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Aliases for CCDC146 Gene

Aliases for CCDC146 Gene

  • Coiled-Coil Domain Containing 146 2 3
  • KIAA1505 4

External Ids for CCDC146 Gene

Summaries for CCDC146 Gene

GeneCards Summary for CCDC146 Gene

CCDC146 (Coiled-Coil Domain Containing 146) is a Protein Coding gene. An important paralog of this gene is CFAP58.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC146 Gene

Genomics for CCDC146 Gene

Genomic Location for CCDC146 Gene

Start:
77,122,434 bp from pter
End:
77,329,533 bp from pter
Size:
207,100 bases
Orientation:
Plus strand

Genomic View for CCDC146 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC146 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC146 Gene

Regulatory Elements for CCDC146 Gene

Proteins for CCDC146 Gene

  • Protein details for CCDC146 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYE0-CC146_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 146
    Protein Accession:
    Q8IYE0
    Secondary Accessions:
    • A8K8X6
    • Q9P223

    Protein attributes for CCDC146 Gene

    Size:
    955 amino acids
    Molecular mass:
    112806 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA96029.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC146 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC146 Gene

Proteomics data for CCDC146 Gene at MOPED

Post-translational modifications for CCDC146 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC146 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC146 Gene

Domains for CCDC146 Gene

Protein Domains for CCDC146 Gene

ProtoNet:
genes like me logo Genes that share domains with CCDC146: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC146 Gene

Function for CCDC146 Gene

Gene Ontology (GO) - Molecular Function for CCDC146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CCDC146: view

miRNA for CCDC146 Gene

miRTarBase miRNAs that target CCDC146

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCDC146 Gene

Localization for CCDC146 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC146 Gene COMPARTMENTS Subcellular localization image for CCDC146 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCDC146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005814 centriole IDA 25074808
genes like me logo Genes that share ontologies with CCDC146: view

Pathways for CCDC146 Gene

SuperPathways for CCDC146 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC146 Gene

None

No data available for Pathways by source for CCDC146 Gene

Transcripts for CCDC146 Gene

mRNA/cDNA for CCDC146 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC146 Gene

Coiled-coil domain containing 146:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC146 Gene

No ASD Table

Relevant External Links for CCDC146 Gene

GeneLoc Exon Structure for
CCDC146
ECgene alternative splicing isoforms for
CCDC146

Expression for CCDC146 Gene

mRNA expression in normal human tissues for CCDC146 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCDC146 Gene

SOURCE GeneReport for Unigene cluster for CCDC146 Gene Hs.113940

genes like me logo Genes that share expressions with CCDC146: view

Orthologs for CCDC146 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC146 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC146 36
  • 99.51 (n)
  • 99.48 (a)
CCDC146 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC146 36
  • 89.91 (n)
  • 87.96 (a)
CCDC146 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC146 36
  • 88.67 (n)
  • 87.57 (a)
CCDC146 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc146 36
  • 80.04 (n)
  • 77.53 (a)
Ccdc146 16
Ccdc146 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC146 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC146 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc146 36
  • 79.89 (n)
  • 77.96 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 54 (a)
OneToMany
-- 37
  • 43 (a)
OneToMany
CCDC146 36
  • 60.96 (n)
  • 48.98 (a)
lizard
(Anolis carolinensis)
Reptilia CCDC146 37
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc146 36
  • 60.93 (n)
  • 51.24 (a)
zebrafish
(Danio rerio)
Actinopterygii ccdc146 36
  • 51.99 (n)
  • 40.85 (a)
ccdc146 37
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5882 37
  • 15 (a)
ManyToMany
CG6059 37
  • 14 (a)
ManyToMany
Ory 37
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
OneToOne
Species with no ortholog for CCDC146:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC146 Gene

ENSEMBL:
Gene Tree for CCDC146 (if available)
TreeFam:
Gene Tree for CCDC146 (if available)

Paralogs for CCDC146 Gene

Paralogs for CCDC146 Gene

Pseudogenes.org Pseudogenes for CCDC146 Gene

genes like me logo Genes that share paralogs with CCDC146: view

Variants for CCDC146 Gene

Sequence variations from dbSNP and Humsavar for CCDC146 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs8124 -- 77,295,101(+) TGAAT(C/T)GCTTA utr-variant-3-prime
rs718461 -- 77,204,193(+) AAGAA(C/T)ATGTG intron-variant
rs748629 -- 77,185,046(-) AGATA(A/G)TTATC intron-variant
rs876635 -- 77,207,072(-) AATGG(C/T)CTTTC intron-variant
rs880199 -- 77,206,404(+) TTGAG(G/T)TCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC146 Gene

Variant ID Type Subtype PubMed ID
essv14753 CNV CNV 17122850
dgv2104e1 CNV Complex 17122850
nsv428174 CNV Gain 18775914
dgv2106e1 CNV Complex 17122850
dgv233e55 CNV Loss 17911159
dgv22n31 CNV Duplication 19718026
dgv2108e1 CNV Complex 17122850
nsv526097 CNV Gain 19592680
dgv2109e1 CNV Complex 17122850
nsv831038 CNV Loss 17160897
esv34102 CNV Loss 18971310
nsv888508 CNV Gain 21882294
nsv8166 CNV Loss 18304495
esv2664949 CNV Deletion 23128226
esv26954 CNV Loss 19812545
nsv511380 CNV Loss 21212237
nsv8167 CNV Loss 18304495
esv2734692 CNV Deletion 23290073
esv2667964 CNV Deletion 23128226
esv2734693 CNV Deletion 23290073
esv2734696 CNV Deletion 23290073
esv2734697 CNV Deletion 23290073
esv2734698 CNV Deletion 23290073
esv2675079 CNV Deletion 23128226
esv2504283 CNV Deletion 19546169

Relevant External Links for CCDC146 Gene

HapMap Linkage Disequilibrium report
CCDC146

Disorders for CCDC146 Gene

Relevant External Links for CCDC146

Genetic Association Database (GAD)
CCDC146
Human Genome Epidemiology (HuGE) Navigator
CCDC146
genes like me logo Genes that share disorders with CCDC146: view

No data available for UniProtKB/Swiss-Prot for CCDC146 Gene

Publications for CCDC146 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. (PMID: 25074808) Firat-Karalar E.N. … Stearns T. (J. Cell Sci. 2014) 2 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for CCDC146 Gene

Sources for CCDC146 Gene

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