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Aliases for CCDC141 Gene

Aliases for CCDC141 Gene

  • Coiled-Coil Domain Containing 141 2 3 5
  • Coiled-Coil Protein Associated With Myosin II And DISC1 2 3 4
  • CAMDI 3 4
  • Coiled-Coil Domain-Containing Protein 141 3

External Ids for CCDC141 Gene

Previous GeneCards Identifiers for CCDC141 Gene

  • GC02M179407
  • GC02M179694
  • GC02M171562

Summaries for CCDC141 Gene

GeneCards Summary for CCDC141 Gene

CCDC141 (Coiled-Coil Domain Containing 141) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding.

UniProtKB/Swiss-Prot for CCDC141 Gene

  • Plays a critical role in radial migration and centrosomal function.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCDC141 Gene

Genomics for CCDC141 Gene

Regulatory Elements for CCDC141 Gene

Enhancers for CCDC141 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CCDC141 on UCSC Golden Path with GeneCards custom track

Promoters for CCDC141 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CCDC141 Gene

Chromosome:
2
Start:
178,829,757 bp from pter
End:
179,050,118 bp from pter
Size:
220,362 bases
Orientation:
Minus strand

Genomic View for CCDC141 Gene

Genes around CCDC141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCDC141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCDC141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCDC141 Gene

Proteins for CCDC141 Gene

  • Protein details for CCDC141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZP82-CC141_HUMAN
    Recommended name:
    Coiled-coil domain-containing protein 141
    Protein Accession:
    Q6ZP82
    Secondary Accessions:
    • H7C0P1
    • J3KNW6
    • Q8N8H3

    Protein attributes for CCDC141 Gene

    Size:
    1450 amino acids
    Molecular mass:
    166261 Da
    Quaternary structure:
    • Interacts with DISC1. Interacts preferentially with phosphorylated forms of myosin regulatory light chain (MRLC).
    SequenceCaution:
    • Sequence=AAI15379.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAX88845.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC04869.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04869.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=BAC85242.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CCDC141 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCDC141 Gene

Post-translational modifications for CCDC141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCDC141 Gene

No data available for DME Specific Peptides for CCDC141 Gene

Domains & Families for CCDC141 Gene

Gene Families for CCDC141 Gene

Protein Domains for CCDC141 Gene

Suggested Antigen Peptide Sequences for CCDC141 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZP82

UniProtKB/Swiss-Prot:

CC141_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CCDC141: view

Function for CCDC141 Gene

Molecular function for CCDC141 Gene

UniProtKB/Swiss-Prot Function:
Plays a critical role in radial migration and centrosomal function.

Gene Ontology (GO) - Molecular Function for CCDC141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12812986
genes like me logo Genes that share ontologies with CCDC141: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCDC141 Gene

Localization for CCDC141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCDC141 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Co-localized with DISC1 at/around the centrosome. Localizes to the centrosome, at least in part, in a DISC1-dependent manner. {ECO:0000250 UniProtKB:A2AST1}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCDC141 Gene COMPARTMENTS Subcellular localization image for CCDC141 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CCDC141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA --
genes like me logo Genes that share ontologies with CCDC141: view

Pathways & Interactions for CCDC141 Gene

SuperPathways for CCDC141 Gene

No Data Available

Interacting Proteins for CCDC141 Gene

Gene Ontology (GO) - Biological Process for CCDC141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0021799 cerebral cortex radially oriented cell migration IEA --
GO:0051642 centrosome localization IEA --
genes like me logo Genes that share ontologies with CCDC141: view

No data available for Pathways by source and SIGNOR curated interactions for CCDC141 Gene

Drugs & Compounds for CCDC141 Gene

No Compound Related Data Available

Transcripts for CCDC141 Gene

Unigene Clusters for CCDC141 Gene

Coiled-coil domain containing 141:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCDC141 Gene

No ASD Table

Relevant External Links for CCDC141 Gene

GeneLoc Exon Structure for
CCDC141
ECgene alternative splicing isoforms for
CCDC141

Expression for CCDC141 Gene

mRNA expression in normal human tissues for CCDC141 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCDC141 Gene

This gene is overexpressed in Heart - Left Ventricle (x24.7) and Heart - Atrial Appendage (x13.0).

