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Aliases for CCDC157 Gene

Aliases for CCDC157 Gene

  • Coiled-Coil Domain Containing 157 2 3 5
  • KIAA1656 4

External Ids for CCDC157 Gene

Previous GeneCards Identifiers for CCDC157 Gene

  • GC22P029082
  • GC22P030752
  • GC22P013714

Summaries for CCDC157 Gene

GeneCards Summary for CCDC157 Gene

CCDC157 (Coiled-Coil Domain Containing 157) is a Protein Coding gene.

Additional gene information for CCDC157 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC157 Gene

Genomics for CCDC157 Gene

Regulatory Elements for CCDC157 Gene

Enhancers for CCDC157 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H030322 1.5 FANTOM5 ENCODE dbSUPER 25.7 -29.7 -29716 7 HDGF PKNOX1 ARID4B SIN3A YY1 GLIS2 ATF7 RUNX3 SP3 SP5 RNF215 CCDC157 CASTOR1 SEC14L3 TUG1 SF3A1 ENSG00000248751 SEC14L2 ENSG00000249590 MORC2
GH22H030300 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14 -45.7 -45650 20 HDGF FOXA2 PKNOX1 ARNT ZBTB7B YY1 TCF12 GATA2 FOS ATF7 RNF215 CASTOR1 PES1 MORC2 CCDC157 TUG1 SF3A1 SEC14L3 SEC14L2 MTMR3
GH22H030287 1.3 ENCODE dbSUPER 12.7 -66.5 -66478 5 HDGF ATF1 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF121 GLIS2 RNF215 CASTOR1 CCDC157 DUSP18 ENSG00000248751
GH22H030415 1.4 ENCODE dbSUPER 11.3 +64.8 64805 11 MLX FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 TUG1 SF3A1 RNF215 TBC1D10A SEC14L3 PES1 CASTOR1 MORC2 SEC14L2 DUSP18
GH22H030390 1.4 Ensembl ENCODE dbSUPER 11 +34.8 34809 1 ELF3 RB1 ARID4B YBX1 RAD21 ZNF143 FOS RUNX3 IKZF2 MIXL1 TBC1D10A CASTOR1 SF3A1 ENSG00000248751 DUSP18 OSM CCDC157 SEC14L3 ENSG00000181123 TUG1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC157 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC157 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000145212 165 2001 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for CCDC157 Gene

Chromosome:
22
Start:
30,356,635 bp from pter
End:
30,378,658 bp from pter
Size:
22,024 bases
Orientation:
Plus strand

Genomic View for CCDC157 Gene

Genes around CCDC157 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC157 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC157 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC157 Gene

Proteins for CCDC157 Gene

  • Protein details for CCDC157 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q569K6-CC157_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 157
    Protein Accession:
    Q569K6
    Secondary Accessions:
    • Q0VD76
    • Q9BYA4

    Protein attributes for CCDC157 Gene

    Size:
    752 amino acids
    Molecular mass:
    83941 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH92419.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB33326.1; Type=Miscellaneous discrepancy; Note=Intron retention. This sequence is incomplete at the 5- and 3-ends and extensively differs from that shown due to multiple introns.; Evidence={ECO:0000305};

neXtProt entry for CCDC157 Gene

Post-translational modifications for CCDC157 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC157 Gene

Domains & Families for CCDC157 Gene

Gene Families for CCDC157 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC157 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC157 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC157: view

No data available for UniProtKB/Swiss-Prot for CCDC157 Gene

Function for CCDC157 Gene

Phenotypes From GWAS Catalog for CCDC157 Gene

Phenotypes for CCDC157 Gene

GenomeRNAi human phenotypes for CCDC157:
genes like me logo Genes that share phenotypes with CCDC157: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCDC157
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC157 Gene

Localization for CCDC157 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC157 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC157 Gene

Pathways & Interactions for CCDC157 Gene

SuperPathways for CCDC157 Gene

No Data Available

Interacting Proteins for CCDC157 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343087%0d%0a9606.ENSP00000249079%0d%0a
Selected Interacting proteins: Q569K6-CC157_HUMAN ENSP00000343087 for CCDC157 Gene via IID STRING

Gene Ontology (GO) - Biological Process for CCDC157 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC157 Gene

Drugs & Compounds for CCDC157 Gene

No Compound Related Data Available

Transcripts for CCDC157 Gene

mRNA/cDNA for CCDC157 Gene

(12) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC157 Gene

Coiled-coil domain containing 157:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCDC157
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC157 Gene

No ASD Table

Relevant External Links for CCDC157 Gene

GeneLoc Exon Structure for
CCDC157
ECgene alternative splicing isoforms for
CCDC157

Expression for CCDC157 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC157 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC157 Gene

This gene is overexpressed in Testis (x14.4).

Protein differential expression in normal tissues from HIPED for CCDC157 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC157 Gene



Protein tissue co-expression partners for CCDC157 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC157 Gene:

CCDC157

SOURCE GeneReport for Unigene cluster for CCDC157 Gene:

Hs.505597

Evidence on tissue expression from TISSUES for CCDC157 Gene

  • Lung(4.6)
genes like me logo Genes that share expression patterns with CCDC157: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC157 Gene

Orthologs for CCDC157 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC157 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC157 33 34
  • 99.19 (n)
cow
(Bos Taurus)
Mammalia CCDC157 33 34
  • 83.97 (n)
dog
(Canis familiaris)
Mammalia CCDC157 33 34
  • 83.38 (n)
mouse
(Mus musculus)
Mammalia Ccdc157 33 16 34
  • 82.41 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc157 33
  • 81.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC157 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC157 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC157 33 34
  • 60.75 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC157 34
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc157 33
  • 52.77 (n)
zebrafish
(Danio rerio)
Actinopterygii ccdc157 33 34
  • 51.84 (n)
Species where no ortholog for CCDC157 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC157 Gene

ENSEMBL:
Gene Tree for CCDC157 (if available)
TreeFam:
Gene Tree for CCDC157 (if available)

Paralogs for CCDC157 Gene

(1) SIMAP similar genes for CCDC157 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CCDC157: view

No data available for Paralogs for CCDC157 Gene

Variants for CCDC157 Gene

Sequence variations from dbSNP and Humsavar for CCDC157 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000078259 -- 30,363,797(+) GTTCT(C/T)CTGTC intron-variant
rs1000471745 -- 30,368,341(+) CAGCC(A/G)CTTCT intron-variant, downstream-variant-500B
rs1000545210 -- 30,368,511(+) TTGGT(C/T)TAAGC intron-variant, downstream-variant-500B
rs1000598881 -- 30,362,518(+) AGGAG(A/C)CCCAG intron-variant
rs1000937942 -- 30,356,181(+) TATGT(C/T)TGTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC157 Gene

Variant ID Type Subtype PubMed ID
nsv1066179 CNV gain 25217958
nsv1110864 OTHER inversion 24896259
nsv829171 CNV loss 20364138
nsv953067 CNV deletion 24416366

Variation tolerance for CCDC157 Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.74; 86.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC157 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC157

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC157 Gene

Disorders for CCDC157 Gene

Relevant External Links for CCDC157

Human Genome Epidemiology (HuGE) Navigator
CCDC157
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC157

No disorders were found for CCDC157 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC157 Gene

Publications for CCDC157 Gene

  1. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon KS … Liu Q (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 60
  2. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PMID: 23870195) Wojczynski MK … Reilly MP (BMC medical genetics 2013) 3 60
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for CCDC157 Gene

Sources for CCDC157 Gene

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