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Aliases for CCDC151 Gene

Aliases for CCDC151 Gene

  • Coiled-Coil Domain Containing 151 2 3
  • Coiled-Coil Domain-Containing Protein 151 3
  • CILD30 3

External Ids for CCDC151 Gene

Previous GeneCards Identifiers for CCDC151 Gene

  • GC19M011531
  • GC19M011106

Summaries for CCDC151 Gene

Entrez Gene Summary for CCDC151 Gene

  • This gene encodes a protein containing coiled-coil domains. The encoded protein functions in outer dynein arm assembly and is required for motile cilia function. Mutations in this gene result in primary ciliary dyskinesia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

GeneCards Summary for CCDC151 Gene

CCDC151 (Coiled-Coil Domain Containing 151) is a Protein Coding gene. Diseases associated with CCDC151 include ciliary dyskinesia, primary, 30.

UniProtKB/Swiss-Prot for CCDC151 Gene

  • Ciliary protein involved in outer dynein arm assembly and required for motile cilia function.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC151 Gene

Genomics for CCDC151 Gene

Regulatory Elements for CCDC151 Gene

Genomic Location for CCDC151 Gene

Start:
11,420,604 bp from pter
End:
11,435,782 bp from pter
Size:
15,179 bases
Orientation:
Minus strand

Genomic View for CCDC151 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC151 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC151 Gene

Proteins for CCDC151 Gene

  • Protein details for CCDC151 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5D8V7-CC151_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 151
    Protein Accession:
    A5D8V7
    Secondary Accessions:
    • B4DXT0
    • Q96CG5

    Protein attributes for CCDC151 Gene

    Size:
    595 amino acids
    Molecular mass:
    69140 Da
    Quaternary structure:
    • Interacts with CCDC114.

    Alternative splice isoforms for CCDC151 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC151 Gene

Proteomics data for CCDC151 Gene at MOPED

Post-translational modifications for CCDC151 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC151 Gene

No data available for DME Specific Peptides for CCDC151 Gene

Domains for CCDC151 Gene

Protein Domains for CCDC151 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CCDC151 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC151: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC151 Gene

Function for CCDC151 Gene

Molecular function for CCDC151 Gene

UniProtKB/Swiss-Prot Function: Ciliary protein involved in outer dynein arm assembly and required for motile cilia function.

Gene Ontology (GO) - Molecular Function for CCDC151 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with CCDC151: view

Phenotypes for CCDC151 Gene

GenomeRNAi human phenotypes for CCDC151:
genes like me logo Genes that share phenotypes with CCDC151: view

miRNA for CCDC151 Gene

miRTarBase miRNAs that target CCDC151

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCDC151 Gene

Localization for CCDC151 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC151 Gene

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium axoneme.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC151 Gene COMPARTMENTS Subcellular localization image for CCDC151 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCDC151 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005814 centriole ISS --
GO:0005929 cilium ISS --
GO:0005930 axoneme IDA 25192045
GO:0036064 ciliary basal body ISS --
genes like me logo Genes that share ontologies with CCDC151: view

Pathways for CCDC151 Gene

SuperPathways for CCDC151 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC151 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003341 cilium movement IMP 25192045
GO:0030030 cell projection organization IEA --
GO:1902017 regulation of cilium assembly ISS --
genes like me logo Genes that share ontologies with CCDC151: view

No data available for Pathways by source for CCDC151 Gene

Transcripts for CCDC151 Gene

Unigene Clusters for CCDC151 Gene

Coiled-coil domain containing 151:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC151 Gene

No ASD Table

Relevant External Links for CCDC151 Gene

GeneLoc Exon Structure for
CCDC151
ECgene alternative splicing isoforms for
CCDC151

Expression for CCDC151 Gene

mRNA expression in normal human tissues for CCDC151 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC151 Gene

This gene is overexpressed in Testis (6.4) and Pituitary (5.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CCDC151 Gene

SOURCE GeneReport for Unigene cluster for CCDC151 Gene Hs.124010

genes like me logo Genes that share expressions with CCDC151: view

No data available for mRNA Expression by UniProt/SwissProt for CCDC151 Gene

Orthologs for CCDC151 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC151 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC151 35
  • 99.33 (n)
  • 98.82 (a)
CCDC151 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC151 35
  • 81.79 (n)
  • 75.09 (a)
CCDC151 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC151 35
  • 81.39 (n)
  • 74.96 (a)
CCDC151 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc151 35
  • 75.5 (n)
  • 67.4 (a)
Ccdc151 16
Ccdc151 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC151 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ccdc151 35
  • 76.06 (n)
  • 68.08 (a)
lizard
(Anolis carolinensis)
Reptilia CCDC151 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc151 35
  • 56.94 (n)
  • 45.27 (a)
zebrafish
(Danio rerio)
Actinopterygii ccdc151 35
  • 52.63 (n)
  • 40 (a)
ccdc151 36
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14127 36
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for CCDC151:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC151 Gene

ENSEMBL:
Gene Tree for CCDC151 (if available)
TreeFam:
Gene Tree for CCDC151 (if available)

Paralogs for CCDC151 Gene

Selected SIMAP similar genes for CCDC151 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CCDC151: view

No data available for Paralogs for CCDC151 Gene

Variants for CCDC151 Gene

Sequence variations from dbSNP and Humsavar for CCDC151 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs34088 -- 11,432,642(+) TATTA(C/T)GTGTT intron-variant
rs34089 -- 11,431,841(-) ctcag(C/T)cccct intron-variant
rs34090 -- 11,431,728(-) ctcga(A/T)ctcct intron-variant
rs34091 -- 11,431,541(-) agtgc(A/T)aggat intron-variant
rs34092 -- 11,431,371(-) acttt(A/G)ggggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC151 Gene

Variant ID Type Subtype PubMed ID
nsv833752 CNV Loss 17160897
nsv519802 CNV Loss 19592680
nsv911062 CNV Loss 21882294
esv2718178 CNV Deletion 23290073
esv2718179 CNV Deletion 23290073

Relevant External Links for CCDC151 Gene

HapMap Linkage Disequilibrium report
CCDC151
Human Gene Mutation Database (HGMD)
CCDC151

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC151 Gene

Disorders for CCDC151 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CCDC151 Gene including...

Search for CCDC151 Gene in MalaCards »

UniProtKB/Swiss-Prot

CC151_HUMAN
  • Ciliary dyskinesia, primary, 30 (CILD30) [MIM:616037]: A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. {ECO:0000269 PubMed:25192045, ECO:0000269 PubMed:25224326}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with CCDC151: view

Publications for CCDC151 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The coiled-coil domain containing protein CCDC151 is required for the function of IFT-dependent motile cilia in animals. (PMID: 24067530) Jerber J. … Durand B. (Hum. Mol. Genet. 2014) 2 3
  3. CCDC151 mutations cause primary ciliary dyskinesia by disruption of the outer dynein arm docking complex formation. (PMID: 25192045) Hjeij R. … Mitchison H.M. (Am. J. Hum. Genet. 2014) 3 4
  4. Nonsense mutation in coiled coil domain containing 151 gene (CCDC151) causes Primary ciliary dyskinesia. (PMID: 25224326) Alsaadi M.M. … Day I.N. (Hum. Mutat. 2014) 3 4
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for CCDC151 Gene

Sources for CCDC151 Gene

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