CCDC155 Gene
protein-coding GIFtS: 41
GCID: GC19P049891
|
|
coiled-coil domain containing 155
| |
Aliases
for CCDC155 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 1551 2 | | KASH51 2 3 | | KASH Domain-Containing Protein 52 3 | | FLJ326581 | | Protein KASH52 | | Coiled-Coil Domain-Containing Protein 1553 |
Export aliases for CCDC155 gene to outside databasesPrevious GC identifers: GC19P054584 GC19P046269 |
Summaries
for CCDC155 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KASH5_HUMAN, Q8N6L0Function: May be involved in meiotic chromosome dynamics and homolog pairing (By similarity)
|
Genomic Views
for CCDC155 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC155 gene promoter:
TBP Pax-5 Egr-1 MyoD AP-2gamma Egr-4 AP-2beta AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC155
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC155 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.33CCDC155 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P049891: view genomic region
(about GC identifiers)
Start:
|
49,891,475 bp from pter |
End:
|
49,921,256 bp from pter |
Size:
|
29,782 bases |
Orientation:
|
plus strand |
|
Proteins
for CCDC155 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KASH5_HUMAN, Q8N6L0 (See
protein sequence)Recommended Name: Protein KASH5 Size: 562 amino acids; 62783 Da
Subunit: Interacts (via the last 22 AA) with SUN1; this interaction mediates telomere localization (By similarity).Interacts with dynein-dynactin motor complex (By similarity)
Subcellular location: Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side (Potential).Nucleus. Chromosome, telomere (By similarity). Note=Localized exclusively at telomeres from the leptotene to diplotenestages (By similarity)
Secondary accessions: Q96MC3Explore the universe of human proteins at neXtProt for CCDC155: NX_Q8N6L0
CCDC155 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653289.3
ENSEMBL proteins: ENSP00000404220
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
CCDC155 for ontologies About GeneDecksing
CCDC155 Antibody Products:
Assay Products for CCDC155: |
Protein
Domains /
Families
for CCDC155 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCDC155 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N6L0ProtoNet protein and cluster: Q8N6L0 UniProtKB/Swiss-Prot: KASH5_HUMAN, Q8N6L0Domain: The C-terminal 22 AA is required and sufficient for localization to telomeres at the nuclear envelope (Bysimilarity) |
Function
for CCDC155 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KASH5_HUMAN, Q8N6L0Function: May be involved in meiotic chromosome dynamics and homolog pairing (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC155 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC155
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: CCDC155 (NM_144688) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC155 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC155 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC155 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- | | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity |
IEA | -- |
CCDC155 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for CCDC155:
|
Pathways & Interactions
for CCDC155 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC155
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for CCDC155 (Q8N6L02, 3 ENSP000004042204) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006470 | protein dephosphorylation |
IEA | -- |
CCDC155 for ontologies About GeneDecksing
|
Drugs & Compounds
for CCDC155 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC155
Search CenterWatch for drugs/clinical trials and news about CCDC155 / KASH5
|
Transcripts
for CCDC155 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC155 gene: NM_144688.4 Unigene Cluster for CCDC155: Coiled-coil domain containing 155 Hs.662085 [show with all ESTs]Unigene Representative Sequence: NM_1446881 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000447857(uc002pnl.2 uc002pnm.2 uc010emx.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC155 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC155
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CCDC155 (NM_144688) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC155 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC155 |
Additional cDNA sequence: AK057220.1 AK097696.1 BC029811.1 8 DOTS entries: DT.405876 DT.99927574 DT.99930009 DT.100748133 DT.121457231 DT.100660540 DT.121457232 DT.121457246 5 AceView cDNA sequences: AK057220 BC029811 AK097696 NM_144688 AK128169
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC155 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · |
|---|
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| SP1: | | | | | - | | | | - | | | | - | | - | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19b | ^ | 20 | ^ | 21 | ^ | 22 |
|---|
|
| SP1: | - | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for CCDC155
|
Expression
for CCDC155 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC155 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCAGGAGTT
About this image
See CCDC155 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC155
SOURCE GeneReport for Unigene cluster: Hs.662085
SABiosciences Custom PCR Arrays for CCDC155
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC155
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC155 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC155 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC155 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC155 |
Orthologs
for CCDC155 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CCDC155 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for CCDC155 (if available)
TreeFam Gene Tree for CCDC155 (if available) |
Paralogs
for CCDC155 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CCDC155 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC155 (49891475 - 49921256 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CCDC155
2 CNVs: 5110 32261 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC155 |
|
Disorders
/ Diseases
for CCDC155 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CCDC155 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC155 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC155) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A conserved KASH domain protein associates with telome res, SUN1, and dynactin during mammalian meiosis. (PubMed id 22826121)1 Morimoto A....Watanabe Y. (2012)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Human chromosome 19 and related regions in mouse: con servative and lineage-specific evolution. (PubMed id 11441184)1 Dehal P....Stubbs L. (2001)
|
External Searches for CCDC155 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC155 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC155 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC155 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC155 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CCDC155 gene:
Search GeneIP for patents involving CCDC155
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC155 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC155 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC155 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC155 | | | OriGene Protein Over-expression Lysate for CCDC155 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC155 | | OriGene 3'-UTR Clone for CCDC155 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC155 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC155 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CCDC155 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CCDC155 | | OriGene Custom Protein Services for CCDC155 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC155 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC155 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC155 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC155 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC155 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC155 |
| |
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| | | | Search Tocris compounds for CCDC155 |
| |  |  |  |  | | | | |
 |
 |
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 | | | CCDC155 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC155 |
|  |  |  | | | | Search ThermoFisher Antibodies for CCDC155 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC155 |
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