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CCDC157 Gene(Protein Coding)

Coiled-Coil Domain Containing 157

GCID:
GC22P030356
GIFtS:
42
Genes Participants
UDN Logo

Aliases for CCDC157 Gene

Aliases for CCDC157 Gene

  • Coiled-Coil Domain Containing 157 2 3 5
  • KIAA1656 4

External Ids for CCDC157 Gene

Previous GeneCards Identifiers for CCDC157 Gene

  • GC22P029082
  • GC22P030752
  • GC22P013714

Summaries for CCDC157 Gene

GeneCards Summary for CCDC157 Gene

CCDC157 (Coiled-Coil Domain Containing 157) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC157 Gene

Genomics for CCDC157 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CCDC157 Gene

Enhancers for CCDC157 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G030322 1.6 FANTOM5 ENCODE dbSUPER 25.7 -29.7 -29716 8.0 HDGF PKNOX1 WRNIP1 ARID4B SIN3A YY1 TCF12 GLIS2 SP3 SP5 RNF215 CCDC157 CASTOR1 SEC14L3 SF3A1 ENSG00000248751 SEC14L2 ENSG00000249590 LIF OSM
GH22G030300 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14 -45.7 -45650 20.9 HDGF PKNOX1 ARNT SIN3A ZBTB7B YY1 FOS ZNF263 JUNB REST RNF215 CASTOR1 CCDC157 SEC14L3 SEC14L2 MTMR3 LIF TBC1D10A SF3A1 ENSG00000248751
GH22G030287 1.3 ENCODE dbSUPER 12.7 -66.5 -66478 5.0 HDGF ARNT AGO1 WRNIP1 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 RNF215 CASTOR1 CCDC157 DUSP18 ENSG00000248751
GH22G030416 1.4 ENCODE dbSUPER 11.3 +64.8 64805 11.6 MLX CREB3L1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 RNF215 TUG1 SEC14L3 CASTOR1 MORC2 SEC14L2 CCDC157 SEC14L6 SMTN RNU6-564P
GH22G030390 1.4 Ensembl ENCODE dbSUPER 11 +34.8 34809 1.4 ELF3 CBX3 ARID4B YBX1 RAD21 ZNF143 FOS MIXL1 THAP11 ZNF654 CASTOR1 TBC1D10A ENSG00000248751 OSM SF3A1 CCDC157 SEC14L3 ENSG00000181123 LIF SEC14L2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC157 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC157 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000145212 165 2001 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Transcription factor binding sites by QIAGEN in the CCDC157 gene promoter:

Genomic Location for CCDC157 Gene

Chromosome:
22
Start:
30,356,635 bp from pter
End:
30,378,658 bp from pter
Size:
22,024 bases
Orientation:
Plus strand

Genomic View for CCDC157 Gene

Genes around CCDC157 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC157 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC157 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCDC157 Gene

Proteins for CCDC157 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CCDC157 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q569K6-CC157_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 157
    Protein Accession:
    Q569K6
    Secondary Accessions:
    • Q0VD76
    • Q9BYA4

    Protein attributes for CCDC157 Gene

    Size:
    752 amino acids
    Molecular mass:
    83941 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH92419.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB33326.1; Type=Miscellaneous discrepancy; Note=Intron retention. This sequence is incomplete at the 5- and 3-ends and extensively differs from that shown due to multiple introns.; Evidence={ECO:0000305};

neXtProt entry for CCDC157 Gene

Protein Expression for CCDC157 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CCDC157 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC157 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC157 Gene

Domains & Families for CCDC157 Gene

Protein Domains for CCDC157 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC157 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC157: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC157 Gene

Function for CCDC157 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Phenotypes for CCDC157 Gene

GenomeRNAi human phenotypes for CCDC157:
genes like me logo Genes that share phenotypes with CCDC157: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC157 Gene

Localization for CCDC157 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC157 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC157 Gene

