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Aliases for CCDC154 Gene

Aliases for CCDC154 Gene

  • Coiled-Coil Domain Containing 154 2 3 5
  • C16orf29 3 4
  • Coiled-Coil Domain-Containing Protein 154 3
  • Chromosome 16 Open Reading Frame 29 2

External Ids for CCDC154 Gene

Previous HGNC Symbols for CCDC154 Gene

  • C16orf29

Previous GeneCards Identifiers for CCDC154 Gene

  • GC16M001426
  • GC16M001484
  • GC16M001412
  • GC16M001434
  • GC16M001439
  • GC16M001445
  • GC16M001453
  • GC16M001458
  • GC16M001462

Summaries for CCDC154 Gene

GeneCards Summary for CCDC154 Gene

CCDC154 (Coiled-Coil Domain Containing 154) is a Protein Coding gene.

Additional gene information for CCDC154 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC154 Gene

Genomics for CCDC154 Gene

Regulatory Elements for CCDC154 Gene

Enhancers for CCDC154 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H001271 1.1 ENCODE 50 +173.0 173018 1 PKNOX1 SIN3A FEZF1 ZNF2 ZNF302 ZNF416 SP3 REST ZNF662 ZNF592 CRAMP1 WDR90 TELO2 IFT140 ENSG00000261505 TSC2 E4F1 WDR24 ENSG00000260646 UBE2I
GH16H001928 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.6 -484.9 -484880 1 ATF1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF207 ZNF143 ATF7 IFT140 TSC2 CRAMP1 TELO2 UNKL E4F1 UBE2I ERVK13-1 CCDC154 FAHD1
GH16H001377 1.3 ENCODE dbSUPER 22.1 +66.0 66004 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 CBX5 FOS CHTF18 CCDC154 IFT140 CRAMP1 UNKL UBE2I TELO2 TSC2 E4F1 TSR3
GH16H000981 1.2 ENCODE dbSUPER 23.8 +463.4 463369 0 ZNF493 ZNF133 GLI4 ZNF2 GLIS2 ZNF416 KLF7 ZNF548 SP3 MCM3 WDR90 CRAMP1 ENSG00000261505 UBE2I JMJD8 TELO2 ENSG00000260954 UNKL ENSG00000260051 WDR24
GH16H002003 2 FANTOM5 Ensembl ENCODE dbSUPER 14.2 -562.4 -562378 7 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 TBL3 CRAMP1 ZNF598 ENSG00000226890 ENSG00000255513 ENSG00000200059 AMDHD2 ENSG00000261240 ENSG00000260051 ENSG00000261505
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC154 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC154 Gene

Chromosome:
16
Start:
1,433,425 bp from pter
End:
1,444,844 bp from pter
Size:
11,420 bases
Orientation:
Minus strand

Genomic View for CCDC154 Gene

Genes around CCDC154 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC154 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC154 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC154 Gene

Proteins for CCDC154 Gene

  • Protein details for CCDC154 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NI56-CC154_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 154
    Protein Accession:
    A6NI56
    Secondary Accessions:
    • G9JV18

    Protein attributes for CCDC154 Gene

    Size:
    674 amino acids
    Molecular mass:
    76013 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Overexpression suppresses cell proliferation by inducing G2/M arrest.

    Alternative splice isoforms for CCDC154 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC154 Gene

Post-translational modifications for CCDC154 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC154 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC154 Gene

Domains & Families for CCDC154 Gene

Gene Families for CCDC154 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC154 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC154 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC154: view

No data available for UniProtKB/Swiss-Prot for CCDC154 Gene

Function for CCDC154 Gene

Phenotypes From GWAS Catalog for CCDC154 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCDC154
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC154 Gene

Localization for CCDC154 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC154 Gene

Early endosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC154 gene
Compartment Confidence
endosome 4
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CCDC154 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with CCDC154: view

Pathways & Interactions for CCDC154 Gene

SuperPathways for CCDC154 Gene

No Data Available

Interacting Proteins for CCDC154 Gene

Gene Ontology (GO) - Biological Process for CCDC154 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC154 Gene

Drugs & Compounds for CCDC154 Gene

No Compound Related Data Available

Transcripts for CCDC154 Gene

mRNA/cDNA for CCDC154 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC154 Gene

Coiled-coil domain containing 154:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCDC154
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC154 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16
SP1:
SP2: -
SP3: - -
SP4:
SP5: -

Relevant External Links for CCDC154 Gene

GeneLoc Exon Structure for
CCDC154
ECgene alternative splicing isoforms for
CCDC154

Expression for CCDC154 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC154 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC154 Gene

This gene is overexpressed in Testis (x7.0) and Pituitary (x4.1).

Protein differential expression in normal tissues from HIPED for CCDC154 Gene

This gene is overexpressed in Gallbladder (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC154 Gene



Protein tissue co-expression partners for CCDC154 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC154 Gene:

CCDC154

SOURCE GeneReport for Unigene cluster for CCDC154 Gene:

Hs.355232
genes like me logo Genes that share expression patterns with CCDC154: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC154 Gene

Orthologs for CCDC154 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCDC154 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC154 33 34
  • 97.4 (n)
cow
(Bos Taurus)
Mammalia CCDC154 33 34
  • 79.01 (n)
dog
(Canis familiaris)
Mammalia CCDC154 33 34
  • 76.75 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc154 33
  • 75.13 (n)
mouse
(Mus musculus)
Mammalia Ccdc154 33 16 34
  • 74.25 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC154 34
  • 48 (a)
OneToOne
Species where no ortholog for CCDC154 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC154 Gene

ENSEMBL:
Gene Tree for CCDC154 (if available)
TreeFam:
Gene Tree for CCDC154 (if available)

Paralogs for CCDC154 Gene

No data available for Paralogs for CCDC154 Gene

Variants for CCDC154 Gene

Sequence variations from dbSNP and Humsavar for CCDC154 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10903009 Likely benign 1,446,004(+) GGGCC(C/T)GTGTA upstream-variant-2KB, utr-variant-3-prime
rs114884549 Likely benign 1,445,641(+) GCCCC(A/G)GTGCC upstream-variant-2KB, utr-variant-3-prime
rs143409179 Likely benign 1,445,007(+) ACACA(-/ACC)ACCAC upstream-variant-2KB, utr-variant-3-prime, cds-indel
rs150325021 Likely benign 1,445,455(+) CCTGG(A/G)GAGGA upstream-variant-2KB, utr-variant-3-prime
rs60516531 Likely benign 1,446,135(+) CAGGG(A/G)CCACA upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCDC154 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV duplication 17116639
esv2762143 CNV gain 21179565
nsv457331 CNV loss 19166990
nsv471066 CNV loss 18288195
nsv471068 CNV gain 18288195
nsv571160 CNV loss 21841781
nsv571161 CNV gain 21841781
nsv817713 CNV loss 17921354
nsv819259 CNV gain 19587683
nsv819844 CNV gain 19587683
nsv952899 CNV deletion 24416366

Variation tolerance for CCDC154 Gene

Gene Damage Index Score: 7.61; 82.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC154 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC154

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC154 Gene

Disorders for CCDC154 Gene

Relevant External Links for CCDC154

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC154

No disorders were found for CCDC154 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC154 Gene

Publications for CCDC154 Gene

  1. Overexpression of a novel osteopetrosis-related gene CCDC154 suppresses cell proliferation by inducing G2/M arrest. (PMID: 22895184) Liao W … Lu X (Cell cycle (Georgetown, Tex.) 2012) 3 4 60
  2. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for CCDC154 Gene

Sources for CCDC154 Gene

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