Aliases for CCDC146 Gene
External Ids for CCDC146 Gene
- HGNC: 29296
- Entrez Gene: 57639
- Ensembl: ENSG00000135205
- UniProtKB: Q8IYE0
Previous GeneCards Identifiers for CCDC146 Gene
- GC07P076590
- GC07P076673
- GC07P071399
- GC07P076751
Summaries for CCDC146 Gene
GeneCards Summary for CCDC146 Gene
CCDC146 (Coiled-Coil Domain Containing 146) is a Protein Coding gene. An important paralog of this gene is CFAP58.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC146 Gene
Genomics for CCDC146 Gene
Regulatory Elements for CCDC146 Gene
Enhancers for CCDC146 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH07G077245 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 11.7 | +123.4 | 123443 | 1.4 | ELF3 TBP MLX ARID4B DMAP1 THRB RAD21 RARA YY1 TCF12 | FGL2 CCDC146 LOC105375359 GC07M077229 |
| GH07G077154 | 1.2 | Ensembl ENCODE dbSUPER | 10.1 | +34.1 | 34117 | 3.4 | HDGF CTCF RFX1 MTA2 NR2F1 TRIM22 BMI1 CEBPG DPF2 ZBTB40 | FGL2 CCDC146 ENSG00000213542 SPDYE16 ZP3 GC07P077132 GC07M077197 |
| GH07G077247 | 0.8 | ENCODE | 10.6 | +125.0 | 124955 | 0.2 | CTCF PKNOX1 SAP130 ARID4B CEBPG ZNF644 RAD21 YY1 TEAD3 ZNF143 | FGL2 CCDC146 LOC105375359 ENSG00000250990 |
| GH07G077202 | 0.8 | ENCODE | 10.5 | +80.5 | 80518 | 1.8 | TBP PKNOX1 TBL1XR1 WRNIP1 RELA POLR2A EED RELB ETV6 CREM | CCDC146 FGL2 GC07M077229 |
| GH07G077192 | 0.8 | ENCODE | 10.4 | +70.5 | 70547 | 2.0 | TBL1XR1 BMI1 ZBTB40 YY1 CBX5 RELB ETV6 IKZF2 CREM JUNB | CCDC146 FGL2 GC07M077197 GC07P077132 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CCDC146 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CCDC146 gene promoter:
Regulatory Element Products
Genomic Location for CCDC146 Gene
- Chromosome:
- 7
- Start:
- 77,122,434 bp from pter
- End:
- 77,329,533 bp from pter
- Size:
- 207,100 bases
- Orientation:
- Plus strand
Genomic View for CCDC146 Gene
Genes around CCDC146 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q11.23 by Ensembl
- 7q11.23 by Entrez Gene
- 7q11.23 by HGNC
CCDC146 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CCDC146 Gene
Proteins for CCDC146 Gene
-
Protein details for CCDC146 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IYE0-CC146_HUMAN
- Recommended name:
- Coiled-coil domain-containing protein 146
- Protein Accession:
- Q8IYE0
- A8K8X6
- Q9P223
Protein attributes for CCDC146 Gene
- Size:
- 955 amino acids
- Molecular mass:
- 112806 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA96029.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for CCDC146 Gene
Post-translational modifications for CCDC146 Gene
Other Protein References for CCDC146 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CCDC146
- Novus Biologicals Antibodies for CCDC146
- Invitrogen Antibodies for CCDC146
- GeneTex CCDC146 antibody for CCDC146
Protein Products
-
OriGene Purified Proteins for CCDC146
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC146
- Origene Custom Protein Services for CCDC146
- Search GeneTex for Proteins for CCDC146
Assay Products
No data available for DME Specific Peptides for CCDC146 Gene
Domains & Families for CCDC146 Gene
Protein Domains for CCDC146 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for CCDC146 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for CCDC146 Gene
Function for CCDC146 Gene
Phenotypes for CCDC146 Gene
- GenomeRNAi human phenotypes for CCDC146:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCDC146
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CCDC146 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC146 gene
- Search ViGene Biosciences for CCDC146
CRISPR Products
-
OriGene CRISPR knockouts for CCDC146
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC146
- GenScript: Design CRISPR guide RNA sequences for CCDC146
miRNA for CCDC146 Gene
- miRTarBase miRNAs that target CCDC146
miRNA Products
- Search ViGene Biosciences for CCDC146
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCDC146
- Browse OriGene Inhibitory RNA Products For CCDC146
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC146 gene
Clone Products
-
OriGene ORF clones in human for CCDC146
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- VectorBuilder custom plasmid, inducible vectors for CCDC146
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC146
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CCDC146
-
ViGene Biosciences adenoviral particle packaged cDNA for CCDC146 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CCDC146 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC146 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC146 Gene
Localization for CCDC146 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CCDC146 Gene
- Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localized to only one centriole identified as the mother centriole by co-staining with CEP164. {ECO:0000269 PubMed:25074808}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 3 |
| cytosol | 2 |
| golgi apparatus | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005814 | centriole | IEA,IDA | 25074808 |
| GO:0005856 | cytoskeleton | IEA | -- |
Pathways & Interactions for CCDC146 Gene
No Data Available
Interacting Proteins for CCDC146 Gene
Selected Interacting proteins:
Q8IYE0-CC146_HUMAN
ENSP00000285871
for CCDC146 Gene via
UniProtKB
IID
STRING
No data available for Pathways by source and SIGNOR curated interactions for CCDC146 Gene
Transcripts for CCDC146 Gene
mRNA/cDNA for CCDC146 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CCDC146 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CCDC146
-
Santa Cruz Biotechnology (SCBT) CRISPR for CCDC146
- GenScript: Design CRISPR guide RNA sequences for CCDC146
miRNA Products
- Search ViGene Biosciences for CCDC146
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCDC146
- Browse OriGene Inhibitory RNA Products For CCDC146
-
ViGene Biosciences ready-to-package AAV shRNAs for CCDC146 gene
Clone Products
-
OriGene ORF clones in human for CCDC146
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CCDC146
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC146
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CCDC146 Gene
This gene is overexpressed in Platelet (42.0) and Uterus (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC146 Gene
NURSA nuclear receptor signaling pathways regulating expression of CCDC146 Gene:
CCDC146SOURCE GeneReport for Unigene cluster for CCDC146 Gene:
Hs.113940Evidence on tissue expression from TISSUES for CCDC146 Gene
- Lung(2.7)
Primer Products
-
OriGene qPCR primer pairs for CCDC146
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC146 Gene
Orthologs for CCDC146 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CCDC146 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CCDC146 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CCDC146 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Ccdc146 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ccdc146 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CCDC146 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CCDC146 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CCDC146 34 |
|
||
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | CCDC146 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ccdc146 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ccdc146 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Ory 35 |
|
ManyToMany | |
| CG5882 35 |
|
ManyToMany | |||
| CG6059 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for CCDC146 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CCDC146 Gene
Pseudogenes.org Pseudogenes for CCDC146 Gene
Variants for CCDC146 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000019615 | -- | 77,292,625(+) | AAAAA(A/T)AAAAA | intron-variant | |
| rs1000067358 | -- | 77,128,093(+) | AAACA(C/T)ACTGA | intron-variant | |
| rs1000085127 | -- | 77,286,508(+) | GACCC(A/C)AAATG | intron-variant | |
| rs1000150506 | -- | 77,184,700(+) | GAGCA(C/T)AGGAA | intron-variant | |
| rs1000188845 | -- | 77,230,309(+) | TCTTT(G/T)CTTTT | intron-variant |
Residual Variation Intolerance Score:
53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.78;
86.75% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CCDC146 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CCDC146
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC146 Gene
Disorders for CCDC146 Gene
Relevant External Links for CCDC146
No disorders were found for CCDC146 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC146 Gene
Publications for CCDC146 Gene
- Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. (PMID: 25074808) Firat-Karalar E.N. … Stearns T. (J. Cell Sci. 2014) 2 3 4 64
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
Products for CCDC146 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Custom Antibody ServicesOriGene Antibodies for CCDC146
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CCDC146
- Search Origene for MassSpec and Protein Over-expression Lysates for CCDC146
- Origene Custom Protein Services for CCDC146
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CCDC146
- Browse OriGene Inhibitory RNA Products For CCDC146
- OriGene qPCR primer pairs for CCDC146
- OriGene CRISPR knockouts for CCDC146
- OriGene ORF clones in human for CCDC146
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- GenScript: Design CRISPR guide RNA sequences for CCDC146
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- Novus Biologicals Antibodies for CCDC146
- Novus Biologicals proteins and lysates for CCDC146
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for CCDC146 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CCDC146 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CCDC146 gene
- Search ViGene Biosciences for CCDC146
- Horizon Cell Lines for CCDC146
- Cyagen custom Knockout/knockin (KOKI) mouse models for CCDC146
- VectorBuilder custom plasmid, inducible vectors for CCDC146
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CCDC146
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CCDC146 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer