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Aliases for CCDC146 Gene

Aliases for CCDC146 Gene

  • Coiled-Coil Domain Containing 146 2 3 5
  • KIAA1505 4

External Ids for CCDC146 Gene

Previous GeneCards Identifiers for CCDC146 Gene

  • GC07P076590
  • GC07P076673
  • GC07P071399
  • GC07P076751

Summaries for CCDC146 Gene

GeneCards Summary for CCDC146 Gene

CCDC146 (Coiled-Coil Domain Containing 146) is a Protein Coding gene. An important paralog of this gene is CFAP58.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC146 Gene

Genomics for CCDC146 Gene

Regulatory Elements for CCDC146 Gene

Enhancers for CCDC146 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCDC146 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC146 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CCDC146 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCDC146 Gene

77,122,434 bp from pter
77,329,533 bp from pter
207,100 bases
Plus strand

Genomic View for CCDC146 Gene

Genes around CCDC146 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC146 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC146 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC146 Gene

Proteins for CCDC146 Gene

  • Protein details for CCDC146 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil domain-containing protein 146
    Protein Accession:
    Secondary Accessions:
    • A8K8X6
    • Q9P223

    Protein attributes for CCDC146 Gene

    955 amino acids
    Molecular mass:
    112806 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA96029.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC146 Gene


neXtProt entry for CCDC146 Gene

Proteomics data for CCDC146 Gene at MOPED

Post-translational modifications for CCDC146 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC146 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC146 Gene

Domains & Families for CCDC146 Gene

Protein Domains for CCDC146 Gene


Suggested Antigen Peptide Sequences for CCDC146 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC146: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC146 Gene

Function for CCDC146 Gene

genes like me logo Genes that share phenotypes with CCDC146: view

Animal Model Products

CRISPR Products

miRNA for CCDC146 Gene

miRTarBase miRNAs that target CCDC146

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC146 Gene

Localization for CCDC146 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC146 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized to only one centriole identified as the mother centriole by co-staining with CEP164. {ECO:0000269 PubMed:25074808}.

Subcellular locations from

Jensen Localization Image for CCDC146 Gene COMPARTMENTS Subcellular localization image for CCDC146 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
golgi apparatus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for CCDC146 Gene

Pathways & Interactions for CCDC146 Gene

SuperPathways for CCDC146 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CCDC146 Gene


No data available for Pathways by source and SIGNOR curated interactions for CCDC146 Gene

Drugs & Compounds for CCDC146 Gene

No Compound Related Data Available

Transcripts for CCDC146 Gene

mRNA/cDNA for CCDC146 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCDC146 Gene

Coiled-coil domain containing 146:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC146 Gene

No ASD Table

Relevant External Links for CCDC146 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CCDC146 Gene

mRNA expression in normal human tissues for CCDC146 Gene

Protein differential expression in normal tissues from HIPED for CCDC146 Gene

This gene is overexpressed in Platelet (42.0) and Uterus (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC146 Gene

SOURCE GeneReport for Unigene cluster for CCDC146 Gene Hs.113940

genes like me logo Genes that share expression patterns with CCDC146: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCDC146 Gene

Orthologs for CCDC146 Gene

This gene was present in the common ancestor of animals.

Orthologs for CCDC146 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC146 35
  • 89.91 (n)
  • 87.96 (a)
CCDC146 36
  • 88 (a)
(Canis familiaris)
Mammalia CCDC146 35
  • 88.67 (n)
  • 87.57 (a)
CCDC146 36
  • 88 (a)
(Mus musculus)
Mammalia Ccdc146 35
  • 80.04 (n)
  • 77.53 (a)
Ccdc146 16
Ccdc146 36
  • 74 (a)
(Pan troglodytes)
Mammalia CCDC146 35
  • 99.51 (n)
  • 99.48 (a)
CCDC146 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ccdc146 35
  • 79.89 (n)
  • 77.96 (a)
(Monodelphis domestica)
Mammalia CCDC146 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia CCDC146 36
  • 68 (a)
(Gallus gallus)
Aves CCDC146 35
  • 60.96 (n)
  • 48.98 (a)
-- 36
  • 54 (a)
-- 36
  • 43 (a)
(Anolis carolinensis)
Reptilia CCDC146 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc146 35
  • 60.93 (n)
  • 51.24 (a)
(Danio rerio)
Actinopterygii ccdc146 35
  • 51.99 (n)
  • 40.85 (a)
ccdc146 36
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5882 36
  • 15 (a)
CG6059 36
  • 14 (a)
Ory 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for CCDC146:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC146 Gene

Gene Tree for CCDC146 (if available)
Gene Tree for CCDC146 (if available)

Paralogs for CCDC146 Gene

Paralogs for CCDC146 Gene Pseudogenes for CCDC146 Gene

genes like me logo Genes that share paralogs with CCDC146: view

Variants for CCDC146 Gene

Sequence variations from dbSNP and Humsavar for CCDC146 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_050742 -
VAR_061583 -
VAR_061584 -
rs876635 -- 77,207,072(-) AATGG(C/T)CTTTC intron-variant
rs880199 -- 77,206,404(+) TTGAG(G/T)TCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC146 Gene

Variant ID Type Subtype PubMed ID
essv14753 CNV CNV 17122850
dgv2104e1 CNV Complex 17122850
nsv428174 CNV Gain 18775914
dgv2106e1 CNV Complex 17122850
dgv233e55 CNV Loss 17911159
dgv22n31 CNV Duplication 19718026
dgv2108e1 CNV Complex 17122850
nsv526097 CNV Gain 19592680
dgv2109e1 CNV Complex 17122850
nsv831038 CNV Loss 17160897
esv34102 CNV Loss 18971310
nsv888508 CNV Gain 21882294
nsv8166 CNV Loss 18304495
esv2664949 CNV Deletion 23128226
esv26954 CNV Loss 19812545
nsv511380 CNV Loss 21212237
nsv8167 CNV Loss 18304495
esv2734692 CNV Deletion 23290073
esv2667964 CNV Deletion 23128226
esv2734693 CNV Deletion 23290073
esv2734696 CNV Deletion 23290073
esv2734697 CNV Deletion 23290073
esv2734698 CNV Deletion 23290073
esv2675079 CNV Deletion 23128226
esv2504283 CNV Deletion 19546169

Variation tolerance for CCDC146 Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.78; 86.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CCDC146 Gene

Disorders for CCDC146 Gene

Relevant External Links for CCDC146

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CCDC146 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC146 Gene

Publications for CCDC146 Gene

  1. Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. (PMID: 25074808) Firat-Karalar E.N. … Stearns T. (J. Cell Sci. 2014) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). (PMID: 22952603) Hart A.B. … Palmer A.A. (PLoS ONE 2012) 3

Products for CCDC146 Gene

Sources for CCDC146 Gene