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Aliases for CCDC142 Gene

Aliases for CCDC142 Gene

  • Coiled-Coil Domain Containing 142 2 3 5

External Ids for CCDC142 Gene

Previous GeneCards Identifiers for CCDC142 Gene

  • GC02M074555
  • GC02M074703
  • GC02M074436

Summaries for CCDC142 Gene

GeneCards Summary for CCDC142 Gene

CCDC142 (Coiled-Coil Domain Containing 142) is a Protein Coding gene.

Additional gene information for CCDC142 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC142 Gene

Genomics for CCDC142 Gene

Regulatory Elements for CCDC142 Gene

Enhancers for CCDC142 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H074528 1.2 ENCODE 22.3 -46.9 -46918 4 HDGF FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 ZNF143 LBX2 TTC31 CCDC142 PCGF1 DUSP11 MOB1A AUP1 MOGS MTHFD2 ENSG00000273245
GH02H074119 1.1 ENCODE 23.3 +363.0 363046 1 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 FNBP1P1 LOC107985899 PCGF1 CCDC142 WBP1 MRPL53 DUSP11 ENSG00000273245 TTC31 MTHFD2
GH02H074196 1.2 ENCODE 19.3 +284.7 284661 3 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 INO80B PCGF1 ENSG00000273245 DUSP11 WBP1 ALMS1 DGUOK-AS1 AUP1 SEMA4F TTC31
GH02H074575 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -93.7 -93681 3 PKNOX1 MAX CEBPG ZBTB40 BATF RAD21 GATA3 POLR2A EED ETV6 DOK1 LOXL3 HTRA2 AUP1 DQX1 TLX2 PCGF1 LBX2 CCDC142 TTC31
GH02H074583 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -100.5 -100545 1 MAFG BACH1 JUNB DPF2 BATF JUND ZNF316 POLR2A FOS NFE2 LOXL3 DOK1 HTRA2 AUP1 TLX2 PCGF1 CCDC142 TTC31 DQX1 LBX2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCDC142 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC142 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119170 508 1801 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766

Genomic Location for CCDC142 Gene

Chromosome:
2
Start:
74,471,986 bp from pter
End:
74,483,408 bp from pter
Size:
11,423 bases
Orientation:
Minus strand

Genomic View for CCDC142 Gene

Genes around CCDC142 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC142 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC142 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC142 Gene

Proteins for CCDC142 Gene

  • Protein details for CCDC142 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RM4-CC142_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 142
    Protein Accession:
    Q17RM4
    Secondary Accessions:
    • B7ZKV5
    • Q8NBJ3
    • Q8NBV2
    • Q96KA7

    Protein attributes for CCDC142 Gene

    Size:
    750 amino acids
    Molecular mass:
    81643 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11474.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC142 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC142 Gene

Post-translational modifications for CCDC142 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC142 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCDC142 Gene

Domains & Families for CCDC142 Gene

Gene Families for CCDC142 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CCDC142 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CCDC142 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CCDC142: view

No data available for UniProtKB/Swiss-Prot for CCDC142 Gene

Function for CCDC142 Gene

genes like me logo Genes that share phenotypes with CCDC142: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCDC142
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC142 Gene

Localization for CCDC142 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCDC142 gene
Compartment Confidence
extracellular 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CCDC142 Gene

Pathways & Interactions for CCDC142 Gene

SuperPathways for CCDC142 Gene

No Data Available

Interacting Proteins for CCDC142 Gene

Gene Ontology (GO) - Biological Process for CCDC142 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CCDC142 Gene

Drugs & Compounds for CCDC142 Gene

No Compound Related Data Available

Transcripts for CCDC142 Gene

Unigene Clusters for CCDC142 Gene

Coiled-coil domain containing 142:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CCDC142
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC142 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b
SP1: - - - -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7: - -
SP8:
SP9:

Relevant External Links for CCDC142 Gene

GeneLoc Exon Structure for
CCDC142
ECgene alternative splicing isoforms for
CCDC142

Expression for CCDC142 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCDC142 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC142 Gene



Protein tissue co-expression partners for CCDC142 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CCDC142 Gene:

CCDC142

SOURCE GeneReport for Unigene cluster for CCDC142 Gene:

Hs.430199

Evidence on tissue expression from TISSUES for CCDC142 Gene

  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with CCDC142: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCDC142 Gene

Orthologs for CCDC142 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC142 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC142 33 34
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia CCDC142 33 34
  • 84.75 (n)
cow
(Bos Taurus)
Mammalia CCDC142 33 34
  • 82.99 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc142 33
  • 76.65 (n)
mouse
(Mus musculus)
Mammalia Ccdc142 33 16 34
  • 76.14 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC142 34
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC142 34
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CCDC142 34
  • 21 (a)
OneToOne
Species where no ortholog for CCDC142 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC142 Gene

ENSEMBL:
Gene Tree for CCDC142 (if available)
TreeFam:
Gene Tree for CCDC142 (if available)

Paralogs for CCDC142 Gene

No data available for Paralogs for CCDC142 Gene

Variants for CCDC142 Gene

Sequence variations from dbSNP and Humsavar for CCDC142 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000023195 -- 74,479,770(+) TTTAA(G/T)TTTTG intron-variant
rs1000312320 -- 74,480,118(+) TCGAG(A/G)CAATG intron-variant
rs1000398231 -- 74,477,480(+) ATTTG(A/G)TGCCA intron-variant
rs1000687841 -- 74,479,254(+) CAAGA(A/C)ACTGT intron-variant
rs1000739746 -- 74,478,880(+) AACTA(A/G)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC142 Gene

Variant ID Type Subtype PubMed ID
esv2759061 CNV loss 17122850
nsv1127734 CNV deletion 24896259
nsv458185 CNV loss 19166990
nsv515851 CNV loss 19592680
nsv582214 CNV loss 21841781

Variation tolerance for CCDC142 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.99; 60.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC142 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC142

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC142 Gene

Disorders for CCDC142 Gene

Relevant External Links for CCDC142

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC142

No disorders were found for CCDC142 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC142 Gene

Publications for CCDC142 Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. [Novel bidirectional promoter from human genome]. (PMID: 21790010) Orekhova AS … Rubtsov PM (Molekuliarnaia biologiia 2011) 3 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for CCDC142 Gene

Sources for CCDC142 Gene

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