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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCDC150 Gene

protein-coding   GIFtS: 35
GCID: GC02P197504

Coiled-Coil Domain Containing 150

  Search for CCDC150
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 1501 2
Coiled-Coil Domain-Containing Protein 1502

External Ids:    HGNC: 268341   Entrez Gene: 2849922   Ensembl: ENSG000001443957   UniProtKB: Q8NCX03   

Export aliases for CCDC150 gene to outside databases

Previous GC identifers: GC02P197214 GC02P189356


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CCDC150 Gene: 
CCDC150 (coiled-coil domain containing 150) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCDC150 gene promoter:
         TBP   Pax-5   FOXO3   RORalpha2   FOXO3b   Ik-2   POU2F1b   POU2F1a   FOXO3a   POU2F1c   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CCDC150

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC150


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.1   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.1

CCDC150 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC150 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P197504:  view genomic region     (about GC identifiers)

Start:
197,504,278 bp from pter      End:
197,628,214 bp from pter
Size:
123,937 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CC150_HUMAN, Q8NCX0 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 150  
Size: 1101 amino acids; 128761 Da
Sequence caution: Sequence=AAH62658.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: Q6P5U6 Q6P663 Q8N8V5
Alternative splicing: 4 isoforms:  Q8NCX0-1   Q8NCX0-2   Q8NCX0-3   Q8NCX0-4   

Explore the universe of human proteins at neXtProt for CCDC150: NX_Q8NCX0

Explore proteomics data for CCDC150 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NCX0

  • CCDC150 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCDC150 Protein Expression
    REFSEQ proteins: NP_001074008.1  
    ENSEMBL proteins: 
     ENSP00000389008   ENSP00000373827   ENSP00000396153   ENSP00000387257   ENSP00000413957  
     ENSP00000441149   ENSP00000272831   ENSP00000393634  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8NCX0


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for CCDC150:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCDC150 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC150

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCDC150 (CC150)

    Search CenterWatch for drugs/clinical trials and news about CCDC150 / CC150

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCDC150 gene (3 alternative transcripts): 
    NM_001080539.1  NM_173466.1  NM_173646.1  

    Unigene Cluster for CCDC150:

    Coiled-coil domain containing 150
    Hs.132519  [show with all ESTs]
    Unigene Representative Sequence: NM_001080539
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000431807 ENST00000471546(uc002uto.1) ENST00000389175(uc002utp.1 uc010zgs.1)
    ENST00000471033 ENST00000498512 ENST00000495513 ENST00000497159 ENST00000469429
    ENST00000494389 ENST00000460114 ENST00000424427 ENST00000409270 ENST00000448409(uc010zgt.1)
    ENST00000461825 ENST00000465092 ENST00000463826(uc002utq.1) ENST00000487663(uc002utr.1)
    ENST00000461243
    miRNA
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    Inhib. RNA
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC150
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                         Customized lentivirus expression plasmids for stable overexpression of CCDC150 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC150
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC150

    Additional mRNA sequence: 

    AK001064.1 AK096130.1 AK096979.1 AK125768.1 AK299214.1 AK301665.1 AK302685.1 AK303236.1 
    AK309349.1 BC062449.1 BC062658.1 

    10 DOTS entries:

    DT.40128919  DT.101979576  DT.100800045  DT.100649557  DT.100008471  DT.92421940  DT.403049  DT.92012997 
    DT.40129354  DT.95086079 

    24/55 AceView cDNA sequences (see all 55):

    CD358832 BU521851 BF110432 AI203069 BX118969 AK096130 AA887526 AI733091 
    AL834537 BE672583 AI791584 AI025053 AU145475 AI471843 NM_173466 BC062449 
    BX343210 BX370739 AW300223 AI825349 BC062658 BP872039 BX343209 AK001064 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CCDC150    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                    -                                                   
    SP2:              -     -                                   -     -         
    SP3:                                                                        
    SP4:              -                                                         


    ECgene alternative splicing isoforms for CCDC150

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCDC150 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTCTTTGA
    CCDC150 Expression
    About this image


    See CCDC150 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCDC150

    SOURCE GeneReport for Unigene cluster: Hs.132519
        SABiosciences Custom PCR Arrays for CCDC150
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC150

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CCDC150 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc1501 , 5 coiled-coil domain containing 1501, 5 82.2(n)1
    77.34(a)1
      1 (27.06 cM)5
    780161  NM_030025.21  NP_084301.21 
     542506835 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC1506
    Uncharacterized protein
    50(a)
    1 ↔ 1
    GL343280.1(362841-413520)
    zebrafish
    (Danio rerio)
    Actinopterygii CCDC1506
    coiled-coil domain containing 150
    23(a)
    1 ↔ 1
    15(39775669-39816312)


    ENSEMBL Gene Tree for CCDC150 (if available)
    TreeFam Gene Tree for CCDC150 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCDC150 gene

    CCDC150 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCDC150
    PGOHUM00000239595


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1351 SNPs in CCDC150 are shown (see all 1351)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs119041141,2
    C,F,H--197502577(+) TCATGG/TAATAT 1 -- us2k18Minor allele frequency- T:0.13NA CSA WA 384
    rs795542791,2
    C,F--197502593(+) ATTTCC/TGTGAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1932962441,2
    --197502683(+) AAATCA/GGTATG 1 -- us2k10--------
    rs1470684181,2
    C--197502882(+) TCTAA-/CTCTGTA 1 -- us2k10--------
    rs1851103151,2
    --197503012(+) TGAAAA/CCTCTC 1 -- us2k10--------
    rs1887737651,2
    --197503099(+) AAACAC/TACATA 1 -- us2k10--------
    rs1418230351,2
    --197503226(+) GATCGA/GCTCAA 1 -- us2k10--------
    rs1480114741,2
    C--197503249(+) TGGCT-/GGGGG 
            
    GTGGT
    1 -- us2k10--------
    rs784119031,2
    --197503251(+) GGCTGG/TGGTTT 1 -- us2k10--------
    rs790043001,2
    C,F--197503547(+) AACTCA/GGAAAC 1 -- us2k11Minor allele frequency- G:0.03NA 120

    HapMap Linkage Disequilibrium report for CCDC150 (197504278 - 197628214 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CCDC150:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1075947CNV Insertion17803354
    nsv3096CNV Insertion18451855
    esv992569CNV Insertion20482838

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCDC150 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CCDC150)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 284992 HGNC: 26834 AceView: DKFZp434P055andFLJ39660 Ensembl:ENSG00000144395 euGenes: HUgn284992
    ECgene: CCDC150 H-InvDB: CCDC150

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCDC150 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCDC150 gene:
    Search GeneIP for patents involving CCDC150

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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