Protein differential expression in normal tissues from HIPED for CCDC141 Gene

This gene is overexpressed in CD4 Tcells (14.7), Liver, secretome (12.4), Fetal heart (10.7), Heart (10.5), and Monocytes (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CCDC141 Gene



NURSA nuclear receptor signaling pathways regulating expression of CCDC141 Gene:

CCDC141

SOURCE GeneReport for Unigene cluster for CCDC141 Gene:

Hs.324341
genes like me logo Genes that share expression patterns with CCDC141: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CCDC141 Gene

Orthologs for CCDC141 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCDC141 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC530799 34
  • 85.23 (n)
  • 80.04 (a)
CCDC141 35
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC141 34
  • 87.21 (n)
  • 82.93 (a)
CCDC141 35
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc141 34
  • 80.1 (n)
  • 72.86 (a)
Ccdc141 16
Ccdc141 35
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC141 34
  • 99.27 (n)
  • 98.67 (a)
CCDC141 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc141 34
  • 79.77 (n)
  • 71.94 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC141 35
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 50 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves CCDC141 34
  • 65.37 (n)
  • 54.44 (a)
CCDC141 35
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC141 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc141 34
  • 57.86 (n)
  • 46.49 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-122a11.1 34
  • 53.26 (n)
  • 42.49 (a)
CCDC141 (1 of 2) 35
  • 45 (a)
OneToMany
CCDC141 (2 of 2) 35
  • 29 (a)
OneToMany
Species where no ortholog for CCDC141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCDC141 Gene

ENSEMBL:
Gene Tree for CCDC141 (if available)
TreeFam:
Gene Tree for CCDC141 (if available)

Paralogs for CCDC141 Gene

(2) SIMAP similar genes for CCDC141 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for CCDC141 Gene

genes like me logo Genes that share paralogs with CCDC141: view

No data available for Paralogs for CCDC141 Gene

Variants for CCDC141 Gene

Sequence variations from dbSNP and Humsavar for CCDC141 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_047904 -
VAR_047905 -
VAR_047906 -
rs1027713 -- 178,992,039(-) CTTGA(A/G)AAATT intron-variant
rs1032833 -- 178,992,050(-) TTGGG(G/T)ACATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCDC141 Gene

Variant ID Type Subtype PubMed ID
esv3305748 CNV mobile element insertion 20981092
esv3435405 CNV insertion 20981092
esv3584197 CNV loss 25503493
esv3593495 CNV gain 21293372
esv3593496 CNV loss 21293372
esv3593498 CNV loss 21293372
esv3593499 CNV loss 21293372
esv3593500 CNV loss 21293372
esv3893509 CNV loss 25118596
nsv1000545 CNV gain 25217958
nsv1131532 CNV deletion 24896259
nsv3059 CNV insertion 18451855
nsv477711 CNV novel sequence insertion 20440878
nsv508184 CNV deletion 20534489
nsv521818 CNV loss 19592680
nsv583756 CNV loss 21841781
nsv834470 CNV gain 17160897

Variation tolerance for CCDC141 Gene

Gene Damage Index Score: 9.50; 88.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCDC141 Gene

Human Gene Mutation Database (HGMD)
CCDC141
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCDC141

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCDC141 Gene

Disorders for CCDC141 Gene

Relevant External Links for CCDC141

Genetic Association Database (GAD)
CCDC141
Human Genome Epidemiology (HuGE) Navigator
CCDC141
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCDC141

No disorders were found for CCDC141 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CCDC141 Gene

Publications for CCDC141 Gene

  1. CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration. (PMID: 20956536) Fukuda T. … Yanagi S. (J. Biol. Chem. 2010) 2 3 4 65
  2. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 46 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. (PMID: 24952745) Arking D.E. … Newton-Cheh C. (Nat. Genet. 2014) 3 65
  5. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PMID: 23583979) den Hoed M. … Loos R.J. (Nat. Genet. 2013) 3 65

Products for CCDC141 Gene

Sources for CCDC141 Gene

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