Pathways & Interactions for CCDC157 Gene

SuperPathways for CCDC157 Gene

PathCards logo More details on SuperPathways for CCDC157
No Data Available

Interacting Proteins for CCDC157 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343087%0d%0a9606.ENSP00000249079%0d%0a
Selected Interacting proteins: ENSP00000343087 Q569K6-CC157_HUMAN for CCDC157 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CCDC157 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC157 Gene

Drugs & Compounds for CCDC157 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CCDC157 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CCDC157 Gene

(12) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC157 Gene

Coiled-coil domain containing 157:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC157 Gene

No ASD Table

Relevant External Links for CCDC157 Gene

GeneLoc Exon Structure for
CCDC157
ECgene alternative splicing isoforms for
CCDC157

Expression for CCDC157 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC157 Gene

mRNA expression in normal human tissues for CCDC157 Gene
mRNA expression by BioGPS for CCDC157 GenemRNA expression by GTEx for CCDC157 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC157 Gene

This gene is overexpressed in Testis (x14.4).

Protein differential expression in normal tissues from HIPED for CCDC157 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC157 Gene



Protein tissue co-expression partners for CCDC157 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC157 Gene:

CCDC157

SOURCE GeneReport for Unigene cluster for CCDC157 Gene:

Hs.505597

Evidence on tissue expression from TISSUES for CCDC157 Gene

  • Lung(4.6)
genes like me logo Genes that share expression patterns with CCDC157: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC157 Gene

Orthologs for CCDC157 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC157 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CCDC157 34 35
  • 99.19 (n)
cow
(Bos Taurus)
 Mammalia CCDC157 34 35
  • 83.97 (n)
dog
(Canis familiaris)
 Mammalia CCDC157 34 35
  • 83.38 (n)
mouse
(Mus musculus)
 Mammalia Ccdc157 34 16 35
  • 82.41 (n)
rat
(Rattus norvegicus)
 Mammalia Ccdc157 34
  • 81.85 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CCDC157 35
  • 61 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia CCDC157 35
  • 49 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CCDC157 34 35
  • 60.75 (n)
lizard
(Anolis carolinensis)
 Reptilia CCDC157 35
  • 39 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ccdc157 34
  • 52.77 (n)
zebrafish
(Danio rerio)
 Actinopterygii ccdc157 34 35
  • 51.84 (n)
Species where no ortholog for CCDC157 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC157 Gene

ENSEMBL:
Gene Tree for CCDC157 (if available)
TreeFam:
Gene Tree for CCDC157 (if available)

Paralogs for CCDC157 Gene

(1) SIMAP similar genes for CCDC157 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CCDC157: view

No data available for Paralogs for CCDC157 Gene

Variants for CCDC157 Gene

Sequence variations from dbSNP and Humsavar for CCDC157 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000078259 -- 30,363,797(+) GTTCT(C/T)CTGTC intron-variant
rs1000471745 -- 30,368,341(+) CAGCC(A/G)CTTCT intron-variant, downstream-variant-500B
rs1000545210 -- 30,368,511(+) TTGGT(C/T)TAAGC intron-variant, downstream-variant-500B
rs1000598881 -- 30,362,518(+) AGGAG(A/C)CCCAG intron-variant
rs1000937942 -- 30,356,181(+) TATGT(C/T)TGTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC157 Gene

Variant ID Type Subtype PubMed ID
nsv1066179 CNV gain 25217958
nsv1110864 OTHER inversion 24896259
nsv829171 CNV loss 20364138
nsv953067 CNV deletion 24416366

Variation tolerance for CCDC157 Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.74; 86.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC157 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC157

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC157 Gene

Disorders for CCDC157 Gene

Relevant External Links for CCDC157

Human Genome Epidemiology (HuGE) Navigator
CCDC157
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC157

No disorders were found for CCDC157 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC157 Gene

Publications for CCDC157 Gene

  1. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  2. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PMID: 23870195) Wojczynski M.K. … Reilly M.P. (BMC Med. Genet. 2013) 3 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for CCDC157 Gene

Sources for CCDC157 Gene

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