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Aliases for CCDC141 Gene

Aliases for CCDC141 Gene

  • Coiled-Coil Domain Containing 141 2 3
  • Coiled-Coil Protein Associated With Myosin II And DISC1 2 3 4
  • CAMDI 3 4
  • Coiled-Coil Domain-Containing Protein 141 3

External Ids for CCDC141 Gene

Previous GeneCards Identifiers for CCDC141 Gene

  • GC02M179407
  • GC02M179694
  • GC02M171562

Summaries for CCDC141 Gene

GeneCards Summary for CCDC141 Gene

CCDC141 (Coiled-Coil Domain Containing 141) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CCDC141 Gene

  • Plays a critical role in radial migration and centrosomal function.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC141 Gene

Genomics for CCDC141 Gene

Regulatory Elements for CCDC141 Gene

Genomic Location for CCDC141 Gene

Start:
178,829,757 bp from pter
End:
179,050,111 bp from pter
Size:
220,355 bases
Orientation:
Minus strand

Genomic View for CCDC141 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCDC141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC141 Gene

Proteins for CCDC141 Gene

  • Protein details for CCDC141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZP82-CC141_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 141
    Protein Accession:
    Q6ZP82
    Secondary Accessions:
    • H7C0P1
    • J3KNW6
    • Q8N8H3

    Protein attributes for CCDC141 Gene

    Size:
    1450 amino acids
    Molecular mass:
    166261 Da
    Quaternary structure:
    • Interacts with DISC1. Interacts preferentially with phosphorylated forms of myosin regulatory light chain (MRLC).
    SequenceCaution:
    • Sequence=AAI15379.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAX88845.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC04869.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04869.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=BAC85242.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC141 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC141 Gene

Proteomics data for CCDC141 Gene at MOPED

Post-translational modifications for CCDC141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC141 Gene

No data available for DME Specific Peptides for CCDC141 Gene

Domains for CCDC141 Gene

Gene Families for CCDC141 Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for CCDC141 Gene

Suggested Antigen Peptide Sequences for CCDC141 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZP82

UniProtKB/Swiss-Prot:

CC141_HUMAN :
  • Q6ZP82
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CCDC141: view

Function for CCDC141 Gene

Molecular function for CCDC141 Gene

UniProtKB/Swiss-Prot Function: Plays a critical role in radial migration and centrosomal function.

Gene Ontology (GO) - Molecular Function for CCDC141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0005515 protein binding IPI 12812986
genes like me logo Genes that share ontologies with CCDC141: view

miRNA for CCDC141 Gene

miRTarBase miRNAs that target CCDC141

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CCDC141 Gene

Localization for CCDC141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC141 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Co-localized with DISC1 at/around the centrosome. Localizes to the centrosome, at least in part, in a DISC1-dependent manner. {ECO:0000250 UniProtKB:A2AST1}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC141 Gene COMPARTMENTS Subcellular localization image for CCDC141 gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCDC141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA --
genes like me logo Genes that share ontologies with CCDC141: view

Pathways for CCDC141 Gene

SuperPathways for CCDC141 Gene

No Data Available

Interacting Proteins for CCDC141 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000395995%0d%0a9606.ENSP00000355593%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000299759%0d%0a
Selected Interacting proteins: ENSP00000395995 Q6ZP82-CC141_HUMAN for CCDC141 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for CCDC141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0021799 cerebral cortex radially oriented cell migration IEA --
GO:0051642 centrosome localization IEA --
genes like me logo Genes that share ontologies with CCDC141: view

No data available for Pathways by source for CCDC141 Gene

Transcripts for CCDC141 Gene

Unigene Clusters for CCDC141 Gene

Coiled-coil domain containing 141:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC141 Gene

No ASD Table

Relevant External Links for CCDC141 Gene

GeneLoc Exon Structure for
CCDC141
ECgene alternative splicing isoforms for
CCDC141

Expression for CCDC141 Gene

mRNA expression in normal human tissues for CCDC141 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC141 Gene

This gene is overexpressed in Heart - Left Ventricle (24.7) and Heart - Atrial Appendage (13.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CCDC141 Gene

SOURCE GeneReport for Unigene cluster for CCDC141 Gene Hs.324341

genes like me logo Genes that share expressions with CCDC141: view

No data available for mRNA Expression by UniProt/SwissProt for CCDC141 Gene

Orthologs for CCDC141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC141 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC141 35
  • 99.27 (n)
  • 98.67 (a)
CCDC141 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCDC141 36
  • 80 (a)
OneToOne
LOC530799 35
  • 85.23 (n)
  • 80.04 (a)
dog
(Canis familiaris)
Mammalia CCDC141 35
  • 87.21 (n)
  • 82.93 (a)
CCDC141 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc141 35
  • 80.1 (n)
  • 72.86 (a)
Ccdc141 16
Ccdc141 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CCDC141 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ccdc141 35
  • 79.77 (n)
  • 71.94 (a)
chicken
(Gallus gallus)
Aves CCDC141 35
  • 65.37 (n)
  • 54.44 (a)
CCDC141 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC141 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc141 35
  • 57.86 (n)
  • 46.49 (a)
zebrafish
(Danio rerio)
Actinopterygii CCDC141 (1 of 2) 36
  • 45 (a)
OneToMany
CCDC141 (2 of 2) 36
  • 29 (a)
OneToMany
si:dkeyp-122a11.1 35
  • 53.26 (n)
  • 42.49 (a)
Species with no ortholog for CCDC141:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC141 Gene

ENSEMBL:
Gene Tree for CCDC141 (if available)
TreeFam:
Gene Tree for CCDC141 (if available)

Paralogs for CCDC141 Gene

Selected SIMAP similar genes for CCDC141 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for CCDC141 Gene

genes like me logo Genes that share paralogs with CCDC141: view

No data available for Paralogs for CCDC141 Gene

Variants for CCDC141 Gene

Sequence variations from dbSNP and Humsavar for CCDC141 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs340330 -- 179,052,047(-) ttttc(A/G)ccgtc upstream-variant-2KB
rs340331 -- 179,051,445(-) TTGTT(C/G)CCTTC upstream-variant-2KB
rs340332 -- 179,050,711(-) GGTAA(A/C)AGCAA upstream-variant-2KB
rs340333 -- 179,050,667(-) ACTTG(A/G)AAACC upstream-variant-2KB
rs340334 -- 179,050,394(-) TGCAT(C/G)AGAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CCDC141 Gene

Variant ID Type Subtype PubMed ID
nsv834470 CNV Gain 17160897
nsv521818 CNV Loss 19592680
nsv3059 CNV Insertion 18451855
nsv875455 CNV Loss 21882294
nsv875456 CNV Loss 21882294
dgv4372n71 CNV Loss 21882294
dgv4373n71 CNV Loss 21882294
dgv4374n71 CNV Loss 21882294
esv270025 CNV Insertion 20981092
nsv508184 CNV Loss 20534489

Relevant External Links for CCDC141 Gene

HapMap Linkage Disequilibrium report
CCDC141

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC141 Gene

Disorders for CCDC141 Gene

Relevant External Links for CCDC141

Genetic Association Database (GAD)
CCDC141
Human Genome Epidemiology (HuGE) Navigator
CCDC141
genes like me logo Genes that share disorders with CCDC141: view

No data available for UniProtKB/Swiss-Prot for CCDC141 Gene

Publications for CCDC141 Gene

  1. CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration. (PMID: 20956536) Fukuda T. … Yanagi S. (J. Biol. Chem. 2010) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 48
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. (PMID: 12812986) Morris J.A. … Austin C.P. (Hum. Mol. Genet. 2003) 3

Products for CCDC141 Gene

  • antibodies-online peptides for CCDC141
  • antibodies-online antibodies for CCDC141
  • antibodies-online kits for CCDC141

Sources for CCDC141 Gene

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