aliases for CCDC158 Gene

  • Coiled-Coil Domain Containing 158 2 3 5

External Ids for CCDC158 Gene

Previous GeneCards Identifiers for CCDC158 Gene

  • GC04M077454
  • GC04M077234
  • GC04M072986

Summaries for CCDC158 Gene

GeneCards Summary for CCDC158 Gene

CCDC158 (Coiled-Coil Domain Containing 158) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC158 Gene

Genomics for CCDC158 Gene

Regulatory Elements for CCDC158 Gene

Enhancers for CCDC158 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F076380 0.2 ENCODE 29.2 +41.2 41218 0.9 ZFP69B ZFHX2 KLF1 EGR2 CCDC158 STBD1 RNU6-1000P FAM47E SCARB2 SHROOM3 GC04M076357 RPL36AP18
GH04F076377 0.5 Ensembl ENCODE 22.9 +44.0 43998 1.0 PKNOX1 ZNF133 FEZF1 THRB RAD21 RFX5 GATA2 ZNF366 MIXL1 ZNF654 CCDC158 ENSG00000199857 RPL36AP18 RNU6-1000P STBD1 FAM47E SCARB2 SHROOM3 GC04M076357
GH04F076448 0.8 ENCODE 22.2 -27.7 -27677 1.3 ATF3 CEBPA CEBPB MNT YY1 CCDC158 ENSG00000199857 RPL36AP18 RNU6-1000P RNU6-145P STBD1 SHROOM3 ENSG00000249278
GH04F076449 0.7 ENCODE 18.9 -25.9 -25907 0.3 CCDC158 ENSG00000199857 RPL36AP18 RNU6-1000P RNU6-145P SHROOM3 ENSG00000249278
GH04F076304 0.5 ENCODE 17.1 +114.9 114911 4.4 MLX ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 GLIS2 KLF7 ZNF263 CCDC158 STBD1 FAM47E SCARB2 RNU6-1000P NUP54 GC04M076318
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CCDC158 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC158 Gene

Chromosome:
4
Start:
76,312,997 bp from pter
End:
76,421,893 bp from pter
Size:
108,897 bases
Orientation:
Minus strand

Genomic View for CCDC158 Gene

Genes around CCDC158 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC158 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC158 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC158 Gene

Proteins for CCDC158 Gene

  • Protein details for CCDC158 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5M9N0-CD158_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 158
    Protein Accession:
    Q5M9N0
    Secondary Accessions:
    • Q8IYQ1
    • Q8N7D4
    • Q8N7E3

    Protein attributes for CCDC158 Gene

    Size:
    1113 amino acids
    Molecular mass:
    127140 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05347.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05359.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BC035224; Type=Frameshift; Positions=204; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC158 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC158 Gene

Post-translational modifications for CCDC158 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC158 Gene

Domains & Families for CCDC158 Gene

Protein Domains for CCDC158 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC158 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC158: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC158 Gene

Function for CCDC158 Gene

Phenotypes for CCDC158 Gene

GenomeRNAi human phenotypes for CCDC158:
genes like me logo Genes that share phenotypes with CCDC158: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC158 Gene

Localization for CCDC158 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC158 Gene COMPARTMENTS Subcellular localization image for CCDC158 gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC158 Gene

Pathways & Interactions for CCDC158 Gene

SuperPathways for CCDC158 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC158 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC158 Gene

Transcripts for CCDC158 Gene

Unigene Clusters for CCDC158 Gene

Coiled-coil domain containing 158:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC158 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^
SP1: -
SP2: - - - - - - - - - - - -
SP3:
SP4:

ExUns: 22 ^ 23 ^ 24 ^ 25
SP1:
SP2:
SP3:
SP4:

Relevant External Links for CCDC158 Gene

GeneLoc Exon Structure for
CCDC158
ECgene alternative splicing isoforms for
CCDC158

Expression for CCDC158 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC158 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC158 Gene

This gene is overexpressed in Testis (x30.8).

Protein differential expression in normal tissues from HIPED for CCDC158 Gene

This gene is overexpressed in Cervix (27.0), Lymph node (17.7), and Amniocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC158 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCDC158 Gene:

CCDC158

SOURCE GeneReport for Unigene cluster for CCDC158 Gene:

Hs.529680
genes like me logo Genes that share expression patterns with CCDC158: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CCDC158 Gene

Orthologs for CCDC158 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC158 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC158 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia CCDC158 34 35
  • 91.19 (n)
cow
(Bos Taurus)
Mammalia CCDC158 34 35
  • 90.5 (n)
mouse
(Mus musculus)
Mammalia Ccdc158 34 16 35
  • 85.95 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc158 34
  • 85.81 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC158 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC158 35
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC158 35
  • 47 (a)
OneToOne
Species where no ortholog for CCDC158 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC158 Gene

ENSEMBL:
Gene Tree for CCDC158 (if available)
TreeFam:
Gene Tree for CCDC158 (if available)

Paralogs for CCDC158 Gene

No data available for Paralogs for CCDC158 Gene

Variants for CCDC158 Gene

Sequence variations from dbSNP and Humsavar for CCDC158 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000618 -- 76,390,715(+) actca(A/G)tgatc intron-variant
rs10000821 -- 76,387,217(+) gtctt(A/G)catgt intron-variant
rs10001182 -- 76,400,104(+) ATTTT(C/T)gtatg intron-variant
rs10001396 -- 76,329,354(+) GCTGA(C/G)GCAGG intron-variant
rs10002302 -- 76,395,987(+) GCTAC(C/T)TATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC158 Gene

Variant ID Type Subtype PubMed ID
esv2759262 CNV loss 17122850
esv3601052 CNV loss 21293372
nsv10526 CNV gain 18304495
nsv1128078 CNV deletion 24896259
nsv1161115 CNV deletion 26073780
nsv441891 CNV loss 18776908
nsv7363 OTHER inversion 18451855
nsv950056 CNV duplication 24416366
nsv967765 CNV duplication 23825009
nsv967766 CNV duplication 23825009

Variation tolerance for CCDC158 Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.08; 75.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC158 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC158

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC158 Gene

Disorders for CCDC158 Gene

Relevant External Links for CCDC158

Genetic Association Database (GAD)
CCDC158
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC158

No disorders were found for CCDC158 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC158 Gene

Publications for CCDC158 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PMID: 21282530) Vandamme J. … Angrand P.O. (Mol. Cell. Proteomics 2011) 3 64
  5. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) KAPttgen A. … Fox C.S. (Nat. Genet. 2010) 3 64

Products for CCDC158 Gene

Sources for CCDC158 Gene

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