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Aliases for CCDC157 Gene

Aliases for CCDC157 Gene

  • Coiled-Coil Domain Containing 157 2 3 5
  • KIAA1656 4

External Ids for CCDC157 Gene

Previous GeneCards Identifiers for CCDC157 Gene

  • GC22P029082
  • GC22P030752
  • GC22P013714

Summaries for CCDC157 Gene

GeneCards Summary for CCDC157 Gene

CCDC157 (Coiled-Coil Domain Containing 157) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC157 Gene

Genomics for CCDC157 Gene

Regulatory Elements for CCDC157 Gene

Promoters for CCDC157 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC157 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC157 Gene

Chromosome:
22
Start:
30,356,635 bp from pter
End:
30,378,658 bp from pter
Size:
22,024 bases
Orientation:
Plus strand

Genomic View for CCDC157 Gene

Genes around CCDC157 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC157 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC157 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC157 Gene

Proteins for CCDC157 Gene

  • Protein details for CCDC157 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q569K6-CC157_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 157
    Protein Accession:
    Q569K6
    Secondary Accessions:
    • Q0VD76
    • Q9BYA4

    Protein attributes for CCDC157 Gene

    Size:
    752 amino acids
    Molecular mass:
    83941 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH92419.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB33326.1; Type=Miscellaneous discrepancy; Note=Intron retention. This sequence is incomplete at the 5- and 3-ends and extensively differs from that shown due to multiple introns.; Evidence={ECO:0000305};

neXtProt entry for CCDC157 Gene

Proteomics data for CCDC157 Gene at MOPED

Post-translational modifications for CCDC157 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC157 Gene

No data available for DME Specific Peptides for CCDC157 Gene

Domains & Families for CCDC157 Gene

Protein Domains for CCDC157 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC157 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC157: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC157 Gene

Function for CCDC157 Gene

Phenotypes for CCDC157 Gene

GenomeRNAi human phenotypes for CCDC157:
genes like me logo Genes that share phenotypes with CCDC157: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC157 Gene

Localization for CCDC157 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC157 Gene COMPARTMENTS Subcellular localization image for CCDC157 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC157 Gene

Pathways & Interactions for CCDC157 Gene

SuperPathways for CCDC157 Gene

No Data Available

Interacting Proteins for CCDC157 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343087%0d%0a9606.ENSP00000249079%0d%0a9606.ENSP00000368516%0d%0a
Selected Interacting proteins: ENSP00000343087 for CCDC157 Gene via STRING

Gene Ontology (GO) - Biological Process for CCDC157 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC157 Gene

Drugs & Compounds for CCDC157 Gene

No Compound Related Data Available

Transcripts for CCDC157 Gene

mRNA/cDNA for CCDC157 Gene

(14) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC157 Gene

Coiled-coil domain containing 157:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC157 Gene

No ASD Table

Relevant External Links for CCDC157 Gene

GeneLoc Exon Structure for
CCDC157
ECgene alternative splicing isoforms for
CCDC157

Expression for CCDC157 Gene

mRNA expression in normal human tissues for CCDC157 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC157 Gene

This gene is overexpressed in Testis (x14.4).

Protein differential expression in normal tissues from HIPED for CCDC157 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC157 Gene



SOURCE GeneReport for Unigene cluster for CCDC157 Gene Hs.505597

genes like me logo Genes that share expression patterns with CCDC157: view

Protein tissue co-expression partners for CCDC157 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CCDC157 Gene

Orthologs for CCDC157 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC157 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC157 35
  • 83.97 (n)
  • 78.36 (a)
CCDC157 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC157 35
  • 83.38 (n)
  • 78.33 (a)
CCDC157 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc157 35
  • 82.41 (n)
  • 77.09 (a)
Ccdc157 16
Ccdc157 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC157 35
  • 99.19 (n)
  • 97.98 (a)
CCDC157 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc157 35
  • 81.85 (n)
  • 75.74 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC157 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC157 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC157 35
  • 60.75 (n)
  • 47.35 (a)
CCDC157 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC157 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc157 35
  • 52.77 (n)
  • 43.19 (a)
zebrafish
(Danio rerio)
Actinopterygii ccdc157 35
  • 51.84 (n)
  • 43.76 (a)
ccdc157 36
  • 35 (a)
OneToOne
Species with no ortholog for CCDC157:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC157 Gene

ENSEMBL:
Gene Tree for CCDC157 (if available)
TreeFam:
Gene Tree for CCDC157 (if available)

Paralogs for CCDC157 Gene

(1) SIMAP similar genes for CCDC157 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CCDC157: view

No data available for Paralogs for CCDC157 Gene

Variants for CCDC157 Gene

Sequence variations from dbSNP and Humsavar for CCDC157 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_038999 -
VAR_039000 -
rs740223 - 30,366,151(-) CATGT(C/T)GAGGT intron-variant, reference, missense
rs740222 -- 30,365,951(-) AGCCA(C/G/T)GTGGC intron-variant, utr-variant-5-prime
rs1076295 -- 30,365,248(+) tcaga(C/T)agagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC157 Gene

Variant ID Type Subtype PubMed ID
nsv829171 CNV Loss 20364138
nsv914970 CNV Loss 21882294

Variation tolerance for CCDC157 Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.74; 86.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC157 Gene

HapMap Linkage Disequilibrium report
CCDC157

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC157 Gene

Disorders for CCDC157 Gene

Relevant External Links for CCDC157

Human Genome Epidemiology (HuGE) Navigator
CCDC157
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC157

No disorders were found for CCDC157 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC157 Gene

Publications for CCDC157 Gene

  1. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 67
  2. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PMID: 23870195) Wojczynski M.K. … Reilly M.P. (BMC Med. Genet. 2013) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CCDC157 Gene

Sources for CCDC157 Gene

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