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Aliases for CCDC149 Gene

Aliases for CCDC149 Gene

  • Coiled-Coil Domain Containing 149 2 3 5

External Ids for CCDC149 Gene

Previous GeneCards Identifiers for CCDC149 Gene

  • GC04M024418
  • GC04M024437
  • GC04M024150

Summaries for CCDC149 Gene

GeneCards Summary for CCDC149 Gene

CCDC149 (Coiled-Coil Domain Containing 149) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC149 Gene

Genomics for CCDC149 Gene

Regulatory Elements for CCDC149 Gene

Enhancers for CCDC149 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F024978 1 FANTOM5 ENCODE 20.9 +0.7 685 2.1 CTCF ZNF654 ZNF680 JUN TRIM22 REST RAD21 POLR2A ZNF143 SMC3 CCDC149 DHX15 GC04P024947
GH04F024911 1 FANTOM5 ENCODE 17.3 +67.7 67658 1.8 GTF2F1 ZNF687 CBX3 MAX SP2 CHD1 SIN3A MNT ZNF592 YY1 CCDC149 GC04P024947 GC04M024806
GH04F024973 1.3 FANTOM5 Ensembl ENCODE 10.7 +5.5 5503 3.4 GATAD2A CTCF CEBPB CEBPG RAD21 ZBTB40 TEAD3 E2F1 ZKSCAN8 CEBPA CCDC149 DHX15 GC04P024947
GH04F025088 0.8 Ensembl 11.5 -108.4 -108397 0.8 BCOR PKNOX1 TBL1XR1 CREB3L1 TAL1 MAX CCNT2 ZNF316 NCOR1 HES1 LGI2 CCDC149 SEL1L3 GC04M024941 LOC105374534
GH04F025153 0.8 ENCODE 10 -174.7 -174705 3.0 ELF3 ATF1 ARID4B RAD21 YY1 CREM MIXL1 CEBPB PPARG RFX3 ANAPC4 CCDC149 PI4K2B SEPSECS PIR60918
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC149 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC149 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001238259 4 401 CTCF ZNF654 ZNF680 TRIM22 REST RAD21 POLR2A SMC3 ZNF143

Genomic Location for CCDC149 Gene

Chromosome:
4
Start:
24,806,117 bp from pter
End:
24,980,204 bp from pter
Size:
174,088 bases
Orientation:
Minus strand

Genomic View for CCDC149 Gene

Genes around CCDC149 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC149 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC149 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC149 Gene

Proteins for CCDC149 Gene

  • Protein details for CCDC149 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZUS6-CC149_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 149
    Protein Accession:
    Q6ZUS6
    Secondary Accessions:
    • A6NJE7
    • B4DK90
    • B4DZG3
    • G5EA04
    • Q6NW41
    • Q8N3K8

    Protein attributes for CCDC149 Gene

    Size:
    474 amino acids
    Molecular mass:
    52796 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH57761.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH67735.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86142.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86142.1; Type=Frameshift; Positions=30; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC149 Gene

neXtProt entry for CCDC149 Gene

Post-translational modifications for CCDC149 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CCDC149 Gene

Domains & Families for CCDC149 Gene

Protein Domains for CCDC149 Gene

Suggested Antigen Peptide Sequences for CCDC149 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC149: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC149 Gene

Function for CCDC149 Gene

Phenotypes for CCDC149 Gene

genes like me logo Genes that share phenotypes with CCDC149: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC149 Gene

Localization for CCDC149 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC149 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CCDC149 Gene

Pathways & Interactions for CCDC149 Gene

SuperPathways for CCDC149 Gene

No Data Available

Interacting Proteins for CCDC149 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000374260%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000266069%0d%0a
Selected Interacting proteins: ENSP00000374260 Q6ZUS6-CC149_HUMAN for CCDC149 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CCDC149 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC149 Gene

Transcripts for CCDC149 Gene

Unigene Clusters for CCDC149 Gene

Coiled-coil domain containing 149:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC149 Gene

No ASD Table

Relevant External Links for CCDC149 Gene

GeneLoc Exon Structure for
CCDC149
ECgene alternative splicing isoforms for
CCDC149

Expression for CCDC149 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CCDC149 Gene

Protein differential expression in normal tissues from HIPED for CCDC149 Gene

This gene is overexpressed in Islet of Langerhans (46.0), Heart (17.0), and Pancreas (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC149 Gene



Protein tissue co-expression partners for CCDC149 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCDC149 Gene:

CCDC149

SOURCE GeneReport for Unigene cluster for CCDC149 Gene:

Hs.106432
genes like me logo Genes that share expression patterns with CCDC149: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CCDC149 Gene

Orthologs for CCDC149 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC149 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC149 34 35
  • 99.43 (n)
cow
(Bos Taurus)
Mammalia CCDC149 34 35
  • 89.08 (n)
dog
(Canis familiaris)
Mammalia CCDC149 34 35
  • 85.26 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc149 34
  • 82.63 (n)
mouse
(Mus musculus)
Mammalia Ccdc149 34 16 35
  • 82.06 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC149 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC149 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC149 34 35
  • 75.55 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC149 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc149 34
  • 68.46 (n)
zebrafish
(Danio rerio)
Actinopterygii ccdc149a 34 35
  • 65.81 (n)
ccdc149b 35
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14868 35
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F29G6.2 35
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6413 35
  • 43 (a)
OneToOne
Species where no ortholog for CCDC149 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCDC149 Gene

ENSEMBL:
Gene Tree for CCDC149 (if available)
TreeFam:
Gene Tree for CCDC149 (if available)

Paralogs for CCDC149 Gene

No data available for Paralogs for CCDC149 Gene

Variants for CCDC149 Gene

Sequence variations from dbSNP and Humsavar for CCDC149 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000139 -- 24,870,759(+) TGCTG(C/T)TTATA intron-variant
rs10002411 -- 24,876,868(+) TACAG(C/T)GCTAA intron-variant
rs10002547 -- 24,962,920(+) atCTT(C/T)GTAAA intron-variant
rs10003397 -- 24,943,395(+) cctta(C/T)acctt intron-variant
rs10004137 -- 24,977,415(+) ACGTG(C/T)ATTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC149 Gene

Variant ID Type Subtype PubMed ID
nsv829888 CNV gain 17160897
nsv829887 CNV gain+loss 17160897
nsv593827 CNV loss 21841781
nsv1145027 CNV deletion 24896259
nsv1114499 CNV deletion 24896259
esv3599951 CNV loss 21293372
esv3599950 CNV loss 21293372
esv3599949 CNV loss 21293372
esv3412 CNV loss 18987735
esv3333123 CNV insertion 20981092
esv27291 CNV loss 19812545
esv2727306 CNV deletion 23290073
esv2658939 CNV deletion 23128226
esv2499911 CNV deletion 19546169
esv2023485 CNV deletion 18987734

Variation tolerance for CCDC149 Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.70; 96.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC149 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC149

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC149 Gene

Disorders for CCDC149 Gene

Relevant External Links for CCDC149

Human Genome Epidemiology (HuGE) Navigator
CCDC149
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC149

No disorders were found for CCDC149 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC149 Gene

Publications for CCDC149 Gene

  1. Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia. (PMID: 17457313) Christoforou A. … Evans K.L. (Mol. Psychiatry 2007) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. (PMID: 25130324) Cai D.C. … Hagoort P. (Genes Brain Behav. 2014) 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64

Products for CCDC149 Gene

Sources for CCDC149 Gene

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