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Aliases for CCDC153 Gene

Aliases for CCDC153 Gene

  • Coiled-Coil Domain Containing 153 2 3 5

External Ids for CCDC153 Gene

Previous GeneCards Identifiers for CCDC153 Gene

  • GC11M118567
  • GC11M119060
  • GC11M115000

Summaries for CCDC153 Gene

GeneCards Summary for CCDC153 Gene

CCDC153 (Coiled-Coil Domain Containing 153) is a Protein Coding gene.

Additional gene information for CCDC153 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC153 Gene

Genomics for CCDC153 Gene

Regulatory Elements for CCDC153 Gene

Enhancers for CCDC153 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H118433 1.9 VISTA Ensembl ENCODE dbSUPER 5.1 +768.2 768198 8.2 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 VPS11 HINFP TMEM25 KMT2A CCDC84 IFT46 ARCN1 THY1 LOC101929089 ENSG00000254873
GH11H119690 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.9 -490.2 -490204 12.6 ELF3 PKNOX1 ZFP64 ARID4B THRB RAD21 RARA EGR1 ATF7 RCOR1 CCDC153 NECTIN1 TRIM29 LOC105369525 RNU6-1123P
GH11H119106 1.1 ENCODE 6.2 +98.3 98307 3.9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF766 ZNF143 FOS HINFP CCDC153 DPAGT1 C2CD2L
GH11H119680 1.1 Ensembl ENCODE dbSUPER 5.2 -474.8 -474773 1.2 CTCF MAZ CTBP1 GATA3 POLR2A RAD21 RFX5 CCDC153 RNU6-1123P LOC105369525
GH11H118529 1 ENCODE 4.6 +675.4 675364 3.3 HDGF ATF1 ARID4B SIN3A DMAP1 ZNF2 ETS1 GLIS2 ZNF207 KLF7 BCL9L ENSG00000254909 UBE4A RPL23AP64 ARCN1 IFT46 ENSG00000254428 KMT2A ENSG00000245869 DPAGT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC153 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC153 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045742 -514 2401 SIN3A YY1 GLIS2 ZNF143 KLF7 ATF7 RUNX3 SP3 SP5 REST

Genomic Locations for CCDC153 Gene

Genomic Locations for CCDC153 Gene
chr11:119,189,638-119,206,286
(GRCh38/hg38)
Size:
16,649 bases
Orientation:
Minus strand
chr11:119,060,347-119,067,479
(GRCh37/hg19)

Genomic View for CCDC153 Gene

Genes around CCDC153 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC153 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC153 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC153 Gene

Proteins for CCDC153 Gene

  • Protein details for CCDC153 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q494R4-CC153_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 153
    Protein Accession:
    Q494R4

    Protein attributes for CCDC153 Gene

    Size:
    210 amino acids
    Molecular mass:
    23858 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC153 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC153 Gene

Post-translational modifications for CCDC153 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC153 Gene

Domains & Families for CCDC153 Gene

Gene Families for CCDC153 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC153 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC153 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q494R4

UniProtKB/Swiss-Prot:

CC153_HUMAN :
  • Belongs to the UPF0610 family.
Family:
  • Belongs to the UPF0610 family.
genes like me logo Genes that share domains with CCDC153: view

Function for CCDC153 Gene

Phenotypes From GWAS Catalog for CCDC153 Gene

Gene Ontology (GO) - Molecular Function for CCDC153 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC153: view

Phenotypes for CCDC153 Gene

GenomeRNAi human phenotypes for CCDC153:
genes like me logo Genes that share phenotypes with CCDC153: view

Animal Model Products

miRNA for CCDC153 Gene

miRTarBase miRNAs that target CCDC153

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC153 Gene

Localization for CCDC153 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC153 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC153 Gene

Pathways & Interactions for CCDC153 Gene

SuperPathways for CCDC153 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC153 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC153 Gene

Drugs & Compounds for CCDC153 Gene

No Compound Related Data Available

Transcripts for CCDC153 Gene

mRNA/cDNA for CCDC153 Gene

(13) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC153 Gene

Coiled-coil domain containing 153:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC153 Gene

No ASD Table

Relevant External Links for CCDC153 Gene

GeneLoc Exon Structure for
CCDC153
ECgene alternative splicing isoforms for
CCDC153

Expression for CCDC153 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC153 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC153 Gene

This gene is overexpressed in Pituitary (x6.1) and Testis (x5.5).

Protein differential expression in normal tissues from HIPED for CCDC153 Gene

This gene is overexpressed in Adipocyte (33.2), Heart (26.9), and Pancreatic juice (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC153 Gene



Protein tissue co-expression partners for CCDC153 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC153 Gene:

CCDC153

SOURCE GeneReport for Unigene cluster for CCDC153 Gene:

Hs.114777
genes like me logo Genes that share expression patterns with CCDC153: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC153 Gene

Orthologs for CCDC153 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC153 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC153 33 34
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia CCDC153 33 34
  • 81.74 (n)
mouse
(Mus musculus)
Mammalia Ccdc153 33 16 34
  • 78.73 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc153 33
  • 78.73 (n)
cow
(Bos Taurus)
Mammalia CCDC153 33 34
  • 76.88 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC153 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC153 33 34
  • 57.29 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc153 33
  • 50.17 (n)
zebrafish
(Danio rerio)
Actinopterygii ccdc153 33 34
  • 47.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToOne
Species where no ortholog for CCDC153 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC153 Gene

ENSEMBL:
Gene Tree for CCDC153 (if available)
TreeFam:
Gene Tree for CCDC153 (if available)

Paralogs for CCDC153 Gene

No data available for Paralogs for CCDC153 Gene

Variants for CCDC153 Gene

Sequence variations from dbSNP and Humsavar for CCDC153 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs371567712 Likely benign 119,206,429(+) GGCAA(C/T)GTGAA upstream-variant-2KB, reference, synonymous-codon
rs527849757 Likely benign 119,206,261(+) TCCCC(A/G)CGGCC upstream-variant-2KB
rs548262208 Likely benign 119,206,322(+) CGGCG(A/G)CCGGG upstream-variant-2KB, utr-variant-5-prime
rs569014495 Likely benign 119,206,312(+) GCGGC(A/G)GCGGC upstream-variant-2KB, utr-variant-5-prime
rs878854755 Likely benign 119,206,622(+) AAGGC(A/C)GGCTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC153 Gene

Variant ID Type Subtype PubMed ID
nsv556468 CNV loss 21841781
nsv556467 CNV loss 21841781
esv3627886 CNV loss 21293372

Variation tolerance for CCDC153 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.33; 76.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC153 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC153

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC153 Gene

Disorders for CCDC153 Gene

Relevant External Links for CCDC153

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC153

No disorders were found for CCDC153 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC153 Gene

Publications for CCDC153 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for CCDC153 Gene

Sources for CCDC153 Gene

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