CCDC141 Gene
protein-coding GIFtS : 45
GCID: GC02 M179694
coiled-coil domain containing 141
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Aliasesfor CCDC141 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Coiled-Coil Domain Containing 141 1 2 CAMDI1 2 FLJ395021 Coiled-Coil Domain-Containing Protein 1412 Coiled-Coil Protein Associated With Myosin II And DISC12
Export aliases for CCDC141 gene to outside databases Previous GC identifers: GC02M179407 GC02M171562
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Summariesfor CCDC141 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor CCDC141 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_005403.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CCDC141 gene promoter: GR SRY HSF2 GR-alpha LCR-F1 Pax-4a Nkx5-1 RORalpha2 FOXL1 Other transcription factors Search SABiosciences Chromatin IP Primers for CCDC141 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC141
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2q31.2 Ensembl cytogenetic band: 2q31.2 HGNC cytogenetic band: 2q31.2 CCDC141 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M179694: view genomic region
(about GC identifiers )
Start:
179,694,484 bp from pter
End:
179,914,813 bp from pter
Size:
220,330 bases
Orientation:
minus strand
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Proteinsfor CCDC141 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CC141_HUMAN, Q6ZP82 (See
protein sequence )Recommended Name: Coiled-coil domain-containing protein 141 Size : 875 amino acids; 100581 Da
Sequence caution : Sequence=AAX88845.1; Type=Erroneous gene model prediction; Sequence=BAC04869.1; Type=Erroneousinitiation; Note=Translation N-terminally extended; Sequence=BAC04869.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence;
Secondary accessions : Q8N8H3Alternative splicing : 2 isoforms : Q6ZP82-1 Q6ZP82-2 Explore the universe of human proteins at neXtProt for CCDC141: NX_Q6ZP82 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6ZP82 CCDC141 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_775919.3 ENSEMBL proteins: ENSP00000344627 ENSP00000390190 ENSP00000388745 ENSP00000386503 ENSP00000395995 ENSP00000295723 Human Recombinant Protein Products: CCDC141 Antibody Products: Assay Products for CCDC141:
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Protein
Domains / Familiesfor CCDC141 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CCDC141 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q6ZP82 ProtoNet protein and cluster: Q6ZP82
UniProtKB/Swiss-Prot: CC141_HUMAN, Q6ZP82 Similarity : Contains 1 Ig-like (immunoglobulin-like) domain
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Functionfor CCDC141 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC141 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC141OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CCDC141 (NM_173648 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC141 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCDC141
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC141
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
CCDC141 for ontologies About GeneDecksing
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Pathways & Interactionsfor CCDC141 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CCDC141 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for CCDC141 (Q6ZP82 1 , 3 ENSP00000344627 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor CCDC141 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CCDC141 Search CenterWatch for drugs/clinical trials and news about CCDC141 / CC141
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Transcriptsfor CCDC141 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CCDC141 gene: NM_173648.3 Unigene Cluster for CCDC141:
Coiled-coil domain containing 141 Hs.324341 [show with all ESTs ] Unigene Representative Sequence: NM_173648 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000472828 ENST00000480419 ENST00000343876 ENST00000443758 ENST00000446116 ENST00000409284 (uc002ung.3 ) ENST00000498142 ENST00000420890 (uc002une.2 )ENST00000295723 (uc002unf.1 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC141 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC141OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CCDC141 (NM_173648 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CCDC141 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCDC141
Additional cDNA sequence: AK096821.1 AK129847.1 AL832777.1 BC108697.1 BC115378.2 BX649042.1
7 DOTS entries : DT.91676964 DT.101981652
DT.91748373 DT.99946523 DT.100734763 DT.86856247 DT.95079038 24/29 AceView cDNA sequences (see all 29 ):
NM_173648 BU682794 AK129847 BF792795 CF552536 BF792488 BM723756 AA447398 BV182329 AL832777 BM480069 AL599223 BX096872 AL589419 BX502855 BX649042 CD172530 AA447397 AK096821 BX489839 BM679954 BF791356 BU431543 BF968135 GeneLoc Exon Structure
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Expression for CCDC141 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CCDC141 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image CCDC141 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See CCDC141 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CCDC141 SOURCE GeneReport for Unigene cluster: Hs.324341 SABiosciences Custom PCR Arrays for CCDC141 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CCDC141Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CCDC141 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CCDC141 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CCDC141 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC141
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Orthologsfor CCDC141 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for CCDC141 gene from 6/14 species (see all 14 ) About this table
ENSEMBL Gene Tree for CCDC141 (if available)TreeFam Gene Tree for CCDC141 (if available)
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Paralogsfor CCDC141 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CCDC141 gene 2 SIMAP similar genes for CCDC141 using alignment to 7 protein entries: CC141_HUMAN (see all proteins ):KIAA0992 MUSK
CCDC141 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for CCDC141 PGOHUM00000259770
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Genomic Variantsfor CCDC141 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 2 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CCDC141 (179694484 - 179914813 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for CCDC141 1 CNV : 4319
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CCDC141
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Disorders
/ Diseasesfor CCDC141 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CCDC141 for disorders About GeneDecksing 3 diseases for CCDC141 : About MalaCards essential hypertension hypertension schizophrenia Human Genome Epidemiology (HuGE) Navigator: CCDC141 (1 document)Export disorders for CCDC141 gene to outside databases
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Publicationsfor CCDC141 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CCDC141 gene integrated from 9 sources : (articles sorted by number of sources associating them with CCDC141) Utopia : connect your pdf to the dynamic world of online information
CAMDI, a Novel Disrupted in Schizophrenia 1 (DISC1)-b inding Protein, Is Required for Radial Migration. (PubMed id 20956536) 1 , 3 Fukuda T....Yanagi S. (2010) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175) 1 Ehret G.B....Chakravarti A. (2009) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 2 Hillier L.W....Wilson R.K. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. (PubMed id 12812986) 1 Morris J.A.... Austin C.P. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CCDC141 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CCDC141 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CCDC141 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CCDC141 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CCDC141 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CCDC141 gene: Search GeneIP for patents involving CCDC141 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CCDC141 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CCDC141 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CCDC141 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CCDC141 OriGene Protein Over-expression Lysate for CCDC141 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CCDC141 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC141 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CCDC141 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CCDC141 OriGene Custom Protein Services for CCDC141 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CCDC141 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CCDC141 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CCDC141 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CCDC141 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CCDC141 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CCDC141
Search Tocris compounds for CCDC141
CCDC141 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CCDC141
ThermoFisher Antibodies for CCDC141
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CCDC141
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Expression for CCDC141
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Genomic Views for CCDC141
Intellectual Property for CCDC141
Orthologs for CCDC141
Paralogs for CCDC141
Pathways / Interactions for CCDC141
Products for CCDC141
Proteins for CCDC141
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