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CCDC153 Gene(Protein Coding)

Coiled-Coil Domain Containing 153

GCID:
GC11M119189
GIFtS:
45
Genes Participants
UDN Logo

Aliases for CCDC153 Gene

Aliases for CCDC153 Gene

  • Coiled-Coil Domain Containing 153 2 3 5

External Ids for CCDC153 Gene

Previous GeneCards Identifiers for CCDC153 Gene

  • GC11M118567
  • GC11M119060
  • GC11M115000

Summaries for CCDC153 Gene

GeneCards Summary for CCDC153 Gene

CCDC153 (Coiled-Coil Domain Containing 153) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC153 Gene

Genomics for CCDC153 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CCDC153 Gene

Enhancers for CCDC153 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G118433 1.9 VISTA Ensembl ENCODE dbSUPER 5.1 +768.2 768198 8.2 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ZNF610 IFT46 THY1 CCDC84 TMEM25 LOC101929089 ENSG00000254873 ATP5L HINFP DSCAML1 ARCN1
GH11G119690 1.8 FANTOM5 Ensembl ENCODE dbSUPER 4.9 -490.2 -490204 12.6 PKNOX1 ZFP64 ARID4B ZNF48 FOS SP5 TBX21 SMARCA4 RCOR2 GLIS1 CCDC153 NECTIN1 TRIM29 LOC105369525 RNU6-1123P
GH11G119106 1.1 ENCODE 6.2 +98.3 98307 3.9 HDGF FOXA2 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF766 FOS HINFP LOC101929133 CCDC153 DPAGT1 C2CD2L
GH11G119680 1.1 Ensembl ENCODE dbSUPER 5.1 -474.8 -474773 1.2 CTCF MAZ RAD21 ZNF316 MAFF CTBP1 HNRNPL MAFK CCDC153 RNU6-1123P LOC105369525
GH11G118529 1.1 ENCODE 4.5 +675.4 675364 3.3 HDGF ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 IFT46 ENSG00000254909 UBE4A THY1 RPL23AP64 BCL9L RPL5P30 ENSG00000254428 ARCN1 DSCAML1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC153 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC153 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045742 -514 2401 CREB3L1 WRNIP1 SIN3A YY1 GLIS2 ZNF143 KLF7 SP3 SP5 REST

Transcription factor binding sites by QIAGEN in the CCDC153 gene promoter:

Genomic Location for CCDC153 Gene

Chromosome:
11
Start:
119,189,638 bp from pter
End:
119,206,286 bp from pter
Size:
16,649 bases
Orientation:
Minus strand

Genomic View for CCDC153 Gene

Genes around CCDC153 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC153 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC153 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CCDC153 Gene

Proteins for CCDC153 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CCDC153 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q494R4-CC153_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 153
    Protein Accession:
    Q494R4

    Protein attributes for CCDC153 Gene

    Size:
    210 amino acids
    Molecular mass:
    23858 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CCDC153 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC153 Gene

Protein Expression for CCDC153 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CCDC153 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC153 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC153 Gene

Domains & Families for CCDC153 Gene

Protein Domains for CCDC153 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC153 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q494R4

UniProtKB/Swiss-Prot:

CC153_HUMAN :
  • Belongs to the UPF0610 family.
Family:
  • Belongs to the UPF0610 family.
genes like me logo Genes that share domains with CCDC153: view

No data available for Gene Families for CCDC153 Gene

Function for CCDC153 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Gene Ontology (GO) - Molecular Function for CCDC153 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC153: view

Phenotypes for CCDC153 Gene

GenomeRNAi human phenotypes for CCDC153:
genes like me logo Genes that share phenotypes with CCDC153: view

Animal Model Products

CRISPR Products

miRNA for CCDC153 Gene

miRTarBase miRNAs that target CCDC153

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC153 Gene

Localization for CCDC153 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC153 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC153 Gene

Pathways & Interactions for CCDC153 Gene

SuperPathways for CCDC153 Gene

PathCards logo More details on SuperPathways for CCDC153
No Data Available

Gene Ontology (GO) - Biological Process for CCDC153 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC153 Gene

Drugs & Compounds for CCDC153 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CCDC153 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CCDC153 Gene

(13) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC153 Gene

Coiled-coil domain containing 153:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC153 Gene

No ASD Table

Relevant External Links for CCDC153 Gene

GeneLoc Exon Structure for
CCDC153
ECgene alternative splicing isoforms for
CCDC153

Expression for CCDC153 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC153 Gene

mRNA expression in normal human tissues for CCDC153 Gene
mRNA expression by GTEx for CCDC153 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC153 Gene

This gene is overexpressed in Pituitary (x6.1) and Testis (x5.5).

Protein differential expression in normal tissues from HIPED for CCDC153 Gene

This gene is overexpressed in Adipocyte (33.2), Heart (26.9), and Pancreatic juice (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC153 Gene



Protein tissue co-expression partners for CCDC153 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC153 Gene:

CCDC153

SOURCE GeneReport for Unigene cluster for CCDC153 Gene:

Hs.114777
genes like me logo Genes that share expression patterns with CCDC153: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC153 Gene

Orthologs for CCDC153 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC153 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CCDC153 34 35
  • 99.21 (n)
dog
(Canis familiaris)
 Mammalia CCDC153 34 35
  • 81.74 (n)
mouse
(Mus musculus)
 Mammalia Ccdc153 34 16 35
  • 78.73 (n)
rat
(Rattus norvegicus)
 Mammalia Ccdc153 34
  • 78.73 (n)
cow
(Bos Taurus)
 Mammalia CCDC153 34 35
  • 76.88 (n)
oppossum
(Monodelphis domestica)
 Mammalia CCDC153 35
  • 59 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CCDC153 34 35
  • 57.29 (n)
tropical clawed frog
(Silurana tropicalis)
 Amphibia ccdc153 34
  • 50.17 (n)
zebrafish
(Danio rerio)
 Actinopterygii ccdc153 34 35
  • 47.91 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 35 (a)
 OneToOne
Species where no ortholog for CCDC153 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC153 Gene

ENSEMBL:
Gene Tree for CCDC153 (if available)
TreeFam:
Gene Tree for CCDC153 (if available)

Paralogs for CCDC153 Gene

No data available for Paralogs for CCDC153 Gene

Variants for CCDC153 Gene

Sequence variations from dbSNP and Humsavar for CCDC153 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs371567712 Likely benign 119,206,429(+) GGCAA(C/T)GTGAA upstream-variant-2KB, reference, synonymous-codon
rs527849757 Likely benign 119,206,261(+) TCCCC(A/G)CGGCC upstream-variant-2KB
rs548262208 Likely benign 119,206,322(+) CGGCG(A/G)CCGGG upstream-variant-2KB, utr-variant-5-prime
rs569014495 Likely benign 119,206,312(+) GCGGC(A/G)GCGGC upstream-variant-2KB, utr-variant-5-prime
rs878854755 Likely benign 119,206,622(+) AAGGC(A/C)GGCTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC153 Gene

Variant ID Type Subtype PubMed ID
esv3627886 CNV loss 21293372
nsv556467 CNV loss 21841781
nsv556468 CNV loss 21841781

Variation tolerance for CCDC153 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.33; 76.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC153 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC153

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC153 Gene

Disorders for CCDC153 Gene

Relevant External Links for CCDC153

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC153

No disorders were found for CCDC153 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC153 Gene

Publications for CCDC153 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for CCDC153 Gene

Sources for CCDC153 Gene

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