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Aliases for CCDC155 Gene

Aliases for CCDC155 Gene

  • Coiled-Coil Domain Containing 155 2 3 5
  • KASH Domain-Containing Protein 5 3 4
  • KASH5 3 4
  • Coiled-Coil Domain-Containing Protein 155 4
  • Protein KASH5 3

External Ids for CCDC155 Gene

Previous GeneCards Identifiers for CCDC155 Gene

  • GC19P054584
  • GC19P049891
  • GC19P046269

Summaries for CCDC155 Gene

GeneCards Summary for CCDC155 Gene

CCDC155 (Coiled-Coil Domain Containing 155) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and dynein complex binding.

UniProtKB/Swiss-Prot for CCDC155 Gene

  • May be involved in meiotic chromosome dynamics and homolog pairing.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC155 Gene

Genomics for CCDC155 Gene

Regulatory Elements for CCDC155 Gene

Enhancers for CCDC155 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F049325 1.5 FANTOM5 Ensembl ENCODE 31.2 -59.2 -59180 6.4 PKNOX1 CREB3L1 RAD21 ZEB1 YY1 ZNF121 SCRT2 ZNF143 CREM THAP11 CCDC155 TEAD2 PLEKHA4 KDELR1 ENSG00000268157 ENSG00000197813 RRAS GRWD1 TMEM143 PTH2
GH19F049403 1.1 Ensembl ENCODE 41.2 +15.7 15687 1.4 PKNOX1 GLI4 ZNF2 ZNF366 ZNF391 EGR2 ZNF263 SP3 TBX21 ZNF843 CCDC155 DKKL1 GC19P049399 PIR32242 LOC105372433
GH19F049390 1.2 Ensembl ENCODE 35.5 +3.2 3234 1.9 HDGF PKNOX1 ARNT ARID4B YBX1 ZNF2 ZNF143 DEK SP3 JUNB CCDC155 DKKL1 BCL2L12 GC19P049399 PIR32242
GH19F049332 1.3 FANTOM5 ENCODE 29.9 -52.9 -52859 5.0 HDGF TBP HDAC1 TBL1XR1 WRNIP1 YBX1 ZBTB40 ELK1 ZNF143 ETV6 DKKL1 CCDC155 CD37 ALDH16A1 BCL2L12 FLT3LG IRF3 SNRNP70 ENSG00000197813
GH19F049359 1.1 ENCODE 32.6 -25.9 -25887 4.8 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 DKKL1 CCDC155 GRWD1 AKT1S1 NUP62 LOC400710 TEAD2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC155 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC155 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001419804 -118 601 BCOR POLR2A TRIM24 E2F6 SMARCA5 ZNF740 L3MBTL2 RNF2 ZBTB2 NRF1

Genomic Location for CCDC155 Gene

Chromosome:
19
Start:
49,388,218 bp from pter
End:
49,417,999 bp from pter
Size:
29,782 bases
Orientation:
Plus strand

Genomic View for CCDC155 Gene

Genes around CCDC155 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC155 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC155 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC155 Gene

Proteins for CCDC155 Gene

  • Protein details for CCDC155 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6L0-KASH5_HUMAN
    Recommended name:
    Protein KASH5
    Protein Accession:
    Q8N6L0
    Secondary Accessions:
    • Q96MC3

    Protein attributes for CCDC155 Gene

    Size:
    562 amino acids
    Molecular mass:
    62783 Da
    Quaternary structure:
    • Interacts (via the last 22 AA) with SUN1; this interaction mediates telomere localization. Interacts with dynein-dynactin motor complex.

neXtProt entry for CCDC155 Gene

Post-translational modifications for CCDC155 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CCDC155 Gene

Domains & Families for CCDC155 Gene

Protein Domains for CCDC155 Gene

Suggested Antigen Peptide Sequences for CCDC155 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6L0

UniProtKB/Swiss-Prot:

KASH5_HUMAN :
  • The C-terminal 22 AA is required and sufficient for localization to telomeres at the nuclear envelope.
Domain:
  • The C-terminal 22 AA is required and sufficient for localization to telomeres at the nuclear envelope.
genes like me logo Genes that share domains with CCDC155: view

No data available for Gene Families for CCDC155 Gene

Function for CCDC155 Gene

Molecular function for CCDC155 Gene

UniProtKB/Swiss-Prot Function:
May be involved in meiotic chromosome dynamics and homolog pairing.

Gene Ontology (GO) - Molecular Function for CCDC155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IEA --
GO:0070840 dynein complex binding IEA --
genes like me logo Genes that share ontologies with CCDC155: view
genes like me logo Genes that share phenotypes with CCDC155: view

Animal Models for CCDC155 Gene

MGI Knock Outs for CCDC155:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC155 Gene

Localization for CCDC155 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC155 Gene

Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Nucleus. Chromosome, telomere. Note=Localized exclusively at telomeres from the leptotene to diplotene stages. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC155 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
golgi apparatus 3
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CCDC155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region ISS --
GO:0000800 lateral element IEA --
GO:0005634 nucleus IEA --
GO:0005640 nuclear outer membrane IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with CCDC155: view

Pathways & Interactions for CCDC155 Gene

SuperPathways for CCDC155 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC155 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IEA --
GO:0007015 actin filament organization IEA --
GO:0007129 synapsis IEA --
GO:0007283 spermatogenesis IEA --
GO:0034397 telomere localization IEA --
genes like me logo Genes that share ontologies with CCDC155: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC155 Gene

Transcripts for CCDC155 Gene

mRNA/cDNA for CCDC155 Gene

(10) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC155 Gene

Coiled-coil domain containing 155:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC155 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - -
SP2: - - - -
SP3:
SP4: - -
SP5: - -
SP6:
SP7:

ExUns: 19b ^ 20 ^ 21 ^ 22
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for CCDC155 Gene

GeneLoc Exon Structure for
CCDC155
ECgene alternative splicing isoforms for
CCDC155

Expression for CCDC155 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC155 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC155 Gene

This gene is overexpressed in Testis (x36.5), Brain - Cerebellum (x7.9), and Brain - Cerebellar Hemisphere (x6.0).

Protein differential expression in normal tissues from HIPED for CCDC155 Gene

This gene is overexpressed in Cervix (45.2), Pancreas (15.2), and Adrenal (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCDC155 Gene



Protein tissue co-expression partners for CCDC155 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC155 Gene:

CCDC155

SOURCE GeneReport for Unigene cluster for CCDC155 Gene:

Hs.662085
genes like me logo Genes that share expression patterns with CCDC155: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CCDC155 Gene

Orthologs for CCDC155 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC155 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC155 34 35
  • 97.03 (n)
cow
(Bos Taurus)
Mammalia CCDC155 34 35
  • 85.16 (n)
dog
(Canis familiaris)
Mammalia CCDC155 34 35
  • 84.7 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc155 34
  • 77.88 (n)
mouse
(Mus musculus)
Mammalia Ccdc155 34 16 35
  • 77.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC155 35
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC155 35
  • 42 (a)
OneToOne
Species where no ortholog for CCDC155 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC155 Gene

ENSEMBL:
Gene Tree for CCDC155 (if available)
TreeFam:
Gene Tree for CCDC155 (if available)

Paralogs for CCDC155 Gene

No data available for Paralogs for CCDC155 Gene

Variants for CCDC155 Gene

Sequence variations from dbSNP and Humsavar for CCDC155 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10403958 -- 49,386,988(+) ggagg(C/G)gggag intron-variant, upstream-variant-2KB
rs10405154 -- 49,395,819(+) CTCCC(A/G)GCAAC reference, missense
rs10405724 -- 49,396,243(+) CTGGA(C/T)TTTTT intron-variant
rs10408609 -- 49,392,792(+) ctgta(A/G)tccca intron-variant, upstream-variant-2KB
rs10409838 -- 49,393,060(+) CTGCA(A/G)AGAAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC155 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV gain+loss 18304495
nsv953599 CNV deletion 24416366
nsv138000 CNV insertion 16902084
esv3644623 CNV loss 21293372
esv2718714 CNV deletion 23290073
esv2718713 CNV deletion 23290073
dgv52n68 CNV loss 17160897

Variation tolerance for CCDC155 Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC155 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC155

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC155 Gene

Disorders for CCDC155 Gene

Relevant External Links for CCDC155

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC155

No disorders were found for CCDC155 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC155 Gene

Publications for CCDC155 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N. … Roth F.P. (Mol. Syst. Biol. 2016) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 64
  5. A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis. (PMID: 22826121) Morimoto A. … Watanabe Y. (J. Cell Biol. 2012) 3 64

Products for CCDC155 Gene

Sources for CCDC155 Gene

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