CCDC149 Gene
protein-coding GIFtS: 38
GCID: GC04M024809
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coiled-coil domain containing 149
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Aliases
for CCDC149 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 1491 2 | | DKFZp761B1071 | | Coiled-Coil Domain-Containing Protein 1492 |
Export aliases for CCDC149 gene to outside databasesPrevious GC identifers: GC04M024418 GC04M024437 GC04M024150 |
Summaries
for CCDC149 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CCDC149 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006316.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC149 gene promoter:
AhR E2F-4 E2F-3a E2F-5 E2F-2 LCR-F1 Arnt CP2 E2F E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC149
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC149 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p15.2 Ensembl cytogenetic band: 4p15.2 HGNC cytogenetic band: 4p15.2CCDC149 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M024809: view genomic region
(about GC identifiers)
Start:
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24,807,739 bp from pter |
End:
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24,981,826 bp from pter |
Size:
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174,088 bases |
Orientation:
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minus strand |
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Proteins
for CCDC149 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CC149_HUMAN, Q6ZUS6 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 149 Size: 474 amino acids; 52796 Da
Sequence caution: Sequence=AAH57761.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAH67735.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC86142.1;Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC86142.1; Type=Frameshift; Positions=30;
Secondary accessions: A6NJE7 B4DK90 B4DZG3 G5EA04 Q6NW41 Q8N3K8Alternative splicing: 6 isoforms: Q6ZUS6-1 Q6ZUS6-2 Q6ZUS6-3 Q6ZUS6-4 Q6ZUS6-5 Q6ZUS6-6 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CCDC149: NX_Q6ZUS6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZUS6
CCDC149 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001124198.1 NP_775734.2
ENSEMBL proteins: ENSP00000425715 ENSP00000374260 ENSP00000427529 ENSP00000425402 ENSP00000395668
Human Recombinant Protein Products:
CCDC149 Antibody Products:
Assay Products for CCDC149: |
Protein
Domains /
Families
for CCDC149 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CCDC149 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6ZUS6ProtoNet protein and cluster: Q6ZUS6 |
Function
for CCDC149 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC149 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC149 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CCDC149 (NM_001130726) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC149 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CCDC149 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC149 |
|
Pathways & Interactions
for CCDC149 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC149
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/11 Interacting proteins for CCDC149 (Q6ZUS63 ENSP000003742604) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
|
Drugs & Compounds
for CCDC149 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC149
Search CenterWatch for drugs/clinical trials and news about CCDC149 / CC149
|
Transcripts
for CCDC149 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC149 gene (2 alternative transcripts): NM_001130726.2 NM_173463.4 Unigene Cluster for CCDC149: Coiled-coil domain containing 149 Hs.106432 [show with all ESTs]Unigene Representative Sequence: NM_1734639 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000504487(uc003gra.2 uc003grc.3 uc003grd.3 uc011bxr.2)
ENST00000389609 ENST00000502801 ENST00000505471 ENST00000507096 ENST00000508236
ENST00000324309(uc003gre.3) ENST00000512432 ENST00000428116
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC149 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC149 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CCDC149 (NM_001130726) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC149 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CCDC149 |
Additional cDNA sequence: AF086111.1 AK023472.1 AK125353.1 AK296454.1 AK302905.1 BC057761.1 BC067735.1 4 DOTS entries: DT.92421471 DT.209192 DT.100010874 DT.99946232 24/85 AceView cDNA sequences (see all 85): AA490318 BM726153 AF086111 AA365507 NM_173463 AW749981 BG390125 AL834257 AI379084 BM683386 BM697808 AA010870 CR610515 BE348248 BX438866 BE672667 AI807917 AA490417 AA234549 BC057761 AL545028 BQ671265 BG706499 BG152885
GeneLoc Exon Structure
|
Expression
for CCDC149 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC149 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CCDC149 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC149
SOURCE GeneReport for Unigene cluster: Hs.106432
SABiosciences Custom PCR Arrays for CCDC149
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC149
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCDC149 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC149 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC149 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC149 |
Orthologs
for CCDC149 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CCDC149 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for CCDC149 (if available)
TreeFam Gene Tree for CCDC149 (if available) |
Paralogs
for CCDC149 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CCDC149 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for CCDC149
1 CNV: 98654
5 Indels: 91976 43167 63776 80208 46621 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC149 |
|
Disorders
/ Diseases
for CCDC149 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CCDC149 for disorders About GeneDecksing
4  diseases for CCDC149: About MalaCardsfanconi's anemia bipolar disorder anemia schizophrenia
Human Genome Epidemiology (HuGE) Navigator: CCDC149 (0 documents)
Export disorders for CCDC149 gene to outside databases
|
Publications
for CCDC149 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC149 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with CCDC149) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia. (PubMed id 17457313)1, 3 Christoforou A....Evans K.L. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
- Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)1 Satoh J....Tabunoki H. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
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External Searches for CCDC149 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CCDC149 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC149 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC149 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC149 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CCDC149 gene:
Search GeneIP for patents involving CCDC149
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC149 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC149 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC149 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC149 | | | OriGene Protein Over-expression Lysate for CCDC149 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC149 | | OriGene 3'-UTR Clone for CCDC149 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC149 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC149 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CCDC149 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for CCDC149 |
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 | | | CCDC149 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC149 |
|  |  |  | | | | Search ThermoFisher Antibodies for CCDC149 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CCDC149 |
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