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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCDC157 Gene

protein-coding   GIFtS: 38
GCID: GC22P030752

coiled-coil domain containing 157
  Search for CCDC157
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CCDC157    

Aliases
for CCDC157 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Coiled-Coil Domain Containing 1571 2
Coiled-Coil Domain-Containing Protein 1572
KIAA16563

External Ids:    HGNC: 338541   Entrez Gene: 5506312   Ensembl: ENSG000001878607   UniProtKB: Q569K63   

Export aliases for CCDC157 gene to outside databases

Previous GC identifers: GC22P029082 GC22P013714


Summaries
for CCDC157 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for CCDC157 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCDC157 gene promoter:
         SRF   E2F-4   E2F-3a   E2F-5   p53   E2F-2   GATA-2   E2F   E2F-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CCDC157

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC157


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

CCDC157 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC157 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P030752:  view genomic region     (about GC identifiers)

Start:
 30,752,624 bp from pter      End:
 30,774,647 bp from pter
Size:
 22,024 bases      Orientation:
 plus strand

Proteins
for CCDC157 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CC157_HUMAN, Q569K6 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 157  
Size: 752 amino acids; 83941 Da
Sequence caution: Sequence=AAH92419.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB33326.1; Type=Miscellaneous discrepancy; Note=Intron retention. This sequence is incomplete at the 5'- and
3'-ends and extensively differs from that shown due to multiple introns;
Secondary accessions: Q0VD76 Q9BYA4

Explore the universe of human proteins at neXtProt for CCDC157: NX_Q569K6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q569K6

    • CCDC157 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001017437.2  
    ENSEMBL proteins: 
     ENSP00000382720   ENSP00000385357   ENSP00000387491   ENSP00000401837   ENSP00000343087  

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    Protein Domains /
    Families
    for CCDC157 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q569K6


    Function
    for CCDC157 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    1 GenomeRNAi human phenotype for CCDC157:
     Increased S DNA content 


    Pathways & Interactions
    for CCDC157 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC157

    Drugs & Compounds
    for CCDC157 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CCDC157
    Search CenterWatch for drugs/clinical trials and news about CCDC157 / CC157 

    Transcripts
    for CCDC157 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CCDC157 gene: 
    NM_001017437.2  

    Unigene Cluster for CCDC157:

    Coiled-coil domain containing 157
    Hs.505597  [show with all ESTs]
    Unigene Representative Sequence: CR936833
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399824 ENST00000405659(uc011aku.2 uc011akv.2) ENST00000445005
    ENST00000430839 ENST00000475975 ENST00000482413 ENST00000338306

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    hsa-miR-3194-5p
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    Inhib. RNA
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    Additional cDNA sequence: 

    BC018040.1 BC092419.1 BC119799.1 BC127255.1 CR936833.1 

    9 DOTS entries:

    DT.40297698  DT.75198061  DT.219200  DT.70103525  DT.75196711  DT.40214068  DT.95271017  DT.40214031 
    DT.439908 

    GeneLoc Exon Structure


    Expression
    for CCDC157 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCDC157 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGCCTGTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CCDC157 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CCDC157 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCDC157

    SOURCE GeneReport for Unigene cluster: Hs.505597
        SABiosciences Custom PCR Arrays for CCDC157
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC157

    Orthologs
    for CCDC157 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CCDC157 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ccdc1571 , 5 coiled-coil domain containing 1571, 5 82.41(n)1
    77.09(a)1    		   11 (2.90 cM)5
    2165161  NM_001164620.11  NP_001158092.11 
     41411235 
    chicken
    (Gallus gallus)    		 Aves CCDC1571 coiled-coil domain containing 157 61.24(n)
    48.63(a)    		   417010  XM_415300.3  XP_415300.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CCDC1576
    		 --
    		 43(a)
    		 1 ↔ 1
    		 GL343417.1(125201-127940)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-242m24.61 si:ch211-242m24.6 50.98(n)
    43.42(a)    		   368731  XM_002663174.2  XP_002663220.2 


    ENSEMBL Gene Tree for CCDC157 (if available)
    TreeFam Gene Tree for CCDC157 (if available) 

    Paralogs
    for CCDC157 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CCDC157 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/164 NCBI SNPs in CCDC157 are shown (see all 164)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs59976211,2
    		C,F,H,--30754972(+) CCTGAC/TACTTG 1 -- int17Minor allele frequency- T:0.08NS EA WA CSA 536
    rs1901237521,2
    		--30755120(+) AGATGC/GTTTGC 1 -- int10--------
    rs57530921,2
    		C,F,--30755168(+) GATTTC/ATTTAT 1 -- int18Minor allele frequency- A:0.36WA NA CSA EA 367
    rs57530931,2
    		C,F,--30755172(+) TCTTTA/CTTTCT 1 -- int17Minor allele frequency- C:0.35WA NA CSA EA 366
    rs569271761,2
    		C,--30755322(+) ATGTGG/AGCATG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1180453281,2
    		--30755525(+) CATTTG/ACTGAA 1 -- int11Minor allele frequency- A:0.01NA 120
    rs96088901,2
    		H--30755526(+) atttgC/Ttgaat 1 -- int14Minor allele frequency- T:0.00NS EA 416
    rs749303561,2
    		C,--30755548(+) ATCCAA/GCCCTC 1 -- int13Minor allele frequency- G:0.09NA WA 240
    rs1400895291,2
    		--30755667(+) TAATAC/TCATAA 1 -- int10--------
    rs1821995521,2
    		C,--30755674(+) ATAAAA/TATGTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CCDC157 (30752624 - 30774647 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CCDC157: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for CCDC157 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CCDC157 for disorders           About MalaCards

    CCDC157 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: CCDC157 (1 document)

    Export disorders for CCDC157 gene to outside databases

    Publications
    for CCDC157 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCDC157 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CCDC157)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    4. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PubMed id 11258795)2 Hirosawa M....Ohara O. (2001)
    5. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)

    External Searches for CCDC157 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CCDC157 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 550631 HGNC: 33854 Ensembl:ENSG00000187860 euGenes: HUgn550631 ECgene: CCDC157
    H-InvDB: CCDC157

    Other Databases showing CCDC157 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1656

    Specialized Databases showing CCDC157 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCDC157 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CCDC157 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CCDC157 gene:
    Search GeneIP for patents involving CCDC157

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CCDC157 gene

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    About This Section

     
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