CCDC148 Gene
protein-coding GIFtS: 41
GCID: GC02M159027
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coiled-coil domain containing 148
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Aliases
for CCDC148 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil Domain Containing 1481 2 | | MGC1255881 | | Coiled-Coil Domain-Containing Protein 1482 |
Export aliases for CCDC148 gene to outside databasesPrevious GC identifers: GC02M158737 GC02M150916 |
Summaries
for CCDC148 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CCDC148 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CCDC148 gene promoter:
Elk-1 p53 HNF-4alpha2 CUTL1 HNF-4alpha1 PPAR-gamma1 PPAR-gamma2 CP1C CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for CCDC148
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC148 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q24.1 Ensembl cytogenetic band: 2q24.1 HGNC cytogenetic band: 2q24.1CCDC148 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M159027: view genomic region
(about GC identifiers)
Start:
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159,027,593 bp from pter |
End:
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159,313,265 bp from pter |
Size:
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285,673 bases |
Orientation:
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minus strand |
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Proteins
for CCDC148 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CC148_HUMAN, Q8NFR7 (See
protein sequence)Recommended Name: Coiled-coil domain-containing protein 148 Size: 591 amino acids; 71076 Da
Sequence caution: Sequence=AAI07598.1; Type=Frameshift; Positions=383;
Secondary accessions: F5H839 Q3B7I3 Q3B7I4 Q3KR41 Q4ZG12 Q4ZG23 Q53TM6 Q96BN5 Q96LM2Alternative splicing: 4 isoforms: Q8NFR7-1 Q8NFR7-2 Q8NFR7-3 Q8NFR7-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CCDC148: NX_Q8NFR7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NFR7
CCDC148 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001165108.1 NP_620158.3
ENSEMBL proteins: ENSP00000283233 ENSP00000398372 ENSP00000386674 ENSP00000415540 ENSP00000400751 ENSP00000415343 ENSP00000386583 ENSP00000443740
Human Recombinant Protein Products:
CCDC148 Antibody Products:
Assay Products for CCDC148: |
Protein
Domains /
Families
for CCDC148 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8NFR7 |
Function
for CCDC148 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC148 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC148 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CCDC148 (NM_138803) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC148 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC148 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC148 |
|
Pathways & Interactions
for CCDC148 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC148
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for CCDC148 (Q8NFR73 ENSP000002832334) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CCDC148 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CCDC148
Search CenterWatch for drugs/clinical trials and news about CCDC148 / CC148
|
Transcripts
for CCDC148 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CCDC148 gene (2 alternative transcripts): NM_001171637.1 NM_138803.3 Unigene Cluster for CCDC148: Coiled-coil domain containing 148 Hs.668597 [show with all ESTs]Unigene Representative Sequence: NM_1388039 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000283233(uc002tzq.3 uc002tzr.3 uc010foh.3) ENST00000454257
ENST00000409187 ENST00000448656 ENST00000417066 ENST00000451554(uc010foi.2)
ENST00000409889(uc002tzs.2) ENST00000491563 ENST00000536771(uc010fok.2 uc010foj.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC148 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC148 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CCDC148 (NM_138803) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC148 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC148 |
Additional cDNA sequence: AF458588.1 AK123220.1 AK308783.1 AK309246.1 AK311042.1 BC015395.1 BC031994.1 BC105928.1 BC107596.1 BC107597.1 4 DOTS entries: DT.75101069 DT.101978518 DT.100746804 DT.120963119 24 AceView cDNA sequences: AW615222 AF458588 AK058105 BF593824 NM_138803 BF940211 BX282228 BF940091 BG179320 AI424612 AK123220 AI359353 AI650321 BG678084 AW188468 BF111993 BG291599 BP369440 BC031994 BF594137 BE856330 BC015395 AI634798 AW055164
GeneLoc Exon Structure
|
Expression
for CCDC148 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CCDC148 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATATGGATA
About this image
See CCDC148 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CCDC148
SOURCE GeneReport for Unigene cluster: Hs.668597
SABiosciences Custom PCR Arrays for CCDC148
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC148
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CCDC148 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC148 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC148 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC148 |
Orthologs
for CCDC148 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CCDC148 gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for CCDC148 (if available)
TreeFam Gene Tree for CCDC148 (if available) |
Paralogs
for CCDC148 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CCDC148 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CCDC148 (159027593 - 159277593 bp, first 250kb of CCDC148)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CCDC148
5 CNVs: 78835 90092 90093 63219 35750
Human Gene Mutation Database (HGMD): CCDC148
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC148 |
|
Disorders
/ Diseases
for CCDC148 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 CCDC148 for disorders About MalaCards
CCDC148 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: CCDC148 (4 documents)
Export disorders for CCDC148 gene to outside databases
|
Publications
for CCDC148 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CCDC148 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CCDC148) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Haplotype Association Mapping of Acute Lung Injury in Mice Implicates Activin A Receptor, Type 1. (PubMed id 21297076)1 Leikauf G.D....Prows D.R. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1 Maestrini E....Monaco A.P. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for CCDC148 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CCDC148 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CCDC148 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CCDC148 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CCDC148 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CCDC148 gene:
Search GeneIP for patents involving CCDC148
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CCDC148 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CCDC148 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CCDC148 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CCDC148 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CCDC148 | | OriGene 3'-UTR Clone for CCDC148 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC148 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CCDC148 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CCDC148 | | OriGene Custom Protein Services for CCDC148 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC148 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CCDC148 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC148 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CCDC148 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC148 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC148 |
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 |  |  |  | |
| | | | Search Tocris compounds for CCDC148 |
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 | | | CCDC148 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC148 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CCDC148 |
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