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CCDC153 Gene

protein-coding   GIFtS: 38
GCID: GC11M119060

Coiled-Coil Domain Containing 153

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coiled-Coil Domain Containing 1531 2
Coiled-Coil Domain-Containing Protein 1532

External Ids:    HGNC: 274461   Entrez Gene: 2831522   Ensembl: ENSG000002487127   UniProtKB: Q494R43   

Export aliases for CCDC153 gene to outside databases

Previous GC identifers: GC11M118567 GC11M115000


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCDC153 Gene:
CCDC153 (coiled-coil domain containing 153) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCDC153 gene promoter:
         STAT1   Elk-1   AP-1   ATF-2   STAT1beta   STAT5A   STAT1alpha   PPAR-gamma1   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC153 promoter sequence
   Search Chromatin IP Primers for CCDC153

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC153


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

CCDC153 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC153 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M119060:  view genomic region     (about GC identifiers)

Start:
119,060,347 bp from pter      End:
119,067,479 bp from pter
Size:
7,133 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CC153_HUMAN, Q494R4 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 153  
Size: 210 amino acids; 23858 Da
Alternative splicing: 2 isoforms:  Q494R4-1   Q494R4-2   

Explore the universe of human proteins at neXtProt for CCDC153: NX_Q494R4

Explore proteomics data for CCDC153 at MOPED


See CCDC153 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001138490.1  
ENSEMBL proteins: 
 ENSP00000423567   ENSP00000445431  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q494R4

UniProtKB/Swiss-Prot: CC153_HUMAN, Q494R4
Similarity: Belongs to the UPF0610 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for CCDC153

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2
extracellular1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016020membrane ----

Find genes that share ontologies with CCDC153           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC153
Interactions:

    Search GeneGlobe Interaction Network for CCDC153

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016192vesicle-mediated transport ----

Find genes that share ontologies with CCDC153           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for CCDC153 (CC153)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CCDC153 gene (2 alternative transcripts): 
NM_001033658.1  NM_001145018.1  

Unigene Cluster for CCDC153:

Coiled-coil domain containing 153
Hs.114777  [show with all ESTs]
Unigene Representative Sequence: NM_001145018
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000503566 ENST00000375140(uc010rze.2) ENST00000447948 ENST00000415318

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1 DOTS entry:

DT.403154 

8 AceView cDNA sequences:

BC043548 AA770002 AI801883 BX113026 BI830079 AA782908 AA909102 AA026115 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CCDC153 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGGCGAAGT
CCDC153 Expression
About this image


CCDC153 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Endothelium (Cardiovascular System)
         Endothelial Cells Blood Brain Barrier
 
 Brain (Nervous System)
         Endothelial Cells Blood Brain Barrier
CCDC153 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CCDC153 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.114777
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CCDC153 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ccdc1531 , 5 coiled-coil domain containing 1531, 5 78.73(n)1
69.85(a)1
  9 (24.84 cM)5
2701501  NM_001081369.21  NP_001074838.21 
 442406775 
chicken
(Gallus gallus)
Aves CCDC1531 coiled-coil domain containing 153 57.29(n)
36.68(a)
  769857  XM_001233176.2  XP_001233177.1 
tropical clawed frog
(Xenopus tropicalis)
Amphibia ccdc1531 coiled-coil domain containing 153 50.17(n)
39.29(a)
  101733781  XM_004916047.1  XP_004916104.1 
zebrafish
(Danio rerio)
Actinopterygii ccdc1531 coiled-coil domain containing 153 47.91(n)
34.17(a)
  792470  NM_001111210.1  NP_001104680.1 


ENSEMBL Gene Tree for CCDC153 (if available)
TreeFam Gene Tree for CCDC153 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CCDC153 (see all 152)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1451891711,2
C,F--119061489(+) GGTCCC/TGCTCT 2 Q R mis11Minor allele frequency- T:0.00NA 4550
rs1388819061,2
F--119061496(+) CTCTCC/TGAGAG 2 R G mis11Minor allele frequency- T:0.00NA 4548
rs2000069211,2
--119061510(+) GTTCAC/GCCTCT 2 A G mis10--------
rs2019134991,2
--119061519(+) CTTCCC/TGGGCA 2 Q R mis10--------
rs1423002591,2
--119061679(+) TTCCCA/GCAGTC 1 -- int10--------
rs579734281,2
C--119061814(+) TCATC-/TTTTTT 1 -- int10--------
rs577842401,2
--119061869(+) AGTGGC/TGCGAT 1 -- int10--------
rs454468991,2
C,F--119061872(+) GGCGCG/AATCTC 1 -- int11Minor allele frequency- A:0.06NS 36
rs455141021,2
C--119061879(+) TCTCAG/CCTCAC 1 -- int12Minor allele frequency- C:0.03NS NA 38
rs1858466781,2
--119061922(+) TCCTGC/TCTCAG 1 -- int10--------

HapMap Linkage Disequilibrium report for CCDC153 (119060347 - 119067479 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for CCDC153: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing CCDC153
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CCDC153 gene integrated from 10 sources:
(articles sorted by number of sources associating them with CCDC153)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 283152 HGNC: 27446 AceView: LOC283152 Ensembl:ENSG00000248712 euGenes: HUgn283152
ECgene: CCDC153 H-InvDB: CCDC153

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CCDC153 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CCDC153 gene:
Search GeneIP for patents involving CCDC153

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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