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Aliases for CCDC154 Gene

Aliases for CCDC154 Gene

  • Coiled-Coil Domain Containing 154 2 3 5
  • Coiled-Coil Domain-Containing Protein 154 3
  • Chromosome 16 Open Reading Frame 29 2
  • C16orf29 3

External Ids for CCDC154 Gene

Previous HGNC Symbols for CCDC154 Gene

  • C16orf29

Previous GeneCards Identifiers for CCDC154 Gene

  • GC16M001426
  • GC16M001484
  • GC16M001412
  • GC16M001434
  • GC16M001439
  • GC16M001445
  • GC16M001453
  • GC16M001458

Summaries for CCDC154 Gene

GeneCards Summary for CCDC154 Gene

CCDC154 (Coiled-Coil Domain Containing 154) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC154 Gene

Genomics for CCDC154 Gene

Regulatory Elements for CCDC154 Gene

Enhancers for CCDC154 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G001377 1.4 ENCODE dbSUPER 30.2 +66.0 66004 3.3 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 CBX5 IFT140 CCDC154 JPT2 ENSG00000262528 TSR3 GNPTG RNPS1 CHTF18 TMEM204 LOC105371038
GH16G001928 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.6 -484.9 -484880 1.8 ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF207 ZNF143 IFT140 CCDC154 ERVK13-1 FAHD1 EME2 NME3 JPT2 ENSG00000260447 SNHG19 HAGH
GH16G001419 1.1 ENCODE 22 +24.0 23963 3.5 PKNOX1 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 CCDC154 FAHD1 C16orf91 LOC105371044
GH16G001426 1 Ensembl ENCODE 23.9 +16.7 16690 3.0 CTCF ZNF146 RAD21 ZNF48 BCL11B HIC1 ZFHX2 ZNF143 SMC3 PCBP1 CCDC154 TSR3 CLCN7 LOC105371044 C16orf91
GH16G001097 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.8 +342.6 342563 9.8 FOXA2 ARID4B SIN3A ZNF2 GLIS2 ZNF143 FOS KLF7 SP3 YY2 JPT2 ENSG00000260051 RHOT2 ENSG00000268836 LOC105371038 EME2 IFT140 ENSG00000261505 ZNF598 ENSG00000255513
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC154 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC154 Gene

Chromosome:
16
Start:
1,433,425 bp from pter
End:
1,444,844 bp from pter
Size:
11,420 bases
Orientation:
Minus strand

Genomic View for CCDC154 Gene

Genes around CCDC154 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC154 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC154 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC154 Gene

Proteins for CCDC154 Gene

  • Protein details for CCDC154 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NI56-CC154_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 154
    Protein Accession:
    A6NI56
    Secondary Accessions:
    • G9JV18

    Protein attributes for CCDC154 Gene

    Size:
    674 amino acids
    Molecular mass:
    76013 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Overexpression suppresses cell proliferation by inducing G2/M arrest.

    Alternative splice isoforms for CCDC154 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC154 Gene

Post-translational modifications for CCDC154 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC154 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC154 Gene

Domains & Families for CCDC154 Gene

Protein Domains for CCDC154 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC154 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC154: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC154 Gene

Function for CCDC154 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CCDC154 Gene

Localization for CCDC154 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC154 Gene

Early endosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC154 gene
Compartment Confidence
endosome 4
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for CCDC154 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with CCDC154: view

Pathways & Interactions for CCDC154 Gene

SuperPathways for CCDC154 Gene

No Data Available

Interacting Proteins for CCDC154 Gene

Gene Ontology (GO) - Biological Process for CCDC154 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC154 Gene

Drugs & Compounds for CCDC154 Gene

No Compound Related Data Available

Transcripts for CCDC154 Gene

mRNA/cDNA for CCDC154 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC154 Gene

Coiled-coil domain containing 154:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC154 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16
SP1:
SP2: -
SP3: - -
SP4:
SP5: -

Relevant External Links for CCDC154 Gene

GeneLoc Exon Structure for
CCDC154
ECgene alternative splicing isoforms for
CCDC154

Expression for CCDC154 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC154 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC154 Gene

This gene is overexpressed in Testis (x7.0) and Pituitary (x4.1).

Protein differential expression in normal tissues from HIPED for CCDC154 Gene

This gene is overexpressed in Gallbladder (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC154 Gene



Protein tissue co-expression partners for CCDC154 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC154 Gene:

CCDC154

SOURCE GeneReport for Unigene cluster for CCDC154 Gene:

Hs.355232
genes like me logo Genes that share expression patterns with CCDC154: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC154 Gene

Orthologs for CCDC154 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCDC154 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC154 34 35
  • 97.4 (n)
cow
(Bos Taurus)
Mammalia CCDC154 34 35
  • 79.01 (n)
dog
(Canis familiaris)
Mammalia CCDC154 34 35
  • 76.75 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc154 34
  • 75.13 (n)
mouse
(Mus musculus)
Mammalia Ccdc154 34 16 35
  • 74.25 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC154 35
  • 48 (a)
OneToOne
Species where no ortholog for CCDC154 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCDC154 Gene

ENSEMBL:
Gene Tree for CCDC154 (if available)
TreeFam:
Gene Tree for CCDC154 (if available)

Paralogs for CCDC154 Gene

No data available for Paralogs for CCDC154 Gene

Variants for CCDC154 Gene

Sequence variations from dbSNP and Humsavar for CCDC154 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10903009 Likely benign 1,446,004(+) GGGCC(C/T)GTGTA upstream-variant-2KB, utr-variant-3-prime
rs114884549 Likely benign 1,445,641(+) GCCCC(A/G)GTGCC upstream-variant-2KB, utr-variant-3-prime
rs143409179 Likely benign 1,445,007(+) ACACA(-/ACC)ACCAC upstream-variant-2KB, utr-variant-3-prime, cds-indel
rs150325021 Likely benign 1,445,455(+) CCTGG(A/G)GAGGA upstream-variant-2KB, utr-variant-3-prime
rs60516531 Likely benign 1,446,135(+) CAGGG(A/G)CCACA upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCDC154 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV duplication 17116639
esv2762143 CNV gain 21179565
nsv457331 CNV loss 19166990
nsv471066 CNV loss 18288195
nsv471068 CNV gain 18288195
nsv571160 CNV loss 21841781
nsv571161 CNV gain 21841781
nsv817713 CNV loss 17921354
nsv819259 CNV gain 19587683
nsv819844 CNV gain 19587683
nsv952899 CNV deletion 24416366

Variation tolerance for CCDC154 Gene

Gene Damage Index Score: 7.61; 82.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC154 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC154

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC154 Gene

Disorders for CCDC154 Gene

Relevant External Links for CCDC154

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC154

No disorders were found for CCDC154 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC154 Gene

Publications for CCDC154 Gene

  1. Overexpression of a novel osteopetrosis-related gene CCDC154 suppresses cell proliferation by inducing G2/M arrest. (PMID: 22895184) Liao W. … Lu X. (Cell Cycle 2012) 3 4 64
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for CCDC154 Gene

Sources for CCDC154 Gene

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