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CCDC150 Gene

protein-coding   GIFtS: 36
GCID: GC02P197504

Coiled-Coil Domain Containing 150

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disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coiled-Coil Domain Containing 1501 2
Coiled-Coil Domain-Containing Protein 1502

External Ids:    HGNC: 268341   Entrez Gene: 2849922   Ensembl: ENSG000001443957   UniProtKB: Q8NCX03   

Export aliases for CCDC150 gene to outside databases

Previous GC identifers: GC02P197214 GC02P189356


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CCDC150 Gene:
CCDC150 (coiled-coil domain containing 150) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CCDC150 gene promoter:
         TBP   Pax-5   FOXO3   RORalpha2   FOXO3b   Ik-2   POU2F1b   POU2F1a   FOXO3a   POU2F1c   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CCDC150

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CCDC150


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.1   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.1

CCDC150 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC150 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P197504:  view genomic region     (about GC identifiers)

Start:
197,504,278 bp from pter      End:
197,628,214 bp from pter
Size:
123,937 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CC150_HUMAN, Q8NCX0 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 150  
Size: 1101 amino acids; 128761 Da
Sequence caution: Sequence=AAH62658.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: Q6P5U6 Q6P663 Q8N8V5
Alternative splicing: 4 isoforms:  Q8NCX0-1   Q8NCX0-2   Q8NCX0-3   Q8NCX0-4   

Explore the universe of human proteins at neXtProt for CCDC150: NX_Q8NCX0

Explore proteomics data for CCDC150 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CCDC150 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001074008.1  
    ENSEMBL proteins: 
     ENSP00000389008   ENSP00000373827   ENSP00000396153   ENSP00000387257   ENSP00000413957  
     ENSP00000441149   ENSP00000272831   ENSP00000393634  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8NCX0


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for CCDC150:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CCDC150
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CCDC150
    Interactions:

        Search GeneGlobe Interaction Network for CCDC150

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CCDC150 (CC150)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CCDC150 gene (3 alternative transcripts): 
    NM_001080539.1  NM_173466.1  NM_173646.1  

    Unigene Cluster for CCDC150:

    Coiled-coil domain containing 150
    Hs.132519  [show with all ESTs]
    Unigene Representative Sequence: NM_001080539
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000431807 ENST00000471546(uc002uto.1) ENST00000389175(uc002utp.1 uc010zgs.1)
    ENST00000471033 ENST00000498512 ENST00000495513 ENST00000497159 ENST00000469429
    ENST00000494389 ENST00000460114 ENST00000424427 ENST00000409270 ENST00000448409(uc010zgt.1)
    ENST00000461825 ENST00000465092 ENST00000463826(uc002utq.1) ENST00000487663(uc002utr.1)
    ENST00000461243
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    hsa-miR-7-1* hsa-miR-7-2*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Additional mRNA sequence: 

    AK001064.1 AK096130.1 AK096979.1 AK125768.1 AK299214.1 AK301665.1 AK302685.1 AK303236.1 
    AK309349.1 BC062449.1 BC062658.1 

    10 DOTS entries:

    DT.40128919  DT.101979576  DT.100800045  DT.100649557  DT.100008471  DT.92421940  DT.403049  DT.92012997 
    DT.40129354  DT.95086079 

    Selected AceView cDNA sequences (see all 55):

    BE672583 AK096130 CD358832 AI025053 BX118969 AL834537 AI203069 BU521851 
    BF110432 AU145475 AI791584 AA887526 AI733091 BX343209 NM_173466 BP872039 
    AW300223 BX370739 BX343210 BC062658 AK096979 AW087412 AK125768 CB162450 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC150    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                    -                                                   
    SP2:              -     -                                   -     -         
    SP3:                                                                        
    SP4:              -                                                         


    ECgene alternative splicing isoforms for CCDC150

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CCDC150 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTCTTTGA
    CCDC150 Expression
    About this image

    CCDC150 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CCDC150 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132519
        Custom PCR Arrays for CCDC150
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC150

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CCDC150 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc1501 , 5 coiled-coil domain containing 1501, 5 82.2(n)1
    77.34(a)1
      1 (27.06 cM)5
    780161  NM_030025.21  NP_084301.21 
     542506835 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC1506
    coiled-coil domain containing 150
    50(a)
    1 ↔ 1
    GL343280.1(362841-413520)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ccdc1501 coiled-coil domain containing 150 53.61(n)
    41.06(a)
      100490193  XM_002935154.2  XP_002935200.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005349861 coiled-coil domain-containing protein 150-like 50(n)
    37.26(a)
      100534986  XM_003200080.2  XP_003200128.2 


    ENSEMBL Gene Tree for CCDC150 (if available)
    TreeFam Gene Tree for CCDC150 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CCDC150 gene

    Find genes that share paralogs with CCDC150           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CCDC150
    PGOHUM00000239595


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CCDC150 (see all 1351)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs119041141,2
    C,F,H--197502577(+) TCATGG/TAATAT 1 -- us2k18Minor allele frequency- T:0.13NA CSA WA 384
    rs795542791,2
    C,F--197502593(+) ATTTCC/TGTGAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1932962441,2
    --197502683(+) AAATCA/GGTATG 1 -- us2k10--------
    rs1470684181,2
    C--197502882(+) TCTAA-/CTCTGTA 1 -- us2k10--------
    rs1851103151,2
    --197503012(+) TGAAAA/CCTCTC 1 -- us2k10--------
    rs1887737651,2
    --197503099(+) AAACAC/TACATA 1 -- us2k10--------
    rs1418230351,2
    --197503226(+) GATCGA/GCTCAA 1 -- us2k10--------
    rs1480114741,2
    C--197503249(+) TGGCT-/GGGGG 
            
    GTGGT
    1 -- us2k10--------
    rs784119031,2
    --197503251(+) GGCTGG/TGGTTT 1 -- us2k10--------
    rs790043001,2
    C,F--197503547(+) AACTCA/GGAAAC 1 -- us2k11Minor allele frequency- G:0.03NA 120

    HapMap Linkage Disequilibrium report for CCDC150 (197504278 - 197628214 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CCDC150:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1075947CNV Insertion17803354
    nsv3096CNV Insertion18451855
    esv992569CNV Insertion20482838

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CCDC150 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CCDC150)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284992 HGNC: 26834 AceView: DKFZp434P055andFLJ39660 Ensembl:ENSG00000144395 euGenes: HUgn284992
    ECgene: CCDC150 H-InvDB: CCDC150

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CCDC150 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CCDC150 gene:
    Search GeneIP for patents involving CCDC150

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Block miRNA regulation of human, mouse, rat CCDC150 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CCDC150
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     Custom PCR Arrays for CCDC150 Search Chromatin IP Primers for CCDC150
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     Search Addgene for plasmids for CCDC150
      Search eBioscience for proteins for CCDC150
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      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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