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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CCDC146 Gene

protein-coding   GIFtS: 39
GCID: GC07P076751

Coiled-Coil Domain Containing 146

  Search for CCDC146
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coiled-Coil Domain Containing 1461 2
Coiled-Coil Domain-Containing Protein 1462
KIAA15053

External Ids:    HGNC: 292961   Entrez Gene: 576392   Ensembl: ENSG000001352057   UniProtKB: Q8IYE03   

Export aliases for CCDC146 gene to outside databases

Previous GC identifers: GC07P076590 GC07P076673 GC07P071399


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CCDC146 Gene: 
CCDC146 (coiled-coil domain containing 146) is a protein-coding gene. An important paralog of this gene is CCDC147.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CCDC146 gene promoter:
         SRF   SRF (504 AA)   AP-4   HNF-1A   Evi-1   AREB6   NF-kappaB2   HNF-1   Msx-1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CCDC146 promoter sequence
   Search SABiosciences Chromatin IP Primers for CCDC146

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC146


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

CCDC146 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CCDC146 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P076751:  view genomic region     (about GC identifiers)

Start:
76,751,751 bp from pter      End:
76,958,850 bp from pter
Size:
207,100 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 76,084,997-76,257,584     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CC146_HUMAN, Q8IYE0 (See protein sequence)
Recommended Name: Coiled-coil domain-containing protein 146  
Size: 955 amino acids; 112806 Da
Sequence caution: Sequence=BAA96029.1; Type=Erroneous initiation;
Secondary accessions: A8K8X6 Q9P223
Alternative splicing: 2 isoforms:  Q8IYE0-1   Q8IYE0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CCDC146: NX_Q8IYE0

Explore proteomics data for CCDC146 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IYE0

  • CCDC146 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CCDC146 Protein Expression
    REFSEQ proteins: NP_065930.2  
    ENSEMBL proteins: 
     ENSP00000388649   ENSP00000285871   ENSP00000413885  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q8IYE0


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CCDC146 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CCDC146

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CCDC146 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC146

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CCDC146 (CC146)

    Search CenterWatch for drugs/clinical trials and news about CCDC146 / CC146

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CCDC146 gene: 
    NM_020879.2  

    Unigene Cluster for CCDC146:

    Coiled-coil domain containing 146
    Hs.113940  [show with all ESTs]
    Unigene Representative Sequence: BX649000
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000415750 ENST00000285871(uc003uga.3) ENST00000461882 ENST00000415740(uc010ldp.3)
    ENST00000461259(uc003ugc.3) ENST00000474733 ENST00000464021 ENST00000478101
    ENST00000488998 ENST00000431197(uc003ufz.1)
    miRNA
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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of CCDC146 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CCDC146
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CCDC146
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC146

    Additional mRNA sequence: 

    AB040938.1 AF461817.1 AK056542.1 AK292491.1 BC029458.1 BC036053.1 BX649000.1 HM370402.1 

    8 DOTS entries:

    DT.100684704  DT.97813628  DT.92419788  DT.443118  DT.100735895  DT.40108249  DT.95192858  DT.95293012 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CCDC146 expression in normal human tissues (normalized intensities)      CCDC146 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CCDC146 Expression
    About this image


    CCDC146 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood

    See CCDC146 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CCDC146

    SOURCE GeneReport for Unigene cluster: Hs.113940
        SABiosciences Custom PCR Arrays for CCDC146
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CCDC146
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC146

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CCDC146 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ccdc1461 , 5 coiled-coil domain containing 1461, 5 79.25(n)1
    76.42(a)1
      5 (9.83 cM)5
    751721  NM_029195.11  NP_083471.11 
     212929615 
    chicken
    (Gallus gallus)
    Aves CCDC1461 coiled-coil domain containing 146 61.11(n)
    49.23(a)
      417723  XM_415968.2  XP_415968.2 
    lizard
    (Anolis carolinensis)
    Reptilia CCDC1466
    Uncharacterized protein
    52(a)
    1 ↔ 1
    5(95088731-95118971)
    zebrafish
    (Danio rerio)
    Actinopterygii ccdc1461 coiled-coil domain containing 146 50.2(n)
    37.32(a)
      767671  NM_001083053.1  NP_001076522.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ory6
    CG58826
    (see all 3)
    --
    16(a)
    15(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    YHet(229033-271450)
    3R(22944368-22947312)


    ENSEMBL Gene Tree for CCDC146 (if available)
    TreeFam Gene Tree for CCDC146 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CCDC146 gene
    CCDC1472  

    CCDC146 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CCDC146
    PGOHUM00000250900


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4467 SNPs in CCDC146 are shown (see all 4467)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1811463111,2
    --71397601(-) TGTCTA/GTGTGT 2 -- us2k10--------
    rs2012559891,2
    C--71397838(-) ATTAC-/AAAAAA 2 -- us2k10--------
    rs1458404851,2
    C--71397842(-) TTCAAC/TTACAA 2 -- us2k10--------
    rs1406639611,2
    C--71398094(-) GATAAA/GTCATT 2 -- us2k10--------
    rs1468863151,2
    --71398127(-) TTATAA/GGCTGT 2 -- us2k10--------
    rs1899498251,2
    --71398617(-) CAGATA/CATATT 2 -- us2k10--------
    rs1843270821,2
    --71398634(-) TCGAAA/CATTTT 2 -- us2k10--------
    rs672159941,2
    C--71398637(-) GCTTCA/GAAAAT 2 -- us2k10--------
    rs1487206141,2
    C--71398746(-) AGTAAC/TAATAA 2 -- us2k10--------
    rs759517331,2
    C--71398750(+) TGTTAC/TTGCAT 2 -- us2k11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for CCDC146 (76751751 - 76958850 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/25 variations for CCDC146 (see all 25):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675079CNV Deletion23128226
    esv2667964CNV Deletion23128226
    esv2734697CNV Deletion23290073
    esv2734696CNV Deletion23290073
    esv2664949CNV Deletion23128226
    esv2734692CNV Deletion23290073
    esv2734698CNV Deletion23290073
    esv2504283CNV Deletion19546169
    esv2734693CNV Deletion23290073
    dgv22n31CNV Duplication19718026

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CCDC146 for disorders           About MalaCards

    CCDC146 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CCDC146
    Human Genome Epidemiology (HuGE) Navigator: CCDC146 (1 document)

    Export disorders for CCDC146 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CCDC146 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CCDC146)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Genome-wide association study of d-amphetamine respons e in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). (PubMed id 22952603)1 Hart A.B....Palmer A.A. (2012)
    5. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1 Speliotes E.K....Loos R.J. (2010)
    6. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    7. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57639 HGNC: 29296 Ensembl:ENSG00000135205 euGenes: HUgn57639 ECgene: CCDC146
    H-InvDB: CCDC146

    (According to HUGE)
    About This Section
    HUGE: KIAA1505

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CCDC146 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CCDC146 gene:
    Search GeneIP for patents involving CCDC146

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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