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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCDC151 Gene

protein-coding   GIFtS: 42
GCID: GC19M011531

Coiled-Coil Domain Containing 151

  Search for CCDC151
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 1511 2
Coiled-Coil Domain-Containing Protein 1512

External Ids:    HGNC: 283031   Entrez Gene: 1159482   Ensembl: ENSG000001980037   UniProtKB: A5D8V73   

Export aliases for CCDC151 gene to outside databases

Previous GC identifers: GC19M011393 GC19M011106


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CCDC151 Gene: 
CCDC151 (coiled-coil domain containing 151) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCDC151 gene promoter:
         E2F-4   E2F-3a   USF1   E2F-5   AML1a   E2F-2   GATA-1   E2F   E2F-1   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCCDC151 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCDC151

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC151


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

CCDC151 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC151 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M011531:  view genomic region     (about GC identifiers)

Start:
11,531,272 bp from pter      End:
11,546,603 bp from pter
Size:
15,332 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CC151_HUMAN, A5D8V7 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 151  
Size: 595 amino acids; 69140 Da
Secondary accessions: Q96CG5

Explore the universe of human proteins at neXtProt for CCDC151: NX_A5D8V7

Explore proteomics data for CCDC151 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A5D8V7

  • CCDC151 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCDC151 Protein Expression
    REFSEQ proteins: NP_659482.3  
    ENSEMBL proteins: 
     ENSP00000348757   ENSP00000467313   ENSP00000466800   ENSP00000467429   ENSP00000442987  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: A5D8V7


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    CCDC151 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CCDC151:
     Increased cell number in G2M,  

    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC151

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCDC151 (CC151)

    Search CenterWatch for drugs/clinical trials and news about CCDC151 / CC151

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCDC151 gene: 
    NM_145045.4  

    Unigene Cluster for CCDC151:

    Coiled-coil domain containing 151
    Hs.124010  [show with all ESTs]
    Unigene Representative Sequence: BC036041
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356392(uc002mrs.3 uc010dxz.3) ENST00000591345 ENST00000591179
    ENST00000586836 ENST00000593281 ENST00000545100(uc002mrr.3)
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CCDC151:
    hsa-miR-4318 hsa-miR-296-5p hsa-miR-892a
    SwitchGear 3'UTR luciferase reporter plasmidCCDC151 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC151
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC151

    Additional mRNA sequence: 

    AK056363.1 AK294355.1 AK302113.1 AK308072.1 BC014252.2 BC036041.1 BC050355.1 BC141828.1 
    BC142637.1 BC144421.1 

    2 DOTS entries:

    DT.205735  DT.100742566 

    24/33 AceView cDNA sequences (see all 33):

    BE257917 BX090543 BE256890 BG330074 BG394371 BM931269 NM_145045 AK056363 
    BC014252 AI686018 AW135078 BE672589 BI819370 BI548500 BG395281 BC036041 
    AI684708 AW104143 BE252751 BM800810 BI859937 BC050355 AW665854 BG471439 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCDC151 expression in normal human tissues (normalized intensities)      CCDC151 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCAGATGG
    CCDC151 Expression
    About this image


    CCDC151 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Fibroblast (Uncategorized)    fully expand to see all 2 entries
             Human Gingival Fibroblasts (HGF)   
     
     Epithelium (Respiratory System)    fully expand to see all 2 entries
             bronchial epithelial cells   
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Tendon & Ligament
             Human periodontal ligament Fibroblasts (HPLF)   
     
     Bone (Muscoskeletal System)
             TGFbeta3+BMP7-induced chondrocytes

    See CCDC151 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCDC151

    SOURCE GeneReport for Unigene cluster: Hs.124010
        SABiosciences Custom PCR Arrays for CCDC151
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC151
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC151

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CCDC151 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc1511 , 5 coiled-coil domain containing 1511, 5 75.78(n)1
    67.57(a)1
      9 (8.01 cM)5
    776091  NM_001163787.11  NP_001157259.11 
     219898715 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC1516
    coiled-coil domain containing 151
    41(a)
    1 ↔ 1
    2(78867859-78901247)
    zebrafish
    (Danio rerio)
    Actinopterygii ccdc1511 coiled-coil domain containing 151 51.81(n)
    38.37(a)
      555601  NM_001077369.2  NP_001070837.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG141271 CG14127 45.21(n)
    30.47(a)
      39345  NM_140263.1  NP_648520.1 


    ENSEMBL Gene Tree for CCDC151 (if available)
    TreeFam Gene Tree for CCDC151 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCDC151 gene
    2 SIMAP similar genes for CCDC151 using alignment to 6 protein entries:     CC151_HUMAN (see all proteins):
    PARK2    ZNF257

    CCDC151 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/267 SNPs in CCDC151 are shown (see all 267)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0507434
    ----see VAR_0507432 R P mis40--------
    rs2013002381,2
    C--11532298(+) ACCCAG/ACCCTA 1 -- int11Minor allele frequency- A:0.00EU 593
    rs1511107151,2
    C--11532383(+) CACGTC/TGTGGC 2 N D mis10--------
    rs771335871,2
    C,F--11532434(+) GAGGCC/TCAGCA 2 S G mis11Minor allele frequency- T:0.05WA 118
    rs1410844931,2
    --11532553(+) GGAAGA/GCTCCA 1 -- int10--------
    rs1836566091,2
    C--11532662(+) GCCACA/GTCTGT 1 -- int10--------
    rs1878655571,2
    --11532671(+) GTGATG/TGGGGA 1 -- int10--------
    rs763301441,2
    F--11532720(+) AGGCCT/GCTTGG 1 -- int11Minor allele frequency- G:0.05WA 118
    rs1112671831,2
    F--11532779(+) AATGGC/TCCTCT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1439810091,2
    C--11533024(+) ACAGA-/GGATGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CCDC151 (11531272 - 11546603 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CCDC151:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718178CNV Deletion23290073
    esv2718179CNV Deletion23290073
    nsv833752CNV Loss17160897
    nsv911062CNV Loss21882294
    nsv519802CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCDC151 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CCDC151)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115948 HGNC: 28303 AceView: MGC20983 Ensembl:ENSG00000198003 euGenes: HUgn115948
    ECgene: CCDC151 H-InvDB: CCDC151

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCDC151 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCDC151 gene:
    Search GeneIP for patents involving CCDC151

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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