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Aliases for CCDC15 Gene

Aliases for CCDC15 Gene

  • Coiled-Coil Domain Containing 15 2 3

External Ids for CCDC15 Gene

Previous GeneCards Identifiers for CCDC15 Gene

  • GC11P124330
  • GC11P124824
  • GC11P120766

Summaries for CCDC15 Gene

GeneCards Summary for CCDC15 Gene

CCDC15 (Coiled-Coil Domain Containing 15) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC15 Gene

Genomics for CCDC15 Gene

Regulatory Elements for CCDC15 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCDC15 Gene

124,954,121 bp from pter
125,041,489 bp from pter
87,369 bases
Plus strand

Genomic View for CCDC15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC15 Gene

Proteins for CCDC15 Gene

  • Protein details for CCDC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 15
    Protein Accession:
    Secondary Accessions:
    • Q9H8U7

    Protein attributes for CCDC15 Gene

    951 amino acids
    Molecular mass:
    110484 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH18540.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for CCDC15 Gene

Proteomics data for CCDC15 Gene at MOPED

Post-translational modifications for CCDC15 Gene

  • Ubiquitination at Lys 128, Lys 443, Lys 595, Lys 725, and Lys 848
  • Modification sites at PhosphoSitePlus

Other Protein References for CCDC15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC15 Gene

Domains & Families for CCDC15 Gene

Protein Domains for CCDC15 Gene


Suggested Antigen Peptide Sequences for CCDC15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC15: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC15 Gene

Function for CCDC15 Gene

Phenotypes for CCDC15 Gene

GenomeRNAi human phenotypes for CCDC15:
genes like me logo Genes that share phenotypes with CCDC15: view

Animal Model Products

miRNA for CCDC15 Gene

miRTarBase miRNAs that target CCDC15

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC15 Gene

Localization for CCDC15 Gene

Subcellular locations from

Jensen Localization Image for CCDC15 Gene COMPARTMENTS Subcellular localization image for CCDC15 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
mitochondrion 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CCDC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with CCDC15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CCDC15 Gene

Pathways & Interactions for CCDC15 Gene

SuperPathways for CCDC15 Gene

No Data Available

Interacting Proteins for CCDC15 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000341684 for CCDC15 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CCDC15 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC15 Gene

Drugs & Compounds for CCDC15 Gene

No Compound Related Data Available

Transcripts for CCDC15 Gene

mRNA/cDNA for CCDC15 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC15 Gene

Coiled-coil domain containing 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC15 Gene

No ASD Table

Relevant External Links for CCDC15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC15 Gene

mRNA expression in normal human tissues for CCDC15 Gene

mRNA differential expression in normal tissues according to GTEx for CCDC15 Gene

This gene is overexpressed in Testis (x10.9).

Protein differential expression in normal tissues from HIPED for CCDC15 Gene

This gene is overexpressed in Plasma (61.9) and Brain (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCDC15 Gene

SOURCE GeneReport for Unigene cluster for CCDC15 Gene Hs.287555

genes like me logo Genes that share expression patterns with CCDC15: view

Protein tissue co-expression partners for CCDC15 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CCDC15 Gene

Orthologs for CCDC15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC15 35
  • 77.29 (n)
  • 64.63 (a)
CCDC15 36
  • 59 (a)
(Canis familiaris)
Mammalia CCDC15 35
  • 78.56 (n)
  • 68.22 (a)
CCDC15 36
  • 61 (a)
(Mus musculus)
Mammalia Ccdc15 35
  • 75.92 (n)
  • 63.62 (a)
Ccdc15 16
Ccdc15 36
  • 59 (a)
(Pan troglodytes)
Mammalia CCDC15 35
  • 98.67 (n)
  • 98.21 (a)
CCDC15 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ccdc15 35
  • 73.92 (n)
  • 63.02 (a)
(Monodelphis domestica)
Mammalia CCDC15 36
  • 27 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
-- 36
  • 46 (a)
(Gallus gallus)
Aves CCDC15 35
  • 57.51 (n)
  • 50 (a)
CCDC15 36
  • 39 (a)
(Anolis carolinensis)
Reptilia CCDC15 36
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc15 35
  • 58.4 (n)
  • 49.62 (a)
(Danio rerio)
Actinopterygii LOC100333818 35
  • 51.56 (n)
  • 42.49 (a)
CCDC15 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for CCDC15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC15 Gene

Gene Tree for CCDC15 (if available)
Gene Tree for CCDC15 (if available)

Paralogs for CCDC15 Gene

No data available for Paralogs for CCDC15 Gene

Variants for CCDC15 Gene

Sequence variations from dbSNP and Humsavar for CCDC15 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs15541 -- 125,041,240(-) CAATA(C/T)ATTTT utr-variant-3-prime
rs1730933 -- 125,009,973(-) acaca(A/C/G/T)gtact intron-variant
rs4128483 -- 124,995,027(-) CAAGA(A/G)TTGCA intron-variant
rs4245060 -- 125,014,901(+) tgccc(A/G)tggaa intron-variant
rs4259837 -- 125,039,907(+) CTTTC(C/T)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC15 Gene

Variant ID Type Subtype PubMed ID
esv2745189 CNV Deletion 23290073
nsv520010 CNV Loss 19592680
esv2745190 CNV Deletion 23290073
esv2479047 CNV Deletion 19546169
esv2256616 CNV Deletion 18987734
esv2745191 CNV Deletion 23290073
esv2745192 CNV Deletion 23290073
nsv39015 CNV Loss 16902084
esv996549 CNV Deletion 20482838
esv1770401 CNV Deletion 17803354
esv2745193 CNV Deletion 23290073

Variation tolerance for CCDC15 Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.98; 84.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC15 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC15 Gene

Disorders for CCDC15 Gene

Relevant External Links for CCDC15

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CCDC15: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC15 Gene

Publications for CCDC15 Gene

  1. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 67
  2. Diagnostic exome sequencing in persons with severe intellectual disability. (PMID: 23033978) de Ligt J. … Vissers L.E. (N. Engl. J. Med. 2012) 67
  3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PMID: 21399614) Jakobsen L. … Andersen J.S. (EMBO J. 2011) 67
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67

Products for CCDC15 Gene

Sources for CCDC15 Gene